Lipid Peroxidation Research最新文献

Designating Vulnerability of Atherosclerotic Plaques 动脉粥样硬化斑块易损性的识别

Lipid Peroxidation Research Pub Date : 2019-12-04 DOI: 10.5772/intechopen.90664

B. Bilen

引用次数: 0

Role of Lipid Peroxidation Process in Neurodegenerative Disorders 脂质过氧化过程在神经退行性疾病中的作用

Lipid Peroxidation Research Pub Date : 2019-09-27 DOI: 10.5772/intechopen.81188

A. Muthuraman, N. Rishitha, N. Paramakrishnan, B. Mahendran, M. Ramesh

引用次数: 7

Royal Jelly and Human Interferon-Alpha (HuIFN-αN3) Affect Proliferation, Glutathione Level, and Lipid Peroxidation in Human Colorectal Adenocarcinoma Cells In Vitro 蜂王浆和人干扰素-α (HuIFN-αN3)对体外人结直肠癌细胞增殖、谷胱甘肽水平和脂质过氧化的影响

Lipid Peroxidation Research Pub Date : 2019-09-03 DOI: 10.5772/intechopen.85777

B. Filipič, L. Gradišnik, Klemen Rihar, A. Pereyra, Damir Đermić, H. Mazija

{"title":"Royal Jelly and Human Interferon-Alpha (HuIFN-αN3) Affect Proliferation, Glutathione Level, and Lipid Peroxidation in Human Colorectal Adenocarcinoma Cells In Vitro","authors":"B. Filipič, L. Gradišnik, Klemen Rihar, A. Pereyra, Damir Đermić, H. Mazija","doi":"10.5772/intechopen.85777","DOIUrl":"https://doi.org/10.5772/intechopen.85777","url":null,"abstract":"The purpose was to investigate the influence of RJ-F(M), 10-hydroxy-2-decenoic acid and HuIFN- α N3 on the proliferation of CaCo-2 cells and ascertain their effects on intracellular glutathione level and lipid peroxidation. The antiproliferative (AP) activity of RJ-F (M) (0.1 g/10 mL PBS), HuIFN- α N3 (1000 IU mL −1 ), 10-HDA (100.0 μmol L −1 ) and their combinations, in the ratios 1:1, 1:2, and 2:1 on CaCo-2 cells were measured. Single RJ-F (M) had a low AP activity: 2.0 (0.5 mg mL −1 ). HuIFN- α N3 had an AP activity of 2.5 (208.33 IU mL −1 ), while 10-HDA had an AP activity of 1.5 (37.5 μmol mL −1 ). AP activity of 3.8 was obtained when RJ-F(M) and HuIFN- α N3 were in the ratio 2:1. In it, the level of GSH was 24.9 ± 2.4 nmol g −3 of proteins (vs. 70.2 ± 3.2 nmol g −3 in the control), and level of MDA was 72.3 ± 3.1 nmol g −3 (vs. 23.6 ± 9.1 nmol g −3 in the control). 10-HDA, together with HuIFN- α N3, is responsible for the inhibition of CaCo-2 cell proliferation in vitro . RJ-F (M) and HuIFN- α N3 applied at 2:1 decreased level of GSH and increased lipid peroxidation via MDA in CaCo-2 cells. Future studies are needed whether these GSH- and MDA-related activities of RJ-F (M), HuIFN- α N3, 10-HDA, and their combinations may decrease the tumorigenicity index and tumorigenic potential of tumor cells in vitro","PeriodicalId":201791,"journal":{"name":"Lipid Peroxidation Research","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133214972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidants from Nigerian Medicinal Plants: What Are the Evidence? 来自尼日利亚药用植物的抗氧化剂:证据是什么?

Lipid Peroxidation Research Pub Date : 2019-07-08 DOI: 10.5772/intechopen.84454

Abubakar Babando Aliyu, Jonathan Ilemona Achika, Joseph Adesina Adewuyi, P. Gangas, H. Ibrahim, Adebayo Ojo Oyewale

{"title":"Antioxidants from Nigerian Medicinal Plants: What Are the Evidence?","authors":"Abubakar Babando Aliyu, Jonathan Ilemona Achika, Joseph Adesina Adewuyi, P. Gangas, H. Ibrahim, Adebayo Ojo Oyewale","doi":"10.5772/intechopen.84454","DOIUrl":"https://doi.org/10.5772/intechopen.84454","url":null,"abstract":"The search for natural antioxidants from plants would continue to be a dominant research interest for many years. This is because of the increasing understanding on the role of oxidative stress in damaging cell structures such as DNA, due to over production of free radicals and reactive oxygen species (ROS) in human systems, which are linked to inflammation, cancer and diabetes. However, phenolic compounds especially from phytochemicals or vegetable foods play important roles in reducing the risk of these diseases and reinforces the importance of natural antioxidants in human health. These antioxidant molecules neutralize or quench the ROS by either hydrogen atom transfer or single electron transfer mechanisms. Thus, the capacity to scavenge ROS and free radicals or inhibits lipid peroxidation is measured quantitatively as the strength of antioxidant activity. Several chemical and biochemical protocols have been used in the evaluation of plant extracts as antioxidants. Overwhelming literature reports have indicated varying degrees of antioxidant efficacies of extracts from Nigerian medicinal plants in comparison to synthetic antioxidants. These efficacies were analyzed to provide insight into the strength of antioxidant activity. This chapter reviewed 250 Nigerian medicinal plants in search of evidence for effective antioxidants.","PeriodicalId":201791,"journal":{"name":"Lipid Peroxidation Research","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116537375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Statins Alone or in Combination with Ezetimibe or PCSK9 Inhibitors in Atherosclerotic Cardiovascular Disease Protection 他汀类药物单用或联用依折麦布或PCSK9抑制剂对动脉粥样硬化性心血管疾病的保护作用

Lipid Peroxidation Research Pub Date : 2019-01-24 DOI: 10.5772/INTECHOPEN.82520

M. Vavlukis, Ana Vavlukis

{"title":"Statins Alone or in Combination with Ezetimibe or PCSK9 Inhibitors in Atherosclerotic Cardiovascular Disease Protection","authors":"M. Vavlukis, Ana Vavlukis","doi":"10.5772/INTECHOPEN.82520","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82520","url":null,"abstract":"Statins have proved to be very effective in reducing atherosclerotic cardiovascular disease (ASCVD) risk, with no apparent threshold at which low-density lipoprotein cholesterol (LDL-C) lowering is not associated with a reduced risk. Yet, several meta-analyses of statin trials show significant on-treatment residual risk of major cardiovascular (CV) events. This finding points to the unmet needs, in terms of LDL-C targets and ASCVD protection, of statin-treated patients, raising the question of statin combination therapy. Ezetimibe is a cholesterol absorption inhibitor, with the potency to decrease LDL-C for about 10–18%, apolipoprotein B (apoB) for 11–16%, while, in combination therapy with statins, leads to an additional LDL-C lowering of 25%, with a total LDL-C lowering of 34–61%. It is also estimated that 10–20% of patients on statin treatment cannot tolerate them. As a result, adequate doses to achieve treatment target, or as recommended for the patient-specific risk profile, cannot be prescribed. Proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibitors are monoclonal antibodies that inhibit the binding of PCSK9 to LDL-C receptors. Besides a very potent lipid-lowering effect, PCSK9 inhibitors have added ASCVD risk reduction benefit due to a very aggressive LDL-C lowering action, especially beneficial in patients who are intolerant to statins.","PeriodicalId":201791,"journal":{"name":"Lipid Peroxidation Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114160980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lipid Peroxidation in Meat and Meat Products 肉和肉制品中的脂质过氧化

Lipid Peroxidation Research Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81533

A. L. F. Pereira, V. K. G. Abreu

引用次数: 29