Pleural and Mediastinal Malignancies最新文献_第6页

Predictors of pleurodesis success 胸膜固定术成功的预测因素

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA2881

R. Mercer, N. Speck, H. Jeffries, J. Macready, N. Kanellakis, N. Maskell, J. Pepperell, T. Saba, A. West, N. Ali, Robert F. Miller, J. Corcoran, R. Asciak, Maged Hassan, R. Hallifax, I. Psallidas, N. Rahman

{"title":"Predictors of pleurodesis success","authors":"R. Mercer, N. Speck, H. Jeffries, J. Macready, N. Kanellakis, N. Maskell, J. Pepperell, T. Saba, A. West, N. Ali, Robert F. Miller, J. Corcoran, R. Asciak, Maged Hassan, R. Hallifax, I. Psallidas, N. Rahman","doi":"10.1183/13993003.CONGRESS-2018.PA2881","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA2881","url":null,"abstract":"Introduction: Patients with malignant pleural effusions (MPE) have a poor life expectancy and a high symptom burden. Definitive management strategies include chest drain and pleurodesis or placement of an indwelling pleural catheter. A meta analysis showed that 76% - 82% of patients had a successful pleurodesis with sterile talc. It has been postulated that patients who experience a greater inflammatory response or experience more pain are more likely to have a successful pleurodesis. Trapped lung is associated with a lower rate of pleurodesis success and it is thought that the number of previous interventions may be related to the development of trapped lung. Methods: A post hoc analysis from the TIME 1 trial was undertaken to establish the accuracy of these hypotheses. 320 patients were included who had a diagnosis of MPE. Results: There was a correlation between the number of previous ipsilateral aspirations and the incidence of trapped lung (p=0.015). Conclusion: Inflammation may play a factor in pleurodesis success as patients with a greater rise in CRP were more likely to have a successful pleurodesis. There is no evidence to support the hypothesis that patients who have more pain are more likely to have a successful pleurodesis. The correlation between the incidence of trapped lung and previous pleural interventions needs further study into whether or not there is a causal relationship.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89392005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and histological analysis of malignant mesothelioma - a comprehensive state-wide study 恶性间皮瘤的临床和组织学分析——一项全面的全国性研究

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2884

Nicola Pferdmenges, V. Krieg, A. Schulze, H. Kajueter, G. Evers, M. Mohr, L. Schmidt, H. Hense, O. Heidinger, R. Wiewrodt

{"title":"Clinical and histological analysis of malignant mesothelioma - a comprehensive state-wide study","authors":"Nicola Pferdmenges, V. Krieg, A. Schulze, H. Kajueter, G. Evers, M. Mohr, L. Schmidt, H. Hense, O. Heidinger, R. Wiewrodt","doi":"10.1183/13993003.congress-2018.pa2884","DOIUrl":"https://doi.org/10.1183/13993003.congress-2018.pa2884","url":null,"abstract":"Background: The cancer registry Northrhine-Westphalia (CR NRW) is state-law based, prospective cancer registry, including all state residents with the diagnosis of cancer (NRW counts approx. 18 million residents). Methods: All MM cases diagnosed and collected between 2010 and 2012 in CR NRW were included (n=1199). 232 cases contained incomplete datasets. In 755 of 967 valid cases (78.1%) the original pathology report was visible, in 468 cases (48.4%) including immunohistochemistry. Results: Of 967 patients with MM 796 were male (82.3%) and 171 female (17.7%), 81.8% were already diseased upon last validation date. Based on ICD-codes 885 patients (91.5%) suffered from pleural MM (C45.0), 72 (7.4%) had peritoneal MM, 2 (0.2%) pericardial MM and 8 (0.8%) had various MM locations. Histology showed predominantly epithelioid growing pattern (60.4%), followed by biphasic growth (13.4%) and sarcomatoid growth (9.4%); in 16.8% the growing pattern was not defined. Median overall survival (OS) of pleural MM was 12.4 months (95%KI 11.3-13.4; all histologies), OS of peritoneal MM was 15.1 months (95%KI 4.5-25.7; all histologies). Multivariate analysis revealed gender, age, histological subtype, cell specific growing features (spindle cell type; papillary type), necrosis, hyaline plaques and proliferation marker Ki67 as independent prognostic factors (p Conclusion: The comprehensive, state-law embedded cancer registry NRW ensures the complete area-wide identification and collection of cancer patients’ course out of 18 million residents. In this very large study MM cell specific growing features and proliferation index could be identified as new independent markers of MM outcome.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81534344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of outcomes from a regional Mesothelioma MDT against the National Lung Cancer Audit (NLCA) Mesothelioma standards 区域性间皮瘤MDT与国家肺癌审计(NLCA)间皮瘤标准结果的比较

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA2889

Maryam Ahmed, J. Lyons, S. Jackson, A. Sharman, M. Dixon, P. Taylor, J. Holme, M. Evison

{"title":"A comparison of outcomes from a regional Mesothelioma MDT against the National Lung Cancer Audit (NLCA) Mesothelioma standards","authors":"Maryam Ahmed, J. Lyons, S. Jackson, A. Sharman, M. Dixon, P. Taylor, J. Holme, M. Evison","doi":"10.1183/13993003.CONGRESS-2018.PA2889","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA2889","url":null,"abstract":"Background: Malignant mesothelioma (MM) is an incurable malignancy with a poor prognosis. In 2014, 43% of patients survived to one year following diagnosis in the UK. There is evidence of patient benefit from regional mesothelioma multidisciplinary team meetings1. The 2016 NLCA Pleural Mesothelioma report defined key recommendations for patients diagnosed with MM in England in 2014. Aims: To evaluate and compare outcomes of patients managed through the Greater Manchester Regional Mesothelioma MDT against the 2016 NLCA findings. Methods: Retrospective review of MM cases discussed at our MDT meeting between April 2016 and February 2018 using data from electronic MDT proformas. Results: Conclusions: Outcomes from our MDT are encouraging and may help build evidence in favour of regional mesothelioma MDTs. In particular, active treatment rates and ensuring equity of access to clinical research appears higher than national figures within this specialist service. References: 1. Bibby, Anna C et al. “What Is the Role of a Specialist Regional Mesothelioma Multidisciplinary Team Meeting? A Service Evaluation of One Tertiary Referral Centre in the UK.” BMJ Open 6.9 (2016): e012092.","PeriodicalId":20113,"journal":{"name":"Pleural and Mediastinal Malignancies","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88970520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytology, chest computed and positron emission tomography correlations in lung cancer malignant pleural effusion. 肺癌恶性胸腔积液的细胞学、胸部计算机和正电子发射断层扫描的相关性。

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2867

C. Brun, M. Cottier, G. Karpathiou, F. Barral, J. Vergnon, M. Froudarakis

引用次数: 0

Determinants of survival in patients with malignant pleural mesothelioma (MPM) managed at a single institution in Liguria, Italy 在利古里亚单一机构管理的恶性胸膜间皮瘤(MPM)患者生存的决定因素

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2880

A. Carletti, L. Benfatto, Vanna Balestracci, P. Canessa

引用次数: 0

Iodopovidone pleurodesis, diferent techniques, excellent efficacy in malignant pleural effusion.. Tanta University experience 碘聚维酮胸膜融合术，技术不同，治疗恶性胸腔积液疗效优异。坦塔大学经历

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA2885

R. Sharshar

引用次数: 1

Needle Based Confocal Laser Endomicroscopy (nCLE) for Diagnosing Malignant Pleural Mesothelioma 针基共聚焦激光内镜诊断恶性胸膜间皮瘤

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.OA496

L. Wijmans, M. Disselhorst, D. M. Bruin, J. Roelofs, O. Mets, P. Bonta, P. Baas, J. Annema

引用次数: 0

Pericardial and pleural metastases: clinical and histological differences 心包和胸膜转移:临床和组织学差异

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2874

G. Karpathiou, Mousa Mobarki, Sirine Hathroubi, M. Stachowicz, A. Patoir, O. Tiffet, M. Péoc'h, M. Froudarakis

引用次数: 0

Survival of patients with malignant pleural effusions: a three-year prospective self-experience study 恶性胸腔积液患者的生存率:一项为期三年的前瞻性自我体验研究

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2890

I. Novakov, Filip Sterev

引用次数: 0

Relationship between baseline metabolic 18F-FDG parameters and survival in malignant pleural mesothelioma: A single centre experience 恶性胸膜间皮瘤患者基线代谢18F-FDG参数与生存率的关系:单中心经验

Pleural and Mediastinal Malignancies Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa2888

Y. Kahya, Ç. Soydal, M. Yenigün, E. Ozkan, N. A. Tutkun, S. Enön, N. O. Kucuk, A. Cangır

引用次数: 0