PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.3311

Hafiz Waleed Khan, A. Arshad, Abdul Wahab Mir

引用次数: 0

SEMEN ANALYSIS; CORNER STONE IN EVALUATING INFERTILITY 精液分析;评估不孕症的基石

PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.6150

Aysha Khan, Zunera Shahbaz, S. Yousaf, Abeera Ahmed, F. Sana, F. Sana

{"title":"SEMEN ANALYSIS; CORNER STONE IN EVALUATING INFERTILITY","authors":"Aysha Khan, Zunera Shahbaz, S. Yousaf, Abeera Ahmed, F. Sana, F. Sana","doi":"10.51253/pafmj.v71i6.6150","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.6150","url":null,"abstract":"Objective: To study the patterns and distribution of various abnormal semen parameters in infertile males. \u0000Study Design: Cross sectional study. \u0000Place and Duration of Study: Department of Pathology, Combined Military Hospital, Karachi, from Nov 2019 to Oct 2020. \u0000Methodology: The study included 364 patients who presented with primary and secondary infertility. Consecutive convenient sampling was done. Semen analysis was performed using World Health Organization latest guidelines. Samples were categorized as normospermia, azoospermia, oligospermia, asthenozoospermia and necrospermia. \u0000Results: The study comprised of 364 samples of infertile males. Normal sperm count was observed in 317 (87%) males, azoospermia in 28 (7.6%) and oligospermia in 19 (5.2%) males. Low ejaculated volume and higher non-motile sperms were noted in oligospermia samples in comparison with normospermia samples. Asthenozoospermia was observed in 102 (28%) and oligoasthenospermia was noted in 15 (4.1%) samples. \u0000Conclusion: Good quality semen analysis is a corner stone to diagnose the cause of male infertility.Sperm concentration and motility are the important markers of normal male reproductive system and are related to each other.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91420370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CASE REPORT OF JUVENILE FORM OF METACHROMATIC LEUKODYSTROPHY 少年型异色性脑白质营养不良1例报告

PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.4362

Muhammad Mohsin Sajjad, Sidra Yousaf

引用次数: 0

THE IDEAL PROFILE (INCREASE IN B-LINES/DELTA B-LINES) ON LUNG ULTRASOUND FOR DIAGNOSING WEANING INDUCED PULMONARY EDEMA IN VENTILATED PATIENTS 肺超声诊断通气患者脱机所致肺水肿的理想轮廓(b线/ δ b线增加)

PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.5691

Ghulam Rasheed, Zahid Siddique Shad, Tooba Mehreen, Nusrat Kharadi, Moazma Ramzan, Azmat Abdullah, K. Abbas

{"title":"THE IDEAL PROFILE (INCREASE IN B-LINES/DELTA B-LINES) ON LUNG ULTRASOUND FOR DIAGNOSING WEANING INDUCED PULMONARY EDEMA IN VENTILATED PATIENTS","authors":"Ghulam Rasheed, Zahid Siddique Shad, Tooba Mehreen, Nusrat Kharadi, Moazma Ramzan, Azmat Abdullah, K. Abbas","doi":"10.51253/pafmj.v71i6.5691","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.5691","url":null,"abstract":"Objective: To ascertain the ideal number of B-lines on lung ultrasound for the diagnosis of weaning induced pulmonary edema in ventilated patients. \u0000Study Design: Prospective observational study. \u0000Place and Duration of Study: Department of Medicine, Shifa International Hospital, Islamabad, from Jan to Aug 2020. \u0000Methodology: All the patients over the age of 18 years who were on mechanical ventilation in a medical intensive care unit were included in the study. The patients were given spontaneous breathing trials as a protocol for weaning from mechanical ventilation. Lung ultrasound was performed on 4 points of anterior chest wall before and after spontaneous breathing trials. Before and after spontaneous breathing trials counting of B lines was done on ultrasound of lung and comparison of increase in B lines (Delta-B-lines) was done with reference diagnosis of weaning induced pulmonary edema diagnosed by intensivist who was blinded to the results of lung ultrasound. \u0000Results: The study included 42 patients including 23 (54.8%) men and 19 (45.2%) women. 14 cases failed spontaneous breathing trials. Seven cases (16.7%) had weaning induced pulmonary edema. Delta-B-lines ≥6 diagnosed weaning induced pulmonary edema with 100% accuracy. Out of the remaining seven patients with weaning failure but without weaning induced pulmonary edema, 6 (28.6%) had Delta-B-lines ≥6. The ultrasound lung technique had a 100% sensitivity profile to detect weaning induced pulmonary edema and a specificity of 77.78%. \u0000Conclusion: The study indicates that Delta-B-lines ≥6 diagnosed the weaning induced pulmonary edema with the best accuracy.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88976052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

EVALUATION OF CHONDROPROTECTIVE EFFECTS OF HYALURONIC ACID IN A RAT MODEL OF OSTEOARTHRITIS 透明质酸对骨关节炎大鼠模型软骨保护作用的评价

PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.3984

Noaman Ishaq, S. Ali, Muhammad Waqar Aslam Khan, Kulsoom Farhat, Nausheen Ata, Quratulain Mehdi

{"title":"EVALUATION OF CHONDROPROTECTIVE EFFECTS OF HYALURONIC ACID IN A RAT MODEL OF OSTEOARTHRITIS","authors":"Noaman Ishaq, S. Ali, Muhammad Waqar Aslam Khan, Kulsoom Farhat, Nausheen Ata, Quratulain Mehdi","doi":"10.51253/pafmj.v71i6.3984","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.3984","url":null,"abstract":"Objective: To evaluate the chondroprotective effects of hyaluronic acid in a rat model of osteoarthritis. \u0000Study Design: Laboratory based experimental study. \u0000Place and Duration of Study: Department of Pharmacology, Army Medical College, Rawalpindi, in alliance with National Institute of health, Islamabad and Department of Pathology, Army Medical College Rawalpindi, from Apr to Jun 2019. \u0000Methodology: Sixteen (16) rats of Sprague Dawley breed were procured in this study. Osteoarthritis was induced in right knee joint of rats by surgical resection of medial meniscus and anterior cruciate ligament. They were allocated into two (02) groups with eight (08) rats in both groups. Group-I was control group that was treated with 0.2 ml intra articular saline once weekly for four weeks. While group-II was treatment group that was intra particularly administered with 0.2ml hyaluronic acid once weekly for four weeks. One week after the last dosage, gait pattern of the animals was scored. Then animals were sacrificed and a part of proximal tibia was obtained for histopathologic analysis. \u0000Results: Mean gait score of control group and treatment group was 3.25 ± 0.707 and 1.00 ± 0.756 respectively with a statistically significant p-value of <0.001, while mean histopathological Modified Mankin score of control and treatment group was 11.5 ± 1.195 and 5.50 ± 1.195 respectively with a significant p-value of <0.001. \u0000Conclusion: Intra articular viscosupplementation of hyaluronic acid in rat model of osteoarthritis resulted in improved gait pattern and histopathology.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80951685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary Diagnosis of COVID-19 COVID-19唾液诊断

PAFMJ Pub Date : 2022-01-01 DOI: 10.51253/pafmj.v71i6.5498

Seema Shafiq, Asim Riaz

引用次数: 0

ENDOSCOPIC ENDONASAL DACRYOCYSTORHINOSTOMY: EXPERIENCE OF HUNDRED CASES 鼻内窥镜泪囊鼻腔造瘘术一百例体会

PAFMJ Pub Date : 2021-12-31 DOI: 10.51253/pafmj.v71i6.4251

M. Shahid, Muhammad Awais, Amjad Akram, Syed Abid hassan Naqvi, Omar Zafar, T. Malik

{"title":"ENDOSCOPIC ENDONASAL DACRYOCYSTORHINOSTOMY: EXPERIENCE OF HUNDRED CASES","authors":"M. Shahid, Muhammad Awais, Amjad Akram, Syed Abid hassan Naqvi, Omar Zafar, T. Malik","doi":"10.51253/pafmj.v71i6.4251","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.4251","url":null,"abstract":"Objective: To determine the success rate of Endonasal Endoscopic Dacryocystorhinostomy (Endo-DCR) in cases of chronic dacryocystitis secondary to primary acquired nasolacrimal duct obstruction (NLDO). \u0000Study Design: Quasi-experimental study. \u0000Place and Duration of Study: Department of Oculoplastic Surgery, Armed Forces Institute of Ophthalmology Rawalpindi, from Sep 2018 to Nov 2019. \u0000Methodology: Endo-DCR under General Anaesthesia was performed on 100 patients of primary acquired nasolacrimal duct obstruction causing chronic dacryocystitis. Post-operatively these patients were checked on first post-op day, then on one week and finally four months after surgery. We removed silicone tubes of all the patients four months after surgery. To ensure patency of lacrimal passage, we did syringing and irrigation of lacrimal system of all cases, at conclusion of the study. We chose absence of epiphora and patent lacrimal system on syringing as indicators of successful procedure. \u0000Results: Hundred patients (males 37; females 63) were recruited for this study. Mean age of our sample population was 51.1 ± 29 years. Right nasolacrimal duct obstruction cases were 56 whereas left nasolacrimal duct obstruction cases were 44. Subjective improvement i.e., absence of epiphora was found in 90% patients. We got successful irrigation of lacrimal passages (objective improvement) in 94% of patients. \u0000Conclusion: Endo-DCR yields comparable results to external Dacryocystorhinostomy (Ex DCR). It offers additional benefits of esthetically better outcome, lesser complication rate and short surgery and patient recovery time.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"285 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80257446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYTOGENETIC ANALYSIS OF PATIENTS WITH AMBIGUOUS GENITALIA 阴部不清患者的细胞遗传学分析

PAFMJ Pub Date : 2021-12-31 DOI: 10.51253/pafmj.v71i6.5007

S. Zaidi, A. Mahmood, Rafia Mahmood, A. Latif, H. Robert, Sarah Fatimah

{"title":"CYTOGENETIC ANALYSIS OF PATIENTS WITH AMBIGUOUS GENITALIA","authors":"S. Zaidi, A. Mahmood, Rafia Mahmood, A. Latif, H. Robert, Sarah Fatimah","doi":"10.51253/pafmj.v71i6.5007","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.5007","url":null,"abstract":"Objective: To determine the magnitude and classification of cases of ambiguous genitalia presenting to our setup. \u0000Study Design: Cross-sectional study. \u0000Place and Duration of Study: Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Aug 2018 to Feb 2019. \u0000Methodology: All the patients with ambiguous genitalia referred for cytogenetic analysis, were included in the study. The patients were subjected to a detailed history and physical examination. The record of radiological investigations was were obtained. Cytogenetic analysis was performed using the conventional G-banding technique. Hormonal testing included 17- hydroxyprogesterone (17-OHP) levels was also performed. \u0000Results: Fifty-one cases of ambiguous genitalia were studied. The median age was 15 months. Thirty-three patients (64.7%) had a 46XY karyotype, 17 (33.3%) had a 46XX karyotype while 1 (1.9%) had 45X/46, XY mosaic karyotype. Thirty patients (58.8%) were products of consanguineous marriage. Congenital adrenal hyperplasia was diagnosed in 12 cases (70.5%) of 46 XX karyotype and in 3 cases (9%) of 46XY karyotype. \u0000Conclusion: Ambiguous genitalia, currently categorized as disorders of sex development, are not uncommon in our populartion. Increased awareness and early diagnosis are crucial to prevent life threatening complications of congenital adrenal hyperplasia, to determine sex of rearing, and to counsel the parents or patients.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76244214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MATERNAL OUTCOMES OF PREGNANCY-RELATED ACUTE KIDNEY INJURY 妊娠相关性急性肾损伤的产妇结局

PAFMJ Pub Date : 2021-12-31 DOI: 10.51253/pafmj.v6i6.5813

I. Khattak, S. Khattak, Ayesha Imran, K. Kamal, Umair Yaqoob

{"title":"MATERNAL OUTCOMES OF PREGNANCY-RELATED ACUTE KIDNEY INJURY","authors":"I. Khattak, S. Khattak, Ayesha Imran, K. Kamal, Umair Yaqoob","doi":"10.51253/pafmj.v6i6.5813","DOIUrl":"https://doi.org/10.51253/pafmj.v6i6.5813","url":null,"abstract":"Objective: To determine the frequency of Pregnancy-related acute kidney injury in the Pakistani population and its effect on maternal health. \u0000Study Design: Cross-sectional study. \u0000Place and Duration of the Study: Department of Nephrology and Obstetrics and Gynecology, Combined Military Hospital Kharian, from Jan 2018 to Dec 2020. \u0000Methodology: All pregnant women with normal renal functions at the time of enrolment in the study and no previous history of any kidney disease or renal procedure in the recent past (at least 3 months) before conception were included in our study at Combined Military Hospital Kharian. All participants had serum creatinine tested at enrolment and were inquired specifically about any history of renal disease or any renal procedure in the recent past (at least 3 months old). \u0000Results: Mean maternal age in the study was 29 ± 7.67 years however it ranged from 16-41 years. Around a quarter of acute kidney injury cases occurred in the first and second trimesters combined, with 26 (12%) and 24 (11%) cases in the first and second trimesters, respectively. Thirty percent of acute kidney injury cases were diagnosed in the third trimester. A substantial number 58 (27%) of cases developed azotemia which persisted beyond three months and developed chronic kidney disease of various stages. Regarding maternal outcomes, 166 (77%) mothers recovered completely. However, 43 (20%) patients had some degree pf azotemia, a few cases required permanent renal replacement therapy. \u0000Conclusion: Acute kidney injury is a common problem in our community leading to suboptimal maternal outcomes..............","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87272593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPERIENCE OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-COV-2) - COVID-19 AT A TERTIARY CARE HOSPITAL IN QUETTA, BALUCHISTAN 在俾路支省奎达的一家三级保健医院治疗严重急性呼吸综合征冠状病毒-2 (sars-cov-2) - COVID-19的经验

PAFMJ Pub Date : 2021-12-31 DOI: 10.51253/pafmj.v71i6.6422

Naveed Asif, S. Satti, A. Younas, Mehwish Gilani, W. Shaikh, Q. Ain

{"title":"EXPERIENCE OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-COV-2) - COVID-19 AT A TERTIARY CARE HOSPITAL IN QUETTA, BALUCHISTAN","authors":"Naveed Asif, S. Satti, A. Younas, Mehwish Gilani, W. Shaikh, Q. Ain","doi":"10.51253/pafmj.v71i6.6422","DOIUrl":"https://doi.org/10.51253/pafmj.v71i6.6422","url":null,"abstract":"Objective: To share the experience of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-COVID-19 at a tertiary care hospital in Quetta, Baluchistan. \u0000Study Design: Cross-sectional study. \u0000Place and Duration of Study: Department of Pathology, Combined Military Hospital Quetta, from Mar to Dec 2020. \u0000Methodology: This study included 14,741 study participants presenting to CMH Quetta with signs and symptoms of Coronavirus Disease-19 (COVID-19) and others undergoing COVID-19 PCR for screening purpose. Nasopharyngeal swab collected from these study participants were tested for COVID-19 viral RNA by real-time Reverse Transcription Polymerase Chain reaction (RT-PCR) assay. \u0000Results: Out of these 14,741 study participants, 1886 (12.7%) were found to be SARS-CoV-2 PCR positive. Among 1886 study participants, 1503 (80%) were males while 383 (20%) were females. Mean age of the study participants was 36 ± 14 years. Most frequent clinical presentations were body aches (96.5%), fever (94.1%), cough (66.8%) and loss of appetite (68.2%). Around 67 (3.5%) positive study participants were asymptomatic. \u0000Conclusion: In this study, we observed male predominance but severity of signs and symptoms among female study participants. SARS-COVID-19 caused disease with wide range of clinical spectrum and disease can be fatal as well.","PeriodicalId":19982,"journal":{"name":"PAFMJ","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85281032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

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