Patologiya krovoobrashcheniya i kardiokhirurgiya最新文献

{"title":"Frequency and amplitude structure of ventricular fibrillation of canine heart during ischemia and reperfusion: an experimental study","authors":"M. Gurianov, E. Kharitonova, P. Yablonskiy","doi":"10.21688/1681-3472-2024-1-50-58","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-50-58","url":null,"abstract":"Introduction: Ventricular fibrillation (VF) is a fatal arrhythmia that causes sudden cardiac death in the overwhelming majority of cases (> 80%).Objective: The study was aimed to examine frequency and amplitude structure of VF upon canine heart reperfusion after ischemia within 30–240 s. Methods: Six experiments were conducted on 12 dogs. In each experiment the isolated heart of the one dog was perfused with the blood of the other (supporting) dog. Nine episodes of heart ischemia, lasting 30, 60, 90, 120, 150, 180, 210 and 240 s, were examined in six experiments (72 episodes of heart ischemia at VF in total). Before and after each ischemia episode, ten-minute perfusion and reperfusion were performed at VF, and heart electrograms were recorded. Spectral analysis of electrograms was conducted using Fast Fourier Transform in the range of 0.5–15 Hz. The frequency and proportions of the 1st through the 3rd oscillations of the most powerful frequencies were determined during perfusion, ischemia and reperfusion of the heart at VF (frequency (Hz) — mode; proportions (%) — M±SD; n = 270). Results: The frequency and proportions of the dominant oscillations were stable at perfusion and amounted to 9–10 Hz and 39–41%, respectively, without significant changes after 30-second ischemia (P = 0.09; P = 0.07) and 10-minute reperfusion (from P = 0.07 to P = 0.23; from P = 0.09 to P = 0.21). At the 2nd min of ischemia, the frequency of dominant oscillations decreased to 8.5–9.0  Hz (P = 0.009) but their proportions did not change significantly (P = 0.06). At the 3-4th min of ischemia, the frequency of dominant oscillations decreased to 5.0-7.5 Hz (P = 0.002), and their proportions reduced to 32-33% (P = 0.001). During reperfusion, after 1–2-minute ischemia, the frequency of the dominant oscillations increased to 10.5–12.0 Hz (P = 0.03 and P = 0.002) at the 1st min and decreased to 9.5–10.5 Hz (P = 0.01 and P = 0.009) at the 2nd min of reperfusion processes. After 3–4 minute ischemia, the frequency of dominant oscillations increased to 12.5–14.0 Hz (P = 0.001) at the 1st min and decreased to 10–11 Hz (P = 0.005 and P = 0.007) at the 2nd min of reperfusion processes. Further, the proportions of dominant oscillations after 1–2-minute ischemia decreased to 33–36% (P = 0.003 and P = 0.002) at the 1st min and increased to 39% (P = 0.005 and P = 0.001) at the 2nd min of reperfusion. After 3–4-minute ischemia, the proportion of dominant oscillations remained reduced (32–34%) at the 1st min but increased to 36–40% (P = 0.005 and P = 0.007) at the 2nd min during reperfusion.Conclusion: The organized VF activity was more sensitive to reperfusion than to ischemia, as evidenced by more significant changes in the VF frequency and amplitude structure at reperfusion relative to ischemia. VF was specified by explosive (impulse) destabilization of the organized activity at reperfusion, which manifested itself by an increase in the frequency of dominant FV oscillations at the 1st min","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"39 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote magnetic-guided navigation versus manual radiofrequency ablation approach in the interventional treatment of patients with atrial fibrillation and enlarged left atrium: propensity-score matching assessment","authors":"A. Romanov, V. Beloborodov, V. V. Shabanov, A. Filippenko, D.A. Elesin, V.A. Boboshko, S. Khrushchev, P. Ruzankin","doi":"10.21688/1681-3472-2024-1-59-72","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-59-72","url":null,"abstract":"Introduction: Pulmonary vein ostia isolation (PVI) is the main method for catheter ablation (CA) in patients with atrial fibrillation (AF) who are refractory to antiarrhythmic drug therapy (AAD). The data regarding comparison of the remote magnetic-guided navigation (RMN) and manual (MAN) radiofrequency ablation approaches for PVI in patients with AF and enlarged left atrium (LA) are limited.Objective: The study was aimed to comparison of the safety and long-term efficacy of the radiofrequency CA associated with RMN and MAN using in patients with AF and enlarged LA.Methods: The retrospective cohort included 534 patients (mean age 59.2 ± 8.7 years, 41.6% female) with different AF forms and LA >4.5 cm who underwent PVI between 2016 and 2019. The patients were divided into two groups: the RMN group (n = 267) and MAN group (n = 267). The primary safety objective was associated with preventing perisurgical complications, and the primary efficacy objective was disengagement from AF / atrial flutter (AFl) / AT (atrial tachycardia), lasting > 30 seconds, in the 3-month period after the index procedure without AAD. The comparison of the results with 1:1 propensity score matching (PSM) was applied on the basis of 11 covariates. After PSM, 235 patients were selected for each group. The entire cohort was additionally divided into the subgroups of paroxysmal AF (n = 355) and non-paroxysmal AF (n = 179) to increase efficacy assessment. After PSM, 310 and 136 patients with paroxysmal and non-paroxysmal AF were analyzed, respectively.Results: In the entire cohort after PSM (n = 470) patients were balanced completely according to AF forms. The mean values of LA diameter were 4.98 ± 0.61 cm and 4.94 ± 0.58 cm in the RMN and MAN groups, respectively. The long-term efficacy assessment was performed in 448 patients of the both groups excluding 22 (4.7%) patients due to failed contacts. The median follow-up period was 24 months (minimum 3 and maximum 72 months). In the matched cohorts, perisurgical complications were detected in 11 (4.7%) patients of the MAN group and 2 (0.9%) patients of the RMN group (Р = 0.021, OR = 5.7; 95% CI [1.22, 53.5]). The disengagement from AF/AFl/AT after 36 months of the follow up amounted to 62.6% in the RMN group and 47.9% in the MAN group (for entire follow up, P = 0.005, HR = 1.54; 95% CI [1.14, 2.08]). For paroxysmal AF subgroup (n = 310), the disengagement from AF/AFl/AT after 36 months of the follow was 67.1% in the RMN group and 60.6% in the MAN group (for entire follow up, P = 0.15, HR = 1.34; 95% CI [0.90, 1.98]). In the non-paroxysmal AF subgroup (n = 136), the disengagement from AF/AFl/AT after 36 months of the follow up was higher in the RMN group as compared to the MAN group (59.6% and 30.4%, respectively, for entire follow up, P = 0.005, HR = 2.01; 95% CI [1.23, 3.29]) predominantly due to persistent AF.Conclusion: The present propensity-score matching study evidentiated that RMN CA was superior over manual CA for the inter","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141127363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric oxide and mitochondria injuries in kidney tissue upon a simulation of cardiopulmonary bypass and circulatory arrest: an experimental study","authors":"A. Boyko, N.O. Kamenshchikov, A. G. Miroshnichenko, Y. Podoksenov, Y. Svirko, V. A. Lugovskiy, M. L. Diakova, I. V. Kravchenko, A. Mukhomedzyanov, L. N. Maslov, B. A. Bazarbekova, K. Petlin, D. Panfilov, B. N. Kozlov","doi":"10.21688/1681-3472-2024-1-41-49","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-41-49","url":null,"abstract":"Introduction: Surgical interventions under cardiopulmonary bypass and circulatory arrest are complicated by impaired microcirculation in tissues; during hypoxic period the mitochondria dysfunction becomes the leading pathogenetic factor of ischemia-reperfusion injuries. In this regard, the search for methods of organ protection seems to be an extremely urgent task. The using of nitric oxide can be a promising technique given its pluripotent properties.Objective: The study was aimed to examining of mitochondria injuries in kidney biopsies stipulated by cardiopulmonary bypass and circulatory arrest when simulating cardiac surgery, as well as to assessing the potentials of organ protection with nitric oxide in the experiment.Methods: The study was carried out on Altai breed sheep and included simulating of cardiopulmonary bypass and circulatory arrest. The first group (n = 6) was provided with intraoperative nitric oxide donation. The second group (n = 6) served as a control (without nitric oxide donation). Mitochondria injuries were assessed in kidney biopsies by measuring transmembrane potential and Ca2+-binding capacity of organelles, as well as by determining ATP and lactate concentrations.Results: Nitric oxide therapy was associated with less mitochondria dysfunction in kidney biopsies compared with the control group. There was a steady trend to the amelioration of the energy maintenance in the renal parenchyma in the nitric oxide donation group.Conclusion: A steady trend towards optimizing the energy supply of tissues under cardiopulmonary bypass and circulatory arrest was revealed in an experiment against the background of NO donation at a concentration of 80 ppm.\u0000Received 11 February 2024. Revised 28 March 2024. Accepted 29 March 2024.\u0000Funding: The The study was carried out within the framework of the state assignment “Protection of organs by nitric oxide in cardiovascular surgery: technological support (synthesis and delivery devices), mechanisms for implementing protective effects and impact on clinical outcomes” (topic No. 122123000017-3).\u0000Conflict of interest: The authors declare no conflict of interest.\u0000Contribution of the authors Conception and study design: A.M. Boyko, N.O. Kamenshchikov, Yu.K. Podoksenov, L.N. Maslov, B.N. Kozlov Data collection and analysis: A.M. Boyko, Yu.S. Svirko, V.A. Lugovskiy, A.V. Mukhomedzyanov, B.A. BazarbekovaStatistical analysis: I.V. KravchenkoDrafting the article: A.M. Boyko Critical revision of the article: N.O. Kamenshchikov, A.G. Miroshnichenko, Yu.K. Podoksenov, M.L. Diakova, K.A. Petlin, D.S. Panfilov, B.N. KozlovFinal approval of the version to be published: A.M. Boyko, N.O. Kamenshchikov, A.G. Miroshnichenko, Yu.K. Podoksenov, Yu.S. Svirko, V.A. Lugovskiy, M.L. Diakova, I.V. Kravchenko, A.V. Mukhomedzyanov, L.N. Maslov, B.A. Bazarbekova, K.A. Petlin, D.S. Panfilov, B.N. Kozlov","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"58 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trial sequential analysis in anesthesiology and intensive care: a systematic review","authors":"M. Yadgarov, L. Berikashvili, P. Polyakov, K. Kadantseva, A. Smirnova, I. Kuznetsov, A. Yakovlev, V. Likhvantsev","doi":"10.21688/1681-3472-2024-1-26-40","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-26-40","url":null,"abstract":"Introduction: The reliability of statistical analysis and its results is becoming a focal point in scientific discourse, overshadowing concerns about statistical significance. Systematic reviews and meta-analyses are characterized by a range of serious statistical and methodological limitations, including insufficient statistical power, clinical and statistical heterogeneity, systematic errors, potential low quality of included examinations, limited data availability, and publication bias. In this context, “Trial Sequential Analysis” (TSA) emerges as a promising methodological tool used in combination with meta-analyses to enhance the precision and robustness of scientific conclusions. Objective: The study is aimed to demonstrating potential scenarios for the using TSA and its role in improving the reliability of scientific conclusions through meta-analyses published in Russian journals on anesthesiology-resuscitation, as well as the authors’ own meta-analyses.Methods: This study is a systematic review without a detailed description of the case studies. The search for meta-analyses was conducted using the keywords “meta-analysis”, “mortality”, “delirium”, “sedation”. Two researchers independently reviewed the titles and abstracts of the selected meta-analyses and extracted data. TSA was conducted for all meta-analyses using “TSA software” (Copenhagen, Denmark). Results: 6 studies were considered, and 7 TSA evaluations were performed. Six out of the seven TSA evaluations confirmed the conclusions of the pertinent meta-analyses. In one TSA, the cumulative Z-line did not reach the required sample size, highlighting the need for additional studies to definitively confirm the result. In two TSAs, the sample size in the meta-analysis was insufficient to draw definitive conclusions. The application of TSA in these cases could provide more substantiated and cautious conclusions.Conclusion: This study explores various scenarios for the application of TSA in meta-analyses published in both Russian and international journals in the fields of anesthesiology and resuscitation. The significance of TSA for enhancing the validity and clinical relevance of research findings was substantiated.\u0000Received 3 February 2024. Revised 18 March 2024. Accepted 20 March 2024.\u0000Funding: The study did not have sponsorship.\u0000Conflict of interest: The authors declare no conflict of interest.\u0000Contribution of the authorsConception and study design: M.Ya. YadgarovData collection and analysis: M.Ya. Yadgarov, L.B. Berikashvili, P.A. PolyakovStatistical analysis: M.Ya. Yadgarov, P.A. PolyakovDrafting the article: M.Ya. Yadgarov, L.B. Berikashvili, K.K. Kadantseva, A.V. Smirnova, I.V. Kuznetsov, A.A. YakovlevCritical revision of the article: V.V. LikhvantsevFinal approval of the version to be published: M.Ya. Yadgarov, L.B. Berikashvili, P.A. Polyakov, K.K. Kadantseva, A.V. Smirnova, I.V. Kuznetsov, A.A. Yakovlev, V.V. Likhvantsev","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"7 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140716440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open mitral valve replacement with a balloon-expandable prosthesis using the valve-in-valve technique: a case report","authors":"V. Bazylev, A. Mikulyak, M. Shmatkov, I.Ya. Senzhapov, M.A. Denisov","doi":"10.21688/1681-3472-2024-1-19-25","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-19-25","url":null,"abstract":"Mitral defects are the most common acquired heart disturbances. The only radical treatment for severe valve stenosis or its insufficiency is surgical correction of the defects. The main challenge of implanting a mechanical mitral prosthesis is associated to its thrombosis complication that demands repeated surgical intervention on re-replacement of the mitral prosthesis. Herein, a clinical case of patient P. (58 years old) is presented, who was admitted to the Federal Center for Cardiovascular Surgery (Penza, Russia) with thrombosis of the mitral valve prosthesis and its dysfunction. The patient has already been undergone repeated surgery to replace the mitral valve. The purpose of the clinical case description is to demonstrate the using of open mitral valve replacement method based on the valve-in-valve technique with a transcatheter balloon-expandable prosthesis, its efficacy and safety.The considered method of treatment can simplify the main stage of the surgical intervention; reduce the time of artificial circulation and aortic clamping as well as the number of intraoperative complications. This type of surgical treatment can be considered as an option for re-prosthesis in patients at high surgical risk who are indicated for re-intervention due to impaired function of previously implanted heart valve prosthesis. A clinical case attests the possibility, efficacy and safety of using a balloon-expandable prosthesis for mitral valve replacement with the valve-in-valve technique upon repeated surgical interventions.\u0000Received 12 January 2024. Revised 16 February 2024. Accepted 19 February 2024.\u0000Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.\u0000Funding: The study did not have sponsorship.\u0000Conflict of interest: The authors declare no conflict of interest.\u0000Contribution of the authorsLiterature review: M.A. DenisovDrafting the article: I.Ya. SenzhapovCritical revision of the article: A.I. MikulyakSurgical treatment: V.V. Bazylev, M.G. ShmatkovFinal approval of the version to be published: V.V. Bazylev, A.I. Mikulyak, M.G. Shmatkov, I.Ya. Senzhapov, M.A. Denisov","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To 110th anniversary of cardiac surgeon and researcher Igor N. Meshalkin","authors":"I. Pchelina, A. M. Chernyavskiy","doi":"10.21688/1681-3472-2024-1-7-18","DOIUrl":"https://doi.org/10.21688/1681-3472-2024-1-7-18","url":null,"abstract":"Igor N. Meshalkin (1913–1996) was Soviet cardiac surgeon, Dr. Sci. (Medicine). He was a graduate of the 2nd Moscow State Medical Institute (2nd MSMI, now the N.I. Pirogov Russian National Research Medical University). He was a participant in the Great Patriotic War. Igor N. Meshalkin began his professional career as a medical resident and an assistant of the clinic of faculty surgery in the 2nd MSMI since 1947; then as a medical resident of the Main Military Hospital of the Armed Forces of the USSR since 1951 and an assistant of the general surgery department of the pediatric faculty in the 2nd MSMI since 1954. In 1958–1963, he headed the Department of Acquired Heart Diseases in the Institute of Experimental Biology and Medicine (now the E.N. Meshalkin National Medical Research Center). In 1963–1977, Igor N. Meshalkin was the head of the department in the Central Clinical Hospital of the 4th Main Directorate of the USSR Ministry of Health. His research interests were focused on urgent abdominal surgery, thoracic surgery, mitral stenosis surgery. Igor N. Meshalkin was the author of 55 scientific works including two monographs.\u0000Received 8 November 2023. Accepted 14 November 2023.\u0000Funding: The study did not have sponsorship.\u0000Conflict of interest: The authors declare no conflict of interest.\u0000Contribution of the authors: The authors contributed equally to this article.\u0000Acknowledgment: The authors would like to thank Marina, daughter of Igor N. Meshalkin, for providing personal documents and photographs.","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"1979 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140718880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predictors of abdominal complications after cardiac surgery: a prospective study","authors":"D. Belov, O.S. Abramovskikh, M.A. Zotova, Y. Loginova, A.A. Fokin","doi":"10.21688/1681-3472-2023-4-77-88","DOIUrl":"https://doi.org/10.21688/1681-3472-2023-4-77-88","url":null,"abstract":"Introduction: The prediction of postoperative abdominal complications is a continuing concern in the cardiac surgery. Identifying genetic predictors will allow a better understanding of the pathophysiological mechanisms underlying postoperative disorders and their prevention.Objective: To identify genetic predictors of abdominal complications after heart surgery.Methods: A prospective study was carried out at the Federal Center for Cardiovascular Surgery (Chelyabinsk) involving 72 patients with abdominal complications and 102 controls without such complications. The distribution of genotypes was assessed for adherence to the Hardy-Weinberg distribution using the exact method according to the SNP-HWE algorithm in the PLINK package (version 1.9). To identify marker genes associated with the risk of abdominal complications, 6 models were evaluated for each polymorphic gene: allelic, codominant, dominant, recessive, overdominant, and log-additive. To analyze the SNPs of the IL6 (rs1800795), TNF (rs1800629), and SERPINE1 (rs1799768) genes, real-time polymerase chain reaction (PCR) was performed on a Rotor-Gene 6000 detecting cycler (Corbett Research Pty Ltd., Mortlake, Australia) using primers and probes manufactured by Syntol CJSC (Moscow, Russia) according to the manufacturer's instructions. To analyze the SNPs of the IL1B (rs1143634), CXCL8 (rs4073), IL10 (rs1800872), APOE (rs429358), FABP2 (rs1799883), NOS3 (rs1799983), VEGFA (rs699947) genes, real-time PCR was performed on a DTprime 4 analyzer (DNA-Technology, Moscow, Russia) using primers and probes manufactured by TestGene LLC (Ulyanovsk, Russia) according to the manufacturer's instructions. The determination of the SNP of the TLR3 gene (rs3775291) relied on real-time PCR according to melting curves using TestGene LLC reagent kits on a DTprime 4 device.Results: Two genes, IL1B rs1143634 and FABP2 rs1799883, were found to be associated with the risk of abdominal complications. Following the adjustment for multiple comparisons, only FABP2 rs1799883 remained statistically significant. The rs1799883 polymorphism of the FABP2 gene can be considered a predictor of the risk of abdominal complications and can be evaluated within the codominant and dominant models, which exhibit similar p-values (0.003 and 0.002, respectively). Overall, the analysis of the obtained data suggests that the risk of abdominal complications is associated with the presence of the mutant allele C in the genome, likely due to its dominance. Specifically, in the dominant model, the odds ratio was 3.53 (95% CI 1.62 to 7.70).Conclusion: The most significant markers of the risk of abdominal complications were the IL1B (rs1143634) and FABP2 (rs1799883) genes, of which FABP2 (rs1799883) remained statistically significant after adjusting for multiple comparisons. Its polymorphism as a predictor of abdominal complications can be evaluated within the codominant and dominant models. Received 13 June 2023. Revised 28 November 2023. Accept","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E.N. Meshalkin scientific school of cardiac surgery in Siberia (To the 300th anniversary of the Russian Academy of Sciences)","authors":"I. V. Pchelina, A. M. Chernyavskiy","doi":"10.21688/1681-3472-2023-4-98-108","DOIUrl":"https://doi.org/10.21688/1681-3472-2023-4-98-108","url":null,"abstract":"This article presents historical milestones for E.N. Meshalkin scientific school of cardiac surgery. E.N. Meshalkin was corresponding member of the USSR Academy of Sciences and first director of Meshalkin National Medical Research Center. Publications by E.N. Meshalkin and his followers reflect the study of circulatory organ pathology, physiology, and regeneration, as well as the diagnosis and surgical treatment of heart defects and diseases, including hypothermia and cardiopulmonary bypass. Additionally, they cover methods of anesthesia in cardiac surgery, organ transplantation, and the creation of new equipment, as well as improvements in methods of hemodynamics research. Successors of E.N. Meshalkin scientific school combine high-tech medical care with fundamental research, development, and implementation of innovative diagnostic and treatment methods in cardiac surgery, oncology, neurosurgery, and related fields of medicine. Received 12 December 2023. Accepted 18 December 2023. Funding: The study did not have sponsorship. Conflict of interest: The authors declare no conflict of interest. Contribution of the authors: The authors contributed equally to this article.","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"97 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of spinal cord stimulation on a chronic model of atrial fibrillation in a mini-pig experiment","authors":"V. V. Shabanov, A. Filippenko, V. Beloborodov, T.U. Khalkhoghaev, V. Murtazin","doi":"10.21688/1681-3472-2023-4-43-51","DOIUrl":"https://doi.org/10.21688/1681-3472-2023-4-43-51","url":null,"abstract":"Introduction: Despite the advancement interventional methods for treating atrial fibrillation, the effectiveness of catheter ablation remains poor, especially in patients with persistent and long-persistent atrial fibrillation. Thus, experts continue to explore new treatments for this arrhythmia. The issue of experimental studies investigating the association between spinal cord stimulation and atrial fibrillation is mainly attributed to the lack of optimal algorithms for spinal cord stimulation in animal experiments. Therefore, it is important to develop adequate algorithms for spinal cord stimulation in the chronic model of atrial fibrillation.Objective: To evaluate the impact of spinal cord stimulation on the model of atrial fibrillation in mini-pigs.Methods: In a series of experiments, 6 (100%) successful implantations of electrodes and pacemakers, and spinal cord stimulation electrodes were performed. The electrodes were used to stimulate the atria, creating a model of atrial fibrillation, while the spinal cord stimulation was carried out using an electrode implanted into the spinal canal. During the experiment, an electrophysiological study was performed using an implanted pacemaker. The inducibility of atrial fibrillation was assessed before and after the experiment using various spinal cord stimulation algorithms.Results: There were no complications associated with surgery or stimulation of the atria and spinal cord. Spinal stimulation had a modeling effect on the autonomic nervous system, significantly changing the average heart rate, Wenckebach point, and effective refractory period. When comparing spinal stimulation algorithms, algorithm 1 was found to significantly reduce the atrial fibrillation inducibility.Conclusion: Spinal cord stimulation had a modeling effect on the autonomic nervous system, significantly changing the average heart rate, Wenckebach point, and effective refractory period. Inducibility of atrial fibrillation decreases with changes in the spinal pacing algorithm. Received 15 September 2023. Revised 30 October 2023. Accepted 31 October 2023. Funding: The study was supported by Russian Science Foundation (project No. 22-25-00672). Conflict of interest: The authors declare no conflict of interest. Contribution of the authorsConception and study design: A.G. Filippenko, V.V. Shabanov, V.I. MurtazinData collection and analysis: A.G. Filippenko, T.U. Khalkhoghaev, V.V. BeloborodovStatistical analysis: A.G. Filippenko, V.V. ShabanovDrafting the article: A.G. Filippenko, V.V. BeloborodovCritical revision of the article: V.V. ShabanovFinal approval of the version to be published: V.V. Shabanov, A.G. Filippenko, V.V. Beloborodov, T.U. Khalkhoghaev, V.I. Murtazin","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"79 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral allografts in tricuspid valve position in modern surgery of acquired heart defects: a systematic review","authors":"I. I. Skopin, M. Latyshev, D.V. Britikov","doi":"10.21688/1681-3472-2023-4-7-24","DOIUrl":"https://doi.org/10.21688/1681-3472-2023-4-7-24","url":null,"abstract":"Introduction: In severe recurrent infectious lesions in the right heart, one of the alternative options for bioprosthetics is to implant mitral allografts (donor heart valves) in the tricuspid valve position. Allografts offer numerous benefits, including a configuration that closely resembles a native valve, adaptability to high systemic pressure, absence of foreign elements that can could act as entry points for infections, and antibacterial treatment without lifelong anticoagulant therapy.Objective: To study the feasibility of using a mitral allograft in the tricuspid position based on the analysis of literature data and our own experience.Methods: Searches were conducted in Medline (PubMed), Google Scholar, and Russian Science Citation Index databases using search queries, keywords, and logical operators. The last session was conducted on December 21, 2022. In the initial selection of aforementioned search queries, a total of 4,446 results were obtained (Google Scholar — 3,080, Medline — 1,050, Russian Science Citation Index — 316). After analyzing titles and abstracts, 4,390 studies were excluded due to the insufficient data. Of the remaining studies, 25 scientific papers were excluded due to their duplication. The final group included 31 studies.Results: Based on a systematic literature review, the article presents aspects of the explantation, preparation, and implantation of the mitral allograft in the tricuspid position at the present stage of biotechnology development. The article highlights the main complications, rare clinical observations, and immediate and long-term postoperative results of mitral allograft implantation in the tricuspid position.Conclusion: This technique presents an interesting solution for patients with severe structural changes in the tricuspid valve, but further research is necessary at this stage of biotechnology development. Received 9 March 2023. Revised 7 September 2023. Accepted 11 September 2023. Funding: The study did not have sponsorship. Conflict of interest: The authors declare no conflict of interest. Contribution of the authors: The authors contributed equally to this article.","PeriodicalId":19853,"journal":{"name":"Patologiya krovoobrashcheniya i kardiokhirurgiya","volume":"69 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}