Pharmacy & Pharmacology International Journal最新文献_第3页

Analysis between the location of pharmacies and urban planning in Quitilipi, Chaco from the new economic geography 新经济地理学视角下查科基利皮市药店选址与城市规划的关系分析

Pharmacy & Pharmacology International Journal Pub Date : 2021-05-25 DOI: 10.15406/ppij.2021.09.00332

Gerardo Ariel Saez

引用次数: 0

Effect of artesunate and amodiaquine alone and in combination on plasma biochemical parameters in mice 青蒿琥酯与阿莫地喹单用及联用对小鼠血浆生化指标的影响

Pharmacy & Pharmacology International Journal Pub Date : 2021-05-03 DOI: 10.15406/PPIJ.2021.09.00330

James Abugri, VB Annam, BB Boamah, E. Armah

{"title":"Effect of artesunate and amodiaquine alone and in combination on plasma biochemical parameters in mice","authors":"James Abugri, VB Annam, BB Boamah, E. Armah","doi":"10.15406/PPIJ.2021.09.00330","DOIUrl":"https://doi.org/10.15406/PPIJ.2021.09.00330","url":null,"abstract":"Albino mice are considered a comparable genetic model to humans and it is well established that they also exhibit natural differences in susceptibility to malaria infection. The study was aimed at determining and comparing the effects of artesunate, artesunate+amodiaquine combination, on biochemical parameters such as plasma pH, plasma glucose and plasma cholesterol in the course of administering antimalarial drugs. The effects of artesunate, amodiaquine and a combination of artesunate-amodiaquine on some hematological and biochemical parameters were assessed in this study. Twenty albino mice of eight weeks old were randomly divided into 4 groups based on a specific antimalarial drug administered and one group served as control. Blood sample was obtained at the end of the study and assay was done for glucose concentration, plasma pH, and plasma cholesterol concentrations. Data were expressed as mean±standard errors of mean. Comparisons between control and treated groups of albino mice were performed with one-way analysis of variance (ANOVA), followed by Tukey Kramer post hoc test for multiple comparisons. Statistical significance was set at P<0.05. Plasma pH was not significantly lower (p<0.05) in the antimalarials; artesunate, amodiaquine and artesunate+amodiaquine groups compared to the control group. Plasma glucose was significantly lower in the antimalarials; Artesunate , artesunate+amodiaquine but higher in Amodiaquine compared to the control group. Plasma cholesterol was significantly lower (p<0.05) in the treated groups , Amodiaquine, artesunate+amodiaquine groups compared to the control group. Hence, maximum reduction was seen in the combination group compared to the individual drugs.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"131 1","pages":"77-79"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81039291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Creation of a novel triterpenoid drug that inhibits DNA synthesis 一种抑制DNA合成的新型三萜药物的发明

Pharmacy & Pharmacology International Journal Pub Date : 2021-04-28 DOI: 10.15406/ppij.2021.09.00329

P. Chan, Edward Mak

引用次数: 0

Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions 结核病防治突破:青蒿注射液疗效高

Pharmacy & Pharmacology International Journal Pub Date : 2021-04-23 DOI: 10.15406/PPIJ.2021.09.00328

Pascal Gisenya, Bati Daddy, P. Lutgen

{"title":"Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions","authors":"Pascal Gisenya, Bati Daddy, P. Lutgen","doi":"10.15406/PPIJ.2021.09.00328","DOIUrl":"https://doi.org/10.15406/PPIJ.2021.09.00328","url":null,"abstract":"Objective: The objective is to study in vivo the effect of the administration of Artemisia infusions as supplement in combination with the prescribed WHO treatment. Promising in vitro results needed to be confirmed in vivo before proceeding to larger scale clinical trials. Methods: A first pilot study was run with 5 patients using Artemisia afra infusions and a second one on 10 patients with Artemisia annua infusions. Over 15 days their fever, diurnal and nocturnal coughing, asthenia, Ziehl-Neelsen assay were monitored. Results: Artemisia afra infusions give faster symptoms resolution and healing. After 5 days all TB symptoms had disappeared whilst for Artemisia annua it took 10 days. The Ziehl-Neelsen assay was negative after 10 days for the Artemisia afra treatment and after 15 days for Artemisia annua. Conclusion: These observations on the administration of Artemisia infusions in combination with the conventional WHO treatment gave an astonishingly faster relief of the symptoms than conventional treatment alone. This could be a base to provide a potential natural and inexpensive therapy for TB treatment failure and resistance. More in vivo studies with a larger cohort are required to confirm our findings.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81045620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antioxidant activities of ethanolic extract of Annona muricata against different pro-oxidant induced lipid peroxidation in rat brain and liver 番荔枝醇提物对不同促氧化剂诱导的大鼠脑和肝脏脂质过氧化的抗氧化活性

Pharmacy & Pharmacology International Journal Pub Date : 2021-04-05 DOI: 10.15406/PPIJ.2021.09.00326

E. M. Ale, Adesola Oluwaseun Adeleye, O. Akinseye, Ebenezer Kayode Toluwalase

{"title":"Antioxidant activities of ethanolic extract of Annona muricata against different pro-oxidant induced lipid peroxidation in rat brain and liver","authors":"E. M. Ale, Adesola Oluwaseun Adeleye, O. Akinseye, Ebenezer Kayode Toluwalase","doi":"10.15406/PPIJ.2021.09.00326","DOIUrl":"https://doi.org/10.15406/PPIJ.2021.09.00326","url":null,"abstract":"Background and objective: Over the years, numerous works have documented the antioxidant potency of Annona muricata as well as it medicinal actions against myriad of ailments. However, there is still vague information as regard its antioxidant ability against diverse types of prooxidants. This work is carried out to deduce the antioxidant capacity of ethanol extract of A. muricata against different pro-oxidants in the cerebral and hepatic tissues of rats in in vitro models. Methods: Fresh leaves of A. muricata were washed, air-dried, pulverized and extracted with ethanol. Rats were euthanized and the tissues (brain and liver) were removed and homogenized in 50mM Tris-HCl, pH 7.4. The homogenates were centrifuged for 10min at 4000rpm to obtain a low-speed supernatant that was used for TBARS assay in the presence of extract and five different pro-oxidants; Iron (II) sulphate, hydrogen peroxide, 3-Nitropropionic acid, Sodium nitroprusside and quinolinic acid. Results: The results reveal that A. muricata extract displayed strong potency against lipid peroxidation in both the brain and liver tissue homogenates by inhibiting the production of thiobarbituric acid reactive substances irrespective of the prooxidant used. This polytropic antioxidant ability of A. muricata extract could be linked to its high polyphenolic content which confers on it, a strong redox property as well as a hydrogen donating power. This research therefore paves way for further investigation on the therapeutic actions of A. muricata in lipid peroxidation mediated ailments and diseases.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"271 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72748861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a pharmacist-managed warfarin dosing service in a community hospital 某社区医院药师管理华法林给药服务的评价

Pharmacy & Pharmacology International Journal Pub Date : 2021-03-23 DOI: 10.15406/PPIJ.2021.09.00324

Essie Samuel, S. Thomas, Kinjal Shah, Jonas Arthur

引用次数: 1

The pineal and thymus gland interaction on the immune system stimulation, through the melatonin hormone effect 松果体与胸腺相互作用对免疫系统产生刺激作用，通过褪黑激素发挥作用

Pharmacy & Pharmacology International Journal Pub Date : 2021-03-17 DOI: 10.15406/PPIJ.2021.09.00323

P. Anninos, A. Adamopoulos, N. Anninou, N. Tsagas

引用次数: 0

Safety and labelling in non-EU Countries 非欧盟国家的安全和标签

Pharmacy & Pharmacology International Journal Pub Date : 2021-03-15 DOI: 10.15406/PPIJ.2021.09.00322

Marjan Dzeparoski

引用次数: 0

Analysis of the application of biotechnological vaccines in immunology 生物技术疫苗在免疫学中的应用分析

Pharmacy & Pharmacology International Journal Pub Date : 2021-02-26 DOI: 10.15406/ppij.2021.09.00321

Оlga Y Makаrоvа

引用次数: 0

Association between body composition and genetic polymorphism of tumor necrosis factor alpha in women with breast cancer 乳腺癌患者体内肿瘤坏死因子α基因多态性与机体组成的关系

Pharmacy & Pharmacology International Journal Pub Date : 2021-02-11 DOI: 10.15406/PPIJ.2021.09.00320

R. Rosa, Débora Nascimento da Nóbrega

{"title":"Association between body composition and genetic polymorphism of tumor necrosis factor alpha in women with breast cancer","authors":"R. Rosa, Débora Nascimento da Nóbrega","doi":"10.15406/PPIJ.2021.09.00320","DOIUrl":"https://doi.org/10.15406/PPIJ.2021.09.00320","url":null,"abstract":"The change in body composition can affect the treatment of women who are undergoing treatment. The increase in body composition may present a state of chronic low-grade inflammation that is determined by the increase in fatty acids, produced by inflammatory cytokines such as Tumor Necrosis Factor (TNF-α), which has negative consequences for women with breast cancer. The study aimed to understand the association between body composition and inflammatory processes (TNF-α genetic polymorphism) in women with breast cancer. The research was developed through a literature review. The search was carried out in the SciElo, Pubmed, Lilacs and Google academic databases. 130 articles were found. The selected scientific texts were reduced to 11 for use in the review. There was a predominance of quantitative study design. The strategy used to search for studies were combinations of “oncology”, “polymorphisms”, “obesity”, “body composition” and “inflammatory process”. In the investigations of the high incidence of breast cancer in women and the inflammatory process activated by their own health conditions and treatment, the number of studies found was small. In all studies, the authors confirm that the TNF-α inflammatory process is a fundamental tool for planning cancer care. Future research is needed in order to analyze the habit of life and the environment that the individual is inserted to elucidate the association of altered body composition and breast cancer.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85719060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0