Pharmaceutica acta Helvetiae最新文献_第7页

Taste masking as a consequence of the organisation of powder mixes 由于粉末混合物的组织而造成的味道掩盖

Pharmaceutica acta Helvetiae Pub Date : 1999-12-01 Epub Date: 2000-01-14 DOI: 10.1016/S0031-6865(99)00013-8

J Barra, F Lescure , E Doelker

引用次数: 17

Synthesis and preliminary binding affinities of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine — a new arylpiperazine 新型芳基哌嗪- 1-(1,2-二氢-2-苊基)哌嗪的合成及初步结合亲和力

Pharmaceutica acta Helvetiae Pub Date : 1999-12-01 DOI: 10.1016/S0031-6865(99)00019-9

P. Srinivas, P. Brust, A. Subramanian, S. Raghavan, J. B. Rangisetty, C. Gupta, P. Parimoo

引用次数: 0

Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one 3-氨基-2-甲基巯基喹唑啉-4(3H)- 1 isatin衍生物Schiff和Mannich碱基的合成、抗菌、抗真菌和抗hiv评价

Pharmaceutica acta Helvetiae Pub Date : 1999-12-01 Epub Date: 2000-01-14 DOI: 10.1016/S0031-6865(99)00010-2

S.N. Pandeya , D. Sriram , G. Nath , E. De Clercq

引用次数: 226

Controlled release of diclofenac sodium from sodium alginate beads crosslinked with glutaraldehyde1 戊二醛交联海藻酸钠微球双氯芬酸钠的控释研究

Pharmaceutica acta Helvetiae Pub Date : 1999-12-01 Epub Date: 2000-01-14 DOI: 10.1016/S0031-6865(99)00015-1

Anandrao R Kulkarni, Kumaresh S Soppimath, Tejraj M Aminabhavi

引用次数: 123

Lipoprotein-mimicking biovectorized systems for methotrexate delivery 用于甲氨蝶呤输送的脂蛋白模拟生物载体系统

Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00002-3

Shelly Utreja, A.J Khopade, N.K Jain

{"title":"Lipoprotein-mimicking biovectorized systems for methotrexate delivery","authors":"Shelly Utreja, A.J Khopade, N.K Jain","doi":"10.1016/S0031-6865(99)00002-3","DOIUrl":"10.1016/S0031-6865(99)00002-3","url":null,"abstract":"<div>The present investigation reports a new family of lipid nanoparticles biomimetic of lipoproteins, lipoprotein-mimicking biovectorized systems (LMBVs), for the delivery of methotrexate. LMBVs were prepared by microemulsion congealing technique, and the composition and process were optimized. The palmitoylpolyethylene glycol 4000 (p-PEG 4000) was anchored on LMBVs as apoprotein analogue. Various formulations were prepared and characterized for size and polydispersity, zeta potential, drug entrapment efficiency, anchoring efficiency, release kinetics, pharmacokinetics and tissue distribution. The size was 70–76 nm and the polydispersity was 0.09–0.18. The zeta potential was −63.2 which was reduced to −19.3 after p-PEG 4000 coating. Entrapment efficiency varied from 22.6% to 30.2%. Anchoring efficiency was 74.0±3.9%. The drug release showed zero-order profile. Their circulation half-life was enhanced and exhibited capability to accumulate in tissues for longer periods. The composition of lipidic part of LMBVs and p-PEG 4000 anchoring impart similarity with natural lipoproteins in terms of in vivo behaviour. This new drug carrier named LMBVs, holds promise for targeting and systemic controlled release, which may prove effective in the treatment of various types of cancer.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 6","pages":"Pages 275-279"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00002-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21307310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Evaluation of two fat emulsion inlets for Baxa MM23® automated compounder Baxa MM23®自动合成机的两种脂肪乳液入口的评价

Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00006-0

Jean-Baptiste Rey, Dominique Combeau, Blandine Nouaille-Degorce, Françoise Brion

引用次数: 1

Index 指数

Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00011-4

引用次数: 0

Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers 不同乳化剂混合脂质乳剂配方的理化性质及溶血效果

Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00003-5

Muhannad Jumaa , Peter Kleinebudde , Bernd W Müller

{"title":"Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers","authors":"Muhannad Jumaa , Peter Kleinebudde , Bernd W Müller","doi":"10.1016/S0031-6865(99)00003-5","DOIUrl":"10.1016/S0031-6865(99)00003-5","url":null,"abstract":"<div>The purpose of this study was to elucidate the influence of ternary mixtures of different emulsifiers on the physicochemical properties of lipid emulsions by the aid of simplex lattice design with constraints. The physicochemical properties and the stability during the autoclaving process, as a consequent result, were investigated by examining the changes in particle size, zeta potential, and cloud point. The emulsifiers chosen were lecithin, Synperonic F68 and Tween 80. In addition, their potential for hemolysis was evaluated as it may serve as an in vitro toxicity screening method. The formulations with only Tween 80 as an emulsifier showed a noticeable change in the particle size during autoclaving as well as a remarkable erythrocyte membrane damage. In contrast, phospholipids and Synperonic F68 formulations displayed good stability during autoclaving and showed almost no hemolytic activity. Moreover, mixing Tween 80 with either lecithin or Synperonic F68 improved the stability of these formulations during the autoclaving process. Simultaneously, this led to a remarkable decrease in the hemolytic effect. This observation could be partially correlated with the cloud point, which increased by adding lecithin and was less influenced by adding Synperonic F68. This in turn resulted in an increase in the surface charge, when lecithin was added. This results in a higher resistance of the emulsifier complex to dehydration producing a more stable emulsifier film around the oil droplets. These factors inhibited the flocculation of the emulsifiers and could hinder the coalescence of the oil droplets during the autoclaving process.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 6","pages":"Pages 293-301"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00003-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90477363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Peptides and polypeptides as modulators of the immune response: thymopentin — an example with unknown mode of action 多肽和多肽作为免疫反应的调节剂:胸腺肽-一个作用方式未知的例子

Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00005-9

S Gonser, E Weber, G Folkers

{"title":"Peptides and polypeptides as modulators of the immune response: thymopentin — an example with unknown mode of action","authors":"S Gonser, E Weber, G Folkers","doi":"10.1016/S0031-6865(99)00005-9","DOIUrl":"10.1016/S0031-6865(99)00005-9","url":null,"abstract":"<div>Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. For example, antigenic peptides which can trigger a specific immunological response have been successfully used for vaccination. In contrast, cytokines have to be considered as rather non-specific immunomodulators. In addition, certain peptides with unknown mode of action have shown promising immunomodulating properties. An example is the pentapeptide thymopentin (TP5), which represents the active sequence of the originally described thymopoietin (TP). TP was recently identified as a fragment of the thymopoietins (TMPOs), a family of nuclear proteins. In vitro assays showed that TP5 affects the function of T cells and monocytes measured by enhanced cGMP level and the triggering of cellular signalling, respectively. In vivo studies demonstrated the capability of TP5 to improve an imbalanced immune system. TP5 exhibited important clinical features and further investigations on its mode of action are necessary to rationally create TP5 peptide analogs or peptidomimetics.</div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 6","pages":"Pages 265-273"},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00005-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21307309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

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Pharmaceutica acta Helvetiae Pub Date : 1999-06-01 Epub Date: 1999-07-19 DOI: 10.1016/S0031-6865(99)00012-6

引用次数: 0