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Excitatory amino acid receptors 兴奋性氨基酸受体
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00052-7
G Gaviraghi
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引用次数: 2
Receptors in neurodegenerative diseases, muscarinic cholinergic receptors 神经退行性疾病的受体，毒蕈碱胆碱能受体
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00025-4
Piero Angeli
{"title":"Receptors in neurodegenerative diseases, muscarinic cholinergic receptors","authors":"Piero Angeli","doi":"10.1016/S0031-6865(99)00025-4","DOIUrl":"10.1016/S0031-6865(99)00025-4","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 131-134"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00025-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21659454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Metabotropic glutamate receptors: a structural view point 代谢性谷氨酸受体:结构观点
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00055-2
Roberto Pellicciari, Gabriele Costantino, Antonio Macchiarulo
{"title":"Metabotropic glutamate receptors: a structural view point","authors":"Roberto Pellicciari, Gabriele Costantino, Antonio Macchiarulo","doi":"10.1016/S0031-6865(99)00055-2","DOIUrl":"10.1016/S0031-6865(99)00055-2","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 231-237"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00055-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21659339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Hijacked receptors 被劫持的受体
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00054-0
David J Triggle
{"title":"Hijacked receptors","authors":"David J Triggle","doi":"10.1016/S0031-6865(99)00054-0","DOIUrl":"10.1016/S0031-6865(99)00054-0","url":null,"abstract":"<div><p>Pharmacological receptors are typically defined by their selectivity of ligand recognition, including where appropriate stereoselectivity of interaction. It is increasingly clear that receptors may, in fact, be promiscuous species. This promiscuity arises at several levels of organization: two appear to be of particular importance. A given ligand–receptor complex may couple with different effectors and may generate quite different physiological responses: this is particularly common, although not uniquely so, for G protein-coupled receptors. Or a single receptor may recognize fundamentally different ligands often of significantly different characteristics: a number of viruses gain entry to cells through their interaction at receptors for neurotransmitters, peptides or hormones.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 287-290"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00054-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21659960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cholinergic receptors and neurodegenerative diseases 胆碱能受体与神经退行性疾病
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00021-7
Fulvio Gualtieri
{"title":"Cholinergic receptors and neurodegenerative diseases","authors":"Fulvio Gualtieri","doi":"10.1016/S0031-6865(99)00021-7","DOIUrl":"10.1016/S0031-6865(99)00021-7","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 85-89"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00021-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21660174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Pharmacological evidence of muscarinic receptor heterodimerization 毒蕈碱受体异二聚化的药理学证据
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00041-2
S Chiacchio, M Scarselli, M Armogida, R Maggio
{"title":"Pharmacological evidence of muscarinic receptor heterodimerization","authors":"S Chiacchio,&nbsp;M Scarselli,&nbsp;M Armogida,&nbsp;R Maggio","doi":"10.1016/S0031-6865(99)00041-2","DOIUrl":"10.1016/S0031-6865(99)00041-2","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 315-326"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00041-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21660308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Constitutive activity of G protein coupled receptors and drug action G蛋白偶联受体的组成活性与药物作用
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00042-4
Rob Leurs, Maria Sol Rodriguez Pena, Remko A Bakker, Astrid E Alewijnse, Henk Timmerman
{"title":"Constitutive activity of G protein coupled receptors and drug action","authors":"Rob Leurs,&nbsp;Maria Sol Rodriguez Pena,&nbsp;Remko A Bakker,&nbsp;Astrid E Alewijnse,&nbsp;Henk Timmerman","doi":"10.1016/S0031-6865(99)00042-4","DOIUrl":"10.1016/S0031-6865(99)00042-4","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 327-331"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00042-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21660309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
New dimensions in G protein signalling: Gβ5 and the RGS proteins G蛋白信号传导的新维度:Gβ5和RGS蛋白
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00043-6
William F Simonds, Jian-Hua Zhang
{"title":"New dimensions in G protein signalling: Gβ5 and the RGS proteins","authors":"William F Simonds,&nbsp;Jian-Hua Zhang","doi":"10.1016/S0031-6865(99)00043-6","DOIUrl":"10.1016/S0031-6865(99)00043-6","url":null,"abstract":"<div><p><span>The βγ complex of G-proteins regulates effectors independently of the Gα subunits, such that upon activation G proteins give may signal downstream along one or both pathways. The Gβ</span><sub>5</sub> isoform exhibits much less homology with other Gβ isoforms (∼50%) and is preferentially expressed in brain. The Gβ<sub>5</sub><span> isoform exhibits novel properties in its activation of effector pathways such as MAPK, phospholipase C-β, and adenylyl cyclase type II when compared to Gβ</span><sub>1</sub>. Recently specific native complexes between Gβ5 and the regulator of G protein signaling (RGS) protein-7 (RGS7) and between Gβ<sub>5</sub><span>L (a splice variant with a 42 amino acid N-terminal extension) and RGS9 have been isolated from different retinal fractions. Such findings are not accounted for by current models as only the Gα subunits and not Gβ had been previously implicated in RGS protein function. These recent novel observations further reinforce the view of Gβ</span><sub>5</sub> as a unique and highly specialized G protein subunit.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 333-336"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00043-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21660310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications 兴奋性氨基酸激动剂和拮抗剂:药理学和治疗应用
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00053-9
D.G Trist
{"title":"Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications","authors":"D.G Trist","doi":"10.1016/S0031-6865(99)00053-9","DOIUrl":"10.1016/S0031-6865(99)00053-9","url":null,"abstract":"<div><p><span><span><span>Glutamic acid is the major excitatory </span>neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as </span>ionotropic receptors<span><span>. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical specific agonist activation, selective </span>competitive antagonists together with their structural heterogeneity. These receptors have thus been named </span></span><em>N</em>-methyl-<span>d</span><span><span><span>-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainate receptors. The NMDA receptor has sites in addition to its agonist-binding site and these seem to either positively or negatively modulate the agonist effect. The NMDA receptor also is unique in that another amino acid, glycine, acts as a co-agonist with glutamate. Changes in glutamate transmission have been associated with a number of CNS pathologies; these include, acute stroke, chronic neurodegeneration, chronic pain, depression, drug dependency, </span>epilepsy, </span>Parkinson's Disease and schizophrenia.</span></p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 221-229"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00053-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21659338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 68
Neurotrophin receptor structure and interactions 神经营养因子受体结构和相互作用
Pharmaceutica acta Helvetiae Pub Date : 2000-03-01 DOI: 10.1016/S0031-6865(99)00036-9
Hiroko Yano, Moses V Chao
{"title":"Neurotrophin receptor structure and interactions","authors":"Hiroko Yano,&nbsp;Moses V Chao","doi":"10.1016/S0031-6865(99)00036-9","DOIUrl":"10.1016/S0031-6865(99)00036-9","url":null,"abstract":"","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"74 2","pages":"Pages 253-260"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(99)00036-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21659955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 109
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