Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy最新文献

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Cost‐Effectiveness Analysis of Second‐Line Chemotherapy Agents for Advanced Gastric Cancer 晚期胃癌二线化疗药物的成本-效果分析
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1870
S. Lam, Maya Wai, J. Lau, M. Mcnamara, M. Earl, B. Udeh
{"title":"Cost‐Effectiveness Analysis of Second‐Line Chemotherapy Agents for Advanced Gastric Cancer","authors":"S. Lam, Maya Wai, J. Lau, M. Mcnamara, M. Earl, B. Udeh","doi":"10.1002/phar.1870","DOIUrl":"https://doi.org/10.1002/phar.1870","url":null,"abstract":"Gastric cancer is the fifth most common malignancy and second leading cause of cancer‐related mortality. Chemotherapy options for patients who fail first‐line treatment are limited. Thus the objective of this study was to assess the cost‐effectiveness of second‐line treatment options for patients with advanced or metastatic gastric cancer.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81648634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Managing the Rising Costs and High Drug Expenditures in Critical Care Pharmacy Practice 管理成本上升和高药费在重症药学实践
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1862
Alexander H. Flannery, Komal Pandya, Melanie E. Laine, Philip J. Almeter, J. Flynn
{"title":"Managing the Rising Costs and High Drug Expenditures in Critical Care Pharmacy Practice","authors":"Alexander H. Flannery, Komal Pandya, Melanie E. Laine, Philip J. Almeter, J. Flynn","doi":"10.1002/phar.1862","DOIUrl":"https://doi.org/10.1002/phar.1862","url":null,"abstract":"Pharmaceutical costs for patients in the intensive care unit (ICU) constitute a large portion of hospital drug budgets. Unfortunately, prices for medications commonly used in the ICU are on the rise for a variety of reasons. In particular, the U.S. Food and Drug Administration's Unapproved Drugs Initiative, generic manufacturers cornering the marketplace, drug shortages, and regulatory device changes are major drivers of pharmaceutical price escalation affecting costs in the ICU. Furthermore, traditional high acquisition cost items still pose challenges to controlling costs. To offer strategies to mitigate the rising costs of pharmaceuticals in the ICU setting, we searched the PubMed/Medline and International Pharmaceutical Abstracts databases and other related sources to identify published cost‐saving protocols concerning specific medications that are affected by rising prices or have traditional high acquisition costs. In the absence of specific protocols, we offer possible cost‐saving initiatives based on published literature regarding specific agents or based on our own diverse set of experiences. Finally, we review suggested clinical and operational activities at an institutional level to address these rising drug costs in the ICU setting.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"159 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87878027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Spending on Hepatitis C Antivirals in the United States, 2009–2015 2009-2015年美国丙型肝炎抗病毒药物支出
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1865
K. Suda, Drew J. Halbur, R. Hunkler, Linda M. Matusiak, G. Schumock
{"title":"Spending on Hepatitis C Antivirals in the United States, 2009–2015","authors":"K. Suda, Drew J. Halbur, R. Hunkler, Linda M. Matusiak, G. Schumock","doi":"10.1002/phar.1865","DOIUrl":"https://doi.org/10.1002/phar.1865","url":null,"abstract":"New hepatitis C virus (HCV) antivirals have been shown to be highly effective with minimal adverse effects, but they are costly. Little is known, however, about the impact of the new HCV antivirals on expenditures in the overall U.S. health care system or by health care sector. Thus the objective of this study was to describe HCV antiviral expenditures by agent, year, and health care sector.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"1995 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89108265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Clinical Outcomes of Extended Versus Intermittent Infusion of Piperacillin/Tazobactam in Critically Ill Patients: A Prospective Clinical Trial 延长输注哌拉西林/他唑巴坦与间歇输注哌拉西林/他唑巴坦对危重患者的临床效果:一项前瞻性临床试验
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1875
Sheung-Yin Fan, H. Shum, W. Cheng, Yat-Hei Chan, Sik-Yin McShirley Leung, W. Yan
{"title":"Clinical Outcomes of Extended Versus Intermittent Infusion of Piperacillin/Tazobactam in Critically Ill Patients: A Prospective Clinical Trial","authors":"Sheung-Yin Fan, H. Shum, W. Cheng, Yat-Hei Chan, Sik-Yin McShirley Leung, W. Yan","doi":"10.1002/phar.1875","DOIUrl":"https://doi.org/10.1002/phar.1875","url":null,"abstract":"To determine whether critically ill patients receiving extended‐infusion (EI) piperacillin/tazobactam would have improved clinical outcomes compared with patients receiving intermittent infusions.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"23 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91160334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Cost‐Effectiveness of Histamine2 Receptor Antagonists Versus Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients 组胺2受体拮抗剂与质子泵抑制剂在危重患者应激性溃疡预防中的成本-效果
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1859
Drayton A. Hammond, Niranjan Kathe, Anuj Shah, B. Martin
{"title":"Cost‐Effectiveness of Histamine2 Receptor Antagonists Versus Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients","authors":"Drayton A. Hammond, Niranjan Kathe, Anuj Shah, B. Martin","doi":"10.1002/phar.1859","DOIUrl":"https://doi.org/10.1002/phar.1859","url":null,"abstract":"To determine the cost‐effectiveness of stress ulcer prophylaxis with histamine2 receptor antagonists (H2RAs) versus proton pump inhibitors (PPIs) in critically ill and mechanically ventilated adults.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90313564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
White Paper on Natural Products 天然产品白皮书
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1874
M. Gabay, Judith A. Smith, M. Chavez, M. Goldwire, Scot Walker, Scott A Coon, Rena A. Gosser, A. Hume, M. Musselman, Jennifer A. Phillips, Andrew M. Abe
{"title":"White Paper on Natural Products","authors":"M. Gabay, Judith A. Smith, M. Chavez, M. Goldwire, Scot Walker, Scott A Coon, Rena A. Gosser, A. Hume, M. Musselman, Jennifer A. Phillips, Andrew M. Abe","doi":"10.1002/phar.1874","DOIUrl":"https://doi.org/10.1002/phar.1874","url":null,"abstract":"The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion, natural products remain largely unregulated compared with prescription medications, have moderate‐ to low‐level clinical evidence for efficacy, and continue to have safety concerns, including adulteration and misbranding. As comprehensive medication management experts, clinical pharmacists are uniquely qualified to navigate these concerns and advise patients appropriately. To develop and recommend a suitable care plan involving natural products, clinical pharmacists must establish a strong pharmacist‐patient relationship, assess the appropriateness of therapy, educate the patient regarding key issues, and continuously monitor and follow up on the effectiveness of the care plan. This process should not only occur in an individual community or hospital setting, but also whenever a patient transitions from one care setting to another in cooperation with other clinicians.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73729098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Operational and Clinical Strategies to Address Drug Cost Containment in the Acute Care Setting 业务和临床战略,以解决药物成本控制在急症护理设置
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1858
K. McConnell, O. Guzman, Nisha Pherwani, D. Spencer, Jennifer D Van Cura, K. Shea
{"title":"Operational and Clinical Strategies to Address Drug Cost Containment in the Acute Care Setting","authors":"K. McConnell, O. Guzman, Nisha Pherwani, D. Spencer, Jennifer D Van Cura, K. Shea","doi":"10.1002/phar.1858","DOIUrl":"https://doi.org/10.1002/phar.1858","url":null,"abstract":"To provide clinical and operational strategies to generate drug cost savings in the hospital setting.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79916145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Clinical Experience with Daptomycin in Pediatrics 达托霉素在儿科的临床应用体会
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1872
Katie C. Namtu, Julianna C. Crain, Allison F. Messina, J. Dumois, D. Berman
{"title":"Clinical Experience with Daptomycin in Pediatrics","authors":"Katie C. Namtu, Julianna C. Crain, Allison F. Messina, J. Dumois, D. Berman","doi":"10.1002/phar.1872","DOIUrl":"https://doi.org/10.1002/phar.1872","url":null,"abstract":"The management of gram‐positive infections has been complicated in recent years by the emergence of antimicrobial resistance, leaving fewer options for therapy. Daptomycin is a lipopeptide antibiotic used for the systemic treatment of gram‐positive infections. It has a distinct mechanism of action and a favorable side effect profile, and it requires once/day dosing. Unfortunately, there is a paucity of safety, efficacy, and pharmacokinetic data in neonatal and pediatric patients. The objective of this study was to review our experience with daptomycin use for the treatment of gram‐positive infections in these patient populations.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"76 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83398185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Hormone‐Related Migraine Headaches and Mood Disorders: Treatment with Estrogen Stabilization 激素相关性偏头痛和情绪障碍:雌激素稳定治疗
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1876
J. Warnock, L. Cohen, H. Blumenthal, J. Hammond
{"title":"Hormone‐Related Migraine Headaches and Mood Disorders: Treatment with Estrogen Stabilization","authors":"J. Warnock, L. Cohen, H. Blumenthal, J. Hammond","doi":"10.1002/phar.1876","DOIUrl":"https://doi.org/10.1002/phar.1876","url":null,"abstract":"Because estrogens and the trigeminal system are inherently linked, prescribers who are treating a woman with a hormonally related mood disorder and migraine headaches should consider hormonal options to optimize the patient's treatment. This article discusses the interrelationships of estrogen, serotonin, and the trigeminal system as they relate to menstrual migraine occurrence and hormone‐related mood symptoms. In addition, clinical examples are provided to facilitate the prescribers treating women during reproductive transitions in which declining estrogens are related to their suffering.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88057368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Potential Association between Drug Shortages and High‐Cost Medications 药物短缺与高成本药物之间的潜在联系
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-01-01 DOI: 10.1002/phar.1861
E. Fox, L. Tyler
{"title":"Potential Association between Drug Shortages and High‐Cost Medications","authors":"E. Fox, L. Tyler","doi":"10.1002/phar.1861","DOIUrl":"https://doi.org/10.1002/phar.1861","url":null,"abstract":"Shortages and sudden price increases of certain drugs may both occur emergently, with little to no warning, and they can have a dramatic impact on patient care. Little data are available linking drug shortages and price increases. Many of the same characteristics that may make medications susceptible to shortages can also place them at risk for sudden price increases. These characteristics include unapproved drugs, off‐patent sole‐source medications, and infrequently used medications. We reviewed drug shortage data from the University of Utah Drug Information Service to demonstrate how frequently these characteristics occurred and resulted in higher drug prices. Clinicians can use drug shortage management principles to mitigate the impact of sudden price increases for patients and health care organizations.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":"17 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76992129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
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