Pharmacopsychiatry最新文献_第8页

High Prescribing and State-Level Variation in Z-Drug Use Among Medicare Patients. 医疗保险患者z -药物使用的高处方和州水平差异。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-07-01 DOI: 10.1055/a-2085-2299

Kaitlin E Anderson, Rachel I Gifeisman, James L Basting, Donovan J Harris, Antonica R Rajan, Kenneth L McCall, Brian J Piper

{"title":"High Prescribing and State-Level Variation in Z-Drug Use Among Medicare Patients.","authors":"Kaitlin E Anderson, Rachel I Gifeisman, James L Basting, Donovan J Harris, Antonica R Rajan, Kenneth L McCall, Brian J Piper","doi":"10.1055/a-2085-2299","DOIUrl":"https://doi.org/10.1055/a-2085-2299","url":null,"abstract":"Background: Z-drugs are nonbenzodiazepine hypnotics used for sleep initiation and maintenance; these drugs increase the risk of fall-related injuries in older adults. The American Geriatrics Society's Beers criteria classifies Z-drugs as high-risk and strongly recommends avoiding prescribing Z-drugs to older adults due to adverse effects. The study objectives were to determine the prevalence of Z-drug prescribing among Medicare Part D patients and identify state or specialty-dependent prescribing differences. This study also aimed to determine prescribing patterns of Z-drugs to Medicare patients.Methods: Z-drug prescription data was extracted from the Centers for Medicare and Medicaid Services State Drug Utilization Data for 2018. For all 50 states, the number of prescriptions per 100 Medicare enrollees and days-supply per prescription was determined. The percentage of total prescriptions prescribed by each specialty and the average number of prescriptions per provider within each specialty was also determined.Results: Zolpidem was the most prescribed Z-drug (95.0%). Prescriptions per 100 enrollees were significantly high in Utah (28.2) and Arkansas (26.7) and significantly low in Hawaii (9.3) relative to the national average (17.5). Family medicine (32.1%), internal medicine (31.4%), and psychiatry (11.7%) made up the largest percentages of total prescriptions. The number of prescriptions per provider was significantly high among psychiatrists.Discussion: Contrary to the Beers criteria, Z-drugs are prescribed to older adults at high rates.","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 4","pages":"149-153"},"PeriodicalIF":4.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the World's Strictest COVID-19 Lockdown: Formidable Mental Health Challenges. 重温世界上最严格的COVID-19封锁:艰巨的心理健康挑战。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-07-01 DOI: 10.1055/a-2108-2164

Beier Guan, Ruihua Li, Chuanning Huang, Jiang Du, Min Zhao, Shuyan Liu

{"title":"Revisiting the World's Strictest COVID-19 Lockdown: Formidable Mental Health Challenges.","authors":"Beier Guan, Ruihua Li, Chuanning Huang, Jiang Du, Min Zhao, Shuyan Liu","doi":"10.1055/a-2108-2164","DOIUrl":"https://doi.org/10.1055/a-2108-2164","url":null,"abstract":"Introduction: Many nations have implemented lockdowns to prevent and minimize the spread of infections in healthcare settings. However, the impact of lockdown duration on mental health remains controversial.Methods: We conducted a retrospective study using online questionnaires to assess the mental health status of the general population during the Shanghai lockdown period from March to May 2022. The mental health of the participants was evaluated by the 12-item General Health Questionnaire (GHQ-12), in which a cut-off score of 12 or more indicated psychological distress. A logistic regression model was used to evaluate the relationship between lockdown duration and mental health.Results: Among 2139 participants (mean age: 26.12 years, standard deviation: 6.37, 731 females; 1378 unmarried; 1099 Shanghai residents), approximately 47% reported psychological distress (GHQ-12≥12). Participants exposed to lockdown reported significantly higher GHQ-12 scores (11.93±6.81 vs. 8.73±6.35, p<0.001). In our logistic regression model, participants who experienced the longest lockdown (43-61 days) had a significantly higher risk of psychological distress compared with those who did not (odds ratio: 3.10, 95% confidence interval: 2.06-4.70, p<0.001).Discussion: Lockdown duration significantly affects mental health, with longer lockdown duration being associated with worse mental health status. The relationship between lockdown and mental health should not be neglected in case of lockdown in response to future pandemics.","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 4","pages":"162-164"},"PeriodicalIF":4.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Circadian Rhythmicity and CLOCK Genes in Psychiatry. 昼夜节律和 CLOCK 基因在精神病学中的作用。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 Epub Date: 2023-05-15 DOI: 10.1055/a-2078-4905

Denise Palm, Johannes Thome

引用次数: 0

„AGNP-Preis für Forschung in der Psychopharmakologie“ in Höhe von 5.000 €. “AGNP-Preis研发Psychopharmakologie”相当于5000€.

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-2079-9272

引用次数: 0

The Role of Mood Stabilizers in Children and Adolescents with Anorexia Nervosa: A 1-year Follow-Up, Propensity Score-Matched Study. 情绪稳定剂在儿童和青少年神经性厌食症中的作用:1年随访，倾向评分匹配研究。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-2018-4946

Jacopo Pruccoli, Antonia Parmeggiani

{"title":"The Role of Mood Stabilizers in Children and Adolescents with Anorexia Nervosa: A 1-year Follow-Up, Propensity Score-Matched Study.","authors":"Jacopo Pruccoli, Antonia Parmeggiani","doi":"10.1055/a-2018-4946","DOIUrl":"https://doi.org/10.1055/a-2018-4946","url":null,"abstract":"Background: The existing literature on the use of mood stabilizers (MS) in children and adolescents with anorexia nervosa (AN) is limited, for the most part, to small case studies.Methods: This was an observational, naturalistic, propensity score-matched study. Subjects treated and not-treated with MS were compared by being matched via propensity score on age, sex, concurrent atypical antipsychotics, and concurrent antidepressants. General and AN-specific psychopathology was assessed with Symptom Check List-90-R, Beck Depression Inventory-II, Eating Disorders Inventory-3, and Body Uneasiness Test-A. Potential differences in admission-discharge modifications (body mass index (BMI), psychopathology) among the two groups were assessed. Finally, re-hospitalizations after 1-year follow-up were assessed with Kaplan-Meier analyses.Results: The study enrolled 234 hospitalized patients (15.9+/-3.3 years; 26, 11.1% receiving MS). After propensity-score matching, 26 MS patients matched with 26 MS-not-treated subjects were included. MS were used for a mean of 126.1 (+/-87.3) days, and two cases of side effects were documented (alopecia and somnolence with valproate). No significant difference between MS-treated and not-treated patients emerged concerning admission-discharge improvements in BMI and AN-specific or general psychopathology. The cumulative survival from re-hospitalization at 12 months was 64,4% (95%-CI, 31.3-97.5) for MS and 58.7% (95%-CI, 22.2-95.2) for MS-not-treated subjects. No significant difference in survival rate emerged (hazard ratio, 0.04; Log-rank test: p=0.846).Conclusions: This propensity score-matched study expands on the scant existing evidence of the use and side effects of MS in children and adolescents with AN. These results should be assessed in wider longitudinal samples.","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 3","pages":"118-125"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9476730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synchronization of Fibroblasts Ex Vivo in Psychopharmacology. 体外成纤维细胞同步的精神药理学研究。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-1151-4947

Frank Faltraco, Adriana Uzoni, Liliia Shevchuk, Johannes Thome, Denise Palm

引用次数: 4

„Peter Müller Preis für Forschung im Bereich Schizophrenie“ in Höhe von 5.000€. “彼得。米勒研究精神分裂症”的价格为5000美元€.

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-2079-9476

引用次数: 0

Circadian Clocks in the Regulation of Neurotransmitter Systems. 调节神经递质系统的生物钟。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-1027-7055

Jana-Thabea Kiehn, Frank Faltraco, Denise Palm, Johannes Thome, Henrik Oster

引用次数: 8

Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders. 人源性真皮成纤维细胞作为研究精神疾病昼夜节律的体外研究工具。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-05-01 DOI: 10.1055/a-1147-1552

Denise Palm, Adriana Uzoni, Golo Kronenberg, Johannes Thome, Frank Faltraco

引用次数: 2

The Mini-TRH Test. Mini-TRH测试。

IF 4.3 3区医学

Pharmacopsychiatry Pub Date : 2023-03-01 DOI: 10.1055/a-1978-8348

Johan Spoov

{"title":"The Mini-TRH Test.","authors":"Johan Spoov","doi":"10.1055/a-1978-8348","DOIUrl":"https://doi.org/10.1055/a-1978-8348","url":null,"abstract":"Thyrotropin-releasing hormone (TRH), at doses lower than those needed to stimulate prolactin secretion directly, can almost completely antagonize dopamine inhibition of prolactin release. In normal men, prolactin increases 15 min following an i. v. bolus of 12.5 µg TRH (the mini-TRH test), but not the maximal prolactin response to TRH or basal prolactin, positively correlated with prolactin response to haloperidol and negatively with 24-h urinary excretion of homovanillic acid (HVA). These results suggest that the mini-TRH test is a better estimate of dopamine inhibition of prolactin release than the maximal prolactin response or basal prolactin level. A recent neuroimaging study suggested that in schizophrenia, there is a widely distributed defect in extrastriatal dopamine release, but the patients were not in the most acute phase of psychosis. The evidence is reviewed that this defect extends to tuberoinfundibular dopamine (TIDA) and which symptoms are associated with the test. In patients with acute nonaffective psychosis, the mini-TRH test positively correlated with nonparanoid delusions and memory dysfunction, indicating decreased dopamine transmission in association with these symptoms. In patients with acute drug-naïve first-episode schizophrenia, the mini-TRH test negatively correlated with negative disorganization symptoms and with basal prolactin. The latter correlation suggests the contribution of factors related to maximal prolactin stimulation by TRH; therefore, an alternative dose of 6.25 μg TRH could be used for the mini-TRH test in first-episode patients, allowed by increased sensitivity of the present prolactin tests. Future studies are needed to investigate whether the mini-TRH test could help in finding the optimal antipsychotic medication.","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 2","pages":"51-56"},"PeriodicalIF":4.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9527468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0