Nihon Jinzo Gakkai shi最新文献_第3页

Challenges to regenerate the kidney. 肾脏再生的挑战。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Minoru Takasato

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Recent progress in pediatric nephrology. 儿童肾脏病学的最新进展。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Fumio Nimura

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Epidemiology and pathogenesis of diabetic nephropathy. 糖尿病肾病的流行病学和发病机制。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Miho Shimizu, Kengo Furuichi, Takashi Wada

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[A case of hemangioma at the left renal papilla of the calix with anemia and gross hematuria]. [左肾盏乳头血管瘤伴贫血及肉眼血尿1例]。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Hiroki Uchida, Takeshi Nakata, Miho Suzuki, Yuko Yamasaki, Kaede Ishida, Junji Hiraoka, Akiko Kudo, Eri Hashinaga, Kouhei Aoki, Hiroko Higashi, Naoya Fukunaga, Tomoko Nawata, Hirotaka Shibata

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Plasma pentraxin 3 (PTX3) level is associated with the disease activity of microscopic polyangiitis (MPA). 血浆戊烷素3 (PTX3)水平与显微多血管炎(MPA)的疾病活动性相关。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Satoshi Yamaguchi, Shihomi Maeda, Hiroaki Yonishi, Atsushi Hesaka, Eriko Iwahashi, Koichi Sasaki, Yoshimasa Fujita, Akira Suzuki, Kenji Yokoyama

{"title":"Plasma pentraxin 3 (PTX3) level is associated with the disease activity of microscopic polyangiitis (MPA).","authors":"Satoshi Yamaguchi, Shihomi Maeda, Hiroaki Yonishi, Atsushi Hesaka, Eriko Iwahashi, Koichi Sasaki, Yoshimasa Fujita, Akira Suzuki, Kenji Yokoyama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 20-year-old woman, who was suffering from appetite loss, weight loss and livedo reticularis for one and half months, was referred to our hospital. On admission, laboratory studies demonstrated proteinuria (1.0 g/g Cr), hematuria (erythrocytes': 50 - 99/HPF), ,.enal dysfunction (Cr : 2.09 mg/dL), elevated C reactive protein (CRP: 10.82 mg/dL), elevated MPO-ANCA titer (11.6 U/mL) and elevated pentraxin3 (PTX3: 24.05 ng/mL). Her kidney and skin biopsy revealed massive crescentic necrotizing glomerulonephritis and leukocytoclastic vasculitis, respectively. She was diagnosed with microscopic polyangiitis (MPA), and treated with 500 mg/day of intravenous methyl-prednisolone (mPSL) for 3 days followed by 40 mg/day of oral PSL, rituximab (375 mg/m² once a week for a month) and plasma exchange. When PSL tapered to 30 mg/day in 4 weeks, her renal function was only partially recovered, while the CRP level had been normalized and the MPO-ANCA titer was almost negative (3.6 IU/mL). To evaluate histological activity, a second renal biopsy was conducted, which showed fibrocellular crescents in 32% of her glomeruli. The PTX3 level remained high (14.82 ng/mL) at that point. Taken together, the vasculitis was considered to be active still. Steroid pulse therapy for 3 days was administered again, followed by oral PSL 30 mg/day. Her renal function completely recovered in 70 days. The PTX3 level also normalized in 161 days. PTX3 is one of the short pentraxins, produced by a variety of cell types in response to pro-inflammatory signals such as IL-1 and TNF-α. It was reported that PTX3 reflects activity of vasculitis independently from CRP. In the presenting case, when the second renal biopsy revealed a histologically active lesion of the vasculitis, PTX3 was elevated independently from CRP and MPO-ANCA, suggesting that PTX3 may be a more sensitive marker of the disease activity than other tests.</p>","PeriodicalId":19721,"journal":{"name":"Nihon Jinzo Gakkai shi","volume":"59 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36783589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent progress in the development of biomarkers for diabetic nephropathy. 糖尿病肾病生物标志物的研究进展。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Daijo Inaguma, Shinichi Akiyama, Yukio Yuzawa

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[A case of Evans syndrome in a long-term hemodialysis patient]. [长期血液透析患者埃文斯综合征1例]。

Nihon Jinzo Gakkai shi Pub Date : 2017-01-01

Masayuki Ishikawa, Chihiro Hirose, Jie Zhang, Kenichiro Hori, Satoko Oyama, Katsuhiro Sugano, Ako Ohno, Kimio Tomita

引用次数: 0

[Drug-induced kidney injury by non-steroidal anti-inflammatory drugs: Do COX-2 selective inhibitors and acetaminophen induce kidney injury?]. [非甾体抗炎药引起的药物性肾损伤:COX-2选择性抑制剂和对乙酰氨基酚是否会引起肾损伤?]。

Nihon Jinzo Gakkai shi Pub Date : 2016-01-01

Sumio Hirata, Daisuke Kadowaki, Yuki Narita