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STING is significantly increased in high-grade glioma with high risk of recurrence STING 在高级别胶质瘤中明显增加，复发风险高
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-20 DOI: 10.1080/2162402x.2024.2327682
Meishi Zhong, Manmei Long, Chenjie Han, Saiyan Ji, Qingyuan Yang
{"title":"STING is significantly increased in high-grade glioma with high risk of recurrence","authors":"Meishi Zhong, Manmei Long, Chenjie Han, Saiyan Ji, Qingyuan Yang","doi":"10.1080/2162402x.2024.2327682","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2327682","url":null,"abstract":"In this study, we aimed to comprehensively characterize the potential relationships among the frequently mutated genes, well-known homologous recombination repair (HRR) proteins, and immune protein...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma 淋巴内皮细胞介导的 CD177+Treg 细胞聚集可抑制人食管鳞状细胞癌的抗肿瘤免疫力
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-20 DOI: 10.1080/2162402x.2024.2327692
Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao, Zhe-Xiong Lian
{"title":"Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma","authors":"Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao, Zhe-Xiong Lian","doi":"10.1080/2162402x.2024.2327692","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2327692","url":null,"abstract":"Regulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance to therapies. However, the heterogeneity and function of Treg cells...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trial watch: local anesthetics in cancer therapy 试验观察：癌症治疗中的局部麻醉剂
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-17 DOI: 10.1080/2162402x.2024.2308940
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu
{"title":"Trial watch: local anesthetics in cancer therapy","authors":"Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu","doi":"10.1080/2162402x.2024.2308940","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2308940","url":null,"abstract":"Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140148913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma 瘤内 T 细胞受体重组可预测胰腺导管腺癌患者的总生存率
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-15 DOI: 10.1080/2162402x.2024.2320411
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields
{"title":"Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma","authors":"Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields","doi":"10.1080/2162402x.2024.2320411","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2320411","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, intratumoral T-cell infiltration correlates with improved overall ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140148914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression 体液补体组学--探索作为肾癌进展预测指标的非侵入性补体生物标志物
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-13 DOI: 10.1080/2162402x.2024.2328433
Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina, Marie-Agnes Dragon-Durey
{"title":"Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression","authors":"Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina, Marie-Agnes Dragon-Durey","doi":"10.1080/2162402x.2024.2328433","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2328433","url":null,"abstract":"Despite the progress of anti-cancer treatment, the prognosis of many patients with solid tumors is still dismal. Reliable noninvasive biomarkers are needed to predict patient survival and therapy r...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140129379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trial watch: dexmedetomidine in cancer therapy 试验观察：右美托咪定在癌症治疗中的应用
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-11 DOI: 10.1080/2162402x.2024.2327143
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu
{"title":"Trial watch: dexmedetomidine in cancer therapy","authors":"Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu","doi":"10.1080/2162402x.2024.2327143","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2327143","url":null,"abstract":"Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist that is widely used in intensive and anesthetic care for its sedative and anxiolytic properties. DEX has the capacity to alleviat...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML 骨髓肿瘤微环境、HLA-I 和 HLA-Ib 表达对 MDS 和 CMML 发展为 sAML 的预后影响
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-03-06 DOI: 10.1080/2162402x.2024.2323212
Marcus Bauer, Nadja Jäkel, Andreas Wilfer, Anja Haak, Markus Eszlinger, Katalin Kelemen, Monika Haemmerle, Haifa Kathrin Al-Ali, Barbara Seliger, Claudia Wickenhauser
{"title":"Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML","authors":"Marcus Bauer, Nadja Jäkel, Andreas Wilfer, Anja Haak, Markus Eszlinger, Katalin Kelemen, Monika Haemmerle, Haifa Kathrin Al-Ali, Barbara Seliger, Claudia Wickenhauser","doi":"10.1080/2162402x.2024.2323212","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2323212","url":null,"abstract":"Genetic aberrations and immune escape are fundamental in MDS and CMML initiation and progression to sAML. Therefore, quantitative and spatial immune cell organization, expression of immune checkpoi...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma 溶瘤疫苗病毒表达 GPX4 可显著增强 CD8+T 细胞功能及其对胰腺导管腺癌的影响
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-02-27 DOI: 10.1080/2162402x.2024.2322173
Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong
{"title":"Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma","authors":"Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong","doi":"10.1080/2162402x.2024.2322173","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2322173","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is currently difficult to treat, even when therapies are combined with immune checkpoint blockade (ICB). A novel strategy for immunotherapy would be to maxim...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer 乳酸/GPR81 通过调节 CX3CL1 招募调节性 T 细胞，促进高糖酵解胃癌的免疫抵抗力
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-02-26 DOI: 10.1080/2162402x.2024.2320951
Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo, Yanfeng Hu
{"title":"Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer","authors":"Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo, Yanfeng Hu","doi":"10.1080/2162402x.2024.2320951","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2320951","url":null,"abstract":"Lactate plays an important role in shaping immune tolerance in tumor microenvironment (TME) and correlates with poor prognosis in various solid tumors. Overcoming the immune resistance in an acidic...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139978926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells 精氨酸酶-1 特异性 CD8+ T 细胞对恶性和调节性髓系细胞的反应
IF 7.2 2区 医学
Oncoimmunology Pub Date : 2024-02-22 DOI: 10.1080/2162402x.2024.2318053
Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten, Mads Hald Andersen
{"title":"Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells","authors":"Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten, Mads Hald Andersen","doi":"10.1080/2162402x.2024.2318053","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2318053","url":null,"abstract":"Arginase-1 (Arg1) is expressed by regulatory myeloid cells in the tumor microenvironment (TME), where they play a pro-tumorigenic and T-cell suppressive role. Arg1-specific CD4+ and CD8+ memory T c...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139919352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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