Organic Preparations and Procedures International最新文献_第10页

SbPh3: An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli Reaction SbPh3：Biginelli反应合成二氢嘧啶酮和二氢嘧啶-5-甲酰胺的有效催化剂

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-04-06 DOI: 10.1080/00304948.2023.2190711

Anamika Khaskel, Santosh Kumari Bajiya, Suman Lata, Rakesh K Sharma, Shatabdi Basu

引用次数: 0

Synthesis of Isoxazole-5(4H)-ones Using Citrazinic Acid as an Organocatalyst in Aqueous Conditions 柠檬酸作有机催化剂在水溶液中合成异恶唑-5（4H）-酮

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-03-24 DOI: 10.1080/00304948.2023.2192601

Hanieh Ostadzadeh, H. Kiyani

引用次数: 3

Facile Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculation and in vitro Antifungal Evaluation of 4-Arylidene-1H-pyrazol-5(4H)-ones 4-芳基烯- 1h -吡唑-5(4H)-ones的简单合成、晶体结构、Hirshfeld表面分析、DFT计算及体外抗菌评价

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2178213

Sara Nemouchi , Imène Sehout , Houssem Boulebd , Raouf Boulcina , Amina Bramki , Lamia Bendjeddou , Amani Hind Benahsene , Abdelmadjid Debache

引用次数: 0

Development of an Efficient Alternative Synthesis of the Endothelin Receptor Antagonist Bosentan 内皮素受体拮抗剂波生坦高效替代合成方法的研究

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2170665

Jigar Panchal , Namita Misra , Meenu Devi , Ashima Sharma , Sonika Jain , Pankaj Jain , Jaya Dwivedi , Swapnil Sharma

引用次数: 0

An Original Transposition of the 4-Fluorobenzylamino Group from 1-(4-Fluorobenzylamino)-1-methylsulfanyl-2-nitroethylene in Triflic Acid† 三酸中1-(4-氟基氨基)-1-甲基磺胺基-2-亚硝基4-氟基氨基的原始转位

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2178212

Bamba Fante , N’ta Christelle Mélissa Ambeu-Loko , Souleymane Coulibaly , Yaya Soro , Jean-Marie Coustard

引用次数: 0

An Efficient Procedure for the Synthesis of 2-Arylsubstituted Benzimidazoles Catalyzed by Co (II) Immobilized on Fe3O4@SiO2-NH2/EP@SAA as a Recyclable Nanomagnetic Catalyst 固定化Co（II）催化合成2-芳基取代苯并咪唑的有效方法Fe3O4@SiO2-NH2/EP@SAA作为一种可回收的纳米磁性催化剂

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2181622

Mohammad Nikbin , Ebrahim Mollashahi , Malek Taher Maghsoodlou , Mojtaba Lashkari

{"title":"An Efficient Procedure for the Synthesis of 2-Arylsubstituted Benzimidazoles Catalyzed by Co (II) Immobilized on Fe3O4@SiO2-NH2/EP@SAA as a Recyclable Nanomagnetic Catalyst","authors":"Mohammad Nikbin , Ebrahim Mollashahi , Malek Taher Maghsoodlou , Mojtaba Lashkari","doi":"10.1080/00304948.2023.2181622","DOIUrl":"10.1080/00304948.2023.2181622","url":null,"abstract":"Fast, simple and high-yield synthesis continues to be a major challenge for synthetic organic chemists. Among nitrogen-containing heterocyclic compounds, 1 the benzimidazole ring is an important pharmacophore for modern drug discovery. 2 Benzimidazoles have significant biological properties including anticancer, 3 anti-HIV, 4 antibacterial, 5 anti-ulcer, 6 anti-tumor 7 and enzyme inhibitory 8 properties. Benzimidazoles are also important intermediates in organic reactions. 9 Due to the importance of benzimidazoles, interest in the synthesis of these compounds has increased. The most common method is the condensation of o -aryldiamines and carbonyl compounds, especially aldehydes; and the wide availability of the latter makes this route particularly attractive for the production of 2-arylsubstituted benzimidazoles. 10 Numerous oxidative and catalytic reagents have been employed in this method, including Oxone, 11 In(OTf) 312 , FeCl 3 (cid:1) 6H 2 O, 13 I 2 /KI/K 2 CO 314 , sulfamic acid, 15 KHSO 416 , TBAF, 17 SBSA, 18 TiCl 3 OTf 19 and VOSO 4 . 20 These catalysts have been useful for their own purposes in facilitating the synthesis of the expected compounds. However, some of these methods have disadvantages such as high reaction temperatures, prolonged reaction times, low yields, expense, complex work-up procedures or toxic solvents. So the discovery of mild","PeriodicalId":19681,"journal":{"name":"Organic Preparations and Procedures International","volume":"55 5","pages":"Pages 444-451"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46044612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Tetrahydrobenzo[b]pyrans Promoted by Sodium Stearate as a Lewis Base-Surfactant Combined Catalyst in an Aqueous Micellar Medium 硬脂酸钠作为路易斯碱-表面活性剂复合催化剂在水胶束介质中催化合成四氢苯并[b]吡喃

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2022.2151812

Farzaneh Mohamadpour

{"title":"Synthesis of Tetrahydrobenzo[b]pyrans Promoted by Sodium Stearate as a Lewis Base-Surfactant Combined Catalyst in an Aqueous Micellar Medium","authors":"Farzaneh Mohamadpour","doi":"10.1080/00304948.2022.2151812","DOIUrl":"10.1080/00304948.2022.2151812","url":null,"abstract":"The use of green catalysts is one of the most crucial elements in the greening of synthetic chemical processes. In line with this, current research initiatives in our lab have concentrated on the creation of green catalysts 1 – 4 for organic synthesis. Surfactant molecules can group together in an aqueous phase under ambient conditions to create micelles, which have a hydrophobic core and a hydrophilic corona. The widespread and in-depth study of micellar surfactants as catalysts for various reactions in aqueous solutions opens the door for more synthesis methods using aqueous media. Sodium stearate is a common surfactant found in frequently-used preparations. However, there are not many studies on organic reactions using sodium stearate as a catalyst. 5 In this context, we present below a straightforward and effective technique for the synthesis of tetrahy-drobenzo[ b ]pyrans using a Lewis base-surfactant-combined (LBSC) catalyzed three-component one-pot reaction in an aqueous micellar medium. Pyrans have such noteworthy pharmacological characteristics (Figure 1) as Chk1 kinase inhibitory, 6 analgesic, 7 anticancer, 8 vasodilatory, 9 antihypertensive, hepatoprotective, cardiotonic, 10 vasodilator, 11 anti-leukemic, 12,13 emetic, 14 anti-anaphylactic, 15 diuretic 16 and anti-Alzheimer 17 properties. Many","PeriodicalId":19681,"journal":{"name":"Organic Preparations and Procedures International","volume":"55 4","pages":"Pages 345-350"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41410183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of a Novel Disubstituted Indole† 新型二取代吲哚†的合成

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2184622

Stephen W. Wright , Gordon W. Gribble

{"title":"Synthesis of a Novel Disubstituted Indole†","authors":"Stephen W. Wright , Gordon W. Gribble","doi":"10.1080/00304948.2023.2184622","DOIUrl":"10.1080/00304948.2023.2184622","url":null,"abstract":"In continuation of our interest to functionalize selectively the indole-2,3 positions, we now describe the synthesis of 2-bromo-1-(phenylsulfonyl)-1H-indol-3-yl trifluoromethanesulfonate (1) as a potentially useful precursor for the selective functionalization of the indole positions. Our synthesis of 1 is shown in Scheme 1. Following the conversion of commercially available 2-aminoacetophenone (2) to sulfonamide 3, the four subsequent reactions to give 1 were performed with only one intermediate purification due to the presumed formation of indigo by-products (blue-purple discoloration), and the possible lachymatory effects of bromide 4. Bromination of 3 to 4 was subject to capricious reaction times, but we found that the addition of catalytic amounts of concentrated HBr eliminated this phenomenon, presumably by supplying sufficient HBr to the mixture to initiate formation of Br2. Over-bromination of 3 was minimized by exclusion of air. The mixture of 4, containing some ketone and dibromoketone, was converted to indolin-3-one 5 in 60% yield after purification. Subsequent bromination to 6 and triflate formation to 1 proceeded in 54% yield for the two steps. Attempts to brominate (NBS, Br2) the known 1-(phenylsulfonyl)-1H-indol-3-yl trifluoromethanesulfonate to afford 1 were not successful. In summary, we disclose a straightforward synthesis of compound 1 from 2-aminoacetophenone. This new 2,3-unsymmetrically-disubstituted indole should find utility in the synthesis of a wide range of indoles in contrast to, for example, 2,3-dihaloindoles for which regioselective reactions have proven difficult.","PeriodicalId":19681,"journal":{"name":"Organic Preparations and Procedures International","volume":"55 5","pages":"Pages 483-486"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43934635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcoholysis of Primary Amides in the Presence of CF3SO3H CF3SO3H存在下伯胺醇解的研究

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2023.2184997

Anton Mastitski , Eerold Vellemäe , Varvara Smorodina , Alar Konist , Jaak Järv

引用次数: 0

Supramolecular β-Cyclodextrin as a Reusable Catalyst for Xanthene Synthesis in Aqueous Medium 水介质中可重复使用的超分子β-环糊精催化剂合成黄原

IF 1.5 4区化学

Organic Preparations and Procedures International Pub Date : 2023-01-01 DOI: 10.1080/00304948.2022.2141047

Farzaneh Mohamadpour

引用次数: 0