Osaka city medical journal最新文献_第6页

Colorectal cancer metastasis to the thyroid. 结直肠癌转移到甲状腺。

Osaka city medical journal Pub Date : 2012-12-01

Takatsugu Yamamoto, Shogo Tanaka, Yusuke Nakamura, Ryoya Hashiba, Kanji Ishihara, Shoji Kubo, Kazuhiro Hirohashi, Kohichi Ohno

引用次数: 0

Thrice-weekly insulin injection with nurse's support for diabetic hemodialysis patients having difficulty with self injection. 有自我注射困难的糖尿病血液透析患者在护士支持下每周三次注射胰岛素。

Osaka city medical journal Pub Date : 2012-06-01

Tetsuo Shoji, Masanori Emoto, Katsuhito Mori, Tomoaki Morioka, Shinya Fukumoto, Tatsuji Takahashi, Akihide Matsumoto, Yoshiki Nishizawa, Masaaki Inaba

引用次数: 0

Detailed observation of arterial healing after stent implantation in swine arteries by using optical coherence tomography. 光学相干断层扫描对猪动脉支架植入术后动脉愈合的详细观察。

Osaka city medical journal Pub Date : 2012-06-01

Satoshi Nishimura, Toru Kataoka, Takao Hasegawa, Yoshiki Kobayashi, Koichiro Asawa, Shinji Nakata, Hiroki Nishioka, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Takashi Muro, Minoru Yoshiyama

{"title":"Detailed observation of arterial healing after stent implantation in swine arteries by using optical coherence tomography.","authors":"Satoshi Nishimura, Toru Kataoka, Takao Hasegawa, Yoshiki Kobayashi, Koichiro Asawa, Shinji Nakata, Hiroki Nishioka, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Takashi Muro, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background: Histopathological examination is not suitable for sequential in vivo analysis of arterial healing after stenting because it can be performed only after the animals are killed. Optical coherence tomography (OCT) provides higher resolution than intravascular ultrasound (IVUS). The aim of this study was to compare arterial healing images after stenting on the basis of the findings of histopathological examination, IVUS, and OCT.Methods: We examined 12 vessels; 12 bare-metal stents were implanted in 6 miniature swine. Histopathological examination, IVUS, and OCT imaging were performed at 1 and 4 weeks after stenting. For quantitative analysis of IVUS and OCT images, we examined cross-sectional frames at 1-mm intervals. For neointimal coverage analysis, the neointimal coverage score was classified into 1 of the 4 categories. A fully covered strut was scored as 3, a partially covered strut was scored as 1 or 2, and an uncovered strut was scored as 0.Results: In IVUS and OCT analyses, the average neointimal thickness increased between 1 and 4 weeks (p < 0.0001). OCT revealed higher scores at 1 and 4 weeks than IVUS did (at week 1, p < 0.0001; at week 4, p < 0.0001). OCT analysis evaluated the neointimal coverage similarly to histopathological examination.Conclusions: On assessment of arterial healing after stenting, we found that the results of the histological examination were more similar to those of the OCT analysis than to those of the IVUS. An OCT imaging device can be used to precisely and sequentially analyze the arterial healing process after stenting.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"58 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31000093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of adverse events of erlotinib with those of gefitinib in patients with non-small cell lung cancer: a case-control study in a Japanese population. 厄洛替尼与吉非替尼在非小细胞肺癌患者中的不良事件比较:一项日本人群的病例对照研究。

Osaka city medical journal Pub Date : 2012-06-01

Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Kazuto Hirata

{"title":"Comparison of adverse events of erlotinib with those of gefitinib in patients with non-small cell lung cancer: a case-control study in a Japanese population.","authors":"Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Kazuto Hirata","doi":"","DOIUrl":"","url":null,"abstract":"Background: Rash, liver dysfunction, and diarrhea are known as adverse events of erlotinib and gefitinib. However, clinical trials with gefitinib have reported different adverse events compared to those with erlotinib. In an in vitro study, cytochrome P450 (CYP) 2D6 was shown to be involved in the metabolism of gefitinib and not of erlotinib. It has been hypothesized that gefitinib therapy results in different adverse events compared to erlotinib therapy.Methods: The frequency of each adverse event was evaluated in a case-control study on Japanese patients who were treated with gefitinib or erlotinib. The CYP2D6 phenotype was categorized into 2 groups according to functional or reduced metabolic levels. In addition, we evaluated the odds ratio (OR) of adverse events with each factor, including CYP2D6 activities as well as treatment types.Results: A total of 112 patients received gefitinib therapy, 74 patients received erlotinib therapy, and 17 patients received erlotinib and gefitinib sequentially. The OR of developing rash with gefitinib versus erlotinib treatment was 0.38 (95% confidence interval [CI], 0.15-0.86). The OR of developing diarrhea with gefitinib versus erlotinib treatment was 0.46 (95% CI, 0.22-0.94). The OR of developing liver dysfunction with gefitinib versus erlotinib treatment was 3.30 (95% CI, 1.59-7.22). Reduced function of CYP2D6 was not associated with an increased risk of any adverse events in both gefitinib and erlotinib cohorts.Conclusions: Erlotinib had higher rate of rash and diarrhea than gefitinib. Liver dysfunction occurred significantly more often in the gefitinib group than in the erlotinib group.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"58 1","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31000095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AGR2 as a potential biomarker of human lung adenocarcinoma. AGR2作为人肺腺癌的潜在生物标志物。

Osaka city medical journal Pub Date : 2012-06-01

Kyukwang Chung, Noritoshi Nishiyama, Hideki Wanibuchi, Shotaro Yamano, Shoji Hanada, Min Wei, Shigefumi Suehiro, Anna Kakehashi

{"title":"AGR2 as a potential biomarker of human lung adenocarcinoma.","authors":"Kyukwang Chung, Noritoshi Nishiyama, Hideki Wanibuchi, Shotaro Yamano, Shoji Hanada, Min Wei, Shigefumi Suehiro, Anna Kakehashi","doi":"","DOIUrl":"","url":null,"abstract":"Background: The present study aimed to identify useful candidate biomarkers of lung adenocarcinoma for clinical diagnosis and treatment using proteomics technology.Methods: We assessed frequently highly overexpressed proteins in 12 cases of lung adenocarcinoma compared with adjacent normal tissue samples by liquid chromatography tandem mass spectrometry (LC-MS/MS) coupled with isobaric tags for relative and absolute quantitation (iTRAQ) technology, and validated the expression of target proteins by immunohistochemistry in 268 lung adenocarcinoma cases. Protein expression and clinicopathological variables were compared statistically for the evaluation of novel biomarkers.Results: One hundred seventy-seven proteins displaying significant quantitative changes compared with adjacent normal-appearing lung tissue were identified in more than 9 out of 12 lung adenocarcinoma patients. Based on the results of liquid chromatography tandem mass spectrometry, Ingenuity Pathway, and immunohistochemical analyses, anterior gradient homolog 2 (AGR2) (upregulated 9.9-fold) was selected as a potential biomarker of human lung adenocarcinoma. AGR2 was positive in 94% of lung adenocarcinoma patients. Negative AGR2 expression was associated with poor survival (p = 0.007).Conclusions: AGR2 is likely to become a biomarker for clinical applications.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"58 1","pages":"13-24"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31000094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aorto-renal bypass surgery normalized blood pressure without antihypertensive medications in a young female patient with renal artery occlusion. 年轻女性肾动脉闭塞患者行主动脉-肾搭桥手术，无降压药物治疗，血压恢复正常。

Osaka city medical journal Pub Date : 2012-06-01

Mikumo Sakaguchi, Shota Fukuda, Kenei Shimada, Yasushi Kono, Koki Nakanishi, Kenichiro Otsuka, Tomoichiro Kubo, Satoshi Jissho, Haruyuki Taguchi, Takeshi Ikuta, Junichi Yoshikawa, Yoshihiro Shimizu, Minoru Yoshiyama

引用次数: 0

Two cases of transthoracic pericardial fenestration for pericardial effusion. 经胸心包开窗治疗心包积液2例。

Osaka city medical journal Pub Date : 2012-06-01

Hiroki Mizoguchi, Masayuki Sakaki, Katsukiyo Kitabayashi, Ai Shibamoto, Kanta Araki, Shigeaki Ohtake

引用次数: 0

Progression of cataracts following photodynamic therapy combined with intravitreous triamcinolone injection in cases of age-related macular degeneration. 光动力治疗联合玻璃体注射曲安奈德治疗老年性黄斑变性后白内障的进展。

Osaka city medical journal Pub Date : 2011-12-01

Hisashi Iwami, Takeya Kohno, Manabu Yamamoto, Mayumi Kaida, Norito Miki, Shinsuke Ataka, Kunihiko Shiraki

{"title":"Progression of cataracts following photodynamic therapy combined with intravitreous triamcinolone injection in cases of age-related macular degeneration.","authors":"Hisashi Iwami, Takeya Kohno, Manabu Yamamoto, Mayumi Kaida, Norito Miki, Shinsuke Ataka, Kunihiko Shiraki","doi":"","DOIUrl":"","url":null,"abstract":"Background: To present long-term data on the progression of cataracts following photodynamic therapy (PDT) combined with 4 mg intravitreal triamcinolone acetonide (IVTA) for age-related macular degeneration (AMD).Methods: Fifty-seven phakic eyes of 56 patients underwent the treatment between October 2004 and November 2006. The follow-up period ranged from 12 to 38 months with 3 months interval of observation and repeated treatment at recurrence.Results: Cataract progression was noted in 40 eyes 5-21 months after treatment, consisting of 4 eyes between 3 and < 6 months after treatment, 22 eyes between 6 and < 12 months, 8 eyes between 12 and < 18 months, and 6 eyes between 18 and < 24 months. The percentage of the eyes with cataract progression began to decrease 5 months after treatment and, occurred most frequently during the period from 6 months to 12 months after treatment. There was no significant difference in age, follow-up period, or the frequency of the treatment between the cataract progression group and the non progression group. Twenty four eyes underwent surgery 10-31 months after treatment, showing significant improvement in visual acuity.Conclusions: This study showed high incidence of cataract during a long-term follow-up after PDT combined with IVTA and significant reduction of visual acuity due to cataract.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"57 2","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30523490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case. 组织病理学结果显示粒细胞集落刺激因子产生升结肠癌:1例报告。

Osaka city medical journal Pub Date : 2011-12-01

Yushi Fujiwara, Osamu Yamazaki, Satoshi Takatsuka, Ryoji Kaizaki, Takeshi Inoue

{"title":"Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case.","authors":"Yushi Fujiwara, Osamu Yamazaki, Satoshi Takatsuka, Ryoji Kaizaki, Takeshi Inoue","doi":"","DOIUrl":"","url":null,"abstract":"Various types of granulocyte colony-stimulating factor (G-CSF)-producing malignant tumors have been reported. However, a G-CSF-producing colorectal cancer is rare. We present a case of G-CSF-producing ascending colon cancer. An 81-year-old man was referred to our hospital with right lower abdominal pain. A colon fiberscopy revealed an ascending colon tumor, and histological examination revealed tubular adenocarcinoma. He was admitted due to worsening abdominal pain. Although laboratory data showed an elevated white blood cell (WBC) count of 17000/mm3 with 77.8% neutrophils, elevated C-reaction protein (CRP) was insignificant (1.06 mg/dL), and he was afebrile. Because computed tomography indicated that the tumor penetrated into surrounding tissue, a semi-urgent ileocecal resection was performed. An abscess was not located. The tumor was staged as T3N2aM0 and as stage IIB according to the TNM classification. Microscopically, significant neutrophil infiltration between cancer cells was observed, suggesting the presence of a G-CSF-producing tumor. Immunohistochemical staining using a G-CSF antibody revealed cytoplasmic staining in cancer cells. The serum concentration of G-CSF upon admission was 334 pg/mL. After surgical resection, the WBC count decreased to within a normal range. These findings confirmed the diagnosis of G-CSF-producing ascending colon cancer. The prognosis of G-CSF-producing tumors is considered to be poor. Early diagnosis and surgical treatment are needed for patients with G-CSF-producing tumors, and continuous careful follow-up is required.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"57 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30523495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower skin temperature decreases maximal cycling performance. 较低的皮肤温度会降低最大循环性能。

Osaka city medical journal Pub Date : 2011-12-01

Daiki Imai, Kazunobu Okazaki, Shinya Matsumura, Takashi Suzuki, Taiki Miyazawa, Akina Suzuki, Ryosuke Takeda, Takeshi Hamamoto, Tetsuo Zako, Takashi Kawabata, Toshiaki Miyagawa

{"title":"Lower skin temperature decreases maximal cycling performance.","authors":"Daiki Imai, Kazunobu Okazaki, Shinya Matsumura, Takashi Suzuki, Taiki Miyazawa, Akina Suzuki, Ryosuke Takeda, Takeshi Hamamoto, Tetsuo Zako, Takashi Kawabata, Toshiaki Miyagawa","doi":"","DOIUrl":"","url":null,"abstract":"Background: It is known that external cooling of body regions involved in exercise, prior to exercise, decreases anaerobic performance. However, there have been no studies reporting the effects of whole body skin surface cooling before exercise on maximal anaerobic capacity. In order to clarify the effects, we compared power output during the Wingate anaerobic test between preconditioning by exposure to temperature 10 degrees C and 25 degrees C.Methods: Eight healthy males carried out the Wingate test for 30 seconds, after pre-conditioning for 60 minutes using a perfusion suit with water at a temperature of 10 degrees C or 25 degrees C. We evaluated the peak power (PP) and peak power slope (PS) of the power output.Results: Mean skin temperature (T(sk)) at 60 minutes of pre-conditioning in the 10 degrees C trial was significantly lower than in the 25 degrees C trial (p < 0.05). PP and also PS were significantly lower in the 10 degrees C trial than in the 25 degrees C trial. Changes (Δ) in PP between the 10 degrees C trial and the 25 degrees C trial were strongly correlated with ΔT(sk) and Δ in thigh and leg skin temperature (ΔT(thigh) and ΔT(leg), respectively), whereas ΔPS was strongly correlated with ΔT(sk), but not with ΔT(thigh) and ΔT(leg).Conclusions: Whole body skin surface cooling prior to exercise restricts anaerobic capacity, especially in the initial phase of exercise.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"57 2","pages":"67-77"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30523494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0