Osaka city medical journal最新文献_第4页

Psychiatric comorbidity in children with high-functioning pervasive developmental disorder. 高功能广泛性发育障碍儿童的精神共病。

Osaka city medical journal Pub Date : 2014-06-01

Hiroto Kusaka, Dai Miyawaki, Yuta Nakai, Hiroaki Okamoto, Eri Futoo, Ayako Goto, Yu Okada, Koki Inoue

{"title":"Psychiatric comorbidity in children with high-functioning pervasive developmental disorder.","authors":"Hiroto Kusaka, Dai Miyawaki, Yuta Nakai, Hiroaki Okamoto, Eri Futoo, Ayako Goto, Yu Okada, Koki Inoue","doi":"","DOIUrl":"","url":null,"abstract":"Background: In previous studies for children with pervasive developmental disorder (PDD), the prevalence for psychiatric comorbidities has varied because of their methodological differences. In this research, our PDD subjects were strictly limited by age and IQ scores, and we utilized a semi-structured interview to diagnose their coexisting disorders. The purpose of this study is to identify reliable prevalence and types of psychiatric comorbidities in children with high-functioning PDD (HFPDD).Methods: The subjects were 49 children aged 6-15 years with HFPDD. In order to diagnose the comorbidities among them, we used the Japanese version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version.Results: Forty-eight cases (98%) met the criteria for at least one comorbidity. The median number of the present comorbidities per child was 2, and the mode was 2. Depression (37%), attention deficit hyperactivity disorder (49%), and oppositional defiant disorder (45%) were frequently observed.Conclusions: Our finding indicates the high prevalence of comorbidities and the variety of the comorbid disorders in children with HFPDD. It is important to be aware of those comorbid disorders to provide the children with effective treatments.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"60 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32711329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholangiocarcinoma in a middle-aged patient working at a printing plant. 在印刷厂工作的中年患者胆管癌。

Osaka city medical journal Pub Date : 2014-06-01

Shogo Tanaka, Nobusuke Fukumoto, Kohichi Ohno, Sayaka Tanaka, Masahiko Ohsawa, Takatsugu Yamamoto, Yasuni Nakanuma, Shoji Kuboo

{"title":"Cholangiocarcinoma in a middle-aged patient working at a printing plant.","authors":"Shogo Tanaka, Nobusuke Fukumoto, Kohichi Ohno, Sayaka Tanaka, Masahiko Ohsawa, Takatsugu Yamamoto, Yasuni Nakanuma, Shoji Kuboo","doi":"","DOIUrl":"","url":null,"abstract":"A 39-year-old male with elevated serum transferases consulted our hospital in September 2010. Since 1999, he had worked at a printing company using organic solvents. Cholangiography revealed stenosis of the left hepatic duct with peripheral dilation, stricture of the right hepatic duct, and irregularity of the extrahepatic bile duct. As a preoperative diagnosis of sclerosing cholangitis and cholangiocarcinoma was made, extended left hepatectomy with resection of the extrahepatic bile duct and anastomosis of the anterior and posterior branches of the bile duct and the jejunum (Roux-en Y reconstruction) were performed. A histological examination showed papillary carcinoma of the medial hepatic bile duct with intraductal growth, and biliary intraepithelial neoplasia-2/3 lesions from the medial hepatic bile duct to the right hepatic and the common bile ducts. Chronic cholangitis was shown around the tumors. Postoperatively, the patient was treated with adjuvant chemo-radiation, and he is doing well 30 months after the operation, without recurrence. Unknown causes, including exposure to organic solvents, might have induced chronic bile duct injury and contributed to the development of cholangiocarcinoma.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"60 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32711333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of levothyroxine supplementation in extremely low birth weight infants who have transient hypothyroidism without thyroid-stimulating hormone elevation. 补充左旋甲状腺素对极低出生体重婴儿短暂性甲状腺功能减退无促甲状腺激素升高的作用。

Osaka city medical journal Pub Date : 2014-06-01

Shiho Nomura, Hitoshi Ikegami, Hiroshi Wada, Hiroshi Tamai, Masahisa Funato, Haruo Shintaku

{"title":"Role of levothyroxine supplementation in extremely low birth weight infants who have transient hypothyroidism without thyroid-stimulating hormone elevation.","authors":"Shiho Nomura, Hitoshi Ikegami, Hiroshi Wada, Hiroshi Tamai, Masahisa Funato, Haruo Shintaku","doi":"","DOIUrl":"","url":null,"abstract":"Background: Preterm infants show transient hypothyroxinemia without thyroid-stimulating hormone (TSH) elevation. In addition, the degree of neurodevelopmental delay in preterm infants become severe according to the decreasing gestational age (GA). Because of the crucial role of thyroid hormones in brain development, hypothyroxinemia has the potential to cause developmental delay; however, the effectiveness of thyroxine (T4) supplementation on developmental outcomes remains controversial. To resolve these issues, we evaluated the clinical course of transient hypothyroxinemia and the effects of levothyroxine (LT4) supplementation in extremely low birth weight (ELBW) infants.Methods: Serum levels of free T4 (FT4) and TSH were examined in 36 ELBW infants from 7 days after birth. LT4 (5-10 microg/kg/day) was orally administered to 18 of 36 infants with a low serum FT4 level (< 0.4 ng/dL) or normal serum FT4 levels and a clinical manifestation of hypothyroidism, whereas remaining 18 patients without a low serum FT4 level or clinical hypothyroidism were not given LT4 supplementation as control subjects. Infants were followed-up at a corrected age of 12 months, and clinical outcome was compared between infants that received LT4 and those that did not.Results: ELBW infants showed low serum FT4 levels without TSH elevation. During hospitalization and at follow-up, LT4-administered infants with low serum FT4 levels showed a shorter GA compared with the control group. There were no other statistically significant differences in clinical outcomes at 12 months of corrected age between LT4-administered and control groups.Conclusions: Our results show that shorter GA is associated with lower serum FT4 levels. Shorter GA is known to cause developmental delay, however, LT4 supplementation prevents the developmental delay of ELBW infants with transient hypothyroxinemia.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"60 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32711332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between oxidative stress and aortic valve stenosis in humans: an immunohistochemical study. 氧化应激与人类主动脉瓣狭窄的关系:免疫组织化学研究。

Osaka city medical journal Pub Date : 2013-12-01

Satoko Wada, Kenichi Sugioka, Takahiko Naruko, Yasuyuki Kato, Toshihiko Shibata, Takeshi Inoue, Mayumi Inaba, Masahiko Ohsawa, Minoru Yoshiyama, Makiko Ueda

{"title":"Relationship between oxidative stress and aortic valve stenosis in humans: an immunohistochemical study.","authors":"Satoko Wada, Kenichi Sugioka, Takahiko Naruko, Yasuyuki Kato, Toshihiko Shibata, Takeshi Inoue, Mayumi Inaba, Masahiko Ohsawa, Minoru Yoshiyama, Makiko Ueda","doi":"","DOIUrl":"","url":null,"abstract":"Background: Oxidative stress contributes to plaque formation and the destabilization of coronary atherosclerotic lesions. It has been reported that disease processes and clinical risk factors of aortic valve stenosis (AS) are similar to those of atherosclerosis. In this study, we immunohistochemically examined the expression of 4-hydroxy-2-nonenal (4-HNE), an oxidative stress-related molecule, by using surgically resected aortic valve specimens from AS patients.Methods: The study was conducted using aortic valve specimens, surgically obtained from 24 patients with severe AS undergoing aortic valve replacement. We immunohistochemically investigated frozen aortic valve samples with antibodies against smooth muscle cells, macrophages, CD31 and 4-HNE.Results: Morphometric analysis showed that the percentage of the macrophage-positive area and the number of CD31-positive microvessels were significantly higher in AS patients than those in reference cases (macrophages, p < 0.005 and CD31, p < 0.0001). Furthermore, the 4-HNE-positive macrophage score was also significantly higher in AS patients than in reference cases (p < 0.005).Conclusions: 4-HNE was expressed in the stenotic aortic valves in patients with severe AS, suggesting a close relationship between oxidative stress and the progression of calcific AS.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article. 原发性肝神经内分泌癌的术后预后:综述文章。

Osaka city medical journal Pub Date : 2013-12-01

Hiroji Shinkawa, Satoshi Takatsuka, Ryoji Kaizaki, Yushi Fujiwara, Osamu Kurai, Osamu Yamazaki

{"title":"Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article.","authors":"Hiroji Shinkawa, Satoshi Takatsuka, Ryoji Kaizaki, Yushi Fujiwara, Osamu Kurai, Osamu Yamazaki","doi":"","DOIUrl":"","url":null,"abstract":"Background: We examined the course of a primary hepatic neuroendocrine carcinoma (PHNEC) patient and analyzed the postoperative outcome of all reported PHNEC cases.Methods: A literature search for PHNEC cases was performed using PubMed. All reported cases and our present patient were analyzed in this study. Survival analysis was performed using the Kaplan-Meier method. Risk factors for the recurrence of PHNEC following hepatic resection were investigated.Results: A total of 43 patients were analyzed in this study. The 3-, 5-, and 7-year overall survival rates were 55%, 48%, and 48%, respectively. The 3-, 5-, and 7-year overall survival rates in surgery patients were 78% each, and 25%, 17%, and 17%, respectively in nonsurgery patients. Lymph node metastasis posed a significant risk factor for postoperative recurrence.Conclusions: Hepatic surgery is an appropriate therapeutic treatment for PHNEC without distant metastasis nor lymph node metastasis. Adjuvant chemotherapy might be necessary for PHNEC patients with lymph node metastases.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"105-13"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships between occupational stress and depressive symptoms among prison officers in Japan. 日本监狱工作人员职业压力与抑郁症状的关系

Osaka city medical journal Pub Date : 2013-12-01

Yasuhiko Deguchi, Koki Inoue, Tomohiro Muramatsu, Shinichi Iwasaki, Tsuneo Yamauchi, Takehisa Nakao, Masayo Muroya, Yumi Kobayashi, Yasuyuki Kato, Nobuo Kiriike

{"title":"Relationships between occupational stress and depressive symptoms among prison officers in Japan.","authors":"Yasuhiko Deguchi, Koki Inoue, Tomohiro Muramatsu, Shinichi Iwasaki, Tsuneo Yamauchi, Takehisa Nakao, Masayo Muroya, Yumi Kobayashi, Yasuyuki Kato, Nobuo Kiriike","doi":"","DOIUrl":"","url":null,"abstract":"Background: The relationships between occupational stress and depressive symptoms in prison officers have rarely been studied in Japan. Thus, we analyzed the associations between occupational stress factors and depressive symptoms among Japanese prison officers.Methods: This was a cross-sectional study involving 426 male prison officers (20-60-year-old). Depressive symptoms were assessed using the Zung Self-Rating Depression Scale. Using this scale and a cut-off point of 50, the subjects were divided into the \"depressive group\" and \"non-depressive group\". Occupational stress was evaluated using the Generic Job Stress Questionnaire. Comparisons among the groups were performed with multiple logistic regression analysis.Results: Of the 426 subjects, 107 were included in the depressive group. After adjusting for demographic and occupational variables, higher scores for the physical environment, role ambiguity, and quantitative workload and a lower score for social support from co-workers were found to be associated with an increased odds ratio of depressive symptoms.Conclusions: The physical environment, role ambiguity, quantitative workload, and social support from coworkers are associated with depressive symptoms in Japanese prison officers. We hope that educating prison officers about the results of this study and organizational/individual-based improvement strategies will reduce their risk of depression.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"91-8"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time PCR assays for hepatitis C virus RNA (genotype 1) is useful for evaluating virological response to the treatment with peginterferon-alpha2b and ribavirin. 实时PCR检测丙型肝炎病毒RNA(基因型1)可用于评估对聚乙二醇干扰素- α 2b和利巴韦林治疗的病毒学反应。

Osaka city medical journal Pub Date : 2013-12-01

Mika Nakaya, Masaru Enomoto, Hideki Fujii, Sawako Kobayashi, Shuji Iwai, Hiroyasu Morikawa, Akihiro Tamori, Hiroki Sakaguchi, Norifumi Kawada

{"title":"Real-time PCR assays for hepatitis C virus RNA (genotype 1) is useful for evaluating virological response to the treatment with peginterferon-alpha2b and ribavirin.","authors":"Mika Nakaya, Masaru Enomoto, Hideki Fujii, Sawako Kobayashi, Shuji Iwai, Hiroyasu Morikawa, Akihiro Tamori, Hiroki Sakaguchi, Norifumi Kawada","doi":"","DOIUrl":"","url":null,"abstract":"Background: The real-time PCR, such as Abbott RealTime assay, have replaced end-point PCR, such as Amplicor assays, for the measurement of HCV RNA. However, 'response-guided therapy' to use on-treatment response for tailoring the duration of treatment with peginterferon-alpha and ribavirin has not been fully evaluated for real-time PCR.Methods: 43 patients with HCV genotype 1 (24 who had complete early virological responses (cEVR) on Amplicor assay and received 48-week therapy, and 19 who had late virological responses (LVR) and received 72-week therapy) were recruited. Using a RealTime assay, we retrospectively measured HCV RNA in stored sera.Results: In 10 samples obtained during therapy, HCV RNA was undetectable on the Amplicor assay, but detectable on the RealTime assay. Among patients with cEVR on the Amplicor assay, those with detectable HCV RNA on the RealTime assay at week 12 were less likely to have a sustained virological response (SVR) than those without (2/4 vs 17/20, p = 0.116). Among patients with LVR on the Amplicor assay, those with HCV RNA detectable on the RealTime assay at week 24 were significantly less likely to have SVR than those without (1/4 vs 12/15, p = 0.041).Conclusions: The RealTime assay may be useful for tailoring duration of treatment for the patient with HCV genotype 1.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of transthoracic and transesophageal echocardiography for the diagnosis of bicuspid aortic valve: comparison with operative findings. 经胸经食管超声心动图诊断二尖瓣主动脉瓣的准确性:与手术表现的比较。

Osaka city medical journal Pub Date : 2013-12-01

Hisateru Takeda, Takashi Muro, Toshio Saito, Eiichi Hyodo, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Shigefumi Suehiro, Minoru Yoshiyama

{"title":"Diagnostic accuracy of transthoracic and transesophageal echocardiography for the diagnosis of bicuspid aortic valve: comparison with operative findings.","authors":"Hisateru Takeda, Takashi Muro, Toshio Saito, Eiichi Hyodo, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Shigefumi Suehiro, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background: Bicuspid aortic valve (BAV) is associated with an increased risk of aortic valve (AV) dysfunction, aortic dissection, and infective endocarditis. Therefore, its accurate diagnosis is critical. The morphological features of AVs are generally evaluated by transthoracic echocardiography (TTE) or transesophageal echocardiography (TEE), however, the difference in the diagnostic capability of these imaging modalities for detecting BAV remains unclear. Here, we compared these 2 methods to determine their accuracy, and to clarify each role in the diagnosis of BAV.Methods: This blind study evaluated 126 patients (age, 70.3 +/- 7.8 years) who subsequently underwent AV replacement. The number of AV cusps of each patient was estimated by TTE and TEE and compared to the number of AV written in the operative record. Patients with poor echocardiographic images were not excluded.Results: Surgical findings showed 97 tricuspid AVs and 29 BAVs. The sensitivity, specificity, and accuracy for the diagnosis of BAV were 61%, 81%, and 77%, respectively, for TTE and 86%, 90%, and 89%, respectively, for TEE. The accuracy of TEE was significantly higher than that of TTE (p = 0.016). In non-calcified AVs, the accuracy of TTE was similar to that of TEE (96%, each) whereas in calcified AVs, TTE had a lower accuracy than TEE (72% vs 87%, p = 0.011). The feasibility was significantly higher for TEE than for TTE (98% vs 90%, p = 0.003).Conclusions: TEE provides higher accuracy and feasibility than TTE in the diagnosis of BAV, and it should therefore be indicated when morphological features of AVs cannot be evaluated by TTE.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histologically proven hepatocellular carcinoma associated with burned-out nonalcoholic steatohepatitis. 组织学证实的肝细胞癌与燃烧性非酒精性脂肪性肝炎相关。

Osaka city medical journal Pub Date : 2013-12-01

Kazuhisa Kaneda, Takahiro Uenishi, Shigekazu Takemura, Takatsugu Yamamoto, Chikaharu Sakata, Masayuki Sakae, Yorihisa Urata, Kazunori Ohata, Sayaka Tanaka, Kenichi Wakasa, Shoji Kubo

{"title":"Histologically proven hepatocellular carcinoma associated with burned-out nonalcoholic steatohepatitis.","authors":"Kazuhisa Kaneda, Takahiro Uenishi, Shigekazu Takemura, Takatsugu Yamamoto, Chikaharu Sakata, Masayuki Sakae, Yorihisa Urata, Kazunori Ohata, Sayaka Tanaka, Kenichi Wakasa, Shoji Kubo","doi":"","DOIUrl":"","url":null,"abstract":"A 64-year-old Japanese man was referred to our hospital because of liver dysfunction. He had no history of alcohol intake, diabetes, hypertension, and hyperlipidemia, and he was negative for hepatitis viral markers. His body mass index was 30.6 kg/m2. Homeostasis model assessment of insulin resistance was 6.1. Liver biopsy revealed mild steatosis, moderate inflammation, ballooning degeneration, and portal fibrosis with bridging fibrosis; on the basis of these findings, the diagnosis of nonalcoholic steatohepatitis was made. Thereafter, follow-up imaging study was performed every 4 months. At 16 months after liver biopsy, a 3 cm hepatic lesion was detected in the right hepatic lobe by computed tomography. Dynamic computed tomography revealed a hepatic tumor enhanced with contrast medium during the arterial phase and a low-density area during the portal phase. Based on the diagnosis of hepatocellular carcinoma, partial hepatectomy was performed. Histological examination revealed a moderately differentiated hepatocellular carcinoma accompanied by liver cirrhosis without steatosis or ballooning degeneration. Finally, the patient was diagnosed with hepatocellular carcinoma arising from burned-out nonalcoholic steatohepatitis.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 2","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors and outcomes of unrelated bone marrow transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) pre-treated with tyrosine kinase inhibitors. 酪氨酸激酶抑制剂预处理费城染色体阳性急性淋巴细胞白血病(Ph+ALL)非相关骨髓移植的预后因素和结果

Osaka city medical journal Pub Date : 2013-06-01

Takuro Yoshimura, Takahiko Nakane, Asao Hirose, Hideo Koh, Mika Nakamae, Mizuki Aimoto, Mitsutaka Nishimoto, Yoshiki Hayashi, Yoshiki Terada, Hirohisa Nakamae, Masayuki Hino

{"title":"Prognostic factors and outcomes of unrelated bone marrow transplantation for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) pre-treated with tyrosine kinase inhibitors.","authors":"Takuro Yoshimura, Takahiko Nakane, Asao Hirose, Hideo Koh, Mika Nakamae, Mizuki Aimoto, Mitsutaka Nishimoto, Yoshiki Hayashi, Yoshiki Terada, Hirohisa Nakamae, Masayuki Hino","doi":"","DOIUrl":"","url":null,"abstract":"Background: The treatment and prognosis of Acute Lymphoblastic Leukemia (ALL), including Philadelphia chromosome positive ALL (Ph+ALL), a poor prognostic factor, has changed with the introduction of tyrosine kinase inhibitors (TKIs). Nevertheless, allogeneic hematopoietic cell transplantation (allo-HCT) is still recommended as the first-line curative treatment. To date, no study has investigated the prognostic factors and outcomes of unrelated bone marrow transplantation (u-BMT) for Ph+ALL following pre-transplant treatment with a TKI-containing regimen.Methods: We retrospectively evaluated 15 transplantations of 14 patients with Ph+ALL pre-treated with a TKI-containing regimen at our institute. The 14 patients comprised 11 males and 3 females, with a median age of 50 years (range: 19-64). We performed univariate and multivariate analyses of risk factors that contributed to overall survival (OS) or leukemia-free survival (LFS).Results: Three-year OS of the patients with molecular complete remission (MCR) and with non-MCR at transplantation were 89% and 40% (p = 0.006), respectively, and three-year LFS rates were 79% and 0% (p = 0.001), respectively. Univariate analysis revealed that first hematological complete remission (HCR1) and MCR at transplant were significantly related to better OS and LFS. Multivariate analysis showed that MCR at transplant was significantly associated with better OS and LFS.Conclusions: In agreement with a previous study that included other stem cell sources, u-BMT was deemed feasible for the treatment of Ph+ALL. Analysis of a larger cohort is required to clarify the prognostic factors that affect transplant outcome in Ph+ALL since the introduction of TKIs.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"59 1","pages":"9-21"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31626824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0