Osaka city medical journal最新文献_第2页

Effects of Night Shift Work on Nighttime Blood Pressure among Healthy Young Female Medical Workers. 夜班工作对健康年轻女医务工作者夜间血压的影响

Osaka city medical journal Pub Date : 2016-12-01

Ryoko Kitada, Shinichi Iwata, Akihisa Hanatani, Naoki Norioka, Kenichi Sugioka, Masahiko Takagi, Minoru Yoshiyama

{"title":"Effects of Night Shift Work on Nighttime Blood Pressure among Healthy Young Female Medical Workers.","authors":"Ryoko Kitada, Shinichi Iwata, Akihisa Hanatani, Naoki Norioka, Kenichi Sugioka, Masahiko Takagi, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background Although night shift is an independent risk factor of cardiovascular disease (CVD), the underlying mechanisms have not been understood. Nocturnal blood pressure (BP) and increased BP variability are associated with CVD. However, little is known regarding the impact of night shift on nocturnal BP variables. Methods The study population consisted of 30 healthy female medical shift workers (mean age, 28±6 years) with flexible blood vessels (mean cardio-ankle vascular index, 5.8±0.9). Nocturnal BP variables were measured after day and night shifts using a home BP monitoring device. Similarly, sleep status (total sleep time, sleep efficiency, and snoring) were measured using a noncontact radiofrequency sensor. Results Nocturnal diastolic BP variability (7.0±5.3 mm Hg vs 4.7±2.7 mm Hg; p<0.01) was significantly higher after night shift than after day shift, whereas no significant differences in systolic BP variables, mean diastolic BP, and sleep status were observed. Conclusions Among young healthy women with flexible blood vessels, night shift increased nighttime diastolic BP variability, rather than systolic BP variables independent of sleep disorder. These findings imply that increased nighttime diastolic BP variability derived from night shift might stimulate an early- stage atherosclerotic process that predisposes patients to future CVD.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"62 2","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36782787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardio-ankle Vascular Index Associated with Coronary Plaque Burden not Plaque Morphology. 心踝血管指数与冠状动脉斑块负荷相关，而与斑块形态无关。

Osaka city medical journal Pub Date : 2016-12-01

Mikumo Saaguchi, Takao Hasegawa, Shoichi Ehara, Kenji Matsumoto, Masashi Nakagawa, Kenei Shimada, Minoru Yoshiyama

{"title":"Cardio-ankle Vascular Index Associated with Coronary Plaque Burden not Plaque Morphology.","authors":"Mikumo Saaguchi, Takao Hasegawa, Shoichi Ehara, Kenji Matsumoto, Masashi Nakagawa, Kenei Shimada, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background Cardio-ankle vascular index (CAVI) is a marker that reflects the overall stiffness of the aorta, femoral artery, and tibial artery. Several previous reports have shown the usefulness of CAVI for coronary artery disease (CAD) presence and severity. According to coronary angiography (CAG) and intracoronary imaging such as optical coherence tomography (OCT), coronary plaque burden and morphology as predictors of all-cause and cardiovascular mortality were previously evaluated. The aim of our study was to assess the correlation between CAVI value and Gensini's score for the coronary plaque burden as well as CAVI value and plaque morphology by using OCT. Methods A total of 548 consecutive patients who underwent CAG were enrolled in this study. CAVI value was evaluated in all patients, and OCT was performed in 89 of the 548 patients. CAVI ratio is calculated as CAVI/CAVIex (expected normal value of CAVI, which is calculated using patient age and sex). Results On multivariable analysis, sex, age, hypertension, diabetes mellitus, and CAVI were significantly correlated with logarithmized Gensini's score. CAVI values were significantly higher in the groups with CAD, which were 1 vessel disease (VD), 2VD, and 3VD, than in the OVD group (p<0.001). However, there was no statistical significance between CAVI ratio and OCT findings in terms of plaque morphology. Conclusions CAVI might be useful as a routine test for the detection of CAD and the evaluation of atherosclerotic plaque burden but not coronary plaque vulnerability.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"62 2","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36782788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ability of NT-pro-BNP to Diagnose Cardioembolic Etiology in Patients with Acute Ischemic Stroke. NT-pro-BNP诊断急性缺血性脑卒中患者心栓塞病因的能力。

Osaka city medical journal Pub Date : 2016-12-01

Yumiko Okada, Yuzo Terakawa, Takaho Murata, Kazuhito Nakamura, Katsumi Shimotake, Hideho Murata, Kenji Ohata

{"title":"Ability of NT-pro-BNP to Diagnose Cardioembolic Etiology in Patients with Acute Ischemic Stroke.","authors":"Yumiko Okada, Yuzo Terakawa, Takaho Murata, Kazuhito Nakamura, Katsumi Shimotake, Hideho Murata, Kenji Ohata","doi":"","DOIUrl":"","url":null,"abstract":"Background Cardioembolic stroke (CE) is usually associated with a larger ischemic area leading to higher morbidity and mortality rates. No biomarkers for CE are available, which causes difficulty in differential diagnosis of CE from other subtypes of acute ischemic stroke.Methods: We prospectively evaluated consecutive patients with acute ischemic stroke to identify biomarkers that could distinguish between CE and other subtypes of acute ischemic stroke. Etiological diagnoses were identified according to the National Institute of Neurological Disorders and Stroke (NINDS) 111 classification using clinical examinations, computed tomography (CT), magnetic resonance imaging (MRI), cardiac evaluations, and other tests. The biomarkers N-terminal pro-brain natriuretic peptide (NT-pro-BNP), Thrombin-Antithrombin III Complex (TAT), and D-dimer were determined in blood samples collected within 48 hours of onset and compared between groups with and without CE. Non- CE consisted of atherothrombotic brain infarction (ATBI), lacunar infarction (LI), and other stroke subtypes of unknown cause (other).Results: This study included 279 patients diagnosed with acute ischemic stroke. Serum levels of NT-pro- BNP were significantly higher in those with than in those without CE stroke (p<0.0001). Analysis of receiver operating characteristics (ROC) curves indicated that an NT-pro-BNP cutoff of 332 pg/mL provided optimal sensitivity (98.3%) and specificity (75.8%) for distinguishing CE from non-CE.Conclusions: Serum levels of NT-pro-BNP may help in diagnosis of CE during the acute phase and thus allow appropriate therapy t6 prevent subsequent cardiogenic stroke.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"62 2","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36931971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Up-regulation of the MicroRNA miR-30c Induced by High Mobility Group Box 1 in A549 Cells Used as an Alveolar Epithelial Model. 高迁移率组盒1在肺泡上皮A549细胞中诱导MicroRNA miR-30c上调

Osaka city medical journal Pub Date : 2016-12-01

Fumihiro Nagayasu, Kazuhisa Konishi, Naoki Ijiri, Kazuhisa Asai, Yoshihiro Tochino, Hiroshi Kamoi, Hiroshi Kanazawa, Kazuto Hirata

{"title":"Up-regulation of the MicroRNA miR-30c Induced by High Mobility Group Box 1 in A549 Cells Used as an Alveolar Epithelial Model.","authors":"Fumihiro Nagayasu, Kazuhisa Konishi, Naoki Ijiri, Kazuhisa Asai, Yoshihiro Tochino, Hiroshi Kamoi, Hiroshi Kanazawa, Kazuto Hirata","doi":"","DOIUrl":"","url":null,"abstract":"Background: MicroRNAs (miRNAs) have been reported to be involved in multiple diseases, including chronic obstructive pulmonary disease (COPD), a progressive disease in which alveolar apoptosis may play a role. We hypothesized that miRNAs are associated with the response to injury. induced by high mobility group box 1 (HMGB1), a cytokine crucial for the development of COPD, and studied the potential link between HMGB1 and miRNAs.Materials and methods: A549 cells were stimulated with recombinant HMGB1. RNA and protein were extracted and culture supernatants were collected. Molecules downstream of HMGB1 signaling were analyzed by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Expression levels of miRNA were analyzed by quantitative RT-PCR. Cellular injury was evaluated by western blotting of relevant proteins. Apoptosis was evaluated by in situ terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL).Results: HMGB1 treatment of A549 cells resulted in the up-regulation of tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 mRNAs and over expression of matrix metalloprotease (MMP)-7 protein in the supernatant. The miRNA miR-30c was also up-regulated in response to HMGB1 treatment. Cellular injury and apoptosis were observed following HMGB1 treatment, as demonstrated by the oyerexpression of cyclin A2 (CCNA2) and phosphatase and tensin homolog (PTEN) proteins and-b'y decreased levels of pro-caspase-7 protein. The TUNEL assay showed that A549 cells with HMGB1 stimulation underwent apoptosis.Conclusions: Up-regulation of miR-30c and apoptosis of A549 cells were observed following HMGB1 stimulation. Our model demonstrates the potential for utilization of HMGB1 and miR-30c in further studies of alveolar apoptosis in COPD.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"62 2","pages":"121-131"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36921156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Intratracheal Administration of Adipose-derived Stromal Cells on Bleomycin-induced Lung Injury in a Rat Model. 气管内给药脂肪源性基质细胞对博莱霉素所致大鼠肺损伤模型的影响。

Osaka city medical journal Pub Date : 2015-09-01 DOI: 10.1183/13993003.CONGRESS-2015.PA943

M. Uji, A. Nakada, Tatsuo Nakamura, K. Hirata

{"title":"Effect of Intratracheal Administration of Adipose-derived Stromal Cells on Bleomycin-induced Lung Injury in a Rat Model.","authors":"M. Uji, A. Nakada, Tatsuo Nakamura, K. Hirata","doi":"10.1183/13993003.CONGRESS-2015.PA943","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2015.PA943","url":null,"abstract":"BACKGROUND\u0000Mesenchymal stromal cells (MSCs) have been intensively investigated in regenerative medicine. Among the different types of MSCs, adipose tissue-derived stromal cells (ASCs) can be obtained with relatively less invasive techniques. Since ASC administration is a candidate strategy for the treatment of refractory diseases including pulmonary fibrosis, we investigated whether intratracheal injection of ASCs had therapeutic potential against bleomycin (BLM)-induced lung injury in rats.\u0000\u0000\u0000METHODS\u0000BLM was intratracheally administered to rats, and 1 week later ASCs were harvested. Two weeks after BLM treatment, ASCs or phosphate-buffered saline (PBS) were injected autologously into the rats via the trachea A semi-quantitative histological evaluation was conducted to assess the injured lungs, followed by cell tracing at 3 or 6 weeks after BLM instillation.\u0000\u0000\u0000RESULTS\u0000ASC administration did not affect the severity of lung damage on the third week after BLM exposure, but prevented further aggravation of the lung injury, as apparent on the sixth week. A fluorescent cell tracer revealed that the majority of ASCs did not appear to have penetrated inside the lung region injured by BLM on the third week after BLM instillation, but some of these cells sprouted deep into the thick distorted architecture of the injured lung on the sixth week after the BLM instillation.\u0000\u0000\u0000CONCLUSIONS\u0000The results of the present study suggest that ASCs may play a role in the prevention of ongoing aggravation of lung injury in the long term.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"1 1","pages":"81-91"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76817310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Clinical Characteristics of Late Gadolinium Enhancement in Patients with Cardiac Sarcoidosis. 心脏结节病晚期钆增强的临床特征。

Osaka city medical journal Pub Date : 2015-06-01

Kenji Matsumoto, Shoichi Ehara, Mikumo Sakaguchi, Kenichiro Otsuka, Takao Hasegawa, Kenei Shimada, Minoru Yoshiyama

{"title":"Clinical Characteristics of Late Gadolinium Enhancement in Patients with Cardiac Sarcoidosis.","authors":"Kenji Matsumoto, Shoichi Ehara, Mikumo Sakaguchi, Kenichiro Otsuka, Takao Hasegawa, Kenei Shimada, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background: The presence of cardiac involvement in sarcoidosis, a multisystem granulomatous disease of unknown etiology, is associated with very poor prognosis. Therefore, early detection of cardiac sarcoidosis (C-sar) is very important for effective treatment. Recently, the value of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR), which allows visualization of even minute amounts of myocardial damage, has been emphasized in diagnosing C-sar. Although the presence of LGE has been added as a minor criterion for diagnosing C-sar in the most recent Japan Ministry of Health and Welfare (JMHW) guidelines, its clinical utility remains unknown.Methods: A total of 17 patients with biopsy-proven extracardiac sarcoidosis, who underwent CMR and examinations using a sufficient number of modalities to diagnose or exclude C-sar in accordance with the JMHW diagnostic criteria, were retrospectively enrolled in this study. Among these 17 patients, 7 patients were diagnosed with C-sar and 10 with non-C-sar. We investigated the clinical performance of LGE in the detection of cardiac involvement, compared the distribution of LGE with perfusion defects of iodine-123-labeled 15-(p-iodophenyl)-3R,S-methyl pentadecanoic acid (BMIPP) or thallium-201 (201Tl) scintigraphy, and evaluated the prognostic value of LGE on CMR in identifying adverse clinical events.Results: All patients diagnosed with C-sar were positive for LGE and all diagnosed with non-C-sar patients were negative. Evaluation of LGE revealed a broader range of abnormalities than the evaluation of the defects shown by either BMIPP or 201Tl scintigraphy. All adverse events occurred in the C-sar patients with LGE.Conclusions: This study showed that LGE is useful for the detection of cardiac involvement, and it might be a promising tool for determining the prognosis of patients with biopsy-proven extracardiac sarcoidosis.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"61 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34060468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats. 使用气雾发生器经皮二氧化碳治疗可减轻单苦塔林诱导的肺动脉高压大鼠右室功能障碍的发展。

Osaka city medical journal Pub Date : 2015-06-01

Takehiro Yamaguchi, Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Soichi Sano, Masayuki Shiota, Katsuyuki Miura, Hiroshi Iwao, Minoru Yoshiyama

{"title":"Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats.","authors":"Takehiro Yamaguchi, Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Soichi Sano, Masayuki Shiota, Katsuyuki Miura, Hiroshi Iwao, Minoru Yoshiyama","doi":"","DOIUrl":"","url":null,"abstract":"Background: Highly concentrated carbon dioxide (GO2) is useful for treating ischemic diseases. Therefore, we investigated whether treatment with a few micrometers of CO2 molecules, atomized by two fluid nozzles (CO2 mist), could attenuate the development of right ventricular (RV) dysfunction in pulmonary hypertensive rats.Methods: Six-week-old male Wistar rats were divided into three groups: one that received injected saline; a second that received subcutaneous monocrotaline (MCT; 60 mg/kg) without treatment (PH-UT) group; and a third that received MCT with CO2 mist treatment (PH-CM) after MCT administration. The lower body of each rat was encased in a polyethylene bag, filled with the designated gaseous agent via a gas mist generator, for 30 minutes daily. Hemodynamics and cardiac function were measured at 28 days after beginning MCT administration. Protein levels were measured by western blotting.Results: Rats that received MCT without treatment began to die within 3-4 weeks of the initial administration. However, treatment with CO2 mist extended the survival period of rats in that group. At 28 days after MCT administration, the hemodynamic status, such as the blood pressure and heart rate, involved with left ventricular function, of rats in the PH-UT group were similar to those of rats in the PH-CM group. However, MCT-induced RV weight and RV dysfunction were significantly attenuated by treatment with CO2 mist. Both RV phosphorylated endothelial nitric oxide synthase and heat shock protein 72 levels increased significantly in the PH-CM group, compared to the PH-UT group.Conclusions: Percutaneous CO2 mist therapy may alleviate RV dysfunction in patients with pulmonary hypertension.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"61 1","pages":"31-41"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-term Results of Endovascular Treatment for Infrarenal Aortic Stenosis and Occlusion. 肾下主动脉狭窄闭塞的血管内治疗中期结果分析。

Osaka city medical journal Pub Date : 2015-06-01

Etsuji Sohgawa, Yukimasa Sakai, Mineyoshi Nango, Hisayuki Cho, Atsushi Jogo, Shinichi Hamamoto, Akira Yamamoto, Yukio Miki

{"title":"Mid-term Results of Endovascular Treatment for Infrarenal Aortic Stenosis and Occlusion.","authors":"Etsuji Sohgawa, Yukimasa Sakai, Mineyoshi Nango, Hisayuki Cho, Atsushi Jogo, Shinichi Hamamoto, Akira Yamamoto, Yukio Miki","doi":"","DOIUrl":"","url":null,"abstract":"Background: Focal stenosis or occlusion of the infrarenal aorta is rare, and treatment is usually conventional bypass or endarterectomy. However, endovascular treatment has advanced in recent years. The purpose of this retrospective study is to report the results of primary stenting for focal infrarenal aortic occlusive disease and clarify the usefulness of endovascular treatment.Methods: This study includes 6 consecutive patients (3 men, 3 women; mean age, 59.3 years) with infrarenal aortic stenosis or occlusion who underwent endovascular intervention at our hospital between April 2009 and February 2014. All patients had bilateral intermittent claudication. The mean preoperative ankle-brachial index (ABI) showed a slight to moderate decrease: right 0.668 and left 0.636. The mean lesion site length was 12.5 mm, the percent stenosis was 90.7%, and calcification was present in 3 patients. Primary stenting was performed in all patients. The stent selected was generally a self-expanding stent (SES). For patients with severe calcification, the stent selected was a balloon-expandable stent (BES).Results: Four patients received an SES and two patients received a BES. The technical success rate was 100%, no complications occurred, and the mean pressure gradient disappeared or decreased. Symptoms resolved in all patients and the postoperative ABI improved: right 0.923 and left 0.968. During a mean follow-up period of 27 months, there were no recurrent symptoms and no restenosis on CT angiography.Conclusions: Endovascular treatment should be considered as a first line treatment for focal infrarenal aortic stenosis and occlusion.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"61 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34060467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pentraxin-3 as a Biomarker for Febrile Neutropenia in Patients with Lung Cancer. penttraxin -3作为肺癌患者发热性中性粒细胞减少症的生物标志物。

Osaka city medical journal Pub Date : 2015-06-01

Noriko Takeda, Kazuhisa Asai, Naoki Ijiri, Norio Yamamoto, Tetsuya Watanabe, Hiroshi Kamoi, Hiroshi Kanazawa, Kazuto Hirata

{"title":"Pentraxin-3 as a Biomarker for Febrile Neutropenia in Patients with Lung Cancer.","authors":"Noriko Takeda, Kazuhisa Asai, Naoki Ijiri, Norio Yamamoto, Tetsuya Watanabe, Hiroshi Kamoi, Hiroshi Kanazawa, Kazuto Hirata","doi":"","DOIUrl":"","url":null,"abstract":"Background: Pentraxin-3 (PTX3) is a newly discovered biomarker for various inflammatory conditions. We measured plasma PTX3 levels in patients with febrile neutropenic lung cancer and examined the utility of PTX3 levels as a biomarker for febrile neutropenia.Methods: Fourteen patients with febrile neutropenic lung cancer were enrolled in the study. In addition, 10 untreated lung cancer patients and 12 healthy adults were enrolled as a disease control group and a healthy control group, respectively. On the day of onset of febrile neutropenia (day 1) and days 3 and 7, PTX3 and C-reactive protein (CRP) levels were measured. In the control groups, PTX3 and CRP levels were measured once.Results: On day 1, plasma CRP levels in febrile neutropenia during chemotherapy or chemoradiotherapy for lung cancer (FN/LC) patients (8.11 ± 6.42 mg/dL) were significantly higher than those in healthy controls (HC) and chemotherapy/chemoradiotherapy-naïve lung cancer (CN/LC) patients (p < 0.05). However, CRP levels of the CN/LC group (0.33 ± 0.02 mg/dL) were also significantly higher than those of the HC group (0.07 ± 0.09 mg/dL) (p < 0.05). In contrast, plasma PTX3 levels of the FN/LC group (6.14 ± 5.28 ng/mL) were significantly higher than those of the HC and CN/LC groups on day 1 (p < 0.05), but PTX3 levels of the CN/LC group (1.60 ± 0.64 ng/mL) were not significantly higher than those of the HC group (1.05 ± 0.25 ng/mL). In the FN/LC group, PTX3 levels peaked immediately on day 1.Conclusions: PTX3 may be a useful biomarker for diagnosis of FN in patients with LC.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"61 1","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy. 伐尼克兰治疗期间吸烟者血管功能和形态的改变。

Osaka city medical journal Pub Date : 2015-06-01

Masanori Kobayashi, Yasuhiko Takemoto, Naoki Norioka, Tomokazu Iguchi, Kenei Shimada, Makiko Maeda, Mina Morimura, Yasushi Fujio, Junichi Azuma, Minoru Yoshiyama, Kazuhiro Hirohashi, Taichi Shuto

{"title":"Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy.","authors":"Masanori Kobayashi, Yasuhiko Takemoto, Naoki Norioka, Tomokazu Iguchi, Kenei Shimada, Makiko Maeda, Mina Morimura, Yasushi Fujio, Junichi Azuma, Minoru Yoshiyama, Kazuhiro Hirohashi, Taichi Shuto","doi":"","DOIUrl":"","url":null,"abstract":"Background: Varenicline has been reported to achieve high rates of smoking cessation. It remains undetermined whether varenicline therapy improves vascular function in smokers.Methods: Consecutive Seventy-two smokers (age 57 ± 12 years) who succeeded in complete smoking cessation and 46 normal healthy volunteers (age 24 ± 3 years) with no cardiovascular risk factors were enrolled into this study. Vascular function and structure were assessed by flow-mediated dilation (FMD), nitroglycerin-induced vasodilation, and brachial artery intima-media thickness (baIMT) at baseline and 20 weeks after the initiation of varenicline therapy in smokers. FMD and baIMT were measured simultaneously using a semi-automatic vessel wall-tracking software program. 75 μg dose of a nitroglycerin tablet were sublingually administered for the nitroglycerin-induced vasodilation measurement.Results: Exhaled-carbon monoxide concentration decreased significantly (20.0 ± 11.1 ppm at baseline vs 1.9 ± 1.5 ppm after 20 weeks, p < 0.001). FMD was significantly improved after 20 weeks (4.09% ± 1.83% at baseline vs 4.77% ± 2.33% after 20 weeks, p = 0.010), whereas nitroglycerin-induced vasodilation and baIMT were not significantly changed.Conclusions: Smoking cessation with varenicline therapy significantly increased FMD without significant changes of nitroglycerin-induced vasodilation or baIMT from baseline to 20 weeks. It appears to improve vascular function in smokers, which depends on endothelial function rather than on vascular smooth muscle function or changes in vascular structure.","PeriodicalId":19613,"journal":{"name":"Osaka city medical journal","volume":"61 1","pages":"19-30"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34127301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0