Open Journal of Internal Medicine最新文献

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Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea 羟基脲对镰状细胞病患者腿部溃疡的影响
Open Journal of Internal Medicine Pub Date : 2020-12-31 DOI: 10.17140/imoj-4-114
J. Manjunath, Fnu Nutan
{"title":"Leg Ulcer in Patient with Sickle Cell Disease on Hydroxyurea","authors":"J. Manjunath, Fnu Nutan","doi":"10.17140/imoj-4-114","DOIUrl":"https://doi.org/10.17140/imoj-4-114","url":null,"abstract":"Leg ulcers are a painful side-effect commonly seen in patients with long-term use of hydroxyurea. We describe an ulcer in a patient with sickle cell disease (SCD) with an 8-year history of hydroxyurea use. Wound care team used cadexomer-iodine topical and collagenase to aid in healing. There are limited options for the treatment of these ulcers beside the cessation of hydroxyurea, a very effective drug in reducing painful sickle cell episodes. It is imperative to be aware of this complication to prevent expensive tests and further work up. Future study into alternative treatment of hydroxyurea-induced leg ulcers for sickle cell patients is necessary.","PeriodicalId":19579,"journal":{"name":"Open Journal of Internal Medicine","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90627942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levamisole in Medicine 医学上的左旋咪唑
Open Journal of Internal Medicine Pub Date : 2018-12-30 DOI: 10.17140/imoj-2-e001
Fnu Nutan
{"title":"Levamisole in Medicine","authors":"Fnu Nutan","doi":"10.17140/imoj-2-e001","DOIUrl":"https://doi.org/10.17140/imoj-2-e001","url":null,"abstract":"","PeriodicalId":19579,"journal":{"name":"Open Journal of Internal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74838637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma Patients 来那度胺、强的松龙联合治疗日本老年多发性骨髓瘤的疗效和安全性
Open Journal of Internal Medicine Pub Date : 2018-12-30 DOI: 10.17140/IMOJ-2-106
H. Hanamoto, A. Fujii, M. Fujita, R. Fujiwara, K. Emoto, Keigo Sano, Shuji Minamoto, H. Yagi
{"title":"Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma Patients","authors":"H. Hanamoto, A. Fujii, M. Fujita, R. Fujiwara, K. Emoto, Keigo Sano, Shuji Minamoto, H. Yagi","doi":"10.17140/IMOJ-2-106","DOIUrl":"https://doi.org/10.17140/IMOJ-2-106","url":null,"abstract":"Object Adverse events of steroids such as infections are likely to occur in the elderly patients with multiple myeloma. We examined the efficacy and safety of lenalidomide and prednisolone therapy in which the dosage of steroid was reduced in the elderly patients in Japan. Method We retrospectively analyzed 22 elderly relapsed/refractory and newly diagnosed refractory multiple myeloma patients treated at our hospital between January 2011 and February 2015. Treatment efficacy was assessed according to the International Uniform Response Criteria for Multiple Myeloma and adverse events by National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) Ver. 4.0 Easy R (EZR) was used for statistical analysis. Result Complete response (CR), very good partial response and partial response was found in 3, 1 and 18 patients, respectively. The overall three-year survival rate was 58% and time to next treatment was 1 year in 49% of patients. The adverse events were leukopenia (G1-2 23%, G3 9%), anemia (32% G1-2 and 18% G3) and thrombocytopenia (14% G1-2 and 9% G3). Non-hematological adverse events included rash (41% G1-2 and 23% G3), peripheral nerve disorder (23% G1-2, none above G3), and G3-4 renal failure in 10%. Infections of G3 occurred in 5%, and there was no deep-vein thrombosis. Conclusion Lenalidomide and low-dose prednisolone can be safely and effectively administered in elderly patients.","PeriodicalId":19579,"journal":{"name":"Open Journal of Internal Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73658680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Philosophy of Internal Medicine – Osler and Hinohara-ism 内科哲学-奥斯勒和日之原主义
Open Journal of Internal Medicine Pub Date : 2018-12-30 DOI: 10.17140/imoj-2-107
H. Bando
{"title":"Philosophy of Internal Medicine – Osler and Hinohara-ism","authors":"H. Bando","doi":"10.17140/imoj-2-107","DOIUrl":"https://doi.org/10.17140/imoj-2-107","url":null,"abstract":"","PeriodicalId":19579,"journal":{"name":"Open Journal of Internal Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72936990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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