Yayin Fang, Jamiya Kirkland, Isis J Amaye, Patrice Jackson-Ayotunde, Matthew George
{"title":"Molecular Docking Studies on Anticonvulsant Enaminones Inhibiting Voltage-Gated Sodium Channels.","authors":"Yayin Fang, Jamiya Kirkland, Isis J Amaye, Patrice Jackson-Ayotunde, Matthew George","doi":"10.4236/ojpc.2019.94015","DOIUrl":"https://doi.org/10.4236/ojpc.2019.94015","url":null,"abstract":"<p><p>Epilepsy is described as the most common chronic brain disorder. A typical symptom of epilepsy results in uncontrolled convulsions caused by temporary excessive neuronal discharges. Although, several new anticonvulsants have been introduced, some types of seizures have still not been adequately controlled with these new and current therapies. There is an urgent need to develop new anticonvulsant drugs to control the many different types of seizures. Many studies have shown that the epilepsies involve more than one mechanism and therefore may be responsible for the various types of observed seizures. Recently reported studies have shown that a group of newly synthesized 6 Hz active anticonvulsant fluorinated N-benzamide enaminones to exhibited selective inhibitions of voltage-gated sodium (Na<sub>v</sub>) channels. Na<sub>v</sub> channels are responsible for the initial inward currents during the depolarization phases of the action potential in excitable cells. The activation and opening of Na<sub>v</sub> channels result in the initial phases of action potentials. We hypothesize that there is an essential pharmacophore model for the interactions between these enaminones and the active sites of Na<sub>v</sub> channels. The research reported here is focused on molecular docking studies of the interactions that occur between the fluorinated N-benzamide enaminones and the Na<sub>v</sub> channels. These studies may open an avenue for designing anticonvulsant drugs by inhibiting Na<sub>v</sub> channels.</p>","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130903/pdf/nihms-1697797.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39000984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization of Amino Acid Based Molecular Micelles with Molecular Modeling.","authors":"Alexander Billiot, Yayin Fang, Kevin F Morris","doi":"10.4236/ojpc.2019.94014","DOIUrl":"https://doi.org/10.4236/ojpc.2019.94014","url":null,"abstract":"<p><p>The enantiomers of chiral drugs often have different potencies, toxicities, and biochemical properties. Therefore, the FDA and other worldwide regulatory agencies require manufactures to test and prove the enantiomeric purity of chiral drugs. Amino acid based molecular micelles (AABMM) have been used in chiral CE separations since the 1990's because of their low environmental impact and because their properties can easily be tuned by changing the amino acids in the chiral surfactant headgroups. Using molecular dynamics simulations to investigate the structures and properties of AABMM is part of an ongoing study focusing on investigating and elucidating the factors responsible for chiral recognition with AABMM. The results will be useful for the proper design and selection of more efficient chiral selectors. The micelles investigated contained approximately twenty covalently linked surfactant monomers. Each monomer was in turn composed of an undecyl hydrocarbon chain bound to a dipeptide headgroup containing of all combinations of L-Alanine, L-Valine, and L-Leucine. These materials are of interest because they are effective chiral selectors in capillary electrophoresis separations. Molecular dynamics simulation analyses were used to investigate how the sizes and positions of the headgroup amino acid R-groups affected the solvent accessible surface areas of each AABMM chiral center. In addition, headgroup dihedral angle analyses were used to investigate how amino acid R-group size and position affected the overall headgroup conformations. Finally, distance measurements were used to study the structural and conformational flexibilities of each AABMM headgroup. All analyses were performed in the context of a broader study focused on developing structure-based predictive tools to identify the factors responsible for (a) self-assembly, (b) function, (c) higher ordered structure and (d) molecular recognition of these amino acid based molecular micelles.</p>","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130901/pdf/nihms-1697798.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39000983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determination of arsenic, copper and lead in the water of villages of Chalkidiki, Greece","authors":"M. Anagnostopoulou, N. Ward","doi":"10.17352/OJC.000014","DOIUrl":"https://doi.org/10.17352/OJC.000014","url":null,"abstract":"Arsenic, copper and lead metals are serious contaminants for human health. These metals are all toxic above a minimum concentration. In the present study twenty two water samples (eleven sites - non and acidified) from villages Nea Silata, Nea Triglia, Eleochoria, Nea Plagia, Tenedos and Sozopolis, municipality of Poligiros, prefecture of Chalkidiki, Greece were collected for quantitatively determination of arsenic, copper-65 and lead-208 by Hydride Generation - Atomic Absorption Spectroscopy (HG-AAS) and Inductively Coupled Plasma - Mass Spectrometry (ICP-MS). The kinds of water were categorized as: drinking water, irrigation water and geothermal water. The results exhibited normal levels for all the three heavy metals under examination apart from geothermal water at Eleochoria village and in some cases for irrigation water at Nea Triglia and Tenedos villages for which the levels of arsenic were a little elevated. Drinking water samples from Nea Plagia and Nea Triglia villages showed lower heavy metal levels than the official Maximum Contaminant Levels (MCL) and therefore the water at these villages is considered to be potable.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86966471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Loai Aljerf, Davoud Dastan, S. Sajjadifar, S. Bhatnagar, P. Ukaogo, F. Dehmchi
{"title":"Guidelines for the preparation and isolation of Radionuclides produced with In-house Cyclotrons Bombardments","authors":"Loai Aljerf, Davoud Dastan, S. Sajjadifar, S. Bhatnagar, P. Ukaogo, F. Dehmchi","doi":"10.17352/OJC.000013","DOIUrl":"https://doi.org/10.17352/OJC.000013","url":null,"abstract":"Carrier-free radioisotopes and cyclotrons are largely manufactured and sold in market in high prices, even many challenges are facing isotopes production in industry. Thus, we came here to introduce valuable and easy working conditions using different thick target materials under well-defined irradiations to separate some important isotopes. As a result, in carrier-free form, the present work has successfully isolated seventeen most common cosmogenic and biological radioisotopes recommended by the IAEA-TECDOC-1211, Charged Particle Cross-section Database for Medical Radioisotope Production: Diagnostic Radioisotopes and Monitor Reactions, and the IAEA, in addition to US National Nuclear Data Center (NNDC) databases.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90818623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ammar Ehab, Mohamed Izham Mohamed Ibrahim, Marel Magdi, Mohamed Ayman, N. Zidan, Abdelbaset Osman, S. Ashraf, Mayar Mohamed, Mirna Magdy, Marina Hany, Marise Adly, Nourhan Kamel, Amr Maher, Ammar Yaser, Yara Ahmed, Amal Abdelkarim, Marehan Ehab, Rana Wael, R. Hathout
{"title":"Alzheimer’s disease and its current treatments; Is there a possibility for a cure?","authors":"Ammar Ehab, Mohamed Izham Mohamed Ibrahim, Marel Magdi, Mohamed Ayman, N. Zidan, Abdelbaset Osman, S. Ashraf, Mayar Mohamed, Mirna Magdy, Marina Hany, Marise Adly, Nourhan Kamel, Amr Maher, Ammar Yaser, Yara Ahmed, Amal Abdelkarim, Marehan Ehab, Rana Wael, R. Hathout","doi":"10.17352/OJC.000012","DOIUrl":"https://doi.org/10.17352/OJC.000012","url":null,"abstract":"Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys the memory and the thinking skills, and eventually the ability to carry out the simplest tasks. This has motivated lots of scientists to search for an ultimate treatment or cure for this serious disease. There are various causes & risk factors which cause AD and are the reasons for its progression. The drugs used in AD are usually a combination between different classes but never those of the same class such as Acetyl cholinesterase inhibitors which increase the availability of acetylcholine & NMDA receptors antagonists such as memantine. Most of the currently used drugs are mainly used to treat the symptoms, but lately some drugs have shown some promise in both treating & curing AD such as Aducanumab which is in the final phases of the clinical trials that resulted in the clearing of Amyloid plaques affecting cells communication. Since there are newly discovered causes of the disease, there are various other approaches in dealing with AD which will be discussed thoroughly in this review article.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87372298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colorimetric determination of chromium in aluminium alloys by diphenylcarbazide method","authors":"Peter Chikezie Ayogu and Fabian Ifeanyi Eze","doi":"10.17352/OJC.000011","DOIUrl":"https://doi.org/10.17352/OJC.000011","url":null,"abstract":"A concise method for the determination of chromium in aluminium alloys colorimetrically by the use of diphenylcarbazide is described. The method is based on measurement of the violet colour formed between chromate III ion (Cr3+) and diphenylcarbazide. The diphenylcarbazide forms a violet complex which absorbs at 540 nm. Other interfering metal ions including manganese and iron were masked by making alkaline with sodium hydroxide (NaOH). Potassium heptaoxodichromate (VI) K2Cr2O7 solution (283ppm) was used as standard. Three aliquots (2ml, 5ml and 10ml) of standards were used for measurement. The solutions of samples were made in aquaregia and colour reagent added. Absorbance of standard as well as samples was measured at 540 nm using a colorimeter. A working curve obtained from known concentrations of standard was used to calculate the concentration of chromium in each sample. The findings show that colorimetric determination of chromium by diphenylcarbazide method is a simple, effective and valuable alternative method for the determination of chromium in aluminium alloys.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84803041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The antioxidant status in Trichinella Spiralis-infected rats, improved by Selenium supplementation","authors":"M. Gabrashanska, S. Petkova, S. Teodorova","doi":"10.17352/OJC.000010","DOIUrl":"https://doi.org/10.17352/OJC.000010","url":null,"abstract":"Appearance of free radicals and membrane lipid peroxidation are one of the most typical unwelcome effects caused by trichinellosis (a parasite infection).","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91063487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Multiplicative Degree Based Topological Indices of Circulant Graph","authors":"Ghulam Hussain, Saba Noreen, Waseem Khaild","doi":"10.30538/PSRP-OJC2018.0002","DOIUrl":"https://doi.org/10.30538/PSRP-OJC2018.0002","url":null,"abstract":"Topological indices are numerical numbers associated with a graph that helps to predict many properties of underlined graph. In this paper we aim to compute multiplicative topological indices of Circulant graph.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75152464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimation of Fexofenadine HCl and Pseudoephedrine HCl by Spectrophotometer and TLC in Combined Tablet Dosage Form","authors":"S. Mahmood, Zaheer Ahmad, M. Arshad","doi":"10.30538/PSRP-OJC2018.0001","DOIUrl":"https://doi.org/10.30538/PSRP-OJC2018.0001","url":null,"abstract":"The objective of the present work was to develop and validate of an analytical method for the quantitative determination of Fexo. HCL and Pseudo. HCl in a combined tablet dosage form by UV − V is spectrophotometry and TLC. The main problem was to separate the two active ingredient from a single bilayered tablet because both the A.P.I’s were soluble in the same solvents. As media selection, distilled water and ethanol (1 : 1) were used for Pseudo. HCl and methanol for Fexo. HCl, in which both the drugs were soluble and stable for a sufficient time. Both drugs were measured at 220nm and 247nm, where they showed maximum absorbance. Beer Lambert’s law was obeyed at concentration range 4− 14 ppm and 5 − 30 ppm for Fexo. HCl and Pseudo HCl respectively. Fexo. HCl (Y = 0.0643x + 0.9370) was measured with correlation coefficient r = 0.9574 and Pseudo. HCl (Y = 0.0843x+0.0219) with correlation coefficient r = 0.9992. The results of analysis have been validated statistically and recovery studies were carried out as 99.29%±0.943 and 99.29%±0.941 which were close to the assay value 100.1% & 100.6 %. Precision of the method was measured which showed results for SD (99.57 % & 99. 51% ) and % RSD (99.53 % & 99.54). The proposed method may be suitably applied for the analysis of Fexo. HCl and Pseudo.HCl in tablet pharmaceutical formulation for routine analysis.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85762871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Zagreb Polynomials and redefined Zagreb indices of line graph of HAC5C6C7[p,q] Nanotube","authors":"A. Rehman, W. Khalid","doi":"10.30538/PSRP-OJC2018.0004","DOIUrl":"https://doi.org/10.30538/PSRP-OJC2018.0004","url":null,"abstract":"The application of graph theory in chemical and molecular structure research far exceeds people’s expectations, and it has recently grown exponentially. In the molecular graph, atoms are represented by vertices and bonded by edges. In this report, we study the Zagreb-polynomials of line graph of HAC5C6C7[p, q] and compute some degree-based topological indices from it.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82301477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}