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Biohydrogels for medical applications: A short review 医学应用的生物水凝胶:简要综述
IF 1.7
Organic Communications Pub Date : 2018-09-29 DOI: 10.25135/ACG.OC.49.18.06.108
Yunis Moukbi, F. Oktar, B. Ozbek, D. Ficai, A. Ficai, E. Andronescu, M. Eroglu, O. Gunduz
{"title":"Biohydrogels for medical applications: A short review","authors":"Yunis Moukbi, F. Oktar, B. Ozbek, D. Ficai, A. Ficai, E. Andronescu, M. Eroglu, O. Gunduz","doi":"10.25135/ACG.OC.49.18.06.108","DOIUrl":"https://doi.org/10.25135/ACG.OC.49.18.06.108","url":null,"abstract":"Hydrogels have been widely used as drug delivery systems for scaffold production (in different soft and hard tissue engineering, including bones), thanks to their biocompatibility and biodegradability. In addition to the possibility of synthesizing a wide range of hydrogels from various natural and synthetic polymers, they are suitable for scaffold production. Moreover, they can have antimicrobial, antitumor and analgesic functions due to their intrinsic properties or through addition of proper biologically active agents. In this article, different types of hydrogels are reviewed alongside their application areas. Different methods are applied for the preparation of hydrogels and their compositions, and are strongly correlated with the morphological and mechanical properties of the synthesized hydrogels, which had a great influence on the performances of the respective scaffolds. The most effective ways to produce the desired scaffolds are mold casting, especially, 3D printing and electrospinning due to the ability to manipulate and control the shape and size of the desired scaffold as well as their microstructure.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":"1 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42084089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4- substitutedphenyl)methylene]-acetohydrazides 新型2-羟基-2,2-双(4-取代苯基)- n '-[(1E)-(3/4-取代苯基)亚甲基]-乙酰肼的合成及抗癌活性(MCF-7, PC-3
IF 1.7
Organic Communications Pub Date : 2018-09-29 DOI: 10.25135/acg.oc.47.18.06.107
İ. Doğan, H. E. Sellitepe, Nuran Kayıkçı, H. Sipahi, R. Reis, N. Yaylı
{"title":"Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4- substitutedphenyl)methylene]-acetohydrazides","authors":"İ. Doğan, H. E. Sellitepe, Nuran Kayıkçı, H. Sipahi, R. Reis, N. Yaylı","doi":"10.25135/acg.oc.47.18.06.107","DOIUrl":"https://doi.org/10.25135/acg.oc.47.18.06.107","url":null,"abstract":"A series of five –CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazide with substituted aromatic aldehydes to give intermediate Schiff bases. Structures of the synthesized compounds were characterized using NMR (1D; 1H, 13C/APT and 2D 1H-1H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral data and elemental analysis. The geometry of compounds 1a-1e were determined to be “E” by NOESY. All the tested compounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 μM). Compounds 1b (18.24 ± 7.62 μM) and 1e (7.62 ± 1.85 μM) have strong anti-proliferative activity on MCF-7 cell line, while compound 1b (45.81 ± 1.10 μM) has the strongest activity on PC-3 cell line.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Photooxygenation of 4-(5-methylfuran-2-yl)aminocyanopyridine derivatives 4-（5-甲基呋喃-2-基）氨基氰基吡啶衍生物的光氧化反应
IF 1.7
Organic Communications Pub Date : 2018-09-29 DOI: 10.25135/acg.oc.50.18.09.881
A. Altundas, B. Aslan
{"title":"Photooxygenation of 4-(5-methylfuran-2-yl)aminocyanopyridine derivatives","authors":"A. Altundas, B. Aslan","doi":"10.25135/acg.oc.50.18.09.881","DOIUrl":"https://doi.org/10.25135/acg.oc.50.18.09.881","url":null,"abstract":"One pot syntheses of six-, seven-membered cycloalkane and pyrane junctured aminocyanopyridines bearing furan unit were successfully prepared from the ketones, 2-((5-methylfuran-2-yl)methylene) malononitrile, and ammonium acetate. Photooxygenation of 2-(4-aminocyanopyridine) substituted 5-methylfurans gave 1,4dicarbonyl functionalized aminocyanopyridine derivatives in good yield in one single operation.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49012884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practical synthesis and electronic study of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives via uncatalyzed domino one-pot, four-component reactions 非催化骨牌一锅四组分反应合成非螺和螺吡喃[2,3-c]吡唑-3-羧酸衍生物及电子研究
IF 1.7
Organic Communications Pub Date : 2018-07-01 DOI: 10.25135/ACG.OC.46.18.05.104
M. F. Mohammat, Muhammad Siddiq Maarop, Z. Shaameri, A. Wibowo, S. A. Johari, A. S. Hamzah
{"title":"Practical synthesis and electronic study of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives via uncatalyzed domino one-pot, four-component reactions","authors":"M. F. Mohammat, Muhammad Siddiq Maarop, Z. Shaameri, A. Wibowo, S. A. Johari, A. S. Hamzah","doi":"10.25135/ACG.OC.46.18.05.104","DOIUrl":"https://doi.org/10.25135/ACG.OC.46.18.05.104","url":null,"abstract":"Organic Synthesis Research Laboratory, Institute of Science, Universiti Teknologi MARA, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA, UiTM Shah Alam,40450 Shah Alam, Selangor, Malaysia Antimicrobial Laboratory, Anti-Infective Branch, Bioactivity Programme, Natural Products Division, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Malaysia","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45401734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
New symmetrical acyclic and alicyclic bisurea derivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies 新型4,4'-亚甲基双（苯基异氰酸酯）对称无环和脂环双脲衍生物的合成、表征、生物活性和抗氧化活性评价及分子对接研究
IF 1.7
Organic Communications Pub Date : 2018-06-02 DOI: 10.25135/acg.oc.41.18.03.069
N. Chamarthi, Venkata Chalapathi Ponne, Harish Pulluru, Janakiramudu Dasari Balija, Sindhu Reddy Gutala, Saritha Venkatareddy Kallimakula, Venkataramaiah Chintha, Rajendra Wudayagiri
{"title":"New symmetrical acyclic and alicyclic bisurea derivatives of 4,4'-methylenebis(phenyl isocyanate): Synthesis, characterization, bioactivity and antioxidant activity evaluation and molecular docking studies","authors":"N. Chamarthi, Venkata Chalapathi Ponne, Harish Pulluru, Janakiramudu Dasari Balija, Sindhu Reddy Gutala, Saritha Venkatareddy Kallimakula, Venkataramaiah Chintha, Rajendra Wudayagiri","doi":"10.25135/acg.oc.41.18.03.069","DOIUrl":"https://doi.org/10.25135/acg.oc.41.18.03.069","url":null,"abstract":"A family of bisurea derivatives of 4,4′-methylenebis(phenyl isocyanate) have been synthesized with simple, effective and efficient procedure in high yields. The new compounds showed moderate bioactivity (at 32.0 μg/μL concentration) against selected bacterial pathogens, viz., Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa; and two fungal species, Candida albicans and Cryptococcus neoformans var. grubii. Alternatively, their antioxidant activity was also evaluated by DPPH radical scavenging assay which revealed that the compounds, 10d, 10e, 10h and 10m exhibited moderate activity. However, the molecular docking studies of all the title compounds showed surprisingly higher binding energies with DNA gyrase A protein of E. coli when compared to the reference, streptomycin. Among the compounds 10e, 10f, 10g, 10k, 10l and 10m showed very good binding energies which implied that they could be promising next generation antimicrobials.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43864332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis and characterization of organic light-emitting molecules possessing 3-(4-methoxyphenyl)thieno[3,2-b]thiophene and boron 含3-(4-甲氧基苯基)噻吩[3,2-b]噻吩和硼的有机发光分子的合成与表征
IF 1.7
Organic Communications Pub Date : 2018-06-02 DOI: 10.25135/ACG.OC.45.18.05.103
M. Cinar, T. Ozturk
{"title":"Synthesis and characterization of organic light-emitting molecules possessing 3-(4-methoxyphenyl)thieno[3,2-b]thiophene and boron","authors":"M. Cinar, T. Ozturk","doi":"10.25135/ACG.OC.45.18.05.103","DOIUrl":"https://doi.org/10.25135/ACG.OC.45.18.05.103","url":null,"abstract":"The donor-acceptor (DA) system, which is one of the main methods implemented in material chemistry, has been widely used to construct low band-gap semiconductors. It is desirable that donor molecules have πconjugation in these structures. Thienothiophene (TT) derivatives have been used extensively as donors and are preferred in optoelectronic applications. As a strong acceptor, boron unit with a vacant p orbital is linked to donor TT groups. Bulky tetraphenylethylene (TPE) subunits were appended as end groups to afford an aggregation-induced emission (AIE).","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2018-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47130861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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