Oncology Research最新文献_第5页

Retraction: miRNA-497 negatively regulates the growth and motility of chondrosarcoma cells by targeting Cdc25A. 撤稿：miRNA-497 通过靶向 Cdc25A 负向调控软骨肉瘤细胞的生长和运动。

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056919

引用次数: 0

The role of cholesterol metabolism in lung cancer. 胆固醇代谢在肺癌中的作用。

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.047933

Weigang Xiu, Xingyu Liu, Kaixin Hu, Qin Zhang, Huashan Shi

{"title":"The role of cholesterol metabolism in lung cancer.","authors":"Weigang Xiu, Xingyu Liu, Kaixin Hu, Qin Zhang, Huashan Shi","doi":"10.32604/or.2024.047933","DOIUrl":"10.32604/or.2024.047933","url":null,"abstract":"Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth, proliferation, and metastasis. The effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells, B cells, macrophages, myeloid-derived suppressor cells, among others. Ongoing research is investigating drugs targeting cholesterol metabolism for clinical treatments. Statins, targeting the cholesterol biosynthesis pathway, are widely employed in lung cancer treatment, either as standalone agents or in combination with other drugs. Additionally, drugs focusing on cholesterol transportation have shown promise as effective therapies for lung cancer. In this review, we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer.","PeriodicalId":19537,"journal":{"name":"Oncology Research","volume":"32 10","pages":"1613-1621"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the role of adipocyte exosomes in cancer progression. 关于脂肪细胞外泌体在癌症进展中的作用的研究进展。

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.043482

Yun Wang, Xiaojiang Li, Dalong Liu, Zhifeng Wang, Jichen Xia, Lijun Wang, Xudong Zhang

{"title":"Research progress on the role of adipocyte exosomes in cancer progression.","authors":"Yun Wang, Xiaojiang Li, Dalong Liu, Zhifeng Wang, Jichen Xia, Lijun Wang, Xudong Zhang","doi":"10.32604/or.2024.043482","DOIUrl":"10.32604/or.2024.043482","url":null,"abstract":"Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging from stromal cell reprogramming to immunological responses, extracellular matrix formation, and modulation of cancer cell activation, expansion, and metastasis, are subject to exosome-mediated cell-to-cell communication. Moreover, exosomes have been implicated in endowing cancer cells with resistance to treatment. Extensive research has explored the potential of exosomes as therapeutic targets and diagnostic indicators. This comprehensive review seeks to provide an in-depth understanding of the pivotal components and roles of exosomes in tumorigenesis, growth, progression, and therapeutic responses. The insights into the multifaceted involvement of exosomes in malignant cancers are essential for the scientific community, fostering the development of novel therapeutic and diagnostic strategies in the relentless pursuit of cancer.","PeriodicalId":19537,"journal":{"name":"Oncology Research","volume":"32 10","pages":"1649-1660"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: MicroRNA-1284 inhibits cell viability and induces apoptosis of ovarian cancer cell line OVCAR3. 撤回：MicroRNA-1284 抑制卵巢癌细胞株 OVCAR3 的细胞活力并诱导其凋亡

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056905

引用次数: 0

Retraction: MicroRNA-520b suppresses proliferation, migration, and invasion of spinal osteosarcoma cells via downregulation of frizzled-8. 撤回：MicroRNA-520b通过下调frizzled-8抑制脊柱骨肉瘤细胞的增殖、迁移和侵袭

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056903

引用次数: 0

Retraction: LINC00052 promotes gastric cancer cell proliferation and metastasis via activating the Wnt/β-Catenin signaling pathway. 撤回：LINC00052通过激活Wnt/β-Catenin信号通路促进胃癌细胞增殖和转移

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056891

引用次数: 0

Retraction: MicroRNA 495 inhibits proliferation and metastasis and promotes apoptosis by targeting TWIST1 in gastric cancer cells. 撤回：MicroRNA 495 通过靶向 TWIST1 抑制胃癌细胞的增殖和转移并促进其凋亡

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056898

引用次数: 0

Retraction: MicroRNA-107 promotes proliferation, migration, and invasion of osteosarcoma cells by targeting tropomyosin 1. 撤回：MicroRNA-107通过靶向肌球蛋白1促进骨肉瘤细胞的增殖、迁移和侵袭

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056901

引用次数: 0

Retraction: miR-183 modulates cell apoptosis and proliferation in tongue squamous cell carcinoma SCC25 cell line. 撤稿：miR-183 可调节舌鳞状细胞癌 SCC25 细胞系的细胞凋亡和增殖。

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.056908

引用次数: 0

Exosomal microRNA let-7c-5p enhances cell malignant characteristics by inhibiting TAGLN in oral cancer. 外泌体 microRNA let-7c-5p 通过抑制口腔癌中的 TAGLN 增强细胞恶性特征。

IF 2 4区医学

Oncology Research Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.32604/or.2024.048191

Y I Li, Tianyi Wang, Haoran Ding, Shiyong Zhuang, Xiaobo Dai, Bing Yan

{"title":"Exosomal microRNA let-7c-5p enhances cell malignant characteristics by inhibiting TAGLN in oral cancer.","authors":"Y I Li, Tianyi Wang, Haoran Ding, Shiyong Zhuang, Xiaobo Dai, Bing Yan","doi":"10.32604/or.2024.048191","DOIUrl":"10.32604/or.2024.048191","url":null,"abstract":"Background: Oral cancer, a malignancy that is prevalent worldwide, is often diagnosed at an advanced stage. MicroRNAs (miRNAs) in circulating exosomes have emerged as promising cancer biomarkers. The role of miRNA let-7c-5p in oral cancer remains underexplored, and its potential involvement in tumorigenesis warrants comprehensive investigation.Methods: Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA content. Isolation of the exosomes was confirmed through transmission electron microscopy. Quantitative PCR was used to assess the miRNA profiles. The effects of let-7c-5p and TAGLN overexpression on oral cancer cell viability, migration, and invasion were analyzed via CCK-8 and Transwell assays. Moreover, we conducted mRNA sequencing of exosomal RNA from exosomes overexpressing let-7c-5p to delineate the gene expression profile and identify potential let-7c-5p target genes.Results: let-7c-5p was upregulated in serum-derived exosomes of patients with oral cancer. Overexpression of let-7c-5p in the TCA8113 and CAL-27 cell lines enhanced their proliferative, migratory, and invasive capacities, and overexpression of let-7c-5p cell-derived exosomes promoted oral cancer cell invasiveness. Exosomal mRNA sequencing revealed 2,551 differentially expressed genes between control cell-derived exosomes and overexpressed let-7c-5p cell-derived exosomes. We further identified TAGLN as a direct target of let-7c-5p, which has been implicated in modulating the oncogenic potential of oral cancer cells. Overexpression of TAGLN reverses the promoting role of let-7c-5p on oral cancer cells.Conclusion: Our findings highlight the role of exosomal let-7c-5p in enhancing oral cancer cell aggressiveness by downregulating TAGLN expression, highlighting its potential as a diagnostic and therapeutic strategy.","PeriodicalId":19537,"journal":{"name":"Oncology Research","volume":"32 10","pages":"1623-1635"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0