Omics A Journal of Integrative Biology最新文献

{"title":"An Immunogenic Cell Death-Enhanced Self-Assembled Nanoparticle-Composite Hydrogel for Postoperative Local Immunotherapy of Melanoma.","authors":"Weili Zhou, Dengming Zhou, Haroon Iqbal, Junfan Zhang, Shengjun Wu, Wenxiang Zhu","doi":"10.1177/15578100261488096","DOIUrl":"https://doi.org/10.1177/15578100261488096","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) can elicit antitumor immunity by inducing immunogenic cell death (ICD), making it an attractive option for postoperative local cancer treatment. However, in solid tumors, aberrant vasculature and an immunosuppressive microenvironment often restrict immune-cell infiltration, thereby weakening the immune benefits of PDT. Here, we develop an ICD-amplifying, self-assembled nanoparticle-hydrogel composite (methacrylate-functionalized fucoidan hydrogel [dFuGMA]-Ce6-Tas nanoparticles [CTNPs]) for local immunotherapy following melanoma resection. In this system, the photosensitizer chlorin e6 and the immunomodulatory/antiangiogenic agent tasquinimod (Tas) spontaneously coassemble into carrier-free nanoparticles (CTNPs), which are subsequently embedded in a photocrosslinkable dFuGMA to enable <i>in situ</i> gelation and coordinated therapy at the surgical site. <i>In vitro</i>, CTNPs markedly enhanced cellular uptake, reactive oxygen species generation, and ICD-associated responses. In a postoperative melanoma model, dFuGMA-CTNPs combined with laser irradiation significantly suppressed tumor regrowth and promoted immune activation, as evidenced by increased dendritic cell maturation (4.6-fold) and enhanced infiltration of CD4⁺ (4.8-fold) and CD8⁺ T cells (5.8-fold). Mechanistically, Tas induced tumor vascular normalization by downregulating the hypoxia-inducible factor 1-alpha/vascular endothelial growth factor axis, thereby synergistically potentiating PDT-triggered ICD and downstream immune responses. Transcriptomic profiling further confirmed modulation of pathways associated with \"immune response\" and \"T cell activation.\" In conclusion, dFuGMA-CTNPs achieves a dual-pathway synergy through ICD enhancement and vascular normalization, providing a precisely localized and translationally feasible immunotherapeutic strategy to prevent postoperative melanoma recurrence.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"15578100261488096"},"PeriodicalIF":2.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149063540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serine/Arginine-Protein Kinase 1 Co-Phosphorylation Signatures Uncover Splicing-Driven Mechanisms in Oncogenic Pathway Modulation.","authors":"Jishna Vijayan, Suhail Subair, Athira Perunelly Gopalakrishnan, Alimath Sambreena, Rajesh Raju, Athira C Rajeev","doi":"10.1177/15578100261488080","DOIUrl":"https://doi.org/10.1177/15578100261488080","url":null,"abstract":"<p><p>Serine/arginine-protein kinase 1 (SRPK1) is a central regulator of alternative splicing whose overexpression drives oncogenic reprogramming in multiple cancers. To understand the phosphorylation dynamics of SRPK1 activity, we performed a systematic integrative phosphoproteomic meta-analysis of 798 profiling and 232 differential human datasets. We identified S51, S309, and S311 as the three predominant Class I phosphosites on SRPK1. High-confidence co-phosphoregulated proteins (Fisher's Exact Test <i>p</i> < 0.05, ≥3 independent studies, ≥3 experimental conditions) revealed an extensive network of splicing factors (SRRM1, SRRM2, GPATCH8) and noncanonical RS-domain proteins (LBR) that function as both substrates and binary interactors, preferentially linked to S309 and S311. Proteogenomic interrogation via cProSite demonstrated significant upregulation of phosphorylation at these sites in breast, ovarian cancer and lung adenocarcinoma cohorts. Downstream substrates and co-regulated proteins further intersected with apoptosis regulators like SIRT2, BAD, FOXO3, and PI3K/Akt pathway components, mechanistically hinting at SRPK1 phosphorylation in apoptosis suppression and uncontrolled proliferation. These co-phosphorylation signatures therefore position SRPK1 as a potential orchestrator of splicing condensates that rewire oncogenic pathways, offering a phosphosite-specific blueprint for targeted splicing modulators and combination immunotherapies in splicing-related malignancies.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"15578100261488080"},"PeriodicalIF":2.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Romiplostim and Avatrombopag in Severe Chemotherapy-Induced Thrombocytopenia: A Serendipitous Finding.","authors":"Ying Chen, Chunyu Sui, Xiayidayi Alm, Tiantian Li, Chun Huang, Tingbo Liu, Lianming Liao","doi":"10.1177/15578100261488083","DOIUrl":"https://doi.org/10.1177/15578100261488083","url":null,"abstract":"<p><p>Chemotherapy-induced thrombocytopenia (CIT) is a severe complication of cancer treatment. Single thrombopoietin receptor agonists (TPO-RAs) often fail in severe/refractory CIT. This study explored the synergistic effect of romiplostim plus avatrombopag for grade 4 CIT.A retrospective analysis was performed on 8 adult patients with nonhematologic malignancies and severe refractory CIT (platelet <25 × 10⁹/L for ≥4 weeks). All received off-label combination therapy (avatrombopag 40 mg/day oral + romiplostim 3 μg/kg/week subcutaneous), with dose titration based on weekly platelet counts. Primary endpoint was platelet ≥100 × 10⁹/L within 8 weeks; safety and chemotherapy resumption were secondary endpoints. Median baseline platelet was 12.5 × 10⁹/L. All eight patients achieved platelet ≥100 × 10⁹/L by week 5 (100% response), with ≥50 × 10⁹/L reached by week 3 for all. No venous thromboembolism, secondary hematologic malignancies, or severe adverse events occurred. Chemotherapy was resumed without CIT-related dose reduction/delay. Romiplostim combined with avatrombopag yields rapid platelet recovery with favorable safety for severe refractory CIT, enabling chemotherapy resumption. It is a promising salvage strategy for single-agent TPO-RA nonresponders, warranting prospective randomized controlled trials for validation.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"15578100261488083"},"PeriodicalIF":2.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yishen Gushu Formula Attenuates Ovariectomy-Induced Bone Loss by Regulating the B-Cell Receptor Signaling Pathway in Rats.","authors":"Bo Jin, Kelin Xiang, Yongjin Li, Zhengpeng Li, Chi Zhang, Xiaoyun Zhang","doi":"10.1177/15578100261489657","DOIUrl":"https://doi.org/10.1177/15578100261489657","url":null,"abstract":"<p><p>Postmenopausal osteoporosis (PMOP) is a skeletal disorder induced by estrogen deficiency. Yishen Gushu formula (YSGSF) has been confirmed to exert positive regulatory effects on bone metabolism, while its underlying mechanism remains to be fully elucidated. In this study, a rat model of PMOP was established via ovariectomy. Following 12 weeks of intervention with YSGSF decoction, its mechanism of action was investigated using Micro-CT, HE staining, RNA sequencing, qRT-PCR, and Western blot. The results demonstrated that YSGSF significantly attenuated bone loss in PMOP rats. A total of 18 differentially expressed genes with expression trends reversed by YSGSF were screened out, and their functions were mainly enriched in B-cell differentiation, immunoglobulin complex, and B-cell receptor (BCR) signaling pathways. The expression levels of <i>CD79A, CD79B, VPREB1</i>, and <i>VPREB3</i> were downregulated after YSGSF intervention. Collectively, YSGSF may alleviate bone microstructure impairment in PMOP rats by downregulating key genes in the BCR pathway and improving the skeletal immune microenvironment.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"15578100261489657"},"PeriodicalIF":2.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Metabolomic Profiling and Bioactivity Evaluation of Browntop Millet (<i>Brachiaria ramosa</i>): Antioxidant and Antidiabetic Potential.","authors":"Muskan Kumari Gupta, Vinay Balodi, Abhishek Dutt Tripathi, Rizwana Haleem, Aparna Agarwal","doi":"10.1177/15578100261484212","DOIUrl":"https://doi.org/10.1177/15578100261484212","url":null,"abstract":"<p><p>The underutilized cereal, Browntop millet (BTM), has a valuable nutritional profile and considerable therapeutic potential. The metabolomic profile of BTM also offered insights into its complex phytochemical profile, aligning with its potential benefits for metabolic health and disease prevention. The liquid chromatography-mass spectrometry analysis identified 349 compounds in BTM, with 257 compounds identified in ChemSpider. Of these, 56 were shown to have medicinal properties, indicating a high degree of diversity in therapeutic potential. These findings highlight the metabolomic complexity and the considerable potential of BTM in health-related fields. Out of these 15 compounds reported to possess antioxidant activity, around 3 enzymes were found to have antidiabetic properties ((-)-ECG-3″-O-ME, a natural inhibitor of α-glucosidase, and 1-Boc-4-(4-Nitrophenyl)piperazine, a potential inhibitor of enzymes like α-Amylase). In this study, the <i>in vitro</i> antioxidant and antidiabetic potential of BTM flour was also studied. Total antioxidant activity of BTM flour was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays, and antidiabetic property was evaluated by α-amylase inhibitory assays. BTM flour exhibited concentration-dependent DPPH scavenging activity, increasing from 14.29% inhibition at 10 µM to 90.00% inhibition at 100 µM, with an IC₅₀ value of 40.77 ± 0.54 µM. The percentage inhibition of the α-amylase assay of BTM and Acarbose was found to be IC₅₀ = 240.91 ± 0.14 µM and 19.36 ± 0.88 µM, respectively. The results suggest that BTM has detectable antioxidant and enzyme inhibitory activities but not as high as the standard reference compounds. In general, the study revealed that BTM contains phytochemicals with possible biological significance. The results are in favor of the potential use of BTM as a functional food ingredient, but additional research is needed to confirm the role of each metabolite and biological efficacy by means of <i>in vivo</i> investigations.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"15578100261484212"},"PeriodicalIF":2.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Bioinformatics and Molecular Docking Analysis Reveals Potential Mechanisms of Coptidis Rhizoma in Intervertebral Disc Degeneration.","authors":"Chang-Ming Xiao, Kai-Quan Zhang, Yang Lei, Hao-Ping Dai, Ming-Zhong Xie, Hao-Zhong Wang","doi":"10.1177/15578100261463855","DOIUrl":"10.1177/15578100261463855","url":null,"abstract":"<p><p>Intervertebral disc degeneration (IVDD) is a major contributor to chronic low back pain and involves extracellular matrix degradation, inflammation, oxidative stress, and immune cell infiltration. This study integrated transcriptomic analysis, network pharmacology, molecular docking, molecular dynamics (MD) simulation, and ADMET prediction to explore potential mechanisms of Coptidis rhizoma (CR) in IVDD. Bioactive CR compounds and predicted targets were identified from TCMSP, SwissADME, and SwissTargetPrediction, and IVDD-related differentially expressed genes were obtained from two GEO datasets after normalization and batch-effect correction. Thirty-six overlapping genes were identified, and network analysis prioritized CCR1, CXCR2, ICAM1, TNF, STAT3, MPO, and MMP9 as core targets. Enrichment analyses highlighted chemokine signaling, cytokine-cytokine receptor interaction, leukocyte transendothelial migration, TNF signaling, IL-17 signaling, and NF-κB signaling. Docking and benchmark analyses indicated favorable predicted binding of Obacunone-CCR1 and Quercetin-MMP9, while 100-ns MD simulation supported the stability of the Obacunone-CCR1 complex. These findings suggest that CR may modulate chemokine-driven immune recruitment and downstream inflammatory-catabolic processes in IVDD, providing a hypothesis-generating basis for experimental validation.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"505-514"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ENTPD2</i> Transcript-Protein Divergence in Colorectal Cancer and Its Association with miR-708-5p: An Integrative Analysis.","authors":"Leyla Ataç Doğan","doi":"10.1177/15578100261463392","DOIUrl":"10.1177/15578100261463392","url":null,"abstract":"<p><p>Ectonucleoside triphosphate diphosphohydrolase 2 (<i>ENTPD2</i>), an enzyme involved in extracellular nucleotide metabolism and purinergic signaling, has been linked to tumor-immune interactions, although its role in colorectal cancer (CRC) remains unclear. This study examined the expression pattern and regulatory context of <i>ENTPD2</i> through integrative analysis of transcriptomic, proteomic, microRNA (miRNA), and single-cell transcriptomic datasets. Transcriptomic analyses showed that <i>ENTPD2</i> mRNA levels are elevated in colorectal tumors compared with normal tissues and that higher expression is associated with shorter relapse-free survival. In contrast, proteomic analyses indicated reduced <i>ENTPD2</i> protein abundance in tumor samples, suggesting a divergence between transcript and protein expression. Analysis of candidate miRNAs identified miR-708-5p as a potential post-transcriptional regulator, supported by its increased expression in CRC and a predicted binding site within the <i>ENTPD2</i> 3'-untranslated region (UTR). Single-cell transcriptomic datasets further indicated that <i>ENTPD2</i> transcripts are mainly detected in malignant epithelial cells. We performed a functional validation using dual-luciferase reporter assays, qRT-PCR, and Western blot analysis in CRC cell lines. Experimental analyses demonstrated that miR-708-5p directly targets the <i>ENTPD2</i> 3'UTR in HCT116 cells and suppresses <i>ENTPD2</i> expression in both HCT116 and HT-29 cells. These findings support a potential contribution of miR-708-5p to <i>ENTPD2</i> regulation in CRC.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"493-504"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Protein Preparation Methods for Quantitative Analysis of Pig Muscle Proteome.","authors":"Didier Viala, Robin Maillet, Arnaud Delavaud, Christophe Chambon, Thierry Sayd, Michel Hébraud","doi":"10.1177/15578100261464022","DOIUrl":"10.1177/15578100261464022","url":null,"abstract":"<p><p>High-throughput shotgun proteomics is often hindered by the incompatibility of detergents with mass spectrometry (MS), making sample preparation a critical bottleneck for accuracy and robustness. This challenge is amplified in muscle proteomics, where the high dynamic range of protein abundance requires highly efficient and reproducible workflows to capture low-abundance proteins. To address this, we performed a systematic benchmarking of five preparation methods-stacking-gel (SG), tube-gel (TG), solid-phase extraction (SPE), filter-aided sample preparation (FASP), and suspension traps (S-TRAP)-using the sarcoplasmic fraction of pig muscle. The protein extracts obtained were subjected to label-free semi-quantitative proteomic analysis using high-performance nano-liquid chromatography coupled to tandem MS. Qualitative and quantitative results were compared using bioinformatics and biostatistics tools. Our study identified 530 proteins with significant variations across methods. S-TRAP provided the highest identification depth, capturing the broadest proteome coverage. Conversely, the TG method demonstrated superior quantitative reproducibility, essential for detecting subtle physiological changes. For translational research, such as meat quality science or muscle-related clinical models, our findings imply that S-TRAP is the preferred choice for discovery-phase proteomics (biomarker hunting), while TG or SG should be prioritized for high-precision validation studies.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"529-540"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Geroprotectors Mapping through Systems Machine Learning and Graph Neural Networks.","authors":"Yuvraj Sharma, Asmita Das","doi":"10.1177/15578100261464019","DOIUrl":"10.1177/15578100261464019","url":null,"abstract":"<p><p>Geroscience offers a transformative paradigm by targeting shared aging hallmarks to enable simultaneous modulation of multiple age-related disorders (ARDs). Yet, current geroprotective interventions often lack mechanistic breadth, as targeting isolated pathways yields limited benefits compared to interventions modulating interconnected regulators of aging biology. To bridge this gap, a systems-level strategy was designed around four key targets, including, Nrf2/Keap1, mTORC1, AMPK, and SIRT1, responsible for regulating oxidative stress, mitochondrial dysfunction, proteostasis, and autophagy. Concurrent regulation of these targets was identified to potentially induce a concerted and sustained geroprotective effect across diverse ARDs. A machine learning-based geroprotector classification model was developed to identify natural compounds capable of executing this integrated strategy. Subsequent drug-likeness screening confirmed favorable pharmacokinetic properties of the predicted compounds, while molecular docking revealed compounds with strong binding affinities with all four geroprotective targets, thereby leading to the identification of a subset of natural compounds with the potential to induce a coordinated geroprotective response. Finally, a graph neural network-based synergy prediction model, trained on known ARD drug combinations, identified five high-confidence pairs composed of four natural compounds, including Baicalein, Pectolinarigenin, Phloretin, and Demethoxycurcumin. These computationally predicted combinations hold the potential to elicit synergistic and comprehensive geroprotective effects across multiple ARDs.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"515-528"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics Integration Reveals Distinct miRNA-Mediated Regulatory Networks at the Transcript and Protein Levels in Idiopathic Pulmonary Fibrosis.","authors":"Min Kyung Kim, Seung Hyun Kim, Sung Woo Park, Jong-Uk Lee","doi":"10.1177/15578100261467222","DOIUrl":"10.1177/15578100261467222","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in multilevel molecular dysregulation in idiopathic pulmonary fibrosis (IPF). However, their function is largely inferred from miRNA-mRNA associations, leaving protein-level consequences poorly defined. We performed an integrated multiomics analysis combining miRNA sequencing, RNA sequencing, and proteomic profiling of primary lung fibroblasts from patients with IPF and controls. Transcriptomic data were obtained from the Gene Expression Omnibus (GSE301181), and donor-matched proteomic data were deposited in Figshare. miRNA-mRNA correlations and miRNA-protein associations were evaluated through integrative correlation and interaction analyses, followed by functional enrichment and network modeling. Thirteen differentially expressed miRNAs were identified and showed widespread negative correlations with 710 differentially expressed genes. In contrast, proteomic integration identified a more restricted subset of 229 miRNA-associated differentially expressed proteins. Functional enrichment revealed broad distribution of miRNA-mRNA associations across extracellular matrix organization, immune signaling, and cell migration pathways, whereas miRNA-protein associations converged on a limited set of biological processes with higher enrichment ratios. Several miRNAs were linked to known fibrosis- and stress-related targets, supporting biological relevance. Together, these findings suggest that integrated protein-level analysis helps refine fibrosis-relevant miRNA regulatory programs in IPF fibroblasts and may improve biological interpretation of disease-associated molecular changes.</p>","PeriodicalId":19530,"journal":{"name":"Omics A Journal of Integrative Biology","volume":" ","pages":"541-550"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}