Oncology reports最新文献

[Corrigendum] Sensitizing TRAIL‑resistant A549 lung cancer cells and enhancing TRAIL‑induced apoptosis with the antidepressant amitriptyline. [勘误]抗抑郁药阿米替林使TRAIL耐药A549肺癌细胞增敏并增强TRAIL诱导的细胞凋亡

IF 3.8 3区医学

Oncology reports Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.3892/or.2025.8920

K M A Zinnah, Sang-Youel Park

{"title":"[Corrigendum] Sensitizing TRAIL‑resistant A549 lung cancer cells and enhancing TRAIL‑induced apoptosis with the antidepressant amitriptyline.","authors":"K M A Zinnah, Sang-Youel Park","doi":"10.3892/or.2025.8920","DOIUrl":"https://doi.org/10.3892/or.2025.8920","url":null,"abstract":"Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, for the cellular morphological images shown in Figs. 3A and 4A on p. 7 and 8 respectively, the centrally placed images (third from the left) were strikingly similar, such that the same data had apparently been included in these figures to show the results from differently performed experiments. After having re‑examined their original data files, the authors realized that the data panel in Fig. 4A properly belonged to Fig. 3, and that this image had been inadvertently included incorrectly in this figure. The revised version of Fig. 4, now featuring the correct data for the 'Amit+/TRAIL+/DR5 siRNA‑/NC ‑' experiment (third panel from the left), is shown on the next page. Note that the correction of this figure does not affect the overall conclusions reported in the paper. The authors are grateful to the Editor of Oncology Reports for allowing them the opportunity to publish this Corrigendum, and apologize to the readership for any inconvenience caused. [Oncology Reports 46: 144, 2021; DOI: 10.3892/or.2021.8095].","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 2","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Corrigendum] Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. 【勘误】Goserelin通过PI3K/AKT信号通路上调叉头盒O1，促进上皮性卵巢癌细胞凋亡。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.3892/or.2025.8910

Ning Zhang, Junjun Qiu, Tingting Zheng, Xiaodan Zhang, Keqin Hua, Ying Zhang

引用次数: 0

Tryptophan metabolism: From physiological functions to key roles and therapeutic targets in cancer (Review). 色氨酸代谢：从生理功能到癌症的关键作用和治疗靶点（综述）。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-30 DOI: 10.3892/or.2025.8919

Jiawei Zhao, Xiaohui Bai, Jingjing Du, Yujing Chen, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Peitao Wu, Siqi Chen, Xinwen Zhang, Jinfeng Yang, Jiamin Jin, Li Gao

{"title":"Tryptophan metabolism: From physiological functions to key roles and therapeutic targets in cancer (Review).","authors":"Jiawei Zhao, Xiaohui Bai, Jingjing Du, Yujing Chen, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Peitao Wu, Siqi Chen, Xinwen Zhang, Jinfeng Yang, Jiamin Jin, Li Gao","doi":"10.3892/or.2025.8919","DOIUrl":"https://doi.org/10.3892/or.2025.8919","url":null,"abstract":"Tryptophan (Trp) metabolism is a complex and important biochemical process in humans. It is vital in protein synthesis and is a precursor of various bioactive molecules. Trp is metabolized through the kynurenine, serotonin and indole pathways, mediating diverse physiological functions, including neurotransmitter synthesis, immune regulation, antioxidant effects, and biosynthesis of niacin and melatonin. These metabolic pathways maintain essential functions under normal physiological conditions. However, they are significantly affected by various types of cancers. Trp metabolites regulate tumor angiogenesis, affect the self‑renewal of cancer stem cells, and participate in immune evasion and cell death through complex mechanisms. As the mechanisms underlying Trp metabolism in diseases are increasingly being elucidated, targeting Trp metabolic pathways has emerged as a promising therapeutic strategy. Further investigation of the molecular mechanisms underlying Trp metabolism and its role in diseases may provide new perspectives and approaches for diagnosing and treating diseases.","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Retracted] MicroRNA‑345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1. 【撤回】MicroRNA‑345通过抑制YAP1抑制肝癌转移。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI: 10.3892/or.2025.8913

Hui Zhang, Hui Liu, Huaqiang Bi

引用次数: 0

[Retracted] Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study. [撤回]羟基酪醇抑制胆管癌肿瘤生长：体内和体外研究

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-26 DOI: 10.3892/or.2025.8918

Shuai Li, Zhiyang Han, Yong Ma, Ruipeng Song, Tiemin Pei, Tongsen Zheng, Jiabei Wang, Dongsheng Xu, Xiang Fang, Hongchi Jiang, Lianxin Liu

{"title":"[Retracted] Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study.","authors":"Shuai Li, Zhiyang Han, Yong Ma, Ruipeng Song, Tiemin Pei, Tongsen Zheng, Jiabei Wang, Dongsheng Xu, Xiang Fang, Hongchi Jiang, Lianxin Liu","doi":"10.3892/or.2025.8918","DOIUrl":"https://doi.org/10.3892/or.2025.8918","url":null,"abstract":"Following the publication of the above paper, a concerned reader drew to the Editor's attention that unexpected similarities existed among the β‑actin control western blots in Figs. 1B, 3E and 3G, albeit with the protein bands featured in a different orientation, and with different dimensions, in Fig. 3E compared with Figs. 1B and 3E. Furthermore, the two leftmost β‑actin blots in Fig. 3G appeared to show unexpected similarities to the β‑actin blots in Fig. 4F, even though different experimental conditions were reported in these figures. Following an independent assessment of the apparent errors that had been made in assembling the data in the three affected figures, the Editor of Oncology Reports has decided that this article should be retracted from the publication on account of a lack of overall confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes for any inconvenience that might result from this retraction. [Oncology Reports 31: 145‑152, 2014; DOI: 10.3892/or.2013.2853].","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEPP1: A prognostic biomarker linked to stroma‑rich and immunosuppressive microenvironment, promoting oxaliplatin resistance in gastric cancer. DEPP1：一种与富基质和免疫抑制微环境相关的预后生物标志物，促进胃癌患者对奥沙利铂的耐药。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI: 10.3892/or.2025.8915

Xudong Qiu, Tao Pan, Tian Kuang, Yanying Shen, Yihan Zheng, Haigang Geng, Bo Ni, Xiang Xia, Chunchao Zhu, Zizhen Zhang, Hui Cao, Lin Tu

{"title":"DEPP1: A prognostic biomarker linked to stroma‑rich and immunosuppressive microenvironment, promoting oxaliplatin resistance in gastric cancer.","authors":"Xudong Qiu, Tao Pan, Tian Kuang, Yanying Shen, Yihan Zheng, Haigang Geng, Bo Ni, Xiang Xia, Chunchao Zhu, Zizhen Zhang, Hui Cao, Lin Tu","doi":"10.3892/or.2025.8915","DOIUrl":"10.3892/or.2025.8915","url":null,"abstract":"Decidual protein induced by progesterone (DEPP1) was identified to exert heterogeneous functions in several cancers, whereas its role in gastric cancer (GC) remains elusive. In the present study, differential expression analysis was conducted using three Gene Expression Omnibus datasets (GSE54129, GSE26942 and GSE3438). Validation of DEPP1 expression was performed using reverse transcription‑quantitative PCR, western blotting and immunofluorescence. Kaplan‑Meier survival and Cox regression analyses were employed to assess the association between DEPP1 expression and the prognosis of patients with GC. Immune infiltration analysis was conducted to explore the correlation between DEPP1 and the tumor microenvironment. The potential of DEPP1 to promote oxaliplatin resistance was assessed using flow cytometry, western blotting, and subcutaneous mouse models. DEPP1 was found to be significantly upregulated in the aforementioned cohorts, which was consistent with the clinical specimens of the present study, and it emerged as an independent risk factor for poor overall survival in patients with GC. A prognostic nomogram was developed to improve prognosis prediction. High DEPP1 expression correlated with increased infiltration of cancer‑associated fibroblasts, endothelial cells, and M2 macrophages, contributing to the development of a stroma‑rich and immunosuppressive microenvironment in GC. Furthermore, high DEPP1 expression was associated with reduced sensitivity to chemotherapy drugs in patients with GC. In vitro and in vivo experiments highlighted DEPP1's crucial role in promoting oxaliplatin resistance in GC. In conclusion, DEPP1 is identified as a promising prognostic biomarker linked to a stroma‑rich and immunosuppressive microenvironment, and it is critical in driving oxaliplatin resistance in GC. These findings may inform personalized therapeutic strategies for patients with GC.","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Retracted] Breast cancer cells are arrested at different phases of the cell cycle following the re‑expression of ARHI. 【缩回】乳腺癌细胞在ARHI重新表达后处于细胞周期的不同阶段。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-26 DOI: 10.3892/or.2025.8916

Xiaoxiao Zuo, Yan Qin, Xiaojin Zhang, Qian Ning, Shan Shao, Minna Luo, Na Yuan, Shangke Huang, Xinhan Zhao

{"title":"[Retracted] Breast cancer cells are arrested at different phases of the cell cycle following the re‑expression of ARHI.","authors":"Xiaoxiao Zuo, Yan Qin, Xiaojin Zhang, Qian Ning, Shan Shao, Minna Luo, Na Yuan, Shangke Huang, Xinhan Zhao","doi":"10.3892/or.2025.8916","DOIUrl":"https://doi.org/10.3892/or.2025.8916","url":null,"abstract":"Subsequently to the publication of the above article, a concerned reader drew the Editor's attention to the fact that, comparing the western blot data shown in Fig. 2 on p. 2360 and Figs. 5 and 6 on p. 2363, two of the β‑actin control protein bands appeared to be shared in common between Figs. 2 and 6, and one of the P21 protein bands in Fig. 6 was strikingly similar to a Cyclin D1 protein band shown in Fig. 5. Furthermore, based on the appearance of the gels, there appeared to be several breaks in the continuity of the gel slices between the second and third lanes in Fig. 6, such that these data were apparently not derived from the same set of experiments. Upon consulting the authors in relation to the unusual features in the abovementioned western blots in this paper, they were unable to offer a satisfactory explanation to account for the presentation of these figures (although offering to repeat the experiments in question). In view of the uncertainties in the affected data, the Editor of Oncology Reports has decided that this paper should be retracted from the Journal on account of a lack of confidence in the data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes for any inconvenience caused. [Oncology Reports 31: 2358‑2364, 2014; DOI: 10.3892/or.2014.3107].","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). 头颈部鳞状细胞癌的三级淋巴样结构（综述）。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.3892/or.2025.8909

Shiqin Hong, Qiyue Wang, Dilong Yu, Juyan Zheng, Ping Huang, Jinping Gu, Yiwen Zhang

引用次数: 0

RNA‑binding protein MBNL1 regulates tumor growth, chemosensitivity and antitumor immunity in lung adenocarcinoma by controlling the expression of tumor suppressor RNF125. RNA结合蛋白MBNL1通过控制肿瘤抑制因子RNF125的表达来调节肺腺癌的肿瘤生长、化疗敏感性和抗肿瘤免疫。

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.3892/or.2025.8907

Yubo Yan, Xianglong Kong, Xiangyuan Jin, Jianlong Bu, Boxiong Ni, Zuqin Rao, Junnan Guo, Shidong Xu

{"title":"RNA‑binding protein MBNL1 regulates tumor growth, chemosensitivity and antitumor immunity in lung adenocarcinoma by controlling the expression of tumor suppressor RNF125.","authors":"Yubo Yan, Xianglong Kong, Xiangyuan Jin, Jianlong Bu, Boxiong Ni, Zuqin Rao, Junnan Guo, Shidong Xu","doi":"10.3892/or.2025.8907","DOIUrl":"10.3892/or.2025.8907","url":null,"abstract":"Ring finger protein 125 (RNF125), a ubiquitin E3 ligase, has been reported to act as a tumor suppressor in several cancers, but its precise function in lung adenocarcinoma (LUAD) has not been elucidated. In the present study, through bioinformatics analysis and immunohistochemistry in LUAD and non‑cancerous samples, it was demonstrated that RNF125 was significantly downregulated in lung cancer. Low levels of RNF125 expression were associated with metastatic status, advanced tumor stage and poor overall survival in LUAD. The results of gain‑ and loss‑of‑function experiments demonstrated that RNF125 inhibited proliferation, colony formation, migration and invasion of LUAD cells. In addition, RNF125 increased the sensitivity of LUAD cells to cisplatin. Mechanistically, RNF125 interacted with programmed cell death ligand 1 (PD‑L1) and reduced PD‑L1 expression levels in LUAD cells. Furthermore, IL‑2 secretion by Jurkat T cells was significantly suppressed when co‑cultured with RNF125‑silenced LUAD cells. NK‑92 cell lysis of RNF125‑silenced LUAD cells was also weaker compared with that of control LUAD cells, suggesting that RNF125 knockdown enhanced the immune evasion ability of LUAD cells. Notably, the results of the present study identified that the RNA‑binding protein muscleblind‑like 1 (MBNL1) is the upstream regulator of RNF125 in LUAD. MBNL1 increased the stability of the RNF125 transcript in LUAD cells and knockdown of RNF125 reversed the antitumor effect of MBNL1 on LUAD cells. In conclusion, the present study demonstrated the tumor suppressor role of RNF125 in LUAD and implicated MBNL1 as an upstream regulator of RNF125 in LUAD. These findings contributed to an improved understanding of the molecular features of LUAD progression.","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"54 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Retracted] RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells. 【撤下】RNA干扰TRIM29抑制结直肠癌细胞迁移和侵袭

IF 3.8 3区医学

Oncology reports Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.3892/or.2025.8908

Weihong Xu, Bin Xu, Yiting Yao, Xiaoling Yu, Hua Cao, Jun Zhang, Jie Liu, Huiming Sheng

引用次数: 0