Oncogene最新文献

{"title":"Editorial Expression of Concern: Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E","authors":"C. Andrieu, D. Taieb, V. Baylot, S. Ettinger, P. Soubeyran, A. De-Thonel, C. Nelson, C. Garrido, A. So, L. Fazli, F. Bladou, M. Gleave, J. L. Iovanna, P. Rocchi","doi":"10.1038/s41388-025-03407-y","DOIUrl":"10.1038/s41388-025-03407-y","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 17","pages":"1208-1208"},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03407-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis","authors":"Christopher S. Gondi, Sajani S. Lakka, Niranjan Yanamandra, Khawar Siddique, Dzung H. Dinh, William C. Olivero, Meena Gujrati, Jasti S. Rao","doi":"10.1038/s41388-025-03401-4","DOIUrl":"10.1038/s41388-025-03401-4","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 19","pages":"1435-1435"},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03401-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperactivated YAP1 is essential for sustainable progression of renal clear cell carcinoma.","authors":"Xiangmin Lv, Jiyuan Liu, Kazi Islam, Jinpeng Ruan, Chunbo He, Peichao Chen, Cong Huang, Hongbo Wang, Anjali Dhar, Madelyn Moness, Davie Shi, Savannah Murphy, Xingeng Zhao, Siyi Yang, Isabelle Montoute, Aneeta Polakkattil, Andie Chung, Emily Ruiz, Brianna Carbajal, Alekhya Padavala, Li Chen, Guohua Hua, Xingcheng Chen, John S Davis, Cheng Wang","doi":"10.1038/s41388-025-03354-8","DOIUrl":"https://doi.org/10.1038/s41388-025-03354-8","url":null,"abstract":"<p><p>The most notable progress in renal clear cell carcinoma (ccRCC) in the past decades is the introduction of drugs targeting the VHL-HIF signaling pathway-associated angiogenesis. However, mechanisms underlying the development of VHL mutation-independent ccRCC are unclear. Here we provide evidence that the disrupted Hippo-YAP signaling contributes to the development of ccRCC independent of VHL alteration. We found that YAP1 and its primary target genes are frequently upregulated in ccRCC and the upregulation of these genes is associated with unfavorable patient outcomes. Research results derived from our in vitro and in vivo experimental models demonstrated that, under normoxic conditions, hyperactivated YAP1 drives the expression of FGFs to stimulate the proliferation of tumor and tumor-associated endothelial cells in an autocrine/paracrine manner. When rapidly growing cancer cells create a hypoxic environment, hyperactivated YAP1 in cancer cells induces the production of VEGF, which promotes the angiogenesis of tumor-associated endothelial cells, leading to improved tumor microenvironment and continuous tumor growth. Our study indicates that hyperactivated YAP1 is essential for maintaining ccRCC progression, and targeting the dual role of hyperactivated YAP1 represents a novel strategy to improve renal carcinoma therapy.</p>","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion","authors":"Santhi D. Konduri,&nbsp;Chilukuri N. Rao,&nbsp;Nirmala Chandrasekar,&nbsp;Anastasia Tasiou,&nbsp;Sanjeeva Mohanam,&nbsp;Yoshiaki Kin,&nbsp;Sajani S. Lakka,&nbsp;Dzung Dinh,&nbsp;William C. Olivero,&nbsp;Meena Gujrati,&nbsp;Donald C. Foster,&nbsp;Walter Kisiel,&nbsp;Jasti S. Rao","doi":"10.1038/s41388-025-03404-1","DOIUrl":"10.1038/s41388-025-03404-1","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 19","pages":"1434-1434"},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03404-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer","authors":"Joy C. Yang,&nbsp;Pengfei Xu,&nbsp;Shu Ning,&nbsp;Logan J. Wasielewski,&nbsp;Hans Adomat,&nbsp;Sung Hee Hwang,&nbsp;Christophe Morisseau,&nbsp;Martin Gleave,&nbsp;Eva Corey,&nbsp;Allen C. Gao,&nbsp;Primo N. Lara Jr,&nbsp;Christopher P. Evans,&nbsp;Bruce D. Hammock,&nbsp;Chengfei Liu","doi":"10.1038/s41388-025-03392-2","DOIUrl":"10.1038/s41388-025-03392-2","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 17","pages":"1204-1206"},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03392-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer","authors":"Vincent Wagner,&nbsp;Molly Morton,&nbsp;Kalpana Deepa Priya Dorayappan,&nbsp;Anna Gonzalez,&nbsp;Lianbo Yu,&nbsp;Takahiko Sakaue,&nbsp;Thomas Conrads,&nbsp;G. Larry Maxwell,&nbsp;Casey Cosgrove,&nbsp;Floor Backes,&nbsp;Qi-En Wang,&nbsp;David E. Cohn,&nbsp;David M. O’Malley,&nbsp;Karuppaiyah Selvendiran","doi":"10.1038/s41388-025-03382-4","DOIUrl":"10.1038/s41388-025-03382-4","url":null,"abstract":"Platinum resistance in high-grade serous ovarian carcinoma (HGSOC) portends a poor prognosis. Although initial platinum-based chemotherapy response rates are high, 15-20% of patients demonstrate primary resistance to platinum therapy and almost all patients will develop platinum resistance in the recurrent setting. No predictive or diagnostic biomarkers have been utilized specific to platinum resistance. This study aimed to identify candidate biomarkers for platinum resistance in HGSOC using an extracellular vesicle (EV) based approach. We found differentially expressed and distinct EV proteins, namely TMEM205 and CFH, in patients with platinum-resistant (PR) HGSOC compared to those of platinum-sensitive (PS) patients, utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS). Expression of these EV proteins were validated in patient-derived PR cell lines as well as in clinically relevant mouse models of HGSOC post-platinum therapy. We corroborated these findings using serum samples from patients with PS and PR-HGSOC. Both EV CFH and EV TMEM205 exhibited excellent diagnostic capability for PR as noted by receiver operating characteristic curves with area under the curve values of 0.95 and 0.84, respectively. The high diagnostic performance of TMEM205 and CFH within EVs compared to the relatively poor performance of conventional serum proteins such as Ca125 suggests their robust potential as non-invasive biomarkers for detecting platinum resistance in HGSOC. Furthermore, the ROC curve for the combined biomarker demonstrated excellent diagnostic performance, with an AUC of 0.973, a true positive rate (TPR) of 0.938, and a false positive rate (FPR) of 0.062. Incorporating this multi-protein biomarker panel alongside established biomarkers further enhances diagnostic accuracy. Serum EV CFH and TMEM205 are promising biomarkers for early detection of platinum resistance in HGSOC and may highlight underlying chemoresistance mechanisms, offering potential future therapeutic targets.","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 17","pages":"1197-1203"},"PeriodicalIF":6.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03382-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas","authors":"Santhi D. Konduri,&nbsp;Francis Ali Osman,&nbsp;Chilukuri N. Rao,&nbsp;Harish Srinivas,&nbsp;Niranjan Yanamandra,&nbsp;Anastasia Tasiou,&nbsp;Dzung H. Dinh,&nbsp;William C. Olivero,&nbsp;Meena Gujrati,&nbsp;Donald C. Foster,&nbsp;Walter Kisiel,&nbsp;Gregory Kouraklis,&nbsp;Jasti S. Rao","doi":"10.1038/s41388-025-03384-2","DOIUrl":"10.1038/s41388-025-03384-2","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 18","pages":"1321-1321"},"PeriodicalIF":6.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03384-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer.","authors":"Xiaohang Xu, Sicong Wang, Hanyi Zhou, Qilong Tan, Zeyong Lang, Yun Zhu, Huadi Yuan, Zixiang Wu, Ling Zhu, Kejia Hu, Wenyuan Li, Dan Zhou, Ming Wu, Xifeng Wu","doi":"10.1038/s41388-025-03338-8","DOIUrl":"https://doi.org/10.1038/s41388-025-03338-8","url":null,"abstract":"<p><p>Alternative polyadenylation (APA) plays a crucial role in cancer development and prognosis. However, the molecular characteristics of APA related to non-small cell lung cancer (NSCLC) susceptibility remain understudied, especially in East Asian populations. In this study, we constructed an atlas of APA-regulated 3' untranslated region (3'UTR) and profiled its genetic regulation in 747 lung tissue samples (including tumors and paired normal tissues) from 417 NSCLC Chinese patients. We verified a significant global shortening of 3'UTRs in tumor samples compared to normal samples and underscored the value of APA-regulation as a prognostic marker. The 3'UTR APA quantitative trait loci (3'aQTL) was identified by regressing the percentage of distal poly(A) site usage index (PDUI) value on genetic variants. We found that a significant proportion 3'aQTLs are independent of genetic regulation of expression and are specific in Chinese. We also conducted a 3'UTR APA transcriptome-wide association study (3'aTWAS) by integrating the APA regulation atlas with a genome-wide association study (GWAS) for NSCLC involving 7035 cases and 185,413 cancer-free controls. We identified NSCLC-associated genes, highlighting TUBB, TEAD3, and PPP1R10. Combining the consistent results from colocalization analysis, differential APA analysis, and survival analysis, we provide novel evidence for the role TUBB APA regulation in NSCLC and identified potential upstream regulators. Overall, our study profiled the APA regulation and highlighted the substantial role of APA in NSCLC carcinogenesis and prognosis in East Asian populations.</p>","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note to: Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma","authors":"O. Kargiotis,&nbsp;C. Chetty,&nbsp;C. S. Gondi,&nbsp;A. J. Tsung,&nbsp;D. H. Dinh,&nbsp;M. Gujrati,&nbsp;S. S. Lakka,&nbsp;A. P. Kyritsis,&nbsp;J. S. Rao","doi":"10.1038/s41388-025-03377-1","DOIUrl":"10.1038/s41388-025-03377-1","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 18","pages":"1320-1320"},"PeriodicalIF":6.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03377-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion","authors":"Sajani S. Lakka,&nbsp;Mannari Rajan,&nbsp;Christopher Gondi,&nbsp;Niranjan Yanamandra,&nbsp;Nirmala Chandrasekar,&nbsp;Sushma L. Jasti,&nbsp;Yoshiaki Adachi,&nbsp;Khawar Siddique,&nbsp;Meena Gujrati,&nbsp;William Olivero,&nbsp;Dzung H. Dinh,&nbsp;Gregory Kouraklis,&nbsp;Athanassios P. Kyritsis,&nbsp;Jasti S. Rao","doi":"10.1038/s41388-025-03395-z","DOIUrl":"10.1038/s41388-025-03395-z","url":null,"abstract":"","PeriodicalId":19524,"journal":{"name":"Oncogene","volume":"44 18","pages":"1319-1319"},"PeriodicalIF":6.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41388-025-03395-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}