Journal of Heterocyclic Chemistry最新文献_第4页

Visible Light Triggered, Catalyst-Free Approach for the Click Synthesis of Imidazole-Fused Nitrogen-Bridgehead Nucleus in EtOH:H2O Medium 在EtOH:H2O介质中催化合成咪唑-融合氮-桥头堡核的可见光触发无催化剂方法

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-21 DOI: 10.1002/jhet.4901

Anjali Jaiswal, Amit Kumar Sharma, Shweta Jaiswal, Anu Mishra, Jaya Singh, Jagdamba Singh, I. R. Siddiqui

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Advances in the Synthesis of 3-Acyl-2-Pyridones: Strategies and Methods for Accessing the Versatile Scaffold 3-酰基-2-吡啶酮的合成研究进展：获得多功能支架的策略和方法

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-16 DOI: 10.1002/jhet.4896

Reena Rani, Sheetu Devi, Neelam Yadav, Sarita Sangwan, Vidhi Dhanda, Vipan Kumar, Sonu Chauhan, Anil Duhan, Ravi Kumar

{"title":"Advances in the Synthesis of 3-Acyl-2-Pyridones: Strategies and Methods for Accessing the Versatile Scaffold","authors":"Reena Rani, Sheetu Devi, Neelam Yadav, Sarita Sangwan, Vidhi Dhanda, Vipan Kumar, Sonu Chauhan, Anil Duhan, Ravi Kumar","doi":"10.1002/jhet.4896","DOIUrl":"https://doi.org/10.1002/jhet.4896","url":null,"abstract":"<div>\u0000 \u0000 The syntheses and bioevaluation of 3-acyl-2-pyridones have garnered significant interest in recent years as a novel class of compounds with diverse biological activities. The bioactivities cover a wide range of therapeutic areas including antimicrobial, antitumor, anti-inflammatory, antifungal, antibiotic, neuritogenic, cytotoxic, and antiviral activities. Therefore, 3-acyl-2-pyridone scaffold offers a versatile platform for the development of new molecules with potential applications in medicinal chemistry. The recent exploration on synthesis and bioevaluation of 3-acyl-2-pyridones has yielded promising results, making them attractive targets for further optimization and development of new therapeutic agents. This review summarizes the available information on total synthesis of 3-acyl-2-pyridone containing natural products, and the other synthetic strategies developed for accessing the 3-acyl pyridones such as multicomponent synthesis, condensation reaction, microwave-assisted synthesis, catalytic hydrogenation reactions, metalation reaction, Michael addition, and formylation reactions. The presented information may serve as a valuable resource for researchers working in the field of medicinal chemistry and drug discovery, stimulating further exploration and development of this intriguing scaffold.\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 1","pages":"25-49"},"PeriodicalIF":2.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of the Isosteric Exchange of Benzene by Thiophene-Core of Phthalocyanine: The Synthesis, Structure and Opto-Electronic Behavior of π-Conjugated Unit Blocks in Materials 酞菁噻吩核对苯等构交换的影响：材料中π共轭单元块的合成、结构和光电行为

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-16 DOI: 10.1002/jhet.4921

Dominika Kendrová, Marcela Gašparová, Anita Andicsová-Eckstein, Tomáš Váry, Kamil Tokár, Zita Tokárová

引用次数: 0

Design, Synthesis of Novel Pyrimidine Derivatives Containing Alkenyl Moieties With Herbicidal Activities 具有除草活性的新型烯基嘧啶衍生物的设计、合成

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-13 DOI: 10.1002/jhet.4895

Wenliang Zhang, Jingjing Chen, Xiaohua Du

{"title":"Design, Synthesis of Novel Pyrimidine Derivatives Containing Alkenyl Moieties With Herbicidal Activities","authors":"Wenliang Zhang, Jingjing Chen, Xiaohua Du","doi":"10.1002/jhet.4895","DOIUrl":"https://doi.org/10.1002/jhet.4895","url":null,"abstract":"<div>\u0000 \u0000 To identify lead compounds with potent herbicidal activity, a range of pyrimidine derivatives containing alkenyl groups were designed, synthesized, and characterized using nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The synthetic pathways for producing these compounds involved substitution reactions, cyclization, hydrolysis, and other processes. The starting materials for each reaction step were readily accessible, facilitating synthesis. The purification of the final product was straightforward, yielding approximately 80%, under mild reaction conditions. Moreover, a pot culture experiment was employed to assess the herbicidal efficacy of the aforementioned compounds. Compounds 6a, 6b, 6h, and 6j demonstrated a significant inhibition against Amaranthus retroflexus, comparable to fomesafen at 150 g a.i./hm2. This suggests that these compounds hold promise as potential lead structures for herbicidal agents. The docking results indicated that the binding energies of compound 6a with protoporphyrinogen oxidase (PPO) were both negative and spontaneous, with numerous interaction active sites. Thus, it is speculated that compound 6a is a PPO inhibitor.\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 1","pages":"5-12"},"PeriodicalIF":2.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Strategies for C-Amino 1,2,3-Triazoles and Their Oxides: A Review c -氨基1,2,3-三唑及其氧化物的合成策略综述

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-12 DOI: 10.1002/jhet.4920

Sofya P. Balabanova, Alexey A. Voronin, Aleksandr M. Churakov, Michael S. Klenov, Vladimir A. Tartakovsky

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Lewis Base Promoted [4+2] Annulation of o-Acylamino-Aryl Morita-Baylis-Hillman Carbonates With Isatylidene Malononitriles: Facile Access to Spiro[Indolin-3,2′-Quinoline] Frameworks 邻酰基氨基-芳基森田- baylis - hillman碳酸盐与异亚基丙二腈的Lewis碱促进[4+2]环化：螺旋[吲哚-3,2 ' -喹啉]框架的便捷获取

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-10 DOI: 10.1002/jhet.4919

Li-Wen Shen, Mao-Dan Luo, Wen-Yi Zhou, Yuan-Ying Luo, Min Xiang, Yun-Qing Jia, Shu-Pei Yuan, Guang-Wei Wang

引用次数: 0

Coumarin Derivatives: Microwave Synthesis and Biological Properties—A Review 香豆素衍生物：微波合成与生物特性--综述

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-10 DOI: 10.1002/jhet.4918

Wissam Habibi, Soumaya Talbi, Salha Hamri, Abderrafia Hafid, Mostafa Khouili

{"title":"Coumarin Derivatives: Microwave Synthesis and Biological Properties—A Review","authors":"Wissam Habibi, Soumaya Talbi, Salha Hamri, Abderrafia Hafid, Mostafa Khouili","doi":"10.1002/jhet.4918","DOIUrl":"https://doi.org/10.1002/jhet.4918","url":null,"abstract":"<div>\u0000 \u0000 Many molecules called coumarins with very varied biological activities and widely used in the food, pharmaceutical, cosmetic, and medical industries. Their structure has a significant impact on their biological activity and their possible applications. Advanced synthesis frequently leads to an increase in the production of various chemical wastes. The amount of hazardous organic substances used and produced is reduced by the application of environmentally friendly synthesis techniques. Numerous techniques are employed in green chemistry, including the use of ionic liquids and deep eutectic solvents, solvent-free synthesis, mechanical synthesis, multicomponent reactions, ultrasound, and microwaves. These green synthesis techniques have been successfully applied to all common condensation reactions for the synthesis of coumarin, including the Perkin, Knoevenagel, Pechmann, Kostanecki-Robinson, and Reformansky reactions. These methods not only reduce the use and production of toxic chemicals, but also improve the yield, purity, and energy consumption of the product. This review summarizes the methods of microwave synthesis of coumarin derivatives, as well as their biological activities.\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 12","pages":"2070-2096"},"PeriodicalIF":2.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible Light Mediated CO2 Fixation Reactions to Produce Carbamates and Carbonates: A Comprehensive Review 可见光介导的二氧化碳固定反应生成氨基甲酸酯和碳酸盐：综述

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-08 DOI: 10.1002/jhet.4882

Asmita Goswami, Monika Verma, Ajay Thakur, Ruchi Bharti, Renu Sharma

引用次数: 0

1,5-Diazocine-Based Diaryl Ketones: Design, Synthesis, and Optoelectronic Properties 1,5-重氮嘧啶基二芳基酮：设计、合成及光电性能

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-04 DOI: 10.1002/jhet.4915

Anjitha Sebastian, Vibhu Darshan, Bijoy Nharangatt, Vijay Kumar Maka, Amrutham Linet, Simi Achankunju, Masaki Nagaoka, Shigeyuki Yagi, Narayanan Unni K. N., Ishita Neogi

{"title":"1,5-Diazocine-Based Diaryl Ketones: Design, Synthesis, and Optoelectronic Properties","authors":"Anjitha Sebastian, Vibhu Darshan, Bijoy Nharangatt, Vijay Kumar Maka, Amrutham Linet, Simi Achankunju, Masaki Nagaoka, Shigeyuki Yagi, Narayanan Unni K. N., Ishita Neogi","doi":"10.1002/jhet.4915","DOIUrl":"https://doi.org/10.1002/jhet.4915","url":null,"abstract":"<div>\u0000 \u0000 Three novel heterocyclic host based on diaryl ketone-tethered 1,5-diazocines were designed and synthesized for applications in phosphorescent organic light-emitting diodes (PhOLEDs). The hosts were derived by anchoring the naphthyl ketone (TBN), anthryl ketone (TBA), and phenanthryl ketone (TBP) to the 1,5-diazocine core. The materials were successfully characterized using spectroscopic techniques. TBN and TBP exhibited low external quantum efficiency of 1.5% and 1.9% when explored as hosts in PhOLED devices. Among the series, TBP exhibited the highest luminance of 4160 cd/m2, maximum luminance efficiency of 6.3 cd/A, and power efficiency of 3.21 lm/w, when doped with Ir(ppy)3 in PhOLED. Nevertheless to our surprise, TBA manifested the lowest device performance than other TBs as a host due to low carrier mobility caused by a highly twisted structure as deciphered from the comparative analysis of single-crystal structure that could impede carrier transport crucial for efficient electroluminescence. The outcomes of electroluminescence were validated and explained with analysis of single-crystal structure, and also with the aid of density functional theory.\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 12","pages":"2040-2049"},"PeriodicalIF":2.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Methoxy Pyrazole-4-Carboxamide Derivatives: Synthesis, Spectral Analyses, Antifungal Activity, In Silico Molecular Docking, ADMET, and DFT Studies n -甲氧基吡唑-4-羧基酰胺衍生物：合成、光谱分析、抗真菌活性、硅分子对接、ADMET和DFT研究

IF 2 3区化学

Journal of Heterocyclic Chemistry Pub Date : 2024-10-02 DOI: 10.1002/jhet.4903

Zi-Ting Luo, Bin Wang, Hong-Ke Wu, Li-Jing Min, Li-Qin Zhang, Xing-Hai Liu

{"title":"N-Methoxy Pyrazole-4-Carboxamide Derivatives: Synthesis, Spectral Analyses, Antifungal Activity, In Silico Molecular Docking, ADMET, and DFT Studies","authors":"Zi-Ting Luo, Bin Wang, Hong-Ke Wu, Li-Jing Min, Li-Qin Zhang, Xing-Hai Liu","doi":"10.1002/jhet.4903","DOIUrl":"https://doi.org/10.1002/jhet.4903","url":null,"abstract":"<div>\u0000 \u0000 Succinate dehydrogenase inhibitor (SDHI) is an important fungicide to control grain diseases. For this reason, a series of novel pyrazole-4-carboxamide derivatives with an N-methoxy group were designed and synthesized. All the target compounds were characterized by 1H NMR, 13C NMR, and HRMS. The compound 3c was further confirmed by X-ray diffraction, which crystallized in the triclinic system, space group P-1, Z = 2. The fungicidal activity results indicated that most of these compounds possessed good activity against Sclerotinia sclerotiorum at 50 ppm. Especially, compound 3h exhibited the best activity with the EC50 is 7.80 μg/mL, which is comparable with the positive control bixafen (EC50 = 6.70 μg/mL). Furthermore, the physicochemical properties, molecular docking simulation, ADMET analyses, DFT of compounds 3h, 3k and two commercial SDHIs, isoflucypram and pydiflumetofen, were investigated in this study.\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 12","pages":"2015-2025"},"PeriodicalIF":2.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0