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Journal of Heterocyclic Chemistry最新文献

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Identification, Synthesis, and Characterization of Process Related Impurities in the Synthesis of Boc-L-Lys(Boc)-OSu Boc-L-Lys(Boc)-OSu 合成过程中相关杂质的鉴定、合成和表征
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-12 DOI: 10.1002/jhet.4884
Amit H. Pakhurde, D. V. P. Kishore, Sandeep A. Kotharkar
{"title":"Identification, Synthesis, and Characterization of Process Related Impurities in the Synthesis of Boc-L-Lys(Boc)-OSu","authors":"Amit H. Pakhurde,&nbsp;D. V. P. Kishore,&nbsp;Sandeep A. Kotharkar","doi":"10.1002/jhet.4884","DOIUrl":"10.1002/jhet.4884","url":null,"abstract":"<div>\u0000 \u0000 <p>Protected lysine esters (Boc-L-Lys(Boc)-OSu) an intermediate of high repute in the peptide synthesis and diverse chemical synthetic applications, was the subject of synthetic process development studies, unveiling process-related impurities. These impurities were synthesized, characterized, and identified by different analytical tools, with their retention times verified by HPLC co-injection with commercial products. Detailed discussions ensued on the potential formation pathways and synthetic strategies of these process-related impurities.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 11","pages":"1710-1720"},"PeriodicalIF":2.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Development on the Heterocycles Derived From In Situ Formation of Aryl Glyoxals by Iodine/DMSO Mediated Oxidation of Methyl Ketones 碘/二甲基亚砜介导甲基酮原位氧化形成芳基乙二醛衍生杂环的最新进展
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-11 DOI: 10.1002/jhet.4880
Hitesh B. Jalani
{"title":"Recent Development on the Heterocycles Derived From In Situ Formation of Aryl Glyoxals by Iodine/DMSO Mediated Oxidation of Methyl Ketones","authors":"Hitesh B. Jalani","doi":"10.1002/jhet.4880","DOIUrl":"10.1002/jhet.4880","url":null,"abstract":"<div>\u0000 \u0000 <p>Controlled oxidation of methyl-ketones to aryl glyoxals using Selenium dioxide and iodine is one of the useful transformation. Regardless the availability of many oxidation reagents, Iodine/DMSO system is very efficient and flexible. This system efficiently allows in situ formation of α-halo ketones and subsequently transforming them directly to useful products. The Iodine/DMSO system allows the selective C<span></span>I and C<span></span>O bond formation, substantially useful for converting them to other bond forming reactions and heterocycles useful in the synthetic and medicinal chemistry. Iodine/DMSO system could be an important alternative strategy due to sustainability, metal-free conditions, allowing multiple/linear domino reactions. This review will focus on heterocyclic systems smartly developed/manipulated by Wu group from methyl-ketones. The scope and limitations of this method and selected examples of applications for the synthesis of interesting molecules are discussed herein.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 11","pages":"1668-1703"},"PeriodicalIF":2.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Benzofuran-Based Hybrid Molecules: Molecular Docking and Antibacterial Activity Against Pseudomonas aeruginosa 苯并呋喃类杂化分子的合成：分子对接和对铜绿假单胞菌的抗菌活性
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-10 DOI: 10.1002/jhet.4887
Carlos J. Cortés-García, Aidme I. Mercado-Madrigal, Viridiana Alejandre-Castañeda, Jose Alberto Patiño-Medina, Verónica Castro-Velázquez, Vicente Rodríguez-González, Martha Isela Ramírez-Díaz, Alejandro Islas-Jácome, Mónica A. Rincón-Guevara, Luis Chacón-García, Victor Meza-Carmen, Erik Díaz-Cervantes
{"title":"Synthesis of Benzofuran-Based Hybrid Molecules: Molecular Docking and Antibacterial Activity Against Pseudomonas aeruginosa","authors":"Carlos J. Cortés-García,&nbsp;Aidme I. Mercado-Madrigal,&nbsp;Viridiana Alejandre-Castañeda,&nbsp;Jose Alberto Patiño-Medina,&nbsp;Verónica Castro-Velázquez,&nbsp;Vicente Rodríguez-González,&nbsp;Martha Isela Ramírez-Díaz,&nbsp;Alejandro Islas-Jácome,&nbsp;Mónica A. Rincón-Guevara,&nbsp;Luis Chacón-García,&nbsp;Victor Meza-Carmen,&nbsp;Erik Díaz-Cervantes","doi":"10.1002/jhet.4887","DOIUrl":"10.1002/jhet.4887","url":null,"abstract":"<div>\u0000 \u0000 <p>A rapid and efficient protocol for synthesizing two series of benzofuran-based hybrid polyheterocycles is presented: benzofuran-isatin and benzofuran <i>N</i>-acylhydrazones, and evaluation of their antibacterial activity both in vitro and in silico against two strains of <i>Pseudomonas aeruginosa</i>, PAO1 and PA14 were determined. Six of the tested compounds were shown to be active against the hypervirulent strain PA14. Docking studies were conducted using RNA polymerase sigmaS protein for <i>P. aeruginosa</i> PAO1 and PqsE protein for <i>P. aeruginosa</i> PA14 to provide additional insights into these results. A pharmacophore model was computed to suggest potential structural derivatives on the target molecules, offering further insights for future research. Finally, 40 novel compounds, including intermediates, were synthesized in a three-step reaction.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 11","pages":"1653-1667"},"PeriodicalIF":2.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fused Thiazolo[2,3-b]Quinazolinone–Chromone Hybrids: Synthesis, Characterization, In Vitro Antibacterial Activity and In Silico Screening 融合的噻唑并[2,3-b]喹唑啉酮-色酮杂化物：合成、表征、体外抗菌活性和硅学筛选
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-08 DOI: 10.1002/jhet.4892
Rajitha Gali, Janardhan Banothu, Punam Salaria, N. N. Subrahmanyeswara Rao, Santosh Kumar Badampudi, M. Amarendar Reddy
{"title":"Fused Thiazolo[2,3-b]Quinazolinone–Chromone Hybrids: Synthesis, Characterization, In Vitro Antibacterial Activity and In Silico Screening","authors":"Rajitha Gali,&nbsp;Janardhan Banothu,&nbsp;Punam Salaria,&nbsp;N. N. Subrahmanyeswara Rao,&nbsp;Santosh Kumar Badampudi,&nbsp;M. Amarendar Reddy","doi":"10.1002/jhet.4892","DOIUrl":"10.1002/jhet.4892","url":null,"abstract":"<div>\u0000 \u0000 <p>Antimicrobial resistance is one of the biggest threats to public health across the globe. Bacteria, fungi, viruses, and protozoans have been exhibiting resistance against antimicrobial drugs making them ineffective. Hence, the development of new antibiotics with a different mode of action is highly desirable. In this study, 10 new chromone-incorporated fused thiazolo[2,3-<i>b</i>]quinazolinone derivatives, <b>8a-j</b>, have been prepared via Biginelli reaction involving aromatic aldehydes, 1-tetralone, and thiourea followed by a reaction with 2-chloro-<i>N</i>-phenylacetamide, and Knoevenagel condensation with 3-formylchromone. All the structures of the compounds were characterized by NMR, FTIR, and mass spectrometry. The in vitro antibacterial activities of all the synthesized compounds against the four different microbial strains were evaluated. Among them, few compounds demonstrated prominent activity against <i>Staphylococcus aureus</i>, <i>Streptococcus pyogenes</i>, and <i>Pseudomonas aeruginosa</i>. No appreciable activity of any compound against <i>Klebsiella pneumoniae</i> was observed. Molecular docking studies were employed to reveal the interactions responsible for the potent compounds' activities against <i>S. aureus</i>, <i>S. pyogenes</i>, and <i>P. aeruginosa.</i> Both in vitro and in silico studies have been carried out by using standard agar well diffusion protocol and Auto Dock Vina in PyRx. The results indicated that compound <b>8c</b> was the potential compound as it showed good affinity toward the receptors of all three organisms. Molecular dynamics simulation of the <b>8c-1JIJ</b> complex for 100 ns further confirmed the potentiality of <b>8c</b>. The pharmacokinetic properties of the compounds indicate that the studied molecules have exhibited a favorable profile.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 11","pages":"1642-1652"},"PeriodicalIF":2.0,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Photophysical Properties and Cytotoxic Activities of Isoxazole-Containing Difluoroboron Complexes 含异噁唑的二氟硼络合物的合成、光物理性质和细胞毒活性
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-05 DOI: 10.1002/jhet.4894
Kirill S. Sadovnikov, Dmitry A. Vasilenko, Nadezhda E. Astakhova, Artem S. Sazonov, Alexei A. Yakushev, Yulia A. Gracheva, Yuri K. Grishin, Victor A. Tafeenko, Elena R. Milaeva, Elena B. Averina
{"title":"Synthesis, Photophysical Properties and Cytotoxic Activities of Isoxazole-Containing Difluoroboron Complexes","authors":"Kirill S. Sadovnikov,&nbsp;Dmitry A. Vasilenko,&nbsp;Nadezhda E. Astakhova,&nbsp;Artem S. Sazonov,&nbsp;Alexei A. Yakushev,&nbsp;Yulia A. Gracheva,&nbsp;Yuri K. Grishin,&nbsp;Victor A. Tafeenko,&nbsp;Elena R. Milaeva,&nbsp;Elena B. Averina","doi":"10.1002/jhet.4894","DOIUrl":"10.1002/jhet.4894","url":null,"abstract":"<div>\u0000 \u0000 <p>A large series of previously unknown isoxazole containing difluoroboron β-diketonate has been designed and synthesized from the available starting compounds. The photophysical properties of obtained compounds were studied, and the effects of the substituents in aromatic and isoxazole cycles of the BF<sub>2</sub> complexes on the fluorescence were investigated. The effect of solvatochromism were demonstrated. Cytotoxic activity against MCF-7 (breast carcinoma), HCT-116 (colon carcinoma), A549 (pulmonary carcinoma) and WI38 (fibroblasts from lung tissue) cell lines was tested and moderate toxicity in the concentration range of 10–100 μM was found for several compounds.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1627-1636"},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concise Synthesis of Azaphenanthrene Alkaloid Eupolauramine Via Au(I)-Catalyzed Cycloisomerization and Intramolecular Ullmann-Type Coupling Reaction 通过金(I)催化的环异构化和分子内乌尔曼型偶联反应简易合成偶氮菲类生物碱大黄素
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-09-02 DOI: 10.1002/jhet.4889
Eunyeong Kim, Young Taek Han
{"title":"Concise Synthesis of Azaphenanthrene Alkaloid Eupolauramine Via Au(I)-Catalyzed Cycloisomerization and Intramolecular Ullmann-Type Coupling Reaction","authors":"Eunyeong Kim,&nbsp;Young Taek Han","doi":"10.1002/jhet.4889","DOIUrl":"10.1002/jhet.4889","url":null,"abstract":"<div>\u0000 \u0000 <p>A concise and efficient synthesis of the γ-lactam-fused azaphenanthrene alkaloid eupolauramine has been achieved. The key feature of the synthesis involves Au(I)-catalyzed cycloisomerization of <i>N</i>-naphthyl aminobutynamide intermediate and subsequent intramolecular Ullmann-type coupling reaction. This study clearly demonstrated the usefulness of coinage metal-catalyzed cycloisomerization strategy in the construction of architecturally sophisticated pyridine-fused heterocyclic scaffolds.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1622-1626"},"PeriodicalIF":2.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Novel 6 H-Furo[3,2-e]Indole Derivatives via One-Pot Three Component Reactions 通过一锅三组份反应合成新型 6H-呋喃并[3,2-e]吲哚衍生物
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-08-28 DOI: 10.1002/jhet.4883
Dan-Dan Wan, Shuang-Ling Wu, Jia-Yan Liu, Dong-Sheng Chen
{"title":"Synthesis of Novel 6\u0000 H-Furo[3,2-e]Indole Derivatives via One-Pot Three Component Reactions","authors":"Dan-Dan Wan,&nbsp;Shuang-Ling Wu,&nbsp;Jia-Yan Liu,&nbsp;Dong-Sheng Chen","doi":"10.1002/jhet.4883","DOIUrl":"10.1002/jhet.4883","url":null,"abstract":"<div>\u0000 \u0000 <p>A one-pot, three-component reaction of ethyl 5-aminobenzofuran-2-carboxylate, arylglyoxals and cyclic 1,3-dicarbonyl compounds in the presence of acetic acid as an organocatalyst in ethanol medium under reflux conditions provided a series of new 6<i>H</i>-furo[3,2-<i>e</i>]indole derivatives in good yields.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1613-1621"},"PeriodicalIF":2.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Oxaazaisowurtzitane Derivatives Via Condensation of p-Toluenesulfonamide With Glyoxal 通过对甲苯磺酰胺与乙二醛缩合合成噁唑烷-乌齐坦衍生物
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-08-27 DOI: 10.1002/jhet.4885
Artyom E. Paromov, Valentina А. Kubasova, Sergey V. Sysolyatin
{"title":"Synthesis of Oxaazaisowurtzitane Derivatives Via Condensation of p-Toluenesulfonamide With Glyoxal","authors":"Artyom E. Paromov,&nbsp;Valentina А. Kubasova,&nbsp;Sergey V. Sysolyatin","doi":"10.1002/jhet.4885","DOIUrl":"10.1002/jhet.4885","url":null,"abstract":"<div>\u0000 \u0000 <p>This work presents the study results on the acid-catalyzed cascade condensation of <i>p</i>-toluenesulfonamide with glyoxal in H<sub>2</sub>SO<sub>4</sub> in order to synthesize aza- and oxaazaisowurtzitanes—a platform for promising high-energy-density compounds—and explore their formation processes. The effects of the ratio of starting reactants, acidity, reaction medium concentration, and temperature on this process were studied in detail. Five novel compounds were derived, including four oxaazaisowurtzitanes comprising one to three aza groups, and one condensation intermediate. The most favorable conditions for the formation of the resultant caged compounds were established and some new regularities of the process were revealed. For instance, the reaction medium concentration was discovered for the first time to influence the generation process of oxaazaisowurtzitanes via direct condensation. The limiting stage of the cage formation process of oxaazaisowurtzitanes was identified. The formation rate of the oxaazaisowurtzitanes was shown to be dependent on their structure. The factor dramatically reducing the yield of the oxaazaisowurtzitanes at elevated synthesis temperature was also revealed.</p>\u0000 </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1602-1612"},"PeriodicalIF":2.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A regiospecific fischer indole reaction with 3-oxo-24-nor-allobetulin 3-oxo-24-nor-allobetulin 与费舍尔吲哚的区域特异性反应
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-08-04 DOI: 10.1002/jhet.4877
Liana Zakirova, Irina Baikova, Alexander Lobov, Yury Gatilov, Dmitriy Polovyanenko, Oxana Каzakova
{"title":"A regiospecific fischer indole reaction with 3-oxo-24-nor-allobetulin","authors":"Liana Zakirova,&nbsp;Irina Baikova,&nbsp;Alexander Lobov,&nbsp;Yury Gatilov,&nbsp;Dmitriy Polovyanenko,&nbsp;Oxana Каzakova","doi":"10.1002/jhet.4877","DOIUrl":"10.1002/jhet.4877","url":null,"abstract":"<p>First case of regiospecific formation of indole fused with a triterpene scaffold is observed. Starting from 3-oxo-24-nor-allobetulin Fischer reaction with phenylhydrazine under the influence of weak acid catalyst led to 3H-indole (indolenine) 4. This process was accompanied by a change in the configuration of the methyl group at C-4 that was confirmed by x-ray diffraction method. On the other hand, 3,2-indole 5 was synthesized under the influence of strong acid catalyst (using phenylhydrazine hydrochloride in AcOH acid or phenylhydrazine in MeOH with a few drops of HCl).</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1597-1601"},"PeriodicalIF":2.0,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141937851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An efficient one-pot, three-component synthesis of novel [1,2,4]triazolo [4′,3′:1,5][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives and their molecular docking studies 新型[1,2,4]三唑并[4′,3′:1,5][1,2,4]三唑并[3,4-b][1,3,4]噻二嗪衍生物的高效一锅三组分合成及其分子对接研究
IF 2 3区 化学
Journal of Heterocyclic Chemistry Pub Date : 2024-07-30 DOI: 10.1002/jhet.4873
Parameshwara Chary Jilloju, Perugu Shyam, Seema Aravind, Rajeswar Rao Vedula
{"title":"An efficient one-pot, three-component synthesis of novel [1,2,4]triazolo [4′,3′:1,5][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives and their molecular docking studies","authors":"Parameshwara Chary Jilloju,&nbsp;Perugu Shyam,&nbsp;Seema Aravind,&nbsp;Rajeswar Rao Vedula","doi":"10.1002/jhet.4873","DOIUrl":"10.1002/jhet.4873","url":null,"abstract":"<p>A series of novel [1,2,4]triazolo[4′,3′:1,5][1,2,4]triazolo[3,4-b][1,3,4]thiadiazines (<b>4a-p</b>) were synthesized from the reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol (<b>1</b>) with different bromoethanones (<b>2a-p</b>) and substituted benzoic acids (<b>3</b>) via a one-pot, three-component reaction with good to excellent yields. The new fused tri-cyclic system was achieved without using a catalyst and metal by cyclo-condensation reaction through a one-pot approach. The structures of newly synthesized molecules were confirmed by using IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, Mass spectral, and analytical data. Molecular docking studies were carried out for the newly synthesized compounds against human cancer receptors (2TKB) with good results.</p>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 10","pages":"1586-1596"},"PeriodicalIF":2.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141870256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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