B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES最新文献

{"title":"Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation","authors":"G. Cao, H. Lam, J. Jude, N. Karmacharya, M. Kan, W. Jester, C. Koziol-White, B. Himes, G. Chupp, S. An, R. Panettieri","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3280","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3280","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125217250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of EGFR in Airway Dysfunction in Mice Following Chlorine Exposure","authors":"K. Makita, Y. Ishii, R. Sun, J.G. Martin","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3297","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3297","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123779502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary System Elastance Increases in Murine Model of Down Syndrome","authors":"K. Boncella, D. Goodman, J. Bilodeaux, H. Farooqi, J. Harral, K. Colvin, B. Smith, M. Yeager","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3306","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3306","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115426205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Diet-Induced Obesity and Chemerin Deficiency on Ozone-Induced Lung Injury and Lung Inflammation","authors":"R. A. Johnston, M. Takahashi, Y. Takahashi, A.W. Pilkington, IV","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3285","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3285","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130397989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Eosinophils in Purinergic Receptor P2X3Expression in Mouse Sensory Neurons","authors":"E.J. Mize","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3282","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3282","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122161439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Chronic Colonization by Pseudomonas Aeruginosa Increases Ciliary Dyskinesia in Cystic Fibrosis Patients","authors":"R. Bonhiver, N. Bricmont, M. Pirotte, M. Wuidart, J. Pirson, H. Boboli, R. Louis, M. Seghaye, C. Kempeneers","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3279","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3279","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121049392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodilins - a New Class of Small Molecules That Blunt Human Airway Smooth Muscle Contractile Protein Accumulation and Allergen-Induced Airway Hyperresponsiveness in Mice","authors":"B. Chen, C.Y. Park, D. Luci, J. Wang, R. Eleanor B, R. Krishnan, V. Gurvich J., S. Byrn, D. Maloney, A. Sperling, Y. Fang, D. Wu, G. Mutlu, R. Hamanaka, S. White, S. Kales, D. Tao, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, J. Fredberg, D. Mccormick, N. O. Dulin, J. Solway","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3296","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3296","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126931722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Development in a Murine Model of CF-Like Lung Disease","authors":"S. Blaskovic, P. Anagnostopoulou, D. Schittny, E. Borisova, Z. Zhou-Suckow, M. Mall, C. Schlepütz, M. Stampanoni, J. Schittny","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3286","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3286","url":null,"abstract":"Unser Ziel ist es, die Lungenentwicklung der Maus mit CF-ähnlichen Lungenerkrankungen während verschiedener Zeitpunkte kurz nach der Geburt zu studieren. Dabei verwenden wir Methoden wie die klassische Stereologie, sowie die 3D-Rekonstruktion von mikro-CT Lungenbildern (bis zu einer Grösse von einem Mikrometer). Letztere wird als innovative Bildanalyse angewendet, um die detaillierte Architektur der grossen und kleinen Atemwege darzustellen.","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128307115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Dysbiosis and Epithelial Dysfunction in Vitamin A-Deficient Lungs","authors":"K. Quiles, W. Johnson, F. Chen","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3303","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3303","url":null,"abstract":"Once believed to be sterile, recent studies now show microbes inhabiting healthy lungs that are dysregulated in patients with chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), and SARS-CoV-2 infection. Other studies have shown an increase in pulmonary disease and recurrent respiratory infections in malnourished patients. According to the World Health Organization, vitamin A deficiency (VAD) is now a major public health issue in low-income communities and many developing countries. While VAD has been shown to alter gene expression and tissue morphology in humans and mice, research suggests the lung microbiome plays an intimate role in the metabolic regulation, pathogen inhibition, and inflammatory responses in the lung. Whether dysbiosis is a cause or consequence of chronic respiratory conditions, or whether retinoic acid (RA) - the bioactive metabolite of Vitamin A - is essential for lung microbiome homeostasis, remains unknown. Therefore, we hypothesize that dietary VAD leads to epithelial remodeling which promotes microbial dysbiosis;the dysbiosis then perpetuates epithelial remodeling via host-microbe interactions. Our preliminary results show anatomical/pathological changes to the epithelium in VAD adult mouse lungs compared to controls (VAS). Using our Nkx2- 1creERT2/dnRAR Rosa26 tdTomato transgenic mouse model that selectively induces VAD in the adult lung epithelium following tamoxifen injections, our data supports the hypothesis that host epithelial aberration associated with dietary VAD is induced locally in the lung and not via distal or systemic mechanisms. Our data also indicates the onset of dysbiosis in adult mouse lungs as early as three weeks post-diet modulation as observed through changes in microbial composition in VAD mice compared to controls. Finally, our bulk RNAseq analysis of host and microbial gene signatures has uncovered mechanisms associated with microbial metabolic functions, ciliopathy, host cellular polarity, and immune response to infection, that are dysregulated in the absence of vitamin A. Further, we have also identified altered transcriptional activity of microbes that are traditionally symbiotic or pathobiotic under normal homeostasis. This work indicates the presence of specific host-microbe interactions that are essential for lung homeostasis and protection against lung infection and disease that are dysregulated or lost in the absence of dietary vitamin A.","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132008973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diacylglycerol Kinase Inhibition Mitigates Mitogen-Induced Airway Smooth Muscle Cell Proliferation","authors":"M. Hernandez, S. Yadav, S. Shah, D. Deshpande","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3307","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3307","url":null,"abstract":"","PeriodicalId":194779,"journal":{"name":"B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134504217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}