Nihon Heikatsukin Gakkai zasshi最新文献_第2页

Effects of amiloride on the contraction of mesenteric artery induced by transmural nerve stimulation. 阿米洛利对跨壁神经刺激所致肠系膜动脉收缩的影响。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-10-01

K Shimamura, K Moriyama, K Yamamoto, S Sunano

引用次数: 0

Effect of 2-methyl-5-hydroxytryptamine on motility of the isolated guinea-pig colon. 2-甲基-5-羟色胺对离体豚鼠结肠运动的影响。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-10-01

M Ishizawa

引用次数: 0

[Study on mechanism of interdigestive migrating contractions of a canine stomach]. [犬胃消化间迁移收缩机制研究]。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-10-01

S Ito

引用次数: 0

[Responses of muscle strips from the internal anal sphincter in Hirschsprung's disease to drugs and electrical field stimulation]. 先天性巨结肠病患者内肛门括约肌肌条对药物和电场刺激的反应。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-08-01 DOI: 10.1540/jsmr1965.26.199

H Matsufuji

{"title":"[Responses of muscle strips from the internal anal sphincter in Hirschsprung's disease to drugs and electrical field stimulation].","authors":"H Matsufuji","doi":"10.1540/jsmr1965.26.199","DOIUrl":"https://doi.org/10.1540/jsmr1965.26.199","url":null,"abstract":"Responses of isolated muscle strips from the rat and the dog internal anal sphincter (IAS) to drugs and electrical field stimulation (EFS) were investigated in vitro for the purpose of clarifying a manner of neural control of IAS. Also, responses of muscle strips from IAS of the patients with Hirschsprung's disease were compared with those of muscle strips from human control IAS. Muscle strips from the dog and human IAS as normal control showed contractions to norepinephrine (NE), which were abolished in the presence of phentolamine and relaxations to isoproterenol. EFS (less than 1 msec) induced relaxations of the muscle strips. These responses to EFS were not affected by either one of phentolamine, propranolol and atropine but were inhibited by tetrodotoxin. Muscle strips from IAS in Hirschsprung's disease contracted to both NE and EFS, the responses of which were abolished in the presence of phentolamine. But no relaxation to EFS of muscle strips from IAS in Hirschsprung's disease was observed. These findings revealed that normal IAS is pharmacologically innervated by alpha-adrenergic excitatory nerve, beta-adrenergic inhibitory nerve and non-adrenergic, non-cholinergic inhibitory nerve and suggested that IAS in Hirschsprung's disease is also affected by alpha-adrenergic excitatory nerve but inhibitory neural control is absent.","PeriodicalId":19426,"journal":{"name":"Nihon Heikatsukin Gakkai zasshi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13257848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[Effect of feeding on recording characteristics of electrogastrography (EGG) in normal subjects]. [进食对正常受试者胃电图记录特征的影响]。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-08-01 DOI: 10.1540/jsmr1965.26.219

Y Okuno, M Hongo, M Yamada, N Nishimura, M Ueno, T Toyota

引用次数: 1

Mechanisms of the depolarization and contracture due to Na removal in the circular muscle of the guinea-pig stomach. 豚鼠胃环肌去钠致去极化和挛缩的机制。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-08-01 DOI: 10.1540/jsmr1965.26.191

Y Nasu, Y Sakamoto

{"title":"Mechanisms of the depolarization and contracture due to Na removal in the circular muscle of the guinea-pig stomach.","authors":"Y Nasu, Y Sakamoto","doi":"10.1540/jsmr1965.26.191","DOIUrl":"https://doi.org/10.1540/jsmr1965.26.191","url":null,"abstract":"Verapamil (10(-6) M) significantly reduced a development of the membrane depolarization and the contracture which were induced by Na removal. The fully developed depolarization, after exposure to Na-free solution, was reduced greatly by verapamil, excess Ca (15 mM) or sodium nitroprusside (10(-6) M), but some depolarization still remained. This remaining depolarization was completely blocked by readmission of 10 mM Na to Na-free solution containing verapamil, excess Ca or sodium nitroprusside. However, Mn (1.5 mM) did not block the depolarization due to Na removal and if Mn was present in Na-free solution, readmission of 15 mM Na to Na-free solution was not able to block the depolarization. On the other hand, the contracture due to Na removal was inhibited by addition of Mn (1.5 mM) or sodium nitroprusside (10(-6) M), but partially by addition of verapamil (10(-6) M) or excess Ca, to Na-free solution. These remaining contractures were also abolished by readmission of 10 mM Na to Na-free solution containing verapamil or excess Ca. Thus, these results suggest that the depolarization and the contracture due to Na removal are induced by increase in cytoplasmic Ca concentrations through (1): verapamil-sensitive Ca channel, (2): Na-Ca exchange system and (3): some mechanism which is inhibited by sodium nitroprusside.","PeriodicalId":19426,"journal":{"name":"Nihon Heikatsukin Gakkai zasshi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13257847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Effect of AS-4370 on gastric emptying--double-blind clinical pharmacological study]. AS-4370对胃排空的影响——双盲临床药理学研究

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-06-01 DOI: 10.1540/jsmr1965.26.161

T Kanaizumi, H Nakano, T Matsui, H Ishikawa, R Shimizu, S Paku, N Kuriya

{"title":"[Effect of AS-4370 on gastric emptying--double-blind clinical pharmacological study].","authors":"T Kanaizumi, H Nakano, T Matsui, H Ishikawa, R Shimizu, S Paku, N Kuriya","doi":"10.1540/jsmr1965.26.161","DOIUrl":"https://doi.org/10.1540/jsmr1965.26.161","url":null,"abstract":"The effect of AS-4370 given in single doses of 2.5, 5 and 10 mg on gastric emptying was investigated using 99mTc-DTPA in healthy volunteers in the placebocontrolled double-blind crossover design. There was no difference in percent activity throughout the period of measurement between AS-4370 2.5 mg and placebo. The percent activity decreased after administration of 5 and 10 mg of AS-4370 in comparison with placebo: the decrease was found during the period from 10 to 18 minutes after start of recording at 5 mg and from 8 to 18 minutes after start of recording at 10 mg. These results demonstrated that AS-4370 at these dose levels apparently accelerated gastric emptying. The analysis of the half emptying time by the crossover method showed that only the time effect was found at 2.5 mg, whereas the half emptying time was obviously shortened at 5 and 10 mg. There was no difference between 5 mg and 10 mg. There was no finding that might warrant a caution in terms of safety. In conclusion, AS-4370 did not affect gastric emptying at 2.5 mg but apparently accelerated gastric emptying at 5 and 10 mg in healthy volunteers.","PeriodicalId":19426,"journal":{"name":"Nihon Heikatsukin Gakkai zasshi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13242819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Diaphragmatic electromyography (DEMG) in achalasia patients]. 贲门失弛缓症患者的膈肌电图(DEMG)。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-06-01 DOI: 10.1540/jsmr1965.26.175

H Ujiie, M Hongo, Y Okuno, M Yamada, T Toyota

{"title":"[Diaphragmatic electromyography (DEMG) in achalasia patients].","authors":"H Ujiie, M Hongo, Y Okuno, M Yamada, T Toyota","doi":"10.1540/jsmr1965.26.175","DOIUrl":"https://doi.org/10.1540/jsmr1965.26.175","url":null,"abstract":"LES pressure increase following diaphragmatic contraction as a pinch-cock action acts as one of the barrier mechanism for gastroesophageal reflux. In achalasia patients, incomplete LES relaxation following wet swallow is one of the characteristic manometric findings, along with loss of peristalsis. On the other hand, it has been reported that swallowing effort or esophageal distention have no effect on the increase of LES pressure induced by diaphragmatic contraction, which condition is similar to achalasia. Therefore, to evaluate that whether diaphragmatic contraction is involved in the cause of achalasia, we recorded diaphragmatic electromyography (DEMG) using bipolar electrodes in 12 achalasia patients and 4 normal subjects. The phasic DEMG amplitude was 80-90 microV in normal subjects and achalasia patients. LES pressure and DEMG amplitude increased during both straight leg raising (SLR) and abdominal distention (AD), both of the maneuver induce diaphragmatic contraction, in normal subjects and achalasia patients similarly. From the data obtained with this equipment, we conclude that diaphragmatic involvement is not likely as a pathogenesis of LES dysfunction in achalasia patients.","PeriodicalId":19426,"journal":{"name":"Nihon Heikatsukin Gakkai zasshi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13242820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ureteral action potential and histological changes in the upper urinary tract receiving the formalin. 输尿管动作电位及上尿路在福尔马林作用下的组织学改变。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-06-01 DOI: 10.1540/jsmr1965.26.183

T Tsuzuki, H Funaki, S Niisato, S Satoh, S Kawamura, K Seo, T Kubo

{"title":"Ureteral action potential and histological changes in the upper urinary tract receiving the formalin.","authors":"T Tsuzuki, H Funaki, S Niisato, S Satoh, S Kawamura, K Seo, T Kubo","doi":"10.1540/jsmr1965.26.183","DOIUrl":"https://doi.org/10.1540/jsmr1965.26.183","url":null,"abstract":"The present study investigates the ureteral action potential and histological changes of pelvi-ureteral system after injection of the formalin into the obstracted ureters or the renal pelvis. In the first experiment, formalin was injected into the obstructed ureters of 18 dogs for 30 minutes. In the second, formalin was injected into the obstracted renal pelvis of 13 dogs for 30 minutes using ureteral balloon catheters, and then renal pelvis were released from obstraction and catheters were removed. In these experiments, ureteral electromyogram were recorded and histological changes of pelvi-ureteral system were also observed microscopically. Results 1. After injection of formalin into the ureters, ureteral action potential disappeared and had not restored. Histologically, damage was observed in the ureteral smooth muscle as well as in the mucosa. 2. After injection of formalin into the renal pelvis, ureteral action potential disappeared in 46% of the ureters. In 54% of the ureters, action potential had not disappeared, however discharge interval became irregular. Histological changes of the renal pelvis was not related to the presence or absence of ureteral action potential. The results of the present study show that ureteral smooth muscle play part in the conduction of the ureteral excitation, and have an irregular autonomic discharge.","PeriodicalId":19426,"journal":{"name":"Nihon Heikatsukin Gakkai zasshi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13242821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder. 胆盐对离体豚鼠胆囊解痉作用的可能机制。

Nihon Heikatsukin Gakkai zasshi Pub Date : 1990-06-01 DOI: 10.1540/jsmr1965.26.143

N Sunagane, T Kobori, T Urono, K Kubota

引用次数: 4