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氯化钴对小鼠腹腔巨噬细胞的抑制作用氯化钴对小鼠腹腔巨噬细胞的抑制作用

职业与健康 Pub Date : 2013-11-15 DOI: 10.13329/j.cnki.zyyjk.2013.22.064

颜勋 | 蔡洪华 | 杨雪 | 端礼荣

引用次数: 0

Effect of oxidative stress on development of silicosis 氧化应激对矽肺发展的影响

职业与健康 Pub Date : 2012-02-28 DOI: 10.5320/WJR.V2.I1.1

R. Miao, Xue-tao Zhang, P. Guo, En-Qi He, Fangmei Zhou, D. Zhao, Ying-yi Zhang

{"title":"Effect of oxidative stress on development of silicosis","authors":"R. Miao, Xue-tao Zhang, P. Guo, En-Qi He, Fangmei Zhou, D. Zhao, Ying-yi Zhang","doi":"10.5320/WJR.V2.I1.1","DOIUrl":"https://doi.org/10.5320/WJR.V2.I1.1","url":null,"abstract":"[Objective]To investigate the change of indicators of oxidative stress in serum of patients with silicosis,and explore the mechanism of the development of silicosis.[Methods]Indicators of oxidative stress in serum including superoxide dismutase(SOD),nitric oxide(NO),serum glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC),nitric oxide synthase(NOS),and lipid malondialdehyde(MDA) were determined in 100 cases of control group,200 cases of dust-exposed group,32 cases of observed group(the original diagnosed 0 + patients) and 130 cases of silicosis group.[Results] Compared with the control group,NO,GSH-Px were significantly increased,and SOD were decreased significantly in dust-exposed group and silicosis group(P0.05,P0.01).Compared with the control group and dust-exposed group,T-AOC,NOS,MDA levels in silicosis group were significantly increased.(P0.05,P0.01).GSH-Px in the silicosis group was increased significantly(P0.01) than that in dust-exposed group.GSH-Px were increased in phase Ⅲ silicosis group than that in observation group and phaseⅠ silicosis group(P0.05).Pearson correlation analysis showed serum GSH-Px had a significant positive correlation with silicosis staging,grouping,seniority exposed to dust,type of work(P0.01).[Conclusion]The imbalance of oxidative and anti-oxidation system is related with the occurrence and development of silicosis.The monitoring on oxidative stress indicators is benefit for the prediction and prognosis assessment of silicosis.","PeriodicalId":19398,"journal":{"name":"职业与健康","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2012-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70776745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

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