Neuroscience and Medicine最新文献_第10页

Improvement in Radicular Symptoms but Continued Facet Arthropathy and Axial Back Pain Following Rupture of a Facet Joint Synovial Cyst 小关节滑膜囊肿破裂后神经根症状的改善，但持续的小关节病变和轴性背痛

Neuroscience and Medicine Pub Date : 2018-03-06 DOI: 10.4236/nm.2018.91006

B. Kratz, T. Buck, Daniel M Cramer

{"title":"Improvement in Radicular Symptoms but Continued Facet Arthropathy and Axial Back Pain Following Rupture of a Facet Joint Synovial Cyst","authors":"B. Kratz, T. Buck, Daniel M Cramer","doi":"10.4236/nm.2018.91006","DOIUrl":"https://doi.org/10.4236/nm.2018.91006","url":null,"abstract":"Lumbar synovial cysts are benign fluid collections thought to form in a background of facet joint degeneration, allowing for fluid to leak from the joint capsule and form cysts in the synovium. Although often asymptomatic, patients with symptomatic synovial cysts will present with low back pain and possibly an associated radiculopathy. Clinicians can consider conservative management, epidural steroid injection, surgical intervention, or facet joint block with aspiration and rupture. This case describes a 59-year-old male facilities manager with intermittent low back pain for one year with worsening right-sided radicular symptoms secondary to a lumbar facet joint synovial cyst in the context of severe facet arthropathy and microinstability. The patient’s low back pain and radicular symptoms were refractory to conservative treatment. Imaging demonstrated a lumbar synovial cyst and subsequent management included transforaminal epidural steroid injection and facet joint block with cyst aspiration and rupture. The patient’s radicular pain resolved but axial lumbar pain returned after 3 weeks of relief. Follow-up imaging demonstrated decreased cyst size with fluid accumulation and joint space widening. Although the cyst was successfully decompressed with resolution of radicular pain, the underlying facet arthropathy remains contributing to persistent axial low back pain and potential for continued degenerative changes including cyst recurrence.","PeriodicalId":19381,"journal":{"name":"Neuroscience and Medicine","volume":"36 12","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2018-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72551655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini Thoracotomy Approach to Upper Thoracic Spine 胸椎上段小型开胸入路

Neuroscience and Medicine Pub Date : 2018-03-06 DOI: 10.4236/NM.2018.91002

Hedaya Hendam, Hatem El-Samouly, H. Behairy, Medhat Noaman, G. Elshafy

{"title":"Mini Thoracotomy Approach to Upper Thoracic Spine","authors":"Hedaya Hendam, Hatem El-Samouly, H. Behairy, Medhat Noaman, G. Elshafy","doi":"10.4236/NM.2018.91002","DOIUrl":"https://doi.org/10.4236/NM.2018.91002","url":null,"abstract":"Upper thoracic spine lesions are characterized by delayed diagnosis due to nonspecific symptoms and its anterior aspect (T1 - T4) is difficult to be approached surgically. This retrospective clinical study was done to assess the efficacy of mini thoracotomy approach in management of these lesions. We studied 14 cases with upper thoracic spine different pathological lesions at levels (T1 - T4). These lesions were indicated for anterior approach surgery. Radiological assessment included plain X-ray, MRI and CT scan thoracic spine. The anaesthesia was specifically selective intubation and unilateral ventilation. All patients were operated upon through mini inter-costal thoracotomy approach (left sided in 13 patients and right sided in 1patient). Out of 14 patients there were 7 males and 7 females. The age range was 20 - 55 years (mean 38.7 years). Preoperative symptoms included vague nonspecific upper thoracic pain in 11 patients, lower limbs weakness in 6 patients, sphincteric disturbance in 5 patients, upper thoracic kyphotic deformity in 4 patients, severe brachialgia in 3 patients and neck pain in 2 cases. The operative time was ranged from 90 - 210 minutes (mean 152 m). Blood loss ranged from 250 to 750 cc (mean 464 cc). Chest tube drainage was inserted in all patients. There were no intra-operative or post-operative surgically related complications and no patients needed ICU admission. The lesions were neoplasms in 8 patients, traumatic fracture dislocation in 3 cases, tuberculous spondylodiscitis in 2 cases and degenerative disc prolapse in 1 case. All patients improved post-operative as regard their pre-operative complaints except one patient. During the follow up period, no mortality was recorded. In conclusion, mini thoracotomy approach seems to be ideal only for patients with mono- or bi-segmental pathology involving the upper thoracic spine.","PeriodicalId":19381,"journal":{"name":"Neuroscience and Medicine","volume":"94 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2018-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83939862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Slow Spinal Cord Compression Inducing by Malignant Peripheral Nerve Sheath Tumors in Cotonou 科托努恶性周围神经鞘肿瘤诱导脊髓缓慢压迫

Neuroscience and Medicine Pub Date : 2018-03-06 DOI: 10.4236/NM.2018.91004

D. Gnonlonfoun, C. Adjien, J. N. Mapaga, L. Hodé, Gérard Goudjinou, A. Sowanou, R. Domingo, Pupchen Gnigone, G. Mambila, D. Affanou, P. K. Ndouongo, D. Houinato

引用次数: 0

Anesthetic Practice in Neurosurgery at University Hospital of Brazzaville (Congo) 布拉柴维尔大学医院神经外科麻醉实习(刚果)

Neuroscience and Medicine Pub Date : 2017-12-04 DOI: 10.4236/NM.2017.84010

Marie Elombila, Hugues Brieux Ekouele Mbaki, G. F. Otiobanda, Gilles Niengo Outsouta

{"title":"Anesthetic Practice in Neurosurgery at University Hospital of Brazzaville (Congo)","authors":"Marie Elombila, Hugues Brieux Ekouele Mbaki, G. F. Otiobanda, Gilles Niengo Outsouta","doi":"10.4236/NM.2017.84010","DOIUrl":"https://doi.org/10.4236/NM.2017.84010","url":null,"abstract":"Aim: To evaluate the anesthetic management of neurosurgical patients in University Hospital of Brazzaville. Materials and methods: We performed a transversal and descriptive study during the period from January to June 2015 into operating room of the University Hospital of Brazzaville. 60 cases of anesthesia have been analyzed. Results: The neurosurgery represented 2.88% of the activity of the operating room in University Hospital of Brazzaville. The average age was 44.7 ± 18.36 years old. The sex ratio was 1.07. The scheduled interventions have concerned 83.4% of cases. Surgical indications were concerned the spine degenerative disease and spinal trauma in 40% and 18.3% of cases respectively. The patients classified ASA I and II were most represented in 40% and 46.7% of cases respectively. General anesthesia was used in 98.4% of cases. The peroperative complications were represented by arterial hypotension (31.7%), hemorrhage (11.7%), bradycardia (5%), difficult intubation (3.3%) and one case of peroperative cardiac arrest. The blood transfusion rate was 18.7%. The stay in ICU concerned 8.3% of the cases. We recorded three cases (5%) of death in our series. Conclusion: The neuroanesthesia knows an evolution in our country because of increasing number of neurosurgeons; it’s necessary to train medical staff in her practice.","PeriodicalId":19381,"journal":{"name":"Neuroscience and Medicine","volume":"21 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2017-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82150481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common Prothrombotic Gene Mutations in Cerebral Venous Sinus Thrombosis in North-West of Iran 伊朗西北部脑静脉窦血栓形成常见的血栓前基因突变

Neuroscience and Medicine Pub Date : 2017-12-04 DOI: 10.4236/NM.2017.84009

Elyar Sadeghi-Hokmabadi, E. Sakhinia, M. Farhoudi, Somayyeh Hasaneh, M. Ghojazadeh, M. Farzi, S. Andalib, M. Nemati, Omid Abbaszadeh, R. Rikhtegar, Reshad Mirnour

{"title":"Common Prothrombotic Gene Mutations in Cerebral Venous Sinus Thrombosis in North-West of Iran","authors":"Elyar Sadeghi-Hokmabadi, E. Sakhinia, M. Farhoudi, Somayyeh Hasaneh, M. Ghojazadeh, M. Farzi, S. Andalib, M. Nemati, Omid Abbaszadeh, R. Rikhtegar, Reshad Mirnour","doi":"10.4236/NM.2017.84009","DOIUrl":"https://doi.org/10.4236/NM.2017.84009","url":null,"abstract":"Objective: Cerebral venous sinus thrombosis (CVST) is a life-threatening cerebrovascular disease which has high prevalence and mortality rate in Iran. Thrombophilia caused by gene mutation is a common cause of CVST. The present study aimed at assessing the prevalence of thrombophilic gene mutations in Iranian CVST patients and then comparing it with normal population. Materials and methods: In a case-control study, polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) and amplification-refractory mutation system (ARMS-PCR) were carried out to detect common thrombophilic mutations in 70 CVST patients. Next, it was compared with 82 sex- and age-matched healthy controls. Results: Factor-V-Leiden, Factor-V-Leiden HR2, Factor prothrombin II, MTHFR (667C/T) and MTHFR (1298A/C) prevalence were significantly high in cases of CVST as compared to the controls (P values: 0.012, 0.019, 0.007 and 0.036, respectively). However, there was no significant difference between the two groups in plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), beta-fibrinogen (FGB), Factor VIII, Factor XIII, and tissue plasminogen activator (tPA) mutations. Conclusion: The findings of the present study suggest that Factor V-Leiden, Factor-V-Leiden HR2, prothrombin II (G20210A), and MTHFR (667C/T & 1298A/C) mutations are more frequent in CVST. Detection of these mutations may help clinicians to decide on the duration of treatment and referral to genetic counseling for valuable prevention.","PeriodicalId":19381,"journal":{"name":"Neuroscience and Medicine","volume":"5 1","pages":"68-76"},"PeriodicalIF":0.0,"publicationDate":"2017-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87654071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Post-Stroke Epilepsy within a Teaching Hospital in Cotonou, Benin 贝宁科托努一家教学医院的中风后癫痫

Neuroscience and Medicine Pub Date : 2017-12-04 DOI: 10.4236/NM.2017.84007

D. Gnonlonfoun, C. Adjien, M. Agbétou, T. Adoukonou, J. N. Mapaga, Gérard Goudjinou, D. Houinato

引用次数: 3

Norepinephrine Induces BDNF and Activates CREB and Discriminates among Protein Kinase C Isoforms in Cultured Embryonic Hippocampal Neurons 去甲肾上腺素诱导胚胎海马神经元BDNF、激活CREB及区分蛋白激酶C亚型

Neuroscience and Medicine Pub Date : 2017-12-04 DOI: 10.4236/NM.2017.84008

Michael J. Chen, A. Russo-Neustadt

{"title":"Norepinephrine Induces BDNF and Activates CREB and Discriminates among Protein Kinase C Isoforms in Cultured Embryonic Hippocampal Neurons","authors":"Michael J. Chen, A. Russo-Neustadt","doi":"10.4236/NM.2017.84008","DOIUrl":"https://doi.org/10.4236/NM.2017.84008","url":null,"abstract":"Medications acting as mood stabilizers work by enhancing and maintaining the concentration of circulating synaptic neurotransmitters, which then activate a plethora of various intracellular signal transduction and second messenger cascades. Previously, we showed that two of these cascades, the PI-3K and MAPK pathways, are activated by cross-talk with the protein kinase A cAMP cascade and by brain-derived neurotrophic factor (BDNF), an immediate-early gene whose expression is the result of phosphorylation of the transcription factor, cAMP response element binding protein (CREB). In the current study, we extend these findings to include the protein kinase C (PKC) pathway. Western blotting studies show that application of norepinephrine to cultured hippocampal neurons leads to increased expression of BDNF, phosphorylation of CREB, activation of growth-associated protein-43 (GAP-43) and activation of PKCμ and PKCt538. Because GAP-43 is a putative substrate for PKC, the results of this study lend further support of a G-protein coupled receptor cross-talking to an entirely distinct intracellular pathway that is known to be involved in neuritogenesis.","PeriodicalId":19381,"journal":{"name":"Neuroscience and Medicine","volume":"42 1","pages":"53-67"},"PeriodicalIF":0.0,"publicationDate":"2017-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91279467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

West Syndrome Secondary to Biotinidase Deficiency about a Case 生物素酶缺乏继发西证1例

Neuroscience and Medicine Pub Date : 2017-08-24 DOI: 10.4236/NM.2017.83004

Madiha Abouelarais, N. Mekaoui, Fatima Zohra Oudghiri, K. Mammad, L. Karboubi, Badr sououd Benjelloun Dakhama

引用次数: 1

Outcomes of Evacuation Extradural Hematoma via Craniotomy under Local Anesthesia 局部麻醉下开颅清除硬膜外血肿的效果

Neuroscience and Medicine Pub Date : 2017-08-24 DOI: 10.4236/NM.2017.83006

Moazzam Sheikh, Ifrah Shahnawaz, M. Abdullah, O. Kamal, R. Naheed, A. Bushra, M. Nadeem

引用次数: 3

Neurofibromatosis Type 1 in Four Children Cases 儿童1型神经纤维瘤病4例分析

Neuroscience and Medicine Pub Date : 2017-08-24 DOI: 10.4236/NM.2017.83005

C. Mammad, N. Mekaoui, F. Z. Ouadghiri, K. Mammad, B. Dakhama

引用次数: 1