NPJ Aging and Mechanisms of Disease最新文献

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Message from the new Co-Editor-in-Chief. 来自新任联合主编的信息。

IF 5

NPJ Aging and Mechanisms of Disease Pub Date : 2017-02-15 eCollection Date: 2017-01-01 DOI: 10.1038/s41514-017-0003-1

Shin-Ichiro Imai

引用次数: 0

Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress. 衰老诱导应激下听觉细胞线粒体功能和形态损伤。

IF 5

NPJ Aging and Mechanisms of Disease Pub Date : 2017-01-25 eCollection Date: 2017-01-01 DOI: 10.1038/s41514-017-0002-2

Teru Kamogashira, Ken Hayashi, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba

{"title":"Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress.","authors":"Teru Kamogashira, Ken Hayashi, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba","doi":"10.1038/s41514-017-0002-2","DOIUrl":"https://doi.org/10.1038/s41514-017-0002-2","url":null,"abstract":"We aimed at determining the mitochondrial function in premature senescence model of auditory cells. Short exposure to H2O2 (1 h, 0.1 mM) induced premature cellular senescence in House Ear Institute-Organ of Corti 1 auditory cells. The transmission electron microscopy analysis revealed that damaged mitochondria and autophagosomes containing dense organelles appeared in the auditory cells after short exposure to H2O2. The branch and junction parameters of the skeletonized image of the mitochondria were found to decrease significantly in H2O2-treated cells. A branched reticulum of tubules was poorly formed, featuring coexistence of numerous tiny clusters along with few relatively large entities in the H2O2-treated cells. In terms of bioenergetics, H2O2-treatment led to the dose-dependent decrease in mitochondrial membrane potential in the auditory cells. The fragmented mitochondria (fusion < fission) were in a low potential. In addition, the potential of hyperfused mitochondria (fusion > fission) was slightly lower than the control cells. The short-time exposure of live auditory cells to H2O2 damaged the mitochondrial respiratory capacity without any effect on the baseline ATP production rates. The vulnerability of the mitochondrial membrane potential to the uncoupling reagent was increased after H2O2 treatment. Our findings indicated that the mitochondrial dysfunction due to the decline in the O2 consumption rate should be the first event of premature senescence process in the auditory cells, resulting in the imbalance of mitochondrial fusion/fission and the collapse of the mitochondrial network.","PeriodicalId":19334,"journal":{"name":"NPJ Aging and Mechanisms of Disease","volume":" ","pages":"2"},"PeriodicalIF":5.0,"publicationDate":"2017-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41514-017-0002-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35117622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How does hormesis impact biology, toxicology, and medicine? 激效是如何影响生物学、毒理学和医学的?

IF 5

NPJ Aging and Mechanisms of Disease Pub Date : 2017-01-01 DOI: 10.1038/s41514-017-0013-z

Edward J Calabrese, Mark P Mattson

{"title":"How does hormesis impact biology, toxicology, and medicine?","authors":"Edward J Calabrese, Mark P Mattson","doi":"10.1038/s41514-017-0013-z","DOIUrl":"https://doi.org/10.1038/s41514-017-0013-z","url":null,"abstract":"Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witnessed an expanding recognition of the concept of hormesis, elucidation of its evolutionary foundations, and underlying cellular and molecular mechanisms, and practical applications to improve quality of life. To better inform future basic and applied research, we organized and re-evaluated recent hormesis-related findings with the intent of incorporating new knowledge of biological mechanisms, and providing fundamental insights into the biological, biomedical and risk assessment implications of hormesis. As the literature on hormesis is expanding rapidly into new areas of basic and applied research, it is important to provide refined conceptualization of hormesis to aid in designing and interpreting future studies. Here, we establish a working compartmentalization of hormesis into ten categories that provide an integrated understanding of the biological meaning and applications of hormesis.","PeriodicalId":19334,"journal":{"name":"NPJ Aging and Mechanisms of Disease","volume":"3 ","pages":"13"},"PeriodicalIF":5.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41514-017-0013-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9649500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 324

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