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Antidotal Effect of Vitamin E and C in the Management of Paraquat Intoxication in Rat 维生素E和C对百草枯中毒大鼠的解毒作用

Healthcare Studies Pub Date : 2023-03-28 DOI: 10.58612/hs113

B. Okolonkwo, Ngozi Brisibe, I. George-Opuda

{"title":"Antidotal Effect of Vitamin E and C in the Management of Paraquat Intoxication in Rat","authors":"B. Okolonkwo, Ngozi Brisibe, I. George-Opuda","doi":"10.58612/hs113","DOIUrl":"https://doi.org/10.58612/hs113","url":null,"abstract":"The liver is an essential organ involved in anabolic and catabolic processes in the body. Substance like paraquat is injurious to the liver by way of oxidative damage. Vitamin E and C are known antioxidant used to tackle oxidative stress. The aim of this study was focused at evaluating the antidotal benefit of vitamin E and C in the treatment of paraquat intoxication in rat. Exactly 200 rats were obtained and grouped into four main groups (A, B, C and D) with each group having 50 rats. Except “A” group which was the control, all groups were treated with paraquat in doses of 0.02g, 0.04g and 0.06g respectively every 2 weeks for 3 months. All groups were subdivided into two groups designated as “0” and “VEC” amounting to a total of 8 subgroups. All subgroups with “VEC” designation were treated with 500mg of vitamin E and 2000mg/dl of vitamin C weekly for 3 months. Blood samples collected after treatment duration were via cardiac puncture and blood was assayed for liver enzyme activities. Results revealed that there was a significant increase (p-value<0.05) in liver enzyme activities among the groups (A0, B0, C0 and D0). Also, there was a significant drop in liver enzyme activities after vitamin E and C supplementation.","PeriodicalId":192902,"journal":{"name":"Healthcare Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130242752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake of Modern Family Planning Among Postpartum Women Attending Postnatal Clinic in Busolwe Hospital, Butaleja District, Eastern Uganda 乌干达东部Butaleja区Busolwe医院产后诊所的产后妇女接受现代计划生育

Healthcare Studies Pub Date : 2023-02-16 DOI: 10.58612/hs112

Fred Mubale, A. Auma, Raymond Otim, Nelly Atim

{"title":"Uptake of Modern Family Planning Among Postpartum Women Attending Postnatal Clinic in Busolwe Hospital, Butaleja District, Eastern Uganda","authors":"Fred Mubale, A. Auma, Raymond Otim, Nelly Atim","doi":"10.58612/hs112","DOIUrl":"https://doi.org/10.58612/hs112","url":null,"abstract":"Background: Family planning (FP) is key to preventing the social, economic and health consequences resulting from unintended pregnancies. Failure to control family size and child spacing has pressing negative effects on the health of women, their children, the community and the nation at large. Despite various family planning interventions such as Uganda Family Planning Costed Implementation Plan (UFPCIP) and Postpartum Family Planning Action Plan (PFAP), the unmet FP need still stagnates as high as 28%. Therefore, this study determined the prevalence and assessed the factors associated with modern family planning uptake among postpartum women attending Postnatal Care (PNC) in Busolwe Hospital, Butaleja district, Uganda. Methods: A cross-sectional study was conducted among 361 postpartum mothers attending PNC. Quantitative approach was applied and data collected using pre-tested semi-structured questionnaire. Participants recruited by consecutive sampling. Ethical considerations and approval was sought from Lira University institutional research board (IRB) and data was analyzed using SPSS version 23. Results: A total of 361 participants were recruited for the study. Majority of the participants 167(46.3%) aged between 17-24 years with mean age 26.01 (SD±5.877). Over all 122(34%) was the prevalence of modern FP uptake. Factors independently associated with modern family planning at multivariate analysis were; Education level (P=0.007, OR 0.048, 95% CI 0.005-0.435); occupation (P= 0.039, OR 0.432, 95% CI 0.195-0.958), Income (P=0.000, OR 0.209, 95% CI 0.088-0.494), Side effects (P=0.014, OR 3.062, 95% CI 1.249-7.508), and Perception about many children (P=0.000, OR 0.128, 95% CI 0.049-0.339). Conclusion: The prevalence of modern family planning was low in Butaleja district. This was due to inadequate education among women, unemployment, low-income status, desire for many children and the side effects associated with family planning use.","PeriodicalId":192902,"journal":{"name":"Healthcare Studies","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131514331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorative Effect of Vitamin E and C on Paraquat Induced Nephrotoxicity in Rat 维生素E和C对百草枯致大鼠肾毒性的改善作用

Healthcare Studies Pub Date : 2023-02-16 DOI: 10.58612/hs111

B. Okolonkwo, Ngozi Brisibe, I. George-Opuda

{"title":"Ameliorative Effect of Vitamin E and C on Paraquat Induced Nephrotoxicity in Rat","authors":"B. Okolonkwo, Ngozi Brisibe, I. George-Opuda","doi":"10.58612/hs111","DOIUrl":"https://doi.org/10.58612/hs111","url":null,"abstract":"The kidney is an exceptionally essential organ required for metabolic byproducts elimination in the body and when the kidney is impaired, this role is compromised. Paraquat is a poison that is known to have harmful effect in various organs. Subsequently, the point of this study was to reveal the treatment impact of vitamin E and C in paraquat poisoned kidney in rat. The rat were 200 and they were classified into 4 groups assigned as A, B, C and D. The A group was the control, B, C and D were test groups classified in light of dose of paraquat given. “A” was not treated with paraquat, B, C and D were treated with 0.02g, 0.04g and 0.06g of paraquat separately at regular intervals of 2 weeks for 3 months. Each group had subgroups assigned \"0\" and \"VEC\"; \"0\" subgroups were subgroups not treated with vitamin E while \"VEC\" were subgroups treated with 500mg of vitamin E and 2000mg/dl vitamin C. Treatment of vitamin E and C happened week after week for one month. Both vitamins and paraquat treatment happened orally. After treatment period, the rats were sacrificed and blood sample collected through cardiac puncture for urea and creatinine assay. The outcomes showed that there was no significant difference in urea levels among only paraquat treated groups yet there was a significant increase in creatinine levels among only paraquat treatment groups. There was a significant decrease in creatinine level after vitamin E and C treatment. This study has shown that vitamin E and C is capable of restoring kidney function paraquat induced nephrotoxicity in rat.","PeriodicalId":192902,"journal":{"name":"Healthcare Studies","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128866074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0