Nephrology最新文献_第9页

Augmented mannose-binding lectin levels in primary membranous nephropathy: A pilot study. 原发性膜性肾病患者甘露糖结合凝集素水平增高：一项试点研究。

IF 2.4 4区医学

Nephrology Pub Date : 2024-09-01 Epub Date: 2024-03-21 DOI: 10.1111/nep.14293

Deeksha Pal, Neeraj Inamdar, Prabhjot Kaur, Manphool Singhal, Anupam Lal, Ujjwal Gorsi, Ritambhra Nada, Harbir S Kohli, Vinod Kumar, Raja Ramachandran

{"title":"Augmented mannose-binding lectin levels in primary membranous nephropathy: A pilot study.","authors":"Deeksha Pal, Neeraj Inamdar, Prabhjot Kaur, Manphool Singhal, Anupam Lal, Ujjwal Gorsi, Ritambhra Nada, Harbir S Kohli, Vinod Kumar, Raja Ramachandran","doi":"10.1111/nep.14293","DOIUrl":"10.1111/nep.14293","url":null,"abstract":"There is evidence to suggest that M-type phospholipase A2 (PLA2R) antibodies activate the mannose-binding lectin (MBL) cascade, resulting in glomerular damage and proteinuria in patients with primary membranous nephropathy (PMN). Furthermore, there are few reports indicating that aberrant MBL activation is associated with endothelial dysfunction and accelerated atherosclerosis. While PMN is a common cause of adult nephrotic syndrome, and patients are at increased risk of cardiovascular disease (CVD), there is a lack of research that explores the factors that contribute to this condition. This study aims to determine the MBL levels in PMN and their relation to the clinical activity and endothelial dysfunction in PMN. The MBL levels of 22 biopsy-confirmed PMN patients were assessed at baseline and after 6 months of immunosuppressive therapy. In order to evaluate endothelial dysfunction in PMN patients, flow-mediated vasodilation (FMD) was measured at baseline and after treatment. A total of 22 healthy controls were included in this study to measure MBL levels and FMD. A significant difference was observed between MBL levels in PMN patients and healthy controls (p < .01). MBL levels decreased significantly after immunosuppressive therapy (p = .04). The baseline MBL levels and FMD levels exhibited a strong correlation (Spearman correlation coefficient [ρ] = 0.51: p = .01). In conclusion, the study signals the activation of the MBL cascade and its association with endothelial dysfunction in PMN patients.","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":" ","pages":"617-621"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal thrombotic microangiopathy is associated with poor renal survival in children with immunoglobulin A nephropathy. 肾血栓性微血管病与免疫球蛋白 A 肾病患儿肾脏存活率低有关。

IF 2.4 4区医学

Nephrology Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI: 10.1111/nep.14313

Meng Yang, Le Wang, Xiong-Fei Sun, Dong-Qi Yin

{"title":"Renal thrombotic microangiopathy is associated with poor renal survival in children with immunoglobulin A nephropathy.","authors":"Meng Yang, Le Wang, Xiong-Fei Sun, Dong-Qi Yin","doi":"10.1111/nep.14313","DOIUrl":"10.1111/nep.14313","url":null,"abstract":"Aim: The aim of this study was to examine the clinical and pathological characteristics as well as the prognosis of immunoglobulin A nephropathy (IgAN) accompanied by renal thrombotic microangiopathy (rTMA) in paediatric patients.Methods: After balancing epidemiological characteristics and pathological types between groups, 427 patients (rTMA group: 23, non-rTMA group: 46) were included. The clinical and pathological features, prognosis and clinical risk factors of the two groups were analysed.Results: IgAN-rTMA children showed more severe clinical and pathological manifestations. The findings from the logistic regression analysis indicated that hypercellularity 1 (E1) (HR: 0.805, 95% CI: 0.763 ~ 1.452, P = .016), endocapillary proliferation (HR: 1.214, 95% CI: 0.093 ~ 4.815, P = .025) and C3 staining (HR: 7.554, 95% CI: 2.563 ~ 15.729, P = .037) were the risk factors for rTMA in children with IgAN. The renal survival in rTMA group was lower than non-rTMA group (χ2 = 18.467, P = .000). Cox regression analysis showed that E1 (HR: 7.441, 95% CI: 1.095 ~ 10.768, P = .037), C3 disposition (HR: 3.414, 95% CI: 0.834 ~ 11.578, P = .027) and rTMA (HR: 8.918, 95% CI: 1.032 ~ 16.754, P = .041) were identified as independent risk factors for the development of end-stage renal disease (ESRD).Conclusion: The presence of rTMA had a significant impact on the severity and prognosis of IgAN. And rTMA has been identified as an independent risk factor for the development of renal failure in children diagnosed with IgAN.","PeriodicalId":19264,"journal":{"name":"Nephrology","volume":" ","pages":"579-587"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

17th International Symposium on IgA Nephropathy (IIgANN), 28-30 September, Tokyo. 第 17 届 IgA 肾病国际研讨会（IIgANN），9 月 28-30 日，东京。

IF 2.4 4区医学

Nephrology Pub Date : 2024-09-01 DOI: 10.1111/nep.14374

引用次数: 0

Current understanding and new insights in the treatment of IgA nephropathy. 目前对 IgA 肾病治疗的认识和新见解。

IF 2.4 4区医学

Nephrology Pub Date : 2024-09-01 Epub Date: 2024-07-03 DOI: 10.1111/nep.14340

Yuemiao Zhang, Hong Zhang

引用次数: 0

The pathogenesis of IgAN: Where is pathogenic IgA produced? IgAN 的发病机制：致病性 IgA 从何而来？

IF 2.4 4区医学