NOVEMBER ISSUE最新文献

The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic Mitigations 唐氏综合症大脑中神经祖细胞的斗争:除了症状缓解外，还需要神经调节

NOVEMBER ISSUE Pub Date : 2022-11-15 DOI: 10.47836/mjmhs.18.6.1

K. Ling, P. Cheah

引用次数: 0

Point-of-Care Procalcitonin to Guide the Discontinuation of Antibiotic Treatment in the Intensive Care Unit: A Malaysian Randomised Controlled Trial 护理点降钙素原指导停药在重症监护病房:马来西亚随机对照试验

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.10

W. F. Wan Muhd Shukeri, M. Mat-Nor, Azrina Md Ralib, M. Mazlan, Mohd Hasyizan Hassan

{"title":"Point-of-Care Procalcitonin to Guide the Discontinuation of Antibiotic Treatment in the Intensive Care Unit: A Malaysian Randomised Controlled Trial","authors":"W. F. Wan Muhd Shukeri, M. Mat-Nor, Azrina Md Ralib, M. Mazlan, Mohd Hasyizan Hassan","doi":"10.47836/mjmhs.18.6.10","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.10","url":null,"abstract":"Introduction: This work aims to establish the practicality of simple point-of-care (POC) measurements of procalcitonin (PCT) coupled with the standard PCT-guided antibiotic treatment discontinuation algorithm to guide the cessation of antibiotic treatment in intensive care unit (ICU). Methods: In this randomised-controlled trial, 80 adult patients with suspected bacterial infections were randomised to either the POC PCT-guided arm (n = 40) or the standard-of-care arm (n = 40). The decision to discontinue antibiotic treatment in the POC PCT-guided arm was based on the POC PCT-guided antibiotic-treatment discontinuation strategy, which states that discontinuation is urged once the PCT concentration has reduced by ≥ 80% or to < 0.5 ng/mL. In the standard-of-care arm, the antibiotic-treatment duration followed the local guidelines. Results: The median duration of antibiotic treatment was 6.5 [IQR = 5.0-7.0] days in the POC PCT-guided antibiotic-treatment arm versus 7.5 [IQR = 5.0-14.0] days in the standard-of-care arm (p = 0.010). The mean antibiotic-free days in the first 30 days after study inclusion was 20.7 (SD = 5.3) days in the POC PCT-guided antibiotic-treatment arm versus 16.4 (SD = 7.4) days in the standard-of-care arm (p = 0.004). The number of patients who took an antibiotic for more than 10 days was 2 (5%) in the POC PCT-guided antibiotic-treatment arm versus 13 (32.5%) in the standard-of-care arm (p = 0.002). Conclusion: Antibiotic use in patients with symptoms of bacterial infections in the ICU was substantially minimised with the installation of a POC PCT-guided antibiotic-treatment cessation.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114991396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat 二甲胺四环素对lps诱导的大鼠神经元死亡和记忆损伤的保护作用

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.29

Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, R. Zakaria, I. Long

{"title":"Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat","authors":"Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, R. Zakaria, I. Long","doi":"10.47836/mjmhs.18.6.29","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.29","url":null,"abstract":"Introduction: Minocycline has been demonstrated to have potent effects on neurologic structures and functions in several animal models. However, its neuroprotective properties following a single injection of lipopolysaccharide (LPS) in an adult rat model have not been clearly elucidated. This study investigated minocycline’s neuroprotective effects in the LPS-induced neuroinflammation rat model. Methods: Fifty adult male Sprague Dawley rats were split into five groups at random: (i) control, (ii) distilled water-treated LPS, (iii) 25 mg/kg minocycline-treated LPS, (iv) 50 mg/kg minocycline-treated LPS, and (v) 10 mg/kg memantine-treated LPS. On day 5, LPS (5 mg/kg) was given intraperitoneally once, whereas minocycline and memantine were given once daily for 14 days. Results: LPS was found to significantly induce β-amyloid peptide deposition and neuronal damage, and impair recognition memory, while administration of minocycline dose-dependently reversed these effects. These data suggest that LPS-induced recognition memory impairment by inducing β-amyloid peptide deposition and neuronal damage in the cortical and hippocampal areas. Furthermore, we compared minocycline with memantine administration, and these data suggested better effects in minocycline (50 mg/kg) and comparable effects between minocycline (25 mg/kg) and memantine (10 mg/kg) treatments in reducing β-amyloid peptide deposition, neuronal damage and recognition memory impairment induced by LPS. Conclusion: Minocycline may be a strong contender as an effective preventive-therapeutic drug for neuroinflammatory diseases such as Alzheimer’s disease (AD) based on these findings.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127306475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embracing Online Learning: The Readiness and Perceived Challenges among Health Sciences Distance Learners 拥抱在线学习:健康科学远程学习者的准备和感知挑战

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.33

S. K. Ahmad Sharoni, Nordianna Seman, N. Razali, Zufazlizan Zamri

{"title":"Embracing Online Learning: The Readiness and Perceived Challenges among Health Sciences Distance Learners","authors":"S. K. Ahmad Sharoni, Nordianna Seman, N. Razali, Zufazlizan Zamri","doi":"10.47836/mjmhs.18.6.33","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.33","url":null,"abstract":"Introduction: The shifting of conventional to online learning is prominent in our millennial era. The online pedagogy is dynamic in creating knowledge and simultaneously engaging learners with experts beyond boundaries. Our study aims to determine the readiness of distance learners in embracing online learning and their perceived challenge in accomplishing their academic journey. Methods: We employed the quantitative study design with a cross-sectional survey and this study was conducted in a public university. The health sciences learners who are currently undertaking their distance learning program were recruited by convenience sampling (N=128). The Online Learning Readiness Scale (OLRS) was adopted with its internal consistency ranging from 0.77 to 0.95 for five dimensions of measure. Results: Our results indicate a high level of online learning readiness. In addition, the highest level of readiness in the dimension of computer/internet self-efficacy whereas the least level was the learners’ control. Sixty-eight percent of learners reported poor internet connectivity as the main challenge in online learning. Moreover, we found that gender, age, and the learners’ program were not the significant factors affecting learners’ online learning readiness (p>.05). Conclusion: Our study revealed a high extent of online learning readiness among distance learners that display constructive embracing of current educational technology. Nevertheless, considering the poor internet connection, communication infrastructure needs to be further developed to bridge the gap between millennial learners and the Internet of Things (IoT).","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115054421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Comprehensive Tool for Assessing Postgraduate Students’ Oral Presentations: Importance of the Role of Ergonomics 一个评估研究生口头报告的综合工具的开发和验证:人体工程学的重要性

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.20

M. Mohammadian, V. Gharibi, A. Hayat, R. Cousins, Hamidreza Mokarami

{"title":"Development and Validation of a Comprehensive Tool for Assessing Postgraduate Students’ Oral Presentations: Importance of the Role of Ergonomics","authors":"M. Mohammadian, V. Gharibi, A. Hayat, R. Cousins, Hamidreza Mokarami","doi":"10.47836/mjmhs.18.6.20","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.20","url":null,"abstract":"Introduction: The aim of this exploratory sequential mixed methods study was to develop an oral presentations assessment tool for postgraduate students’ oral presentations. Methods: First, a literature review and the ideas of 319 experienced professors were used to identify domains and potential items to develop the desired tool. Then the psychometric properties of the preliminary tool were measured using face and content validity, inter-rater agreement and test-retest reliability. Results: The qualitative phase indicated there should be four domains in the developed Oral Presentations Assessment Tool: subject knowledge, delivery, content and organization, and ergonomics, and that items in the developed tool should be weighted according to importance for the efficacy of a presentation. The final version included 19 items across four domains. Mean content validity index and content validity ratio scores were 0.93 and 0.76, respectively. Spearman’s rank correlation coefficient for the two evaluation periods was 0.92. The intra-class correlation coefficient was 0.78. Conclusion: The Oral Presentations Assessment Tool has appropriate psychometric properties and can be used as a valid and applicable instrument to assess postgraduate students’ oral presentations. Important cognitive factors in oral presentations in the form of an ergonomic domain was included for the first time, as part of this new comprehensive tool.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114161861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sternal Cleft With Coarctation of Aorta and Vascular Anomalies - Learning Point in Young Stroke 胸骨裂伴主动脉缩窄及血管异常——青少年中风的学习要点

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.49

Ai Jiun Koa, Yong Sim Teh, Ruwei Lim

引用次数: 0

Simultaneous Appearance of Arteritic Anterior Ischemic Optic Neuropathy and Central Retinal Artery Occlusion in Giant Cell Arteritis 巨细胞动脉炎并发动脉前缺血性视神经病变和视网膜中央动脉闭塞

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.46

Say Ting Ooi, Nor Anita Che Omar, A. Yaakub

引用次数: 0

High Titer Inhibitor-Acquired Hemophilia A Treated With Human FVIII Concentrate in Limited Resource: A Case Report 有限资源下用人FVIII浓缩物治疗高效价抑制剂-获得性血友病A: 1例报告

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.43

S. G. Kandinata, U. Y. Bintoro

{"title":"High Titer Inhibitor-Acquired Hemophilia A Treated With Human FVIII Concentrate in Limited Resource: A Case Report","authors":"S. G. Kandinata, U. Y. Bintoro","doi":"10.47836/mjmhs.18.6.43","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.43","url":null,"abstract":"Acquired hemophilia A (AHA) is a rare condition that affects one in a million people each year, and there are not many diagnostics or therapeutic agents available for treatment due to its rarity. This is a case report of a 61-year-old woman who presented with a spontaneous subcutaneous hematoma and multiple extensive bruises in her extremities. There was no prior history of bleeding disorders, and the laboratory results showed an isolated aPTT prolongation with no correction after mixing studies, and a reduction in FVIII activity level along with a high FVIII inhibitor titer (928BU). Furthermore, the diagnosis of idiopathic AHA was made after other secondary causes had been ruled out, and the patient received human FVIII concentrate instead of bypassing agents due to its availability. The patient still experienced clinical improvement despite using this alternative. AHA is currently managed using both hemostasis agents and inhibitor eradication, and they come with several limitations. Human FVIII concentrate therapy is still an option in situations with limited resources, even though it is not recommended in patients with high inhibitor titer levels.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132259246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the Reliability and Validity of the Alberta Infant Motor Scale and Peabody Development Motor Scale in High-risk Infants 阿尔伯塔婴儿运动量表和皮博迪发育运动量表在高危婴儿中的信效度评价

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs.18.6.23

Nour Alhafdhi, Shahad AlOtaiby

{"title":"Assessment of the Reliability and Validity of the Alberta Infant Motor Scale and Peabody Development Motor Scale in High-risk Infants","authors":"Nour Alhafdhi, Shahad AlOtaiby","doi":"10.47836/mjmhs.18.6.23","DOIUrl":"https://doi.org/10.47836/mjmhs.18.6.23","url":null,"abstract":"Introduction: The aim of this study was to investigate the correlation between Alberta Infant Motor Scale (AIMS) scores at 8 months and Peabody Developmental Motor Scale-2 (PDMS-2) and Peabody Developmental Gross Motor Scale-2 (PDMS-GM-2) scores at 18 months and 3 years in high-risk infants. Methods: This retrospective study included 105 high-risk infants at a Saudi Arabian tertiary care facility. Pearson correlation analysis was used for comparing scores. Additional subgroup analyses were performed for participants diagnosed with cerebral palsy at 18 months and for those who received physiotherapy. Result: AIMS scores at 18 months showed stronger correlations with PDMS-GM-2 scores than with PDMS-2 total scores, while these correlations decreased at 3 years. For the cerebral palsy subgroup, correlation with PDMS-2 scores at 18 months was relatively stronger than at 3 years. For the physiotherapy intervention subgroup, correlations with PDMS-GM-2 scores PDMS-2 total scores were similar at 18 months and 3 years. Conclusion: The AIMS predictive validity was lowest at 3 years in high-risk infants. A correlation was higher in participants with physiotherapy intervention and highest in participants with cerebral palsy. Outcome measures and treatment results should be cautiously reported during the first 3 years to prevent over-treating high-risk infants and decrease rehabilitation costs.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132380962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Blood Smear Atypical Lymphocytes Association With Covid-19 Mortality 外周血涂片非典型淋巴细胞与Covid-19死亡率的关系

NOVEMBER ISSUE Pub Date : 2022-11-11 DOI: 10.47836/mjmhs18.6.4

Imran Nazir, G. Ta, K. Khalil, Iffat Imran, Mohammed A Almatrafi, Rabia Muddassir, Bader Al Mutairi, T. Abouelregal

{"title":"Peripheral Blood Smear Atypical Lymphocytes Association With Covid-19 Mortality","authors":"Imran Nazir, G. Ta, K. Khalil, Iffat Imran, Mohammed A Almatrafi, Rabia Muddassir, Bader Al Mutairi, T. Abouelregal","doi":"10.47836/mjmhs18.6.4","DOIUrl":"https://doi.org/10.47836/mjmhs18.6.4","url":null,"abstract":"Introduction: COVID-19 disease is currently pandemic, and its prevalence in Saudi Arabia is concerning. The SARS-CoV-2 virus primarily affects the lungs, but it also affects the haematopoietic system. The atypical lymphocytes on peripheral blood film that have a distinct morphological appearance were of particular interest in this study. Our goal was to see a link between atypical lymphocytes and COVID-19 patient mortality. Methods: This four-month single-centered prospective descriptive study was conducted in Makkah, Saudi Arabia. COVID-19 patients of both genders were randomly selected based on inclusion criteria. The data from the patient’s electronic medical record was extracted. All patients’ peripheral blood film parameters were recorded on days 3, 7, and 14 after admission. The statistical data was analysed using SPSS version 23. The Fisher’s exact test was used to determine the relationship with mortality. A p value of 0.05 was considered significant. Results: The total number of cases enrolled in the study was 226. The patients’ average age was 58 years (SD 0.5289). On the third day of admission, 88.2 % of patients with COVID-19 had atypical lymphocytes, with a mean of 2.35 ± 0.927. A significant correlation (p < 0.001) exists between atypical lymphocytes decreasing percentage number on the 3rd, 7th, and 14th days of admission and death.\u0000Conclusion: The decrease in the number of atypical lymphocytes on peripheral blood film has a significant association with the patients’ mortality. This fact can be used to develop a tailored management strategy based on the observation of peripheral blood film.","PeriodicalId":191865,"journal":{"name":"NOVEMBER ISSUE","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116574614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0