Neuropsychopharmacology最新文献

{"title":"Reframing addiction: It’s not the destination, but the journey","authors":"Emma Childs","doi":"10.1038/s41386-024-01989-x","DOIUrl":"10.1038/s41386-024-01989-x","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"49 12","pages":"1807-1808"},"PeriodicalIF":6.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity","authors":"Shiyu Tang, Sung Won Kim, Amanda Olsen-Dufour, Torben Pearson, Michael Freaney, Erick Singley, Madeline Jenkins, Nathaniel J. Burkard, Aaron Wozniak, Paul Parcon, Shawn Wu, Cheryl L. Morse, Susovan Jana, Jeih-San Liow, Sami S. Zoghbi, Janaina C. M. Vendruscolo, Leandro F. Vendruscolo, Victor W. Pike, George F. Koob, Nora D. Volkow, Robert B. Innis","doi":"10.1038/s41386-024-01988-y","DOIUrl":"10.1038/s41386-024-01988-y","url":null,"abstract":"The cyclic adenosine monophosphate (cAMP) cascade is thought to play an important role in regulating alcohol-dependent behaviors, with potentially opposite effects following acute versus chronic administration. Phosphodiesterase 4 (PDE4) is the primary brain enzyme that metabolizes cAMP, thereby terminating its signal. Radioligand binding to PDE4 serves as an indirect biomarker of cAMP activity, as cAMP-protein kinase A (PKA)-mediated phosphorylation of PDE4 increases its affinity for radioligand binding ~10-fold. Of the four PDE4 subtypes, PDE4B polymorphisms are known to be strongly associated with alcohol and substance use disorders. This study imaged rats with the PDE4B-preferring positron emission tomography (PET) radioligand [18F]PF-06445974 following acute and chronic ethanol administration, aiming to explore the potential of PDE4B PET imaging for future human studies. Compared to the control group treated with saline, acute alcohol administration (i.p. ethanol 0.5 g/kg) significantly increased whole brain uptake of [18F]PF-06445974 as early as 30 minutes post-exposure. This effect persisted at 2 hours, peaked at 4 hours, and diminished at 6 hours and 24 hours post-exposure. In contrast, in a rat model of alcohol dependence, [18F]PF-06445974 brain uptake was significantly reduced at 5 hours post-exposure and was normalized by 3 days. This reduction may reflect long-term adaptation to repeated alcohol-induced activation of cAMP signaling with chronic exposure. Taken together, the results suggest that PET imaging of PDE4B in individuals with alcohol use disorder (AUD) should be considered in conjunction with ongoing trials of PDE4 inhibitors to treat alcohol withdrawal and reduce alcohol consumption.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 2","pages":"444-451"},"PeriodicalIF":6.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-024-01988-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A covert cortical ensemble for learned fear suppression","authors":"Rebecca M. Shansky, Eliza M. Greiner","doi":"10.1038/s41386-024-01991-3","DOIUrl":"10.1038/s41386-024-01991-3","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"49 13","pages":"1949-1950"},"PeriodicalIF":6.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-024-01991-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The might of light for revealing neuropsychiatric mechanisms","authors":"Kutlu Kaya, Hilary P. Blumberg","doi":"10.1038/s41386-024-01974-4","DOIUrl":"10.1038/s41386-024-01974-4","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 1","pages":"335-336"},"PeriodicalIF":6.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging","authors":"Mark M. Gergues, Lahin K. Lalani, Mazen A. Kheirbek","doi":"10.1038/s41386-024-01982-4","DOIUrl":"10.1038/s41386-024-01982-4","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 1","pages":"305-305"},"PeriodicalIF":6.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging ultra-high field (7T) MRI in psychiatric research","authors":"Finnegan J. Calabro, Ashley C. Parr, Valerie J. Sydnor, Hoby Hetherington, Konasale M. Prasad, Tamer S. Ibrahim, Deepak K. Sarpal, Alyssa Famalette, Piya Verma, Beatriz Luna","doi":"10.1038/s41386-024-01980-6","DOIUrl":"10.1038/s41386-024-01980-6","url":null,"abstract":"Non-invasive brain imaging has played a critical role in establishing our understanding of the neural properties that contribute to the emergence of psychiatric disorders. However, characterizing core neurobiological mechanisms of psychiatric symptomatology requires greater structural, functional, and neurochemical specificity than is typically obtainable with standard field strength MRI acquisitions (e.g., 3T). Ultra-high field (UHF) imaging at 7 Tesla (7T) provides the opportunity to identify neurobiological systems that confer risk, determine etiology, and characterize disease progression and treatment outcomes of major mental illnesses. Increases in scanner availability, regulatory approval, and sequence availability have made the application of UHF to clinical cohorts more feasible than ever before, yet the application of UHF approaches to the study of mental health remains nascent. In this technical review, we describe core neuroimaging methodologies which benefit from UHF acquisition, including high resolution structural and functional imaging, single (1H) and multi-nuclear (e.g., 31P) MR spectroscopy, and quantitative MR techniques for assessing brain tissue iron and myelin. We discuss advantages provided by 7T MRI, including higher signal- and contrast-to-noise ratio, enhanced spatial resolution, increased test-retest reliability, and molecular and neurochemical specificity, and how these have begun to uncover mechanisms of psychiatric disorders. Finally, we consider current limitations of UHF in its application to clinical cohorts, and point to ongoing work that aims to overcome technical hurdles through the continued development of UHF hardware, software, and protocols.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 1","pages":"85-102"},"PeriodicalIF":6.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the role of computational neuroimaging in the era of integrative neuroscience","authors":"Alisa M. Loosen, Ayaka Kato, Xiaosi Gu","doi":"10.1038/s41386-024-01946-8","DOIUrl":"10.1038/s41386-024-01946-8","url":null,"abstract":"Computational models have become integral to human neuroimaging research, providing both mechanistic insights and predictive tools for human cognition and behavior. However, concerns persist regarding the ecological validity of lab-based neuroimaging studies and whether their spatiotemporal resolution is not sufficient for capturing neural dynamics. This review aims to re-examine the utility of computational neuroimaging, particularly in light of the growing prominence of alternative neuroscientific methods and the growing emphasis on more naturalistic behaviors and paradigms. Specifically, we will explore how computational modeling can both enhance the analysis of high-dimensional imaging datasets and, conversely, how neuroimaging, in conjunction with other data modalities, can inform computational models through the lens of neurobiological plausibility. Collectively, this evidence suggests that neuroimaging remains critical for human neuroscience research, and when enhanced by computational models, imaging can serve an important role in bridging levels of analysis and understanding. We conclude by proposing key directions for future research, emphasizing the development of standardized paradigms and the integrative use of computational modeling across neuroimaging techniques.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 1","pages":"103-113"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocytic RARγ mediates hippocampal astrocytosis and neurogenesis deficits in chronic retinoic acid-induced depression","authors":"Huixian Huang, Wensi Lu, Ran Luo, Yinyun Zeng, Yuqin Zhang, Xiaohong Su, Xinyi Zhang, Bo Tian, Xuemin Wang","doi":"10.1038/s41386-024-01983-3","DOIUrl":"10.1038/s41386-024-01983-3","url":null,"abstract":"Accumulating clinical evidence indicates that chronic exposure to retinoic acid (RA) may lead to depressive symptoms and even increase the risk of suicidal behavior, which severely limits the clinical long-term application of RA. The exact mechanisms through which RA contributes to the onset of depression remain largely unclear. Here, we administered intraperitoneal injections of all-trans RA to male C57BL/6 J mice over a period of 21 days. Mice subjected to chronic RA exposure displayed depressive-like behaviors, accompanied by impaired hippocampal neurogenesis and heightened RA receptor gamma (RARγ) levels in the ventral hippocampus (vHip). The administration of an RARγ antagonist effectively mitigated these RA-induced neurogenesis impairments and depressive-like behaviors. Chronic exposure to RA was also observed to promote hippocampal astrocytosis and increase astrocytic Rarγ expression in the ventral dentate gyrus (vDG) of hippocampus. Notably, astrocytic RARγ in the vDG was found to be a key factor in the observed hippocampal astrocytosis and neurogenesis impairments, and depressive-like behaviors. Chronic exposure to RA resulted in increased extracellular glutamate levels in neural stem cells (NSCs), accompanied by a decrease in glutamate transporter 1 (GLT-1) expression. Enhancing astrocytic GLT-1 expression was found to alleviate both hippocampal astrocytosis and depressive-like behaviors caused by RA. These findings underscore the critical role of astrocytic RARγ-GLT-1 axis in the development of hippocampal astrocytosis, neurogenesis impairments, and depressive symptoms, suggesting that targeting RARγ-GLT-1 could potentially offer an effective therapeutic approach for depression.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 2","pages":"419-431"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-024-01983-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting checklists in neuroimaging: promoting transparency, replicability, and reproducibility","authors":"Hamed Ekhtiari, Mehran Zare-Bidoky, Arshiya Sangchooli, Alireza Valyan, Anissa Abi-Dargham, Dara M. Cannon, Cameron S. Carter, Hugh Garavan, Tony P. George, Peyman Ghobadi-Azbari, Christoph Juchem, John H. Krystal, Thomas E. Nichols, Dost Öngür, Cyril R. Pernet, Russell A. Poldrack, Paul M. Thompson, Martin P. Paulus","doi":"10.1038/s41386-024-01973-5","DOIUrl":"10.1038/s41386-024-01973-5","url":null,"abstract":"Neuroimaging plays a crucial role in understanding brain structure and function, but the lack of transparency, reproducibility, and reliability of findings is a significant obstacle for the field. To address these challenges, there are ongoing efforts to develop reporting checklists for neuroimaging studies to improve the reporting of fundamental aspects of study design and execution. In this review, we first define what we mean by a neuroimaging reporting checklist and then discuss how a reporting checklist can be developed and implemented. We consider the core values that should inform checklist design, including transparency, repeatability, data sharing, diversity, and supporting innovations. We then share experiences with currently available neuroimaging checklists. We review the motivation for creating checklists and whether checklists achieve their intended objectives, before proposing a development cycle for neuroimaging reporting checklists and describing each implementation step. We emphasize the importance of reporting checklists in enhancing the quality of data repositories and consortia, how they can support education and best practices, and how emerging computational methods, like artificial intelligence, can help checklist development and adherence. We also highlight the role that funding agencies and global collaborations can play in supporting the adoption of neuroimaging reporting checklists. We hope this review will encourage better adherence to available checklists and promote the development of new ones, and ultimately increase the quality, transparency, and reproducibility of neuroimaging research.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 1","pages":"67-84"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-level therapeutic actions of cannabidiol in ketamine-induced schizophrenia psychopathology in male rats","authors":"Charalampos Brakatselos, Alexia Polissidis, George Ntoulas, Michail-Zois Asprogerakas, Olga Tsarna, Anastasia Vamvaka-Iakovou, Gerasimos Nakas, Anastasios Delis, Petros Tzimas, Leandros Skaltsounis, Joana Silva, Foteini Delis, Joao Filipe Oliveira, Ioannis Sotiropoulos, Katerina Antoniou","doi":"10.1038/s41386-024-01977-1","DOIUrl":"10.1038/s41386-024-01977-1","url":null,"abstract":"Repeated administration of ketamine (KET) has been used to model schizophrenia-like symptomatology in rodents, but the psychotomimetic neurobiological and neuroanatomical underpinnings remain elusive. In parallel, the unmet need for a better treatment of schizophrenia requires the development of novel therapeutic strategies. Cannabidiol (CBD), a major non-addictive phytocannabinoid has been linked to antipsychotic effects with unclear mechanistic basis. Therefore, this study aims to clarify the neurobiological substrate of repeated KET administration model and to evaluate CBD’s antipsychotic potential and neurobiological basis. CBD-treated male rats with and without prior repeated KET administration underwent behavioral analyses, followed by multilevel analysis of different brain areas including dopaminergic and glutamatergic activity, synaptic signaling, as well as electrophysiological recordings for the assessment of corticohippocampal and corticostriatal network activity. Repeated KET model is characterized by schizophrenia-like symptomatology and alterations in glutamatergic and dopaminergic activity mainly in the PFC and the dorsomedial striatum (DMS), through a bi-directional pattern. These observations are accompanied by glutamatergic/GABAergic deviations paralleled to impaired function of parvalbumin- and cholecystokinin-positive interneurons, indicative of excitation/inhibition (E/I) imbalance. Moreover, CBD counteracted the schizophrenia-like behavioral phenotype as well as reverted prefrontal abnormalities and ventral hippocampal E/I deficits, while partially modulated dorsostriatal dysregulations. This study adds novel insights to our understanding of the KET-induced schizophrenia-related brain pathology, as well as the CBD antipsychotic action through a region-specific set of modulations in the corticohippocampal and costicostrtiatal circuitry of KET-induced profile contributing to the development of novel therapeutic strategies focused on the ECS and E/I imbalance restoration.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 2","pages":"388-400"},"PeriodicalIF":6.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}