Neurophysiology最新文献

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Ethical Responsibilities of the Authors 作者的道德责任
IF 0.5 4区 医学
Neurophysiology Pub Date : 2024-04-12 DOI: 10.1007/s11062-024-09938-6
{"title":"Ethical Responsibilities of the Authors","authors":"","doi":"10.1007/s11062-024-09938-6","DOIUrl":"https://doi.org/10.1007/s11062-024-09938-6","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Structural Features that Determine the Neurotropic Activity of Thiamine Derivatives 决定硫胺素衍生物神经刺激活性的分子结构特征
IF 0.5 4区 医学
Neurophysiology Pub Date : 2024-04-12 DOI: 10.1007/s11062-024-09939-5
Yu. M. Parkhomenko, A. I. Vovk, Z. S. Protasova, S. A. Chornyy, O. L. Kobzar, S. P. Stepanenko, L. I. Chekhivska
{"title":"Molecular Structural Features that Determine the Neurotropic Activity of Thiamine Derivatives","authors":"Yu. M. Parkhomenko, A. I. Vovk, Z. S. Protasova, S. A. Chornyy, O. L. Kobzar, S. P. Stepanenko, L. I. Chekhivska","doi":"10.1007/s11062-024-09939-5","DOIUrl":"https://doi.org/10.1007/s11062-024-09939-5","url":null,"abstract":"<p>Despite numerous studies, high sensitivity of the brain nerve cells to vitamin B1 (thiamine) deficiency could not be explained solely by the co-enzymatic role of thiamine diphosphate. The molecular mechanisms of a high neurotropicity of thiamine have not yet been finally deciphered. Therefore, it is important to elucidate the relationship between the structure and the biological activity of thiamine and its derivatives. This study was conducted to evaluate the molecular structural features of thiamine and related compounds responsible for their ability to bind to nerve cells. <i>In vitro</i> and <i>in silico</i> methodological approaches were used. The interaction of thiamine and other compounds with isolated plasma membrane synaptosomes (PMS) was studied by a radioligand method using the carbon-labeled [thiazolium-2-<sup>14</sup>C] thiamine. The PMS preparations were obtained from the rat brain by differential centrifugation in a sucrose density gradient. The effect of thiamine derivatives on the viability of isolated thymocytes and neuroblastoma line N1E115 cells was evaluated by the MTT test. Physicochemical parameters of the tested compounds were calculated using Molinspiration software. ADMET properties were predicted using the pkCSM online server. Thiamine-related compounds with a thiazolium ring and with an unsubstituted hydroxyethyl group were found to be promising neuroactive agents. Modification of the aminopyrimidine part in the thiamine molecule provides different degrees of competitiveness of the compound with respect to thiamine. Among the compounds tested, 3-decyloxycarbonylmethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium chloride (DMHT) was identified as the best thiamine antagonist. The ability of DMHT to suppress cell viability <i>in vitro</i> was evaluated. Further DMHT studies are expected to provide knowledge for the development of modulators of thiamine-dependent processes in the nerve cells.</p>","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140590275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergic Effect of Isometric Resistance Training and Subthreshold Electrical Neuromuscular Stimulation on the Excitability of Spinal Motoneurons in Humans 等长阻力训练和阈下神经肌肉电刺激对人体脊髓运动神经元兴奋性的协同作用
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09934-2
K. Takeda, S. Koyama, K. Ushiroyama, Y. Naoi, Y. Saito, H. Sakurai, Y. Kanada, S. Tanabe
{"title":"Synergic Effect of Isometric Resistance Training and Subthreshold Electrical Neuromuscular Stimulation on the Excitability of Spinal Motoneurons in Humans","authors":"K. Takeda, S. Koyama, K. Ushiroyama, Y. Naoi, Y. Saito, H. Sakurai, Y. Kanada, S. Tanabe","doi":"10.1007/s11062-023-09934-2","DOIUrl":"https://doi.org/10.1007/s11062-023-09934-2","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulation of Store-Operated Calcium Entry in Neurons 神经元储存操作钙进入的模拟
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09931-5
E.È. Saftenku
{"title":"Simulation of Store-Operated Calcium Entry in Neurons","authors":"E.È. Saftenku","doi":"10.1007/s11062-023-09931-5","DOIUrl":"https://doi.org/10.1007/s11062-023-09931-5","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Levels of Neurospecific Proteins and Indices of Apoptosis in the Rat Cornea at Chronic Ethanol Consumption: Protective Effects of Thiamine Administration 慢性乙醇消耗大鼠角膜神经特异性蛋白水平和凋亡指标的变化:硫胺素的保护作用
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09932-4
O. S. Pavlova, V. L. Bilous, V. V. Korsa, S. P. Stepanenko, Yu. M. Parkhomenko, A. O. Tykhomyrov
{"title":"Changes in the Levels of Neurospecific Proteins and Indices of Apoptosis in the Rat Cornea at Chronic Ethanol Consumption: Protective Effects of Thiamine Administration","authors":"O. S. Pavlova, V. L. Bilous, V. V. Korsa, S. P. Stepanenko, Yu. M. Parkhomenko, A. O. Tykhomyrov","doi":"10.1007/s11062-023-09932-4","DOIUrl":"https://doi.org/10.1007/s11062-023-09932-4","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EMG Activity of the Shoulder Girdle Muscles of Humans after Surgical Refixation of the Ruptured m. Pectoralis Major Tendon under Conditions of Simple Bimanual Motor Acts 单纯双手运动条件下胸大肌肌腱断裂手术复位后肩带肌肌电图活动
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09936-0
Yu. A. Kulyk, S. S. Strafun, A. V. Gorkovenko
{"title":"EMG Activity of the Shoulder Girdle Muscles of Humans after Surgical Refixation of the Ruptured m. Pectoralis Major Tendon under Conditions of Simple Bimanual Motor Acts","authors":"Yu. A. Kulyk, S. S. Strafun, A. V. Gorkovenko","doi":"10.1007/s11062-023-09936-0","DOIUrl":"https://doi.org/10.1007/s11062-023-09936-0","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Various Empirical-Mode Decomposition Techniques of EEG for the Diagnostics of Epilepsy 不同脑电图经验模态分解技术在癫痫诊断中的比较
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09935-1
B. Gopika, J. E. Jacob
{"title":"Comparison of Various Empirical-Mode Decomposition Techniques of EEG for the Diagnostics of Epilepsy","authors":"B. Gopika, J. E. Jacob","doi":"10.1007/s11062-023-09935-1","DOIUrl":"https://doi.org/10.1007/s11062-023-09935-1","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Expression of LncRNA XIST as an Index Helping to Diagnose Parkinson’s Disease LncRNA XIST高表达作为帕金森病诊断指标的研究
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09933-3
L. Zhang, G. Li, D. Lu, Q. Dai
{"title":"High Expression of LncRNA XIST as an Index Helping to Diagnose Parkinson’s Disease","authors":"L. Zhang, G. Li, D. Lu, Q. Dai","doi":"10.1007/s11062-023-09933-3","DOIUrl":"https://doi.org/10.1007/s11062-023-09933-3","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Augmented Reality in Sports Education and Training for Children with an Autism Spectrum Disorder 增强现实在自闭症谱系障碍儿童运动教育和训练中的应用
4区 医学
Neurophysiology Pub Date : 2023-10-20 DOI: 10.1007/s11062-023-09937-z
A. Fridhi, N. Bali
{"title":"Augmented Reality in Sports Education and Training for Children with an Autism Spectrum Disorder","authors":"A. Fridhi, N. Bali","doi":"10.1007/s11062-023-09937-z","DOIUrl":"https://doi.org/10.1007/s11062-023-09937-z","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modes of Operation of the Endoplasmic Reticulum Ca2+ Transport Systems in Neurons: Insights from the Compartmental Models 神经元内质网Ca2+运输系统的运作模式:从室室模型的见解
4区 医学
Neurophysiology Pub Date : 2023-10-18 DOI: 10.1007/s11062-023-09930-6
E.È. Saftenku
{"title":"Modes of Operation of the Endoplasmic Reticulum Ca2+ Transport Systems in Neurons: Insights from the Compartmental Models","authors":"E.È. Saftenku","doi":"10.1007/s11062-023-09930-6","DOIUrl":"https://doi.org/10.1007/s11062-023-09930-6","url":null,"abstract":"","PeriodicalId":19141,"journal":{"name":"Neurophysiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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