Neurologia i neurochirurgia polska最新文献

{"title":"Intraparenchymal pericatheter cyst: a rare but important manifestation of cerebrospinal shunt failure.","authors":"Diogo Marques, Filipa Castelão, Ricardo Pimentel Silva, Ana Cristina Rios","doi":"10.5603/pjnns.98075","DOIUrl":"10.5603/pjnns.98075","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"136-138"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symbol Digit Modalities Test in progressive multiple sclerosis.","authors":"Bartosz Gajewski, Iwona Karlińska, Mariusz Stasiołek","doi":"10.5603/pjnns.98204","DOIUrl":"10.5603/pjnns.98204","url":null,"abstract":"<p><strong>Introduction: </strong>The Symbol Digit Modalities Test (SDMT) is a highly sensitive neuropsychological tool used for the assessment of information processing speed (IPS) in various neurological disorders.</p><p><strong>State of the art: </strong>In this review, we have focused on the current knowledge regarding the use of SDMT selectively in the evaluation of progressive multiple sclerosis (PMS) patients. A literature review was performed regarding the application of SDMT in PMS, with a focus on the primary progressive and secondary progressive subtypes. Relationships of diverse disease-associated factors with SDMT have been described, including disease course, imaging findings, molecular biomarkers, treatment and others.</p><p><strong>Clinical implications: </strong>SDMT is a very useful and easily applicable instrument in the diagnostic armamentarium of neurologists and neuropsychologists. It is especially valuable in the evaluation of PMS patients, in whom the prevalence of IPS deficits is higher than in relapsing-remitting multiple sclerosis subjects or in healthy individuals.</p><p><strong>Future directions: </strong>An emphasis should be laid on larger study groups and differentiating between individual PMS subtypes and their separate analysis in the context of cognitive assessment.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"221-232"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic cerebellar degeneration - raising awareness for early diagnosis.","authors":"Zuzanna Roszkowska, Adam Surma, Dariusz Koziorowski, Leszek Królicki, Łukasz Milanowski","doi":"10.5603/pjnns.104005","DOIUrl":"https://doi.org/10.5603/pjnns.104005","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":"58 6","pages":"627-628"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated tissue factor pathway inhibitor is associated with intracerebral haemorrhage of unknown cause in young adults.","authors":"Michał Błaż, Paweł Łopatka, Elżbieta Szczygieł-Pilut, Anetta Undas","doi":"10.5603/pjnns.102371","DOIUrl":"https://doi.org/10.5603/pjnns.102371","url":null,"abstract":"<p><strong>Clinical rationale for study: </strong>We have reported that intracerebral haemorrhage (ICH) of unknown cause at a young age is associated with lower prothrombin and factor VII and higher antithrombin activity, along with the formation of looser fibrin networks displaying enhanced lysability. Patients with mild-to-moderate bleeding of unknown cause have elevated levels of free plasma tissue factor pathway inhibitor alpha (fTFPIα), inhibiting the tissue factor-factor VII complex and prothrombinase.</p><p><strong>Aim of study: </strong>We hypothesised that patients with an intracerebral haemorrhage (ICH) of unknown cause may also exhibit higher fTFPIα.</p><p><strong>Material and methods: </strong>We studied 44 adults aged ≤ 50 years following ICH of unknown cause at least three months after the incident, and 47 controls matched for age, sex, BMI, and hypertension. We assessed fTFPIα levels along with plasma fibrin clot permeability, turbidity and fibrinolytic capacity, thrombin generation, coagulation factors, antithrombin, and fibrinolysis proteins.</p><p><strong>Results: </strong>Patients following ICH had 10.8% higher median fTFPIα levels than controls (8.3 [7.6-9.5] vs. 7.4 [6.9-8.5] ng/mL; p = 0.006). fTFPIα was higher in males than in females both in the ICH group (p = 0.0004) and in controls (p = 0.007), and correlated with age (r = 0.38; p = 0.01), fibrinogen (r = -0.39, p = 0.009), PAI-1 antigen (r = -0.32, p = 0.035), and clot maximum absorbance (r = -0.30, p = 0.049), but not with other laboratory variables. Nine patients had fTFPIα levels lower the upper limit of the reference range (i.e. 11.5 ng/mL) and they had a longer lag phase of the turbidity curve (p = 0.023) and clot absorbance (p = 0.042). In univariate analysis, a 1 ng/mL increase in fTFPIα was associated with a 61% greater chance of having an ICH (OR 1.61, 95% CI 1.19-2.18) even after adjusting for potential confounders.</p><p><strong>Conclusions: </strong>Patients with ICH of unknown cause under the age of 50 are characterised by elevated fTFPIα associated with changes in fibrin clot formation and faster PAI-1-dependent lysis.</p><p><strong>Clinical implications: </strong>Our study might suggest a novel potential mechanism underlying ICH.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":"58 6","pages":"600-607"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of glutamine synthetase polymorphisms rs2296521, rs10911021 and rs12136955 with plasma ammonia concentration in valproic acid-treated Egyptian epilepsy patients.","authors":"Wessam El-Sayed, Abdelaziz M Hussein, Ibrahim Elmenshawi, Ghada Helal, Mohammed Abbas, Abdelnaser Badawy, Nedaa A Kiwan, Mahmoud El Tohamy, Ghada Awadalla, Osama A Abulseoud","doi":"10.5603/pjnns.99826","DOIUrl":"10.5603/pjnns.99826","url":null,"abstract":"<p><strong>Introduction: </strong>The use of valproic acid (VPA) in the treatment of some psychiatric and neurological disorders such as bipolar disorder, migraines, and epilepsy is associated with hyperammonemia. However, the mechanism of this negative effect of VPA is unclear. In this study, we investigate gene glutamate-ammonia ligase (GLUL) polymorphisms for the glutamine synthetase (GS) enzyme, a key enzyme that catalyzes the removal of ammonia by incorporating it with glutamate to form glutamine, and we investigate whether it has a relationship with the emergence of hyperammonemia during VPA-based therapy.</p><p><strong>Patients and methods: </strong>We enrolled 180 Egyptian epilepsy patients in this study. Patient history, general and neurological examination and blood samples from arm veins were taken. Real time TaqMan PCR polymorphism for three polymorphism SNPs (rs2296521, rs10911021 and rs12136955) of GLUL was done. We assessed the relationship between the patient features, including three GLUL polymorphisms, and the development of hyperammonemia during VPA-based therapy.</p><p><strong>Results: </strong>We found that the ammonia levels showed a positive correlation with VPA treatment duration (p = 0.015) and a negative correlation with carbamazepine total dose per day (p = 0.027) and with WBCs count (p = 0.026). Also, female patients having rs2296521 SNPs with the A allele and patients having rs10911021 SNPs with the C allele were at high risk for elevated plasma ammonia levels. Moreover, patients having rs12136955 SNPs with the A allele or associated hypertension as a co-morbidity were at high risk for elevated plasma ammonia levels.</p><p><strong>Conclusion: </strong>Female patients who have rs2296521 with the A allele, rs10911021 with the C allele, or rs12136955 with the A allele, are independent risk factors for elevated plasma ammonia levels during VPA-based therapy. Moreover, carbamazepine combined therapy may protect against the development of hyperammonemia in VPA-treated patients.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"519-530"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERPINE1 and MTHFR variants: key targets in the search for genetic determinants in ESUS?","authors":"Anetta Lasek-Bal","doi":"10.5603/pjnns.101597","DOIUrl":"10.5603/pjnns.101597","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"360-362"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saccades in Huntington's Disease.","authors":"Daniel Zielonka","doi":"10.5603/pjnns.101418","DOIUrl":"10.5603/pjnns.101418","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"357-359"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical thrombectomy in very elderly people: shortand long-term outcomes of endovascular stroke treatment in nonagenarians.","authors":"Paweł Wrona, Tomasz Homa, Dominik Wróbel, Dawid Rolkiewicz, Ewa Włodarczyk, Tadeusz Popiela, Agnieszka Slowik, Katarzyna Sawczyńska","doi":"10.5603/pjnns.99386","DOIUrl":"10.5603/pjnns.99386","url":null,"abstract":"<p><strong>Aim of study: </strong>To assess outcomes of mechanical thrombectomy (MT) in nonagenarians suffering from acute ischaemic stroke (AIS) in a 1-year follow-up.</p><p><strong>Clinical rationale for study: </strong>Age is a factor associated with both the occurrence of AIS and a poorer prognosis. As the population ages, the prevalence of AIS among the very old (90 and older) is expected to rise. Data on long-term outcomes of MT, being the optimal treatment of AIS caused by large vessel occlusions, is scarce in the population of nonagenarians.</p><p><strong>Material and methods: </strong>We analysed all AIS patients treated with MT in a single Comprehensive Stroke Centre. We compared two subgroups: nonagenarians (people aged 90-99) and controls ( < 90 years) in terms of cardiovascular risk factors profile, stroke severity, treatment course, presence of in-hospital complications, and outcomes (mortality and good functional outcome defined as modified Rankin Scale ≤ 2) at discharge and at 90- and 365-day follow-ups.</p><p><strong>Results: </strong>Nonagenarians were more commonly female and suffering from atrial fibrillation. They more often developed urinary tract infection during hospitalisation. Stroke severity, treatment course and in-hospital outcomes were comparable between the groups. Nonagenarians had non-significantly higher 90-day and 365-day mortality, and a significantly lower rate of good functional outcomes after 90 days (25.0% vs 57.7%, p = 0.011) and 365 days (31.5% vs 61.0%, p = 0.020).</p><p><strong>Conclusions and clinical implications: </strong>Despite worse outcomes than in younger patients, 25% of nonagenarians were functionally independent three months after MT, and almost one in three of them were so a year after the procedure, thereby showing the benefits of the treatment in this group.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"429-436"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of idebenone treatment in a patient with DNAJC30-associated Leigh Syndrome.","authors":"Kamil Dzwilewski, Karol Chojnowski, Magdalena Krygier, Marta Zawadzka, Magdalena Chylińska, Maria Mazurkiewicz-Bełdzińska","doi":"10.5603/pjnns.100423","DOIUrl":"10.5603/pjnns.100423","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"468-470"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral amyloid angiopathy associated with Alzheimer's Disease: two pathologies from a single peptide?","authors":"Gabriele Gaggero, Davide Taietti, Veronica Parrella, Pietro Fiaschi","doi":"10.5603/pjnns.97901","DOIUrl":"10.5603/pjnns.97901","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"139-141"},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138808330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}