Neurologia i neurochirurgia polska最新文献

{"title":"Helping the patients find their voice.","authors":"Małgorzata Dec-Ćwiek, Anna Julia Krupa, Marcin Siwek","doi":"10.5603/pjnns.102092","DOIUrl":"10.5603/pjnns.102092","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"79-81"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon localised form of axonal injury involving pontes grisei caudatolenticulares.","authors":"Francisca Sena Batista, Filipa Castelão, Carlos Casimiro, Lígia Neves, Denil Champac Tribovane","doi":"10.5603/pjnns.102233","DOIUrl":"10.5603/pjnns.102233","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"82-83"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of redox balance parameters among patients with acute ischaemic stroke.","authors":"Anna Mirończuk, Katarzyna Kapica Topczewska, Jacek Jamiołkowski, Monika Grabia, Agata Czarnowska, Agnieszka Mitrosz, Dominika Jakubowicz Lachowska, Joanna Tarasiuk, Joanna Kulikowska, Paulina Matys, Cezary Grunwald, Monika Chorąży, Katarzyna Socha, Alina Kułakowska, Jan Kochanowicz","doi":"10.5603/pjnns.104354","DOIUrl":"10.5603/pjnns.104354","url":null,"abstract":"<p><strong>Clinical rationale for study: </strong>Oxidative stress (OS) is believed to play a crucial role in the development of neuronal injury associated with ischaemic stroke (IS). The evaluation of redox homeostasis in patients with acute ischaemic stroke (AIS) and its relation to stroke subtypes and short-term outcomes has scarcely been studied, and the findings are unclear.</p><p><strong>Aim of study: </strong>This study evaluates OS and antioxidant status in patients with AIS in the Podlaskie Voivodeship in Poland within 2-5 days of stroke onset, compared to healthy controls.</p><p><strong>Material and methods: </strong>The study involved 187 patients with AIS, with 85 receiving intravenous thrombolysis and/or mechanical thrombectomy, and included 94 healthy controls as a comparison group. The research measured serum total oxidant status (TOS) and total antioxidant status (TAS) using Erel's method-based kits, and calculated the oxidative stress index (OSI).</p><p><strong>Results: </strong>Significant differences were found in TOS levels between patients with AIS and healthy controls (p = 0.049). Serum TAS concentrations were significantly higher in patients with AIS due to large artery atherosclerosis (LAA) than in those with cardioembolism (CE) or small vessel occlusion (SVO) aetiology, as classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria (p = 0.043). Receiver Operating Characteristic (ROC) curve analysis established cut-off values as potential indicators of OS in patients with AIS: TAS < 1.34 mmol/L, TOS > 5.6 μmol H2O2 equiv./L, and OSI > 3.96.</p><p><strong>Conclusions and clinical implications: </strong>Our findings demonstrate that an imbalance of oxidant and antioxidant status might play a role in the pathogenesis of IS. Patients in the initial phase of IS showed increased TOS, but no change in TAS, compared to healthy controls. This suggests effective initial antioxidant defence. TOS levels exhibited potential utility as clinical diagnostic biomarkers in patients with AIS. Although an imbalance towards oxidants may play a role in the pathogenesis of IS, these markers alone do not adequately predict stroke severity. Therefore, an analysis of the oxidant and antioxidant balance could play a crucial role in clarifying the pathogenic pathways of IS, presenting valuable diagnostic and prognostic tools, and identifying novel targets for antioxidant-focused therapies with neuroprotective agents.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"272-282"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive spinal epidural abscess involving entire spinal canal.","authors":"Dariusz Dziubek, Karolina Dziubek, Marcelina Stodolak","doi":"10.5603/pjnns.106423","DOIUrl":"10.5603/pjnns.106423","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"431-433"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erdheim-Chester disease is often complicated by neurological disorders.","authors":"Josef Finsterer, Sounira Mehri","doi":"10.5603/pjnns.102491","DOIUrl":"10.5603/pjnns.102491","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"75-76"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNAJC30 variants can also manifest phenotypically as Leigh/LHON overlap syndrome.","authors":"Josef Finsterer","doi":"10.5603/pjnns.103221","DOIUrl":"10.5603/pjnns.103221","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"77-78"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotoxicity of levodopa/carbidopa intestinal gel preparations can cause polyneuropathy in Parkinson's Disease patients.","authors":"Josef Finsterer","doi":"10.5603/pjnns.104394","DOIUrl":"10.5603/pjnns.104394","url":null,"abstract":"","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"183-184"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic effects of deep brain stimulation in Parkinson's disease - a systematic review and meta-analysis.","authors":"Julia Węgrzynek-Gallina, Tomasz Chmiela, Amadeusz Kasprzyk, Michał Borończyk, Joanna Siuda","doi":"10.5603/pjnns.100297","DOIUrl":"10.5603/pjnns.100297","url":null,"abstract":"<p><strong>Introduction: </strong>Deep brain stimulation (DBS) is an effective therapy for patients with advanced Parkinson's Disease (PD). The significant improvement in motor symptoms is undeniable. However, adverse events from the procedure can also occur.</p><p><strong>Clinical rationale for study: </strong>Several sources have confirmed metabolic changes after a DBS procedure. However, there is no summary of the current state of knowledge about the impact of DBS on metabolic parameters changes expressed in weight gain in PD individuals, something which could guide further research.</p><p><strong>Material and methods: </strong>We conducted a systematic review following PRISMA recommendations on articles evaluating a gain of weight and/or body mass index (BMI) after subthalamic nucleus (STN) DBS, globus pallidus internus (GPi) DBS, and ventral intermediate nucleus of the thalamus (VIM) DBS in patients with PD. Four databases were searched by two independent authors according to the established criteria. The collected data involved body mass, BMI or changes in these parameters before DBS and after the procedure, mean age of patients, disease duration, gender, L-dopa equivalent daily dose, and the Unified Parkinson's Disease Rating Scale part III.</p><p><strong>Results: </strong>Of 1,290 articles found, 30 were evaluated as eligible and were included in the analysis. The study sample size ranged from 10 to 124 patients (mean, 32.6 ± 23.5, N = 1,110). The mean age across studies was 59.8 ± 7.5 (range 51.8 - 66, N = 636) years with mean value of the last follow-up point 13.6 ± 8.9 (range 1-38) months. A meta-analysis was performed for STN-DBS only, due to limited data on GPi-DBS and VIM-DBS. The mean body weight was higher by 6.15 kg one year after STN-DBS procedure (p < 0.001, 95% CI: 4.49-7.81), which was associated with statistically non-significant heterogeneity. It showed an increase in BMI of 1.87 kg/m2 (p < 0.001, 95% CI: 1.11-2.64). In this comprehensive review, possible causes of this state are identified, as well as the DBS impact on glucose and lipid profile.</p><p><strong>Conclusions: </strong>STN-DBS procedures contribute to significant weight gain in PD patients. A precise mechanism of this phenomenon has several possible explanations. Until this issue is fully clarified, we believe it is necessary to continuously monitor metabolic parameters and closely observe cardiometabolic risk in this group of patients.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"338-353"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequently observed polyneuropathy expands phenotypic spectrum of apparently pure autosomal dominant hereditary spastic paraplegias.","authors":"Iwona Stępniak, Maria Rakowicz, Wanda Lipczyńska-Łojkowska, Anna Sobańska, Ewelina Elert-Dobkowska, Wioletta Krysa, Marta Rajkiewicz, Anna Wasielewska-Hobot, Monika Rudzińska, Jacek Pilch, Grzegorz Makowicz, Jacek Zaremba, Anna Sułek","doi":"10.5603/pjnns.101154","DOIUrl":"10.5603/pjnns.101154","url":null,"abstract":"<p><strong>Background: </strong>Hereditary spastic paraplegias (HSPs) are a group of genetically heterogeneous, progressive disorders with a broad spectrum of clinical presentation. Among autosomal dominant inherited forms of HSP, the most common are SPG4, SPG3 and SPG31.</p><p><strong>Material and methods: </strong>Our aim was the clinical characterisation of a large group of patients with SPG4, SPG3 and SPG31. Neurological assessments as well as neuroimaging, electrophysiological, neuropsychological and ophthalmological examinations were performed to characterise in detail the clinical picture in HSP patients.</p><p><strong>Results: </strong>In our study group of 179 individuals from 60 families, three forms of AD-HSP: SPG4, SPG3 and SPG31 were diagnosed in 125, 36 and 18 patients, respectively. 48 of the probands had a positive family history of autosomal dominant hereditary disorder, while the other 12 probands represented apparently isolated cases. The pure form of HSP (pHSP) was found in a large majority (138 symptomatic patients), whereas a distinctly complex phenotype (cHSP) was found only in 32 individuals. The number of patients with cHSP became greater after including the results of electroneurography.</p><p><strong>Conclusions: </strong>The primarily pure form of HSP is present in patients with SPG4, SPG3 and SPG31. Nevertheless, the presence of additional symptoms provides evidence that in AD-HSP not only the cortico-spinal tract is involved. The most common additional symptom is polyneuropathy. We suggest that all patients with a genetic diagnosis of SPG4 and SPG3 should have electrophysiological testing performed, and then periodically repeated, for the purpose of controlling the involvement of peripheral nerves. We found a considerable variability, including in terms of age at onset and the progression rate of disability, mainly in SPG4.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"283-291"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of multiple sclerosis: global trends, regional differences, and clinical implications.","authors":"Katarzyna Kapica-Topczewska, Alina Kułakowska, Jan Kochanowicz, Waldemar Brola","doi":"10.5603/pjnns.103955","DOIUrl":"10.5603/pjnns.103955","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple sclerosis (MS) is one of the most common chronic neurological diseases. It predominantly affects young adults. Recent advances in diagnostic and therapeutic approaches have led to increased recognition and reporting of the disease.</p><p><strong>State of the art: </strong>Global MS prevalence varies significantly by region, and is influenced by environmental, genetic, and healthcare factors. Higher rates are observed in northern latitudes, which has been linked to reduced sunlight exposure and vitamin D deficiency. Advances in diagnostic tools, particularly MRI, have contributed to earlier detection and increased incidence rates.</p><p><strong>Clinical implications: </strong>Gender and age differences in MS epidemiology highlight unique challenges in management. Women are more frequently affected, while men tend to experience a more severe disease course. Paediatric and late-onset MS forms require distinct diagnostic and treatment strategies.</p><p><strong>Future directions: </strong>Research should prioritise understanding regional and demographic variability, the role of genetic-environmental interactions, and the long-term impact of new therapies. Improved global access to healthcare and advanced diagnostics is crucial for addressing disparities in MS management.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"375-384"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}