Mycological Progress最新文献

{"title":"Xylodon lanatus complex and other additions to Xylodon","authors":"Eugene Yurchenko, Janett Riebesehl, Ilya Viner, Viviana Motato-Vásquez, Otto Miettinen","doi":"10.1007/s11557-024-01947-3","DOIUrl":"https://doi.org/10.1007/s11557-024-01947-3","url":null,"abstract":"<p><i>Xylodon lanatus</i> and closely related species were studied with molecular and morphological means. This species complex contains six species, two of which we describe as new. Species in the complex have minutely odontioid hymenophore projections that consist of encrusted, firm-walled hyphae and ellipsoid spores. We assign an epitype for <i>X. lanatus</i>, for which ITS and 28S rDNA sequences were obtained, and amend the concept of <i>X. pseudolanatus</i>. The two new species, both well supported in our phylogenetic analyses, are <i>X.</i> <i>afromontanus</i>, found in Eastern Africa, and <i>X. mantiqueirensis</i>, found in southeastern Brazil. We show the phylogenetic affinity of <i>X. echinatus</i> with <i>X. lanatus</i> for the first time, and according to new data the range of the previous species extends to Sunda Archipelago. We provide scanning electron microscopy illustrations of the crystalline deposits on projecting hyphae for the above-mentioned species. The sixth member of the complex is <i>X. kunmingensis</i>. Outside the <i>X. lanatus</i> complex, we report additional sequenced specimens of <i>X.</i> <i>hyphodontinus</i>. A new species, <i>X. neotropicus</i> from South America, related to <i>X.</i> <i>hyphodontinus</i>, is described. We also describe <i>X. gloeocystidiifer</i> from Ecuador as new species. It is characterised by globose/broadly ellipsoid spores, gloeocystidia and capitate cystidia with a resinous cap. The heterotypic names <i>Hyphodontia yunnanensis</i> and <i>Xylodon yunnanensis</i> are considered. We suggest the previous one is a synonym of the latter.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"257 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139665333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriching soybean with two soil macronutrients through boosting root proliferation with Trichoderma viride","authors":"Subhadip Paul, Jeet Roy, Amitava Rakshit","doi":"10.1007/s11557-024-01948-2","DOIUrl":"https://doi.org/10.1007/s11557-024-01948-2","url":null,"abstract":"<p>Owing to ineffective biological nitrogen (N) fixation, and imbalanced doses of N and potassium (K) fertilization, soybean productivity is declining under intensive cropping practices. This study aimed to find out the effectiveness of <i>Trichoderma viride</i> priming on soybean root growth promotion, and enhancement of soil-N and K uptakes under graded fertilization. Soybean seeds were treated with freshly prepared <i>T. viride</i> BHU-2953 talc. Root lignification, indole acetic acid (IAA) production, and activity of 1-aminocyclopropane-1-carboxylate deaminase (ACCD) were determined to observe root growth-promoting activities. A pot experiment was conducted to evaluate root volume, and soil exploration by roots, i.e., the potential volume of influence (PVI), uptakes of N and K, and different physiological attributes at different growth periods of soybean. Results revealed that biopriming enhanced the root lignification, IAA, and ACCD, assisting more soil volume exploration (PVI) for better N and K acquisitions. Biopriming increased the plant biomasses which ultimately, led to more seed yield than untreated soybeans, receiving even higher N-K doses. The PVI correlated well with root volume (<i>r</i>² = 0.95; <i>P</i> &lt; 0.01), explaining good soil-nutrient foraging by bioprimed soybeans. Hence, we conclude that <i>T. viride</i> priming can enhance the N and K uptakes in soybeans under graded soil fertilization.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"5 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139510192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides","authors":"Winnie Chemutai Sum, Didsanutda Gonkhom, Mahmoud A. A. Ibrahim, Marc Stadler, Sherif S. Ebada","doi":"10.1007/s11557-023-01941-1","DOIUrl":"https://doi.org/10.1007/s11557-023-01941-1","url":null,"abstract":"<p>Preparative high-performance liquid chromatography (HPLC) purification of the ethyl acetate extract derived from dried basidiomes of the European mushroom <i>Hericium coralloides</i> led to the identification of two previously undescribed isoindolinone derivatives named corallocins D and E (<b>1</b>-<b>2</b>). The structures of the compounds were elucidated based on HR-ESI-MS (high-resolution electron spray ionization mass spectrometry), interpretation of 1D and 2D NMR spectra, electronic circular dichroism (ECD) experiments, and comparisons with published and theoretical data. The metabolites were tested for their cytotoxic and antimicrobial effects <i>in vitro</i> where weak to moderate biological effects were observed against HeLa cells (KB 3.1), <i>Mucor hiemalis</i> and <i>Bacillus subtilis</i>.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"9 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of Nematode–Tomato Plant–Mycorrhizal Fungus system for bio based product development","authors":"Sebastián Andrés Garita, Valeria Fernanda Bernardo, Matías González, María Cecilia Arango, Marcela Ruscitti","doi":"10.1007/s11557-023-01939-9","DOIUrl":"https://doi.org/10.1007/s11557-023-01939-9","url":null,"abstract":"<p><i>Nacobbus aberrans</i> is a plant parasitic nematode that causes significant economic losses in the American Continent and is considered a quarantine pest in many countries. Some arbuscular mycorrhizal fungi have shown the ability to reduce the population of this pathogen; however, most studies do not consider other relevant aspects that have to do with the crop or the fungus. The purpose of this work was to select an isolated mycorrhizal fungus based on a comprehensive analysis of the Nematode–Plant–Mycorrhizal Fungus system. The test was conducted on <i>Solanum lycopersicum</i> L. grown in pots. The evaluated isolates were <i>Funneliformis mosseae</i>, <i>Rhizoglomus intraradices A2</i>, and <i>Rhizoglomus intraradices B1</i>. All the isolates reduced the nematode population significantly; however, differences in the content of photosynthetic pigments, soluble proteins, and osmoregulatory metabolites were identified. All of these impacted on the photosynthetic rates of the different treatments. There were also differences in the growth of the fungi within the roots, and in the viability of the fungal structures. The comprehensive analysis of the plant–nematode–fungus group allows us to conclude that the isolate with the greatest capacity to compensate for the negative effect of parasitism, and with the greatest possibility of lasting as a biocontrol agent is <i>Funneliformis mosseae</i>.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"3 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138818479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description of a novel coprophilous Lichtheimia (Mucoromycotina, Mucorales) species with notes on Lichtheimia species and an identification key for the genus","authors":"Mateus Oliveira da Cruz, Hyang Burm Lee, Thalline Rafhaella Leite Cordeiro, Francisca Robervânia Soares dos Santos, Maria Helena Alves, Thuong Thuong Thi Nguyen, Eleni Gentekaki, Vedprakash G. Hurdeal, André Luiz Cabral Monteiro de Azevedo Santiago","doi":"10.1007/s11557-023-01937-x","DOIUrl":"https://doi.org/10.1007/s11557-023-01937-x","url":null,"abstract":"<p>During the assessment of coprophilous mucoralean diversity in northeastern areas of Brazil, a <i>Lichtheimia</i>-like specimen (URM 8358) was isolated from rabbit dung. It was characterized based on morphological, physiological, and molecular analyses of the internal transcribed spacer (ITS), large subunit ribosomal (LSU) and actin DNA sequences. These analyses revealed a novel <i>Lichtheimia</i> species, which is described herein. The novel species forms abundantly branched sporangiophores, with most branches arising near the main sporangia, various-shaped columellae, and irregularly shaped sporangiospores. Furthermore, this manuscript provides notes of all <i>Lichtheimia</i> species, and an identification key for the genus is provided. These findings contribute to the existing knowledge on the taxonomy and distribution of <i>Lichtheimia</i>. Because of the clinical relevance of other <i>Lichtheimia</i> species, we encourage future research to determine whether URM 8358 can be pathogenic to humans.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"39 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138581110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New genera in the lichenized family Gomphillaceae (Ascomycota: Graphidales) focusing on neotropical taxa","authors":"Amanda Barreto Xavier-Leite, Bruno Tomio Goto, Robert Lücking, Marcela Eugenia da Silva Cáceres","doi":"10.1007/s11557-023-01933-1","DOIUrl":"https://doi.org/10.1007/s11557-023-01933-1","url":null,"abstract":"&lt;p&gt;Previous molecular phylogenetic analysis in comparison with phenotype characters of &lt;i&gt;Gomphillaceae&lt;/i&gt; resolved a total of 38 genus-level clades among the studied species, 17 of which in need to be recognized and formally established as new or reinstated genera. The four reinstated genus names, including one validation, are &lt;i&gt;Microxyphiomyces&lt;/i&gt; Bat., Valle &amp; Peres, &lt;i&gt;Psathyromyces&lt;/i&gt; Bat. &amp; Peres, &lt;i&gt;Spinomyces&lt;/i&gt; Bat. &amp; Peres ex Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., and &lt;i&gt;Sporocybomyces&lt;/i&gt; H. Maia. The remaining 13 are newly described: &lt;i&gt;Adelphomyces&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Aptrootidea&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Aulaxinella&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Batistomyces&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Bezerroplaca&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Caleniella&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Monocalenia&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Pseudocalenia&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Roselviria&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Santricharia&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Sipmanidea&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., &lt;i&gt;Verruciplaca&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov., and &lt;i&gt;Vezdamyces&lt;/i&gt; Xavier-Leite, M. Cáceres &amp; Lücking, gen. nov. The following 53 new combinations are introduced for the species included in the new and reinstated genera: &lt;i&gt;Adelphomyces cochlearifer&lt;/i&gt; (Lücking &amp; Sérus.) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. epithallina&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. parvula&lt;/i&gt; (Hafellner &amp; Vězda) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;Aptrootidea amapensis&lt;/i&gt; (Bat. &amp; Poroca) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. atrofusca&lt;/i&gt; (R. Sant.) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. atromuralis&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. marginata&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. triseptata&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. wilsoniorum&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;Aulaxinella corticola&lt;/i&gt; (Kalb &amp; Vězda) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. minuta&lt;/i&gt; (R. Sant.) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;A. multiseptata&lt;/i&gt; (R. Sant.) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;Batistomyces pallidus&lt;/i&gt; (Vězda) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;B. hyalinus&lt;/i&gt; (Kalb &amp; Vězda) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;Bezerroplaca fusconitida&lt;/i&gt; (Lücking) Xavier-Leite, M. Cáceres &amp; Lücking, comb. nov., &lt;i&gt;B. incrustatociliata&lt;/i&gt; (Sérus.) Xavier-Leite, M.","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"69 1-2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138509864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing a new pathosystem for marine pathogens – the green alga Urospora neglecta and its pathogen Sirolpidium litorale sp. nov.","authors":"Anthony T. Buaya, Ichen Tsai, Tatyana A. Klochkova, Marco Thines","doi":"10.1007/s11557-023-01938-w","DOIUrl":"https://doi.org/10.1007/s11557-023-01938-w","url":null,"abstract":"<p>Holocarpic oomycetes, which had fallen into relative scientific obscurity for quite some time, recently regained scientific interest. Among these organisms, some stand out for infecting commercially valuable red algae, such as the nori algae of the genus <i>Pyropia</i>, rendering them economically significant. After having observed simple holocarpic pathogens of green algae in previous sampling trips, most of which we could not fully characterise due to their scarcity, we now discovered a parasite of the widespread littoral green algae <i>Urospora neglecta</i>. This previously unnoticed parasite turned out to be distinct from another green algae-infesting species, <i>Sirolpidium bryopsidis</i>. This finding led us to formally describe it as <i>Sirolpidium litorale</i>, marking the first new species of holocarpic oomycetes of green algae to be found on the shores of Blávík, East Iceland. The ease of cultivation of <i>U. neglecta</i> offers a unique opportunity to establish a genetically tractable system for studying how <i>Sirolpidium</i> interacts with algae. This could help uncover the underlying mechanisms behind the pathogenicity of the species of this genus and provide valuable insights into their ecological roles and evolutionary history.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"31 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138529462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three new Clavulina species from Baiyun Mountain, Guangzhou, China","authors":"Xiao-Xia Huang, Yi-Xin Chen, Zhi-Jun Lin, Ying-Shan Liang, Li-Hong Qiu","doi":"10.1007/s11557-023-01929-x","DOIUrl":"https://doi.org/10.1007/s11557-023-01929-x","url":null,"abstract":"<p>Three new <i>Clavulina</i> species, namely <i>C. baiyunensis</i>, <i>C. minor</i>, and <i>C. lilaceorosea</i>, were described from specimens collected from Baiyun Mountain, Guangzhou, China, based on detailed morphological studies and phylogenetic analyses of the nucleotide sequences of three loci (ITS, LSU, and <i>RPB2</i>). <i>Clavulina baiyunensis</i> is characterized by light brown to brown basidiomata with hyaline tramal hyphae. <i>Clavulina minor</i> has diminutive, dull white to pale brown basidiomata with hyaline tramal hyphae. <i>Clavulina lilaceorosea</i> has pale brown to ochre brown basidiomata with palmate branches, and light brown walls of tramal hyphae. All three new species have abundant clamp connections. A key to the known species of <i>Clavulina</i> from China is provided.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"6 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138529472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TrEase web service: inferring phylogenetic trees with ease","authors":"Bagdevi Mishra, Sebastian Ploch, Claus Weiland, Marco Thines","doi":"10.1007/s11557-023-01931-3","DOIUrl":"https://doi.org/10.1007/s11557-023-01931-3","url":null,"abstract":"<p>Phylogenetic inference is done regularly in many biological studies not focussed on the phylogeny itself, but which use phylogeny as a tool to infer hypotheses for the interpretation of laboratory experiments. However, phylogenetic inference is often performed at low standards in these studies, which can result in wrong interpretations. Using high-standard phylogenetic inference tools usually requires substantial methodological knowledge or is only possible with paid tools. To enable beginners, researchers for which phylogeny is just one tool of many, and scientists in biodiversity discovery a quick and easy access to current phylogenetic methods, the TrEase web service with an intuitive interface was developed. It offers a complete pipeline with commonly used phylogeny-related software, which can run the whole process of sequence acquisition, reference sequence search, alignment and phylogenetic inference with a single execution command once the necessary parameters have been selected from drop-down menus. It allows choosing alternate programmes for each step and also offers the flexibility to use any part of the pipeline independently. Along with providing a compact pipeline, this web service provides several functionalities to avoid manual intervention such as sorting sequences into the same orientation, cutting reference sequences, removal of redundant sequences and the possibility to choose reference sequences from top ‘species’ hits instead of top GenBank entry hits. All resulting trees and intermediate files are made available for download for subsequent use. Thus, the TrEase service offers a barrier-free entry into standard phylogenetic analyses. It is available at http://thines-lab.senckenberg.de/trease.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"143 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138529480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal aromatic-bisabolane sesquiterpenoids—possible peptidylprolyl cis/trans isomerase (Pin1) inhibitors for cancer","authors":"Bayan E. Ainousah, Abdulrahim A. Alzain, Tagyedeen H. Shoaib, Shaimaa G. A. Mohamed, Hazem G. A. Hussein, Gamal A. Mohamed, Sabrin R. M. Ibrahim","doi":"10.1007/s11557-023-01934-0","DOIUrl":"https://doi.org/10.1007/s11557-023-01934-0","url":null,"abstract":"<p>Marine fungi have been proven as potential sources of natural metabolites with significant bioactivities that have not been sufficiently explored. This highlights the need for intensifying research to reach sustainable utilization of this huge factory of biodiverse metabolites. Aromatic-bisabolane sesquiterpenoids (ABSs) are a rare class of monocyclic sesquiterpenoids that have been reported from fungi, gorgonians, corals, sponges, and plants. These metabolites possessed significant bioactivities and intriguing chemical frameworks, indicating their substantial pharmaceutical and/or agricultural values. The current work covered the reported data on fungal ABSs, including their sources, isolation, structure characterization, and bioactivities. In addition, their Pin1 inhibitory potential as anticancer agents was assessed using in silico studies. Out of the compounds studied, 17 compounds showed docking scores which surpassed that of the reference ligand. Among these, three compounds demonstrated superior MM-GBSA binding free energies compared to the reference ligand. These three compounds underwent subsequent MD simulations, confirming the stability of their interactions. These findings suggested aspergoterpenin A, engyodontiumone I, (+)-1-hydroxyboivinianic acid, and methyl(<i>S</i>)-3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl) benzoate as possible new Pin1 inhibitors for further in vitro against prostate and esophageal cancer cells.</p>","PeriodicalId":19111,"journal":{"name":"Mycological Progress","volume":"243 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138529450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}