Morphologia最新文献_第10页

Thyroid papillary carcinoma and hashimoto's autoimmune thyroiditis in patients operated on thyroid diseases in the precarpathian endemic goiter region. 不稳定山区甲状腺疾病手术患者的甲状腺乳头状癌和桥本自身免疫性甲状腺炎。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.22-25

V. Vovk, U. Omelyash

引用次数: 1

Morphological characteristics of the visual cortex in experimental diabetes mellitus. 实验性糖尿病患者视觉皮层的形态学特征。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.170-175

M. Shchur, O. Zhurakivska

引用次数: 0

Histological and immunohistochemical features of the ovarian malignant tumors with different histogenesis. 不同组织发生方式卵巢恶性肿瘤的组织学和免疫组织化学特征。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.120-125

O. Savchenko

引用次数: 0

Morphometric studies of periodontal structures during opioid exposure at the end of six and eight weeks. 阿片类药物暴露6周和8周后牙周结构的形态计量学研究。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.133-137

V. Fik, I. Chelpanova, E. V. Paltоv

引用次数: 0

Anatomic variability of the intercostal neurovascular bundle in human fetuses. 人胎儿肋间神经血管束的解剖学变异性。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.86-92

I. I. Okrim

引用次数: 1

Immunohistochemical features of actinic keratosis. 光化性角化病的免疫组织化学特征。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.7-21

O. O. Oshivalova, L. D. Kaluzhna, I. Shponka, O. Poslavska

{"title":"Immunohistochemical features of actinic keratosis.","authors":"O. O. Oshivalova, L. D. Kaluzhna, I. Shponka, O. Poslavska","doi":"10.26641/1997-9665.2019.3.7-21","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.7-21","url":null,"abstract":"Background. Skin damage by type of actinic keratosis (AK) and squamous cell carcinoma in situ (SCCis) are considered to be precursors to cSCC. A common theory about the gradual transition from normal skin to AK and cSCC. Some scientists believe that AK is the same cancer as cSCC. Objective. To investigate the complex of histological, immunohistochemical characteristics of observations of areas of AK, SCCis and cSCC with the purpose of further improvement of preventive measures. Methods. Bioassays of 20 (50%) patients with AK were used, 10 (25%) were SCCis, and 10 (25%) were CCSCs. The levels of epidermal dysplasia (KIN) have been determined. Light microscopy was performed with a Zeiss Primo Star light microscope using × 10, × 20, × 40 lenses, and a morphometric examination was performed using a Zeiss Primo Star microscope camera - Axiocam ERC 5s with ZEN 2 blue edition licensed software. Statistical processing of the material was performed using Microsoft Office Exel software. Results. When comparing the expression levels of the investigated markers in the AK foci, the \"cancer field\" and the SCC, a significant difference occurred only in the expression level of pcna (p = 0.014 and p = 0.011). With the increase in the level of dysplasia of the epidermis there is a tendency to increase the level of bcl-2 (R2 = 0.815), p53 (R2 = 0.744) vegf mean (R2 = 0.680). Trends in increasing pcna and vegf levels against the background of decreasing levels of bcl-2, p53, and p27 in the SCC zone (R2 = 1.0). Conclusion. The study confirms the scientific opinion about the closeness of immunohistochemical changes in the focus of AK and cSCC.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91169646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnosis of pathomorphological changes in the lungs of pregnant children in certain components of the metabolic syndrome of the mother. 鉴别诊断在某些成分代谢综合征的孕妇的肺病理形态学变化的母亲。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.115-119

O. M. Rudiak

引用次数: 0

Features of the expression of prognostic markers p16, Her2 / new and changes in the corresponding genes in individual phenotypes of cancers of unknown primary origin. 预后标志物p16、Her2 / new的表达特征及相应基因在未知原发癌个体表型中的变化

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.99-106

О. Poslavska, I. Shponka

{"title":"Features of the expression of prognostic markers p16, Her2 / new and changes in the corresponding genes in individual phenotypes of cancers of unknown primary origin.","authors":"О. Poslavska, I. Shponka","doi":"10.26641/1997-9665.2019.3.99-106","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.99-106","url":null,"abstract":"Background. Approximately 2/3 of cancers of unknown primary origin (CUP) are adenocarcinomas with mucin production, the formation of gland-like structures and immunohistochemistry results that can determine the histological subtype, but cannot determine the exact primary place of origin. The remaining 1/3 of CUP is a mixture of non-adenocarcinomas, including squamous cell carcinomas, neuroendocrine carcinomas, small-cell and large-cell undifferentiated carcinomas. Objective. In such cases, molecular profile identification and gene sequencing may be a promising approach to the classification and direct treatment of CUP. Methods. A retrospective analysis of biopsy or postoperative material of 61 patients (34 women and 27 men) aged 26 to 74 years (mean 53.4 ± 11.42; median 52) with an initial diagnosis of CUP was performed. Immunohistochemical studies were carried out according to the protocols of TermoScientific (USA) with antibodies to p16INK4a and HER2/neu. Fluorescence in situ hybridization was performed according to the protocol of ZytoVision GmbH (Germany). Changes in the ERBB2 and CDKN2A genes were evaluated for gene amplification and deletion of the 9p21 locus, respectively, with double-labeled DNA probes. Results. Of the 61 studied cases of CUP, p16 expression was positive in 31 cases (51%), the basis for which was 9 homozygous and 19 heterozygous 9p21 deletions, which were found in all but one of the studied CUP phenotypes. HER2 / neu expression was positive (2 + / 3 +) in 15 of 61 (25%) CUP, but only in 9 of them had actual amplification of the ERBB2 gene on FISH in 5 phenotypes. Conclusion . The reduced number of phenotypes with amplification of the ERBB2 gene makes it more specific for the differential diagnosis of CUP, compared with the deletion of 9p21 (p16 / CDKN2A), which is likely to be universal in acquiring an aggressive course of carcinomas of various localizations.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84383117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of morphological parameters of the thyroid gland in hypertensive SHR rats upon administration of propylthiouracil. 丙硫脲嘧啶对高血压SHR大鼠甲状腺形态学参数的影响。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.93-98

K. Pobelensky, N. V. Kolot, E. Protsenko, V. Padalko, G. Bozhok, E. Legach, О. N. Pobelensky

引用次数: 3

Morphological rearrangements of the rat’s adrenal cortex under conditions of prolonged exposure to heavy metal salts and non-hormonal correction. 长期暴露于重金属盐和非激素校正条件下大鼠肾上腺皮质的形态重排。

Morphologia Pub Date : 2019-09-27 DOI: 10.26641/1997-9665.2019.3.26-31

N. Hryntsova, A. M. Romanіyk, V. Bumeister

引用次数: 2