Nephrology Dialysis Transplantation最新文献

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Music-based interventions in mild cognitive impairment and kidney disease: a scoping review on behalf of CONNECT (Cognitive decline in Nephro-Neurology European Cooperative Target) action. 基于音乐的轻度认知障碍和肾脏疾病干预:代表CONNECT行动(肾神经病学欧洲合作目标的认知衰退)的范围审查。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf041
Filippo Giordano, Stefania Rotella, Giovambattista Capasso, Marco Fiorentino, Loreto Gesualdo
{"title":"Music-based interventions in mild cognitive impairment and kidney disease: a scoping review on behalf of CONNECT (Cognitive decline in Nephro-Neurology European Cooperative Target) action.","authors":"Filippo Giordano, Stefania Rotella, Giovambattista Capasso, Marco Fiorentino, Loreto Gesualdo","doi":"10.1093/ndt/gfaf041","DOIUrl":"10.1093/ndt/gfaf041","url":null,"abstract":"<p><p>Music-based interventions (MBIs) have shown promise in enhancing cognitive and behavioural functions in patients with mild cognitive impairment (MCI). This review aims to synthesize current knowledge on the clinical application of MBIs in MCI and explore their potential use in patients with chronic kidney disease (CKD). A systematic search was conducted in the PubMed, PsycInfo, Cochrane Library and Scopus databases for studies published between January 2013 and October 2023. The search focused on MBIs applied to MCI and CKD patients. We collected data on study design, type of MBIs administered and main clinical outcomes. Sixteen studies were included in this review, ten of which were randomized controlled trials. MBIs ranged from passive music listening (four studies) to active participation in music-making (vocal or singing activities, playing instruments and improvisation, music interventions associated with physical activity, musical stimulation). While no studies specifically focused on CKD patients, cognitive improvements were generally more significant with active interventions, whereas behavioural benefits were more associated with receptive approaches. MBIs showed potential benefits in improving cognitive and depressive symptoms associated with MCI. Given the high prevalence of MCI in CKD patients, future studies should investigate the application of MBIs in this population.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1483-1497"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of acute kidney injury in relapsed and refractory multiple myeloma treated with teclistamab versus CAR-T cells. 特司他单抗与CAR - t细胞治疗复发和难治性多发性骨髓瘤急性肾损伤的发生率
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf004
Mariam Charkviani, Maria Jose Vargas Brochero, Arjunmohan Mohan, Lisa E Vaughan, Tyler B Sandahl, Andre De Menezes Silva Corraes, Yi Lin, Nelson Leung, Sandra M Herrmann
{"title":"Incidence of acute kidney injury in relapsed and refractory multiple myeloma treated with teclistamab versus CAR-T cells.","authors":"Mariam Charkviani, Maria Jose Vargas Brochero, Arjunmohan Mohan, Lisa E Vaughan, Tyler B Sandahl, Andre De Menezes Silva Corraes, Yi Lin, Nelson Leung, Sandra M Herrmann","doi":"10.1093/ndt/gfaf004","DOIUrl":"10.1093/ndt/gfaf004","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Teclistamab, a novel bispecific monoclonal antibody targeting CD3 and B cell maturation antigen (BCMA), and chimeric antigen receptor T cell (CAR-T) therapy are promising options for treating relapsed/refractory multiple myeloma (MM). However, the rates of acute kidney injury (AKI) associated with teclistamab remain inadequately characterized. This study aims to compare the incidence, severity, and outcomes of AKI between patients receiving teclistamab and CAR-T therapy.</p><p><strong>Methods: </strong>This was a retrospective study involving 64 patients with relapsed/refractory MM treated with either teclistamab or CAR-T therapy. All patients had previously received at least four lines of chemotherapy before being treated with either teclistamab or CAR-T. The primary outcome was the incidence of AKI, and secondary outcomes included AKI severity, kidney recovery rates, and mortality. Kaplan-Meier estimates for AKI-free survival were calculated, and hazard ratios (HRs) for AKI risk were determined using Cox proportional hazards models.</p><p><strong>Results: </strong>Sixty-four patients met inclusion criteria for this study (30 received CAR-T and 34 received teclistamab therapy). Among these patients, 14 AKI events occurred in total (22%), with 10 events (29%) in the teclistamab group and four events (13%) in the CAR-T group. AKI-free survival estimates at 180 days after treatment initiation were 68% [95% confidence interval (CI): 53%-87%] for teclistamab patients and 90% (95% CI: 79%-100%) for CAR-T patients. While patients receiving teclistamab were found to have an increased risk of an AKI event compared to those receiving CAR-T therapy, the results were not statistically significant [HR (95% CI): 3.38 (0.93-12.31), P = .065].</p><p><strong>Conclusions: </strong>This study suggests that patients treated with teclistamab may experience a higher incidence of AKI compared to those receiving CAR-T therapy. However, further research is required to determine whether this increased risk is attributable to disease progression or teclistamab itself. These results highlight the need for close kidney function monitoring in patients receiving teclistamab.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1512-1521"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IdeZ protease does not prevent convertase stabilization by C3 nephritic factors in C3 glomerulopathy. 在C3肾小球病变中,IdeZ蛋白酶不能阻止C3肾病因子对转化酶的稳定作用。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf065
Kes H Stevens, Laura M Baas, Nicole C A J van de Kar, Lambertus P W J van den Heuvel, Marloes A H M Michels
{"title":"IdeZ protease does not prevent convertase stabilization by C3 nephritic factors in C3 glomerulopathy.","authors":"Kes H Stevens, Laura M Baas, Nicole C A J van de Kar, Lambertus P W J van den Heuvel, Marloes A H M Michels","doi":"10.1093/ndt/gfaf065","DOIUrl":"10.1093/ndt/gfaf065","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1628-1631"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney aging and chronic kidney disease-another perspective. 肾脏老化和慢性肾脏疾病-另一种观点。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf087
Richard J Glassock, Andrew D Rule, Aleksandar Denic, Pierre Delanaye
{"title":"Kidney aging and chronic kidney disease-another perspective.","authors":"Richard J Glassock, Andrew D Rule, Aleksandar Denic, Pierre Delanaye","doi":"10.1093/ndt/gfaf087","DOIUrl":"10.1093/ndt/gfaf087","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1455-1457"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The autonomic nervous system and inflammation in chronic kidney disease. 慢性肾脏疾病的自主神经系统与炎症。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf020
Carmine Zoccali, Francesca Mallamaci, Mehmet Kanbay, Katherine R Tuttle, Peter Kotanko, Raffaele De Caterina, Guido Grassi, Giuseppe Mancia
{"title":"The autonomic nervous system and inflammation in chronic kidney disease.","authors":"Carmine Zoccali, Francesca Mallamaci, Mehmet Kanbay, Katherine R Tuttle, Peter Kotanko, Raffaele De Caterina, Guido Grassi, Giuseppe Mancia","doi":"10.1093/ndt/gfaf020","DOIUrl":"10.1093/ndt/gfaf020","url":null,"abstract":"<p><p>The autonomic nervous system plays a crucial role in regulating physiological processes and maintaining homeostasis through its two branches: the sympathetic nervous system and the parasympathetic nervous system. Dysregulation of the autonomic system, characterized by increased sympathetic activity and reduced parasympathetic tone, is a common feature in chronic kidney disease (CKD) and cardiovascular disease. This imbalance contributes to a pro-inflammatory state, exacerbating disease progression and increasing the risk for cardiovascular events. The sympathetic system promotes inflammation by releasing catecholamines, which activate adrenergic receptors on immune cells. The parasympathetic system exerts anti-inflammatory effects via the cholinergic anti-inflammatory pathway mediated by the vagus nerve. Targeting the autonomic system to restore the balance between the sympathetic and the parasympathetic components offers promising approaches to reduce inflammation and improve outcomes in CKD and cardiovascular disease. β-Blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers are pharmacological agents that modulate sympathetic activity and have shown anti-inflammatory effects. Lifestyle interventions, such as a healthy diet, physical exercise, mindfulness, and meditation, enhance parasympathetic activity and improve autonomic function. Vagus nerve stimulation has emerged as a promising therapy, demonstrating significant potential in reducing inflammation and improving clinical outcomes in various conditions, including CKD, myocardial infarction, and stroke. Despite mixed results in heart failure trials, vagal nerve stimulation has consistently improved quality-of-life measures. Understanding the mechanisms underlying autonomic system regulation of inflammation can inform the development of novel therapeutic strategies to restore autonomic balance and improve patient outcomes in CKD and cardiovascular disease.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1470-1482"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry. 从儿童期到成年期肾移植和再移植的可及性:ERA Registry的长期数据。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf025
Evgenia Preka, Marjolein Bonthuis, Stephen D Marks, Anneke Kramer, Aiko P J de Vries, Søren S Sørensen, Sevcan A Bakkaloğlu, Claus Bistrup, Timo Jahnukainen, Olga L Rodriguez Arévalo, Lukas Buchwinkler, Mårten Segelmark, J Emilio Sanchez, Miha Arnol, Flor A Ordóñez-Álvarez, Francisco de la Cerda-Ojeda, Lucy A Plumb, Shona Methven, Runolfur Palsson, Torbjörn Lundgren, Héctor Ríos, Alberto Ortiz, Vianda S Stel, Jerome Harambat, Kitty J Jager
{"title":"Access to kidney transplantation and re-transplantation from childhood to adulthood: long-term data from the ERA Registry.","authors":"Evgenia Preka, Marjolein Bonthuis, Stephen D Marks, Anneke Kramer, Aiko P J de Vries, Søren S Sørensen, Sevcan A Bakkaloğlu, Claus Bistrup, Timo Jahnukainen, Olga L Rodriguez Arévalo, Lukas Buchwinkler, Mårten Segelmark, J Emilio Sanchez, Miha Arnol, Flor A Ordóñez-Álvarez, Francisco de la Cerda-Ojeda, Lucy A Plumb, Shona Methven, Runolfur Palsson, Torbjörn Lundgren, Héctor Ríos, Alberto Ortiz, Vianda S Stel, Jerome Harambat, Kitty J Jager","doi":"10.1093/ndt/gfaf025","DOIUrl":"10.1093/ndt/gfaf025","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Knowledge regarding access to first kidney transplantation (KT) and subsequent KT in patients commencing kidney replacement therapy (KRT) in childhood is limited.</p><p><strong>Methods: </strong>Using European Renal Association (ERA) Registry data, we investigated European patients who started KRT below 20 years of age between 1978 and 2019. Access and determinants to first, second, and third KT were assessed using multivariable Cox regression.</p><p><strong>Results: </strong>Totals of 12 623, 4077, and 1186 patients were included while awaiting first, second, and third KT, at median ages of 13.8 (IQR: 7.5-17.4), 20.9 (IQR: 16.5-26.1), and 26.6 (IQR: 20.3-32.8) years, respectively. During the study period, overall access was 87.8%, 72.7%, and 60.5% for first, second, and third KT, respectively, and median time to each KT was 0.9 (IQR: 0.2-2.1), 1.9 (0.6-4.5), and 2.6 (IQR: 1.0-5.3) years. Younger age at KRT initiation (aHR 0-4 vs. 10-14 years: 0.54; 95%CI: 0.51-0.57) and female sex (HR: 0.94; 95%CI: 0.90-0.98) were associated with lower access to first KT. KT candidates between 15 and 19 years had lower access to first and second KT (aHR: 0.69; 95%CI: 0.66-0.73, and aHR: 0.70; 95%CI: 0.61-0.81) compared to 10-14 year-olds. Compared to CAKUT, glomerulonephritis patients had lower access to KT (aHR: 0.75; 95%CI: 0.71-0.80 for first, aHR: 0.89; 95%CI: 0.81-0.98 for second, and aHR: 0.80; 95%CI: 0.66-0.97 for third KT). Similarly, patients with primary renal diseases with high risk of recurrence, had lower chances of receiving a first and second KT (aHR: 0.80; 95%CI: 0.76-0.85 for first, aHR: 0.86; 95%CI: 0.78-0.95 for second KT). Access to re-transplantation was also higher with previous pre-emptive KT and previous graft survival exceeding 5 years.</p><p><strong>Conclusion: </strong>Our study highlights KT access disparities particularly for females, the youngest recipients, high-risk age (15-19 years), and diseases with recurrence risk. Notably, pre-emptive transplants and enduring previous grafts offer advantages regarding re-transplantation.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1580-1589"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nephrology meets AI-environmental perspective. 肾脏病学满足人工智能-环境视角。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf027
Ivo Laranjinha, Anna Peired, Susi Knoeller, Ana Carina Ferreira, Sonja Gracin, Gulay Demirtas, Maryvonne Hourmant
{"title":"Nephrology meets AI-environmental perspective.","authors":"Ivo Laranjinha, Anna Peired, Susi Knoeller, Ana Carina Ferreira, Sonja Gracin, Gulay Demirtas, Maryvonne Hourmant","doi":"10.1093/ndt/gfaf027","DOIUrl":"10.1093/ndt/gfaf027","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1449-1451"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maintaining kidney health in aging societies: a JSN and ERA call to action. 在老龄化社会中维持肾脏健康:JSN和ERA呼吁采取行动。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf068
Alberto Ortiz, Anneke Kramer, Ivan Rychlík, Masaomi Nangaku, Motoko Yanagita, Kitty J Jager, Fergus J Caskey, Vianda S Stel, Naoki Kashihara, Takahiro Kuragano, Yusuke Suzuki, Yoshiaki Takemoto, Hideki Yokoi, Giuseppe Palladino, Danilo Fliser, Roser Torra, Christoph Wanner
{"title":"Maintaining kidney health in aging societies: a JSN and ERA call to action.","authors":"Alberto Ortiz, Anneke Kramer, Ivan Rychlík, Masaomi Nangaku, Motoko Yanagita, Kitty J Jager, Fergus J Caskey, Vianda S Stel, Naoki Kashihara, Takahiro Kuragano, Yusuke Suzuki, Yoshiaki Takemoto, Hideki Yokoi, Giuseppe Palladino, Danilo Fliser, Roser Torra, Christoph Wanner","doi":"10.1093/ndt/gfaf068","DOIUrl":"10.1093/ndt/gfaf068","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular-kidney-metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1498-1511"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red blood cell casts on kidney biopsy and progression of IgA nephropathy. 肾活检的红细胞铸型与IgA肾病的进展。
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf023
Yu-Xuan Yao, Chen Tang, Su-Fang Shi, Pei Chen, Xu-Jie Zhou, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang
{"title":"Red blood cell casts on kidney biopsy and progression of IgA nephropathy.","authors":"Yu-Xuan Yao, Chen Tang, Su-Fang Shi, Pei Chen, Xu-Jie Zhou, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang","doi":"10.1093/ndt/gfaf023","DOIUrl":"10.1093/ndt/gfaf023","url":null,"abstract":"<p><strong>Background: </strong>Renal red blood cell casts (RBCC) are common in IgA nephropathy (IgAN), but their role in kidney disease progression of patients with IgAN remains unclear.</p><p><strong>Methods: </strong>In total, 1425 patients in a Peking University First Hospital IgAN (PKU-IgAN) cohort and 279 patients in the TESTING trial were enrolled to test the association between RBCC and kidney outcome. RBCC was defined as positive (+) when at least one cast was identified within the renal tubules by light microscopy. Kidney endpoint was the composite of the first occurrence of a sustained 30% decrease in estimated glomerular filtration rate or end stage kidney disease or death due to kidney disease. Cox regression analysis was used.</p><p><strong>Results: </strong>In PKU-IgAN, 529 patients (37%) had RBCC; in the TESTING trial, 78 patients (28%) had RBCC. Patients with RBCC had more crescentic lesions, and less segmental sclerosis compared with patients without RBCC. In PKU-IgAN, after a median follow-up of 54 months, 119 patients (22%) with RBCC and 260 patients (29%) without RBCC reached the composite kidney endpoint (P = .009). In multivariable analysis, RBCC was independently associated with composite kidney endpoint [hazard ratios (HR) 0.79; 95% confidence interval (CI) 0.63-0.99; P = .038]. RBCC and immunosuppressive therapy (IST) had an interaction (P = .001). RBCC was independently associated with composite kidney endpoint in patients who received IST (HR 0.56; 95%CI 0.40-0.77; P < .001). In the TESTING trial, after a median follow-up of 57 months, 26 patients (33%) with RBCC, and 96 patients (48%) without RBCC reached the composite kidney endpoint (P = .041). In univariate analysis, RBCC was associated with composite kidney endpoint (HR 0.64; 95%CI 0.42-0.99; P = .047).</p><p><strong>Conclusion: </strong>Renal RBCC was frequent in IgAN and was associated with a higher incidence of acute active lesions and better renal prognosis, especially in those who received IST, warranting particular attention.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"1570-1579"},"PeriodicalIF":5.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint (CONFIDENCE) trial: baseline clinical characteristics. 使用UACR终点(CONFIDENCE)试验,非纳烯酮和恩格列净联合治疗慢性肾病和2型糖尿病患者的疗效:基线临床特征
IF 5.6 2区 医学
Nephrology Dialysis Transplantation Pub Date : 2025-08-01 DOI: 10.1093/ndt/gfaf022
Rajiv Agarwal, Jennifer B Green, Hiddo J L Heerspink, Johannes F E Mann, Janet B McGill, Amy K Mottl, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Meike Brinker, Robert Edfors, Na Li, Markus F Scheerer, Charlie Scott, Masaomi Nangaku
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