Molecular omics最新文献

Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer.

IF 3 4区生物学

Molecular omics Pub Date : 2024-12-12 DOI: 10.1039/d4mo00147h

Irene A George, Janani Sambath, R E Dhawale, Manisha Singh, Vinita Trivedi, R Venkataramanan, Richa Chauhan, Prashant Kumar

{"title":"Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer.","authors":"Irene A George, Janani Sambath, R E Dhawale, Manisha Singh, Vinita Trivedi, R Venkataramanan, Richa Chauhan, Prashant Kumar","doi":"10.1039/d4mo00147h","DOIUrl":"https://doi.org/10.1039/d4mo00147h","url":null,"abstract":"Cisplatin-based concurrent chemoradiotherapy (CCRT) is the standard treatment for cervical patients with locally advanced disease. Despite the improved survival rates and prognosis observed in patients undergoing CCRT, over 30-40% do not achieve complete response and are at risk of locoregional recurrence. Targeting crucial molecules that confer resistance may improve the clinical outcomes of the treatment resistant patient cohort. Herein, we employed a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based phosphoproteomic approach to identify the altered phosphophorylation events, activated kinases and dysregulated pathways involved in treatment resistance. We quantified 2531 unique phosphopeptides mapping to 1099 proteins of which 74 proteins were differentially phosphorylated between the cohorts. Pathway analysis revealed dysregulation of the DNA repair pathway and the proteins involved in DNA repair in the non-responder cohort. Additionally, we identified kinase signature associated with CCRT resistance. Kinases such as CSNK2A1, PRKDC, PLK-1, NEK2, ATM and CDK1 are predicted to be activated in non-responders. In particular, we showed that CSNK2A1 is involved in oncogenesis of cervical cancer and pharmacological inhibition led to reduced cell proliferation, migration and colony formation. Moreover, the combination of the CSNK2A1 inhibitor, silmitasertib with cisplatin demonstrated synergism (combination index < 1) and yielded a beneficial reduction in dosage. The dose reduced combination potentially reduced the proliferative, migratory and colony formation ability in vitro. Our findings highlight the potential of phosphoproteomics to identify clinically significant targets and pathways implicated in CCRT resistance. Our study also indicates that combination therapy could serve as an effective treatment strategy to improve the efficacy of patients undergoing CCRT.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competing technologies: determining the geographical origin of strawberries (Fragaria × ananassa) using laboratory based near-infrared spectroscopy compared to a simple portable device.

IF 3 4区生物学

Molecular omics Pub Date : 2024-12-06 DOI: 10.1039/d4mo00161c

Johannes Brockelt, Felix Schmauder, Kim Brettschneider, Marina Creydt, Stephan Seifert, Markus Fischer

{"title":"Competing technologies: determining the geographical origin of strawberries (Fragaria × ananassa) using laboratory based near-infrared spectroscopy compared to a simple portable device.","authors":"Johannes Brockelt, Felix Schmauder, Kim Brettschneider, Marina Creydt, Stephan Seifert, Markus Fischer","doi":"10.1039/d4mo00161c","DOIUrl":"https://doi.org/10.1039/d4mo00161c","url":null,"abstract":"The application and development of fast and simple screening methods for the authentication of foods has increased continuously in recent years. A widely used analytical technique is Fourier transform near-infrared spectroscopy (FT-NIR). Despite the simple application of FT-NIR analysis, the analyses are usually carried out on benchtop devices in the laboratory. However small, inexpensive and mobile NIR devices could be used on-site. Despite the simple use of FT-NIR analysis, the examinations are usually carried out on a stationary benchtop device in a laboratory. However, in order to be able to perform the application directly on site, the application of small, cost-effective and mobile NIR devices for food analysis is crucial. In this study, both, a benchtop NIR instrument and a handheld NIR device with a lower resolution and analyzed wavenumber range were applied for the differentiation of strawberries from different geographical origins. Distinguishing German and non-German strawberries using linear discriminant analysis (LDA) yielded an accuracy of 91.9% and 84.0% using the benchtop and the handheld devices, respectively. Relevant variables could be assigned to lipids, carbohydrates and proteins. Overall, our study demonstrated for the first time that analyzing the geographical origin of strawberries using NIR spectroscopy is also possible by means of a handheld device.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the mechanism of Qifu Yin in ameliorating memory disorders through pseudo-targeted lipidomics.

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-29 DOI: 10.1039/d4mo00141a

Fuxia Zhao, Jing Wang, Minjun Wu, Jiaqi Fan, Shiqi Liu, Fanying Deng, Shihui Wang, Yangang Cheng, Yan Wang

{"title":"Investigating the mechanism of Qifu Yin in ameliorating memory disorders through pseudo-targeted lipidomics.","authors":"Fuxia Zhao, Jing Wang, Minjun Wu, Jiaqi Fan, Shiqi Liu, Fanying Deng, Shihui Wang, Yangang Cheng, Yan Wang","doi":"10.1039/d4mo00141a","DOIUrl":"10.1039/d4mo00141a","url":null,"abstract":"Memory disorder (MD) is a neurodegenerative disease with an increasing incidence rate that adversely affects the quality of life of patients. Qifu Yin (QFY), a classic traditional Chinese medicine formula used for treating dementia, is known for its neuroprotective properties, although its mechanism of action requires further exploration. In this study, D-galactose combined with aluminum chloride was used to establish an MD rat model, and behavior, histopathology, and related indicators were used to evaluate the pharmacodynamics of the formula in the rats. Furthermore, brain tissues were examined using pseudo-targeted lipidomics analysis, and candidate ion pairs were screened through mass spectrometry using UPLC-Q/Orbitrap HRMS. An sMRM detection method for candidate ion pairs was developed using UHPLC-Q-TRAP-MS/MS and validated. This approach was applied to the lipidomics study of QFY in improving MD. Differential metabolites screened through pseudo-targeted lipidomics were analyzed by employing network pharmacology, and the pathway was verified to explore their mechanism of action. Results demonstrated that QFY could improve memory impairment. A total of 1052 ion pairs were constructed in the pseudo-targeted lipidomics analysis, identifying 33 differential metabolites and 5 metabolic pathways. Furthermore, 31 differential metabolites in MD rats treated with QFY were significantly reversed. Immunohistochemical analysis showed that QFY could inhibit the expression of inflammatory factors. Network pharmacological analysis showed that the calcium signaling pathway was the main signaling pathway, and QFY could significantly reverse the expression levels of mRNA and protein. Thus, QFY can improve memory impairment in rats, which may be related to the regulation of oxidative stress, lipid metabolism disorder and the calcium signaling pathway.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic and metabolic profiling reveals molecular phenotype associated with chemotrophic growth of Rubrivivax benzoatilyticus JA2 on L-tryptophan. 蛋白质组和代谢剖析揭示了 Rubrivivax benzoatilyticus JA2 在 L-色氨酸上趋化生长的分子表型。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-28 DOI: 10.1039/d4mo00170b

Shabbir Ahmad, Mujahid Mohammed, Lakshmi Prasuna Mekala, Sasikala Chintalapati, Ramana Chintalapati

{"title":"Proteomic and metabolic profiling reveals molecular phenotype associated with chemotrophic growth of Rubrivivax benzoatilyticus JA2 on L-tryptophan.","authors":"Shabbir Ahmad, Mujahid Mohammed, Lakshmi Prasuna Mekala, Sasikala Chintalapati, Ramana Chintalapati","doi":"10.1039/d4mo00170b","DOIUrl":"10.1039/d4mo00170b","url":null,"abstract":"Rubrivivax benzoatilyticus strain JA2 is an anoxygenic phototrophic bacterium, able to grow under different growth modes. Particularly under chemotrophic conditions, it produces novel Trp-melanin, anthocyanin-like, and pyomelanin pigments. However, the underlying molecular adaptations of strain JA2 that lead to the formation of novel metabolites under chemotrophic conditions remain unexplored. The present study used iTRAQ-based global proteomic and metabolite profiling to unravel the biochemical processes operating under the L-tryptophan-fed chemotrophic state. Exometabolite profiling of L-tryptophan fed chemotrophic cultures revealed production of diverse indolic metabolites, many of which are hydroxyindole derivatives, along with unique pigmented metabolites. Proteomic profiling revealed a global shift in the proteome and detected 2411 proteins, corresponding to 61.8% proteins expressed. Proteins related to signalling, transcription-coupled translation, stress, membrane transport, and metabolism were highly differentially regulated. Extensive rewiring of amino acid, fatty acid, lipid, and energy metabolism was observed under L-tyrptophan fed chemotrophic conditions. Moreover, energy conservation and cell protection strategies such as efflux pumps involved in the efflux of aromatic compounds were activated. The study demonstrated a correlation between some of the detected indole derivatives and the up-regulation of proteins associated with L-tryptophan catabolism, indicating a possible role of aromatic mono/dioxygenases in the formation of hydroxyindole derivatives and pigments under chemotrophic conditions. The overall study revealed metabolic flexibility in utilizing aromatic compounds and molecular adaptations of strain JA2 under the chemotrophic state.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GRL-PUL: predicting microbe-drug association based on graph representation learning and positive unlabeled learning. GRL-PUL：基于图表示学习和正向无标记学习预测微生物与药物的关联。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-14 DOI: 10.1039/d4mo00117f

Jinqing Liang, Yuping Sun, Jie Ling

{"title":"GRL-PUL: predicting microbe-drug association based on graph representation learning and positive unlabeled learning.","authors":"Jinqing Liang, Yuping Sun, Jie Ling","doi":"10.1039/d4mo00117f","DOIUrl":"10.1039/d4mo00117f","url":null,"abstract":"Extensive research has confirmed the widespread presence of microorganisms in the human body and their crucial impact on human health, with drugs being an effective method of regulation. Hence it is essential to identify potential microbe-drug associations (MDAs). Owing to the limitations of wet experiments, such as high costs and long durations, computational methods for binary classification tasks have become valuable alternatives for traditional experimental approaches. Since validated negative MDAs are absent in existing datasets, most methods randomly sample negatives from unlabeled data, which evidently leads to false negative issues. In this manuscript, we propose a novel model based on graph representation learning and positive-unlabeled learning (GRL-PUL), to infer potential MDAs. Firstly, we screen reliable negative samples by applying weighted matrix factorization and the PU-bagging strategy on the known microbe-drug bipartite network. Then, we combine muti-model attributes and constructed a microbe-drug heterogeneous network. After that, graph attention auto-encoder module, an encoder combining graph convolutional networks and graph attention networks, is introduced to extract informative embeddings based on the microbe-drug heterogeneous network. Lastly, we adopt a modified random forest as the final classifier. Comparison experiments with five baseline models on three benchmark datasets show that our model surpasses other methods in terms of the AUC, AUPR, ACC, F1-score and MCC. Moreover, several case studies show that GRL-PUL could capably predict latent MDAs. Notably, we further verify the effectiveness of a reliable negative sample selection module by migrating it to other state-of-the-art models, and the experimental results demonstrate its ability to substantially improve their prediction performance.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MobiChIP: a compatible library construction method of single-cell ChIP-seq based droplets. MobiChIP：基于液滴的单细胞 ChIP-seq 兼容文库构建方法。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-08 DOI: 10.1039/d4mo00111g

Xianhong Yu, Guantao Zheng, Liting Xu, Weiyi Guo, Guodong Chen, Yiling Zhu, Tingting Li, Mingming Rao, Linyan Wang, Rong Cong, Hao Pei

引用次数: 0

Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells. 持续低氧诱导人主动脉内皮细胞的 HIF-1α 转录反应，而非间歇性低氧。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-08 DOI: 10.1039/d4mo00142g

Rengul Cetin-Atalay, Angelo Y Meliton, Yufeng Tian, Kaitlyn A Sun, Parker S Woods, Kun Woo D Shin, Takugo Cho, Alex Gileles-Hillel, Robert B Hamanaka, Gökhan M Mutlu

{"title":"Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells.","authors":"Rengul Cetin-Atalay, Angelo Y Meliton, Yufeng Tian, Kaitlyn A Sun, Parker S Woods, Kun Woo D Shin, Takugo Cho, Alex Gileles-Hillel, Robert B Hamanaka, Gökhan M Mutlu","doi":"10.1039/d4mo00142g","DOIUrl":"10.1039/d4mo00142g","url":null,"abstract":"Obstructive sleep apnea (OSA) is characterized by intermittent hypoxic environments at the cellular level and is an independent risk factor for the development of cardiovascular disease. Endothelial cell (EC) dysfunction precedes the development of cardiovascular disease; however, the mechanisms by which ECs respond to these intermittent hypoxic events are poorly understood. To better understand EC responses to hypoxia, we examined the effects of sustained hypoxia (SH) and intermittent hypoxia (IH) on the activation of HIF-1α in ECs. While SH stabilized HIF-1α and led to its nuclear localization, IH did not activate HIF-1α and the expression of its target genes. Using RNA-sequencing, we evaluated transcriptional responses of ECs to hypoxia. SH induced the expression of HIF-1α and hypoxia response genes, while IH affected cell-cycle regulation genes. A cytoscape protein-protein interaction network for EC response to hypoxia was created with differentially expressed genes. The network comprises cell-cycle regulation, inflammatory signaling via NF-κB and response to VEGF stimulus subnetworks on which SH and IH had distinct activities. As OSA is associated with elevated catecholamines, we investigated the effect of epinephrine on the EC response to SH and IH. Transcriptomic responses under IH and epinephrine revealed protein-protein interaction networks emphasizing distinct subnetworks, including cytokine-mediated TNFα signaling via NF-κB, Wnt/LRP/DKK signaling and cell cycle regulation. This study reveals differential transcriptomic responses under SH and IH characterised by HIF-1α transcriptional response induced only by SH, but not by IH. The study also features the potential molecular events that may occur at the vascular level in OSA.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of sex, age, ethnicity/race, and body mass index on the cerumen volatilome using two data analysis approaches: binary and semiquantitative† 采用二元和半定量两种数据分析方法，分析性别、年龄、民族/种族和体重指数对耵聍挥发的影响。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-04 DOI: 10.1039/D4MO00071D

João Marcos G. Barbosa, Lurian Caetano David, Camilla Gabriela de Oliveira, Anselmo Elcana de Oliveira and Nelson R. Antoniosi Filho

{"title":"Influence of sex, age, ethnicity/race, and body mass index on the cerumen volatilome using two data analysis approaches: binary and semiquantitative†","authors":"João Marcos G. Barbosa, Lurian Caetano David, Camilla Gabriela de Oliveira, Anselmo Elcana de Oliveira and Nelson R. Antoniosi Filho","doi":"10.1039/D4MO00071D","DOIUrl":"10.1039/D4MO00071D","url":null,"abstract":"Human cerumen analysis is an innovative and non-invasive trend in diagnosing diseases. Recently, new cerumen volatile-based methods using binary (volatile presence/absence) and semiquantitative (volatile intensity) data approaches have shown great potential in detecting biomarkers for cancer, chronic and rare diseases, and xenobiotic exposures. However, to date, the impacts of demographic factors such as body mass index (BMI), sex, age, and ethnicity/race in cerumen data have not been widely described, which can hamper interpretation in biomarker discovery investigations. This study examined the effects of such factors in cerumen, defining the baseline volatile organic metabolites (VOMs) across different physiological groups. Cerumen samples from seventy volunteers were analyzed using headspace/gas chromatography–mass spectrometry (HS/GC–MS) and multivariate statistical analysis using binary and semiquantitative data approaches. In the binary data approach, several VOMs exhibited patterns of high occurrence in some specific demographic groups. However, no pattern of discrimination that could be attributed to demographic factors was observed. In the semiquantitative approach, the relative abundance of cerumen VOMs was more impacted by sex and BMI than age and ethnicity/race. In summary, we describe how cerumen VOM occurrence and abundance are affected by patient phenotype, which can pave the way for more personalized medicine in future cerumen volatile-based methods.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" 10","pages":" 666-677"},"PeriodicalIF":3.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells† 研究从人类诱导多能干细胞分化出的胰腺β样细胞亚群中转录调节因子的主题活动。

IF 3 4区生物学

Molecular omics Pub Date : 2024-11-04 DOI: 10.1039/D4MO00082J

Eric Leclerc, Mikhail Pachkov, Lisa Morisseau, Fumiya Tokito, Cecile Legallais, Rachid Jellali, Masaki Nishikawa, Amar Abderrahmani and Yasuyuki Sakai

{"title":"Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells†","authors":"Eric Leclerc, Mikhail Pachkov, Lisa Morisseau, Fumiya Tokito, Cecile Legallais, Rachid Jellali, Masaki Nishikawa, Amar Abderrahmani and Yasuyuki Sakai","doi":"10.1039/D4MO00082J","DOIUrl":"10.1039/D4MO00082J","url":null,"abstract":"Pancreatic β-cells are composed of different subtypes that play a key role in the control of insulin secretion and thereby control glucose homeostasis. In vitro differentiation of human induced pluripotent stem cells (hiPSCs) into 3D spheroids leads to the generation of β-cell subtypes and thus to the development of islet-like structures. Using this cutting-edge cell model, the aim of the study was to decipher the signaling signature that underlines β-cell subtypes, with a focus on the search for the activity of motifs of important transcription regulators (TRs). The investigation was performed using data from previous single-cell sequencing analysis introduced into the integrated system for motif activity response analysis (ISMARA) of transcription regulators. We extracted the matrix of important TRs activated in the β-cell subpopulation and bi-hormonal-like β-cells. Based on these TRs and their targets, we built specific regulatory networks for main cell subpopulations. Our data confirmed the transcriptomic heterogeneity of the β-cell subtype lineage and suggested a mechanism that could account for the differentiation of β-cell subtypes during pancreas development. We do believe that our findings could be instrumental for understanding the mechanisms that affect the balance of β-cell subtypes, leading to impaired insulin secretion in type 2 diabetes.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" 10","pages":" 654-665"},"PeriodicalIF":3.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipidomics in forensic science: a comprehensive review of applications in drugs, alcohol, latent fingermarks, fire debris, and seafood authentication 法医学中的脂质组学：毒品、酒精、潜伏指痕、火灾残骸和海鲜鉴定中的应用综述。

IF 3 4区生物学

Molecular omics Pub Date : 2024-10-14 DOI: 10.1039/D4MO00124A

Pingyang Liu, Zhanfang Liu, Hong Zhou, Jun Zhu, Zhenwen Sun, Guannan Zhang and Yao Liu

{"title":"Lipidomics in forensic science: a comprehensive review of applications in drugs, alcohol, latent fingermarks, fire debris, and seafood authentication","authors":"Pingyang Liu, Zhanfang Liu, Hong Zhou, Jun Zhu, Zhenwen Sun, Guannan Zhang and Yao Liu","doi":"10.1039/D4MO00124A","DOIUrl":"10.1039/D4MO00124A","url":null,"abstract":"Forensic science, an interdisciplinary field encompassing the collection, examination, and presentation of evidence in legal proceedings, has recently embraced lipidomics as a valuable tool. Lipidomics, a subfield of metabolomics, specializes in the analysis of lipid structures and functions, offering insights into biological processes that can aid forensic investigations. While not a substitute for DNA analysis in personal identification, lipidomics complements this technique by focusing on small biological molecules, with distinct sample requirements. This review comprehensively explores the current applications of lipidomics in forensic science. The review commences with an introduction to the concept and historical background of lipidomics, subsequently delving into its utilization in diverse areas such as drug analysis, ethyl alcohol and substitute assessment, latent fingermark detection, fire debris analysis, and seafood authentication. By showcasing the various biological materials and methods employed, this review underscores the potential of lipidomics as a powerful adjunct in forensic investigations.","PeriodicalId":19065,"journal":{"name":"Molecular omics","volume":" 10","pages":" 618-629"},"PeriodicalIF":3.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0