Archives of Medical Science : AMS最新文献

Overlap between Sjogren’s syndrome and anti-synthetase syndrome: association or coincidence? 干燥综合征和抗合成酶综合征的重叠:关联还是巧合?

Archives of Medical Science : AMS Pub Date : 2022-04-20 DOI: 10.5114/aoms/147430

Gang Wang, N. Zhuo, F. Tian, Zhenhua Wen

引用次数: 0

Application of three-dimensional printing technology for spinal tuberculosis 三维打印技术在脊柱结核中的应用

Archives of Medical Science : AMS Pub Date : 2022-04-20 DOI: 10.5114/aoms/148090

Heng Wang, Wei-jie Dong, Jun Fan, T. Lan, Yuan Li, Kai Tang, Guangxuan Yan, Shibing Qin

引用次数: 1

Grisel syndrome and peripheral arthritis simultaneously occurred in a 7-year-old Chinese boy with Kawasaki disease 7岁川崎病男童同时发生Grisel综合征和周围性关节炎

Archives of Medical Science : AMS Pub Date : 2022-04-20 DOI: 10.5114/aoms/148123

Huang Huang Luo, Guo Zhen Fan, Y. Wu, P. Hu

引用次数: 0

Two complications in patients with systemic lupus erythematosus: lupus cystitis and lupus enteritis 系统性红斑狼疮患者的两种并发症:狼疮膀胱炎和狼疮肠炎

Archives of Medical Science : AMS Pub Date : 2022-04-20 DOI: 10.5114/aoms/146547

Gang Wang, N. Zhuo, F. Tian, Jingyang Li, Zhenhua Wen

引用次数: 5

Ibrutinib attenuated DSS-induced ulcerative colitis, oxidative stress, and the inflammatory cascade by modulating the PI3K/Akt and JNK/NF-κB pathways 伊鲁替尼通过调节PI3K/Akt和JNK/NF-κB通路减轻dss诱导的溃疡性结肠炎、氧化应激和炎症级联反应

Archives of Medical Science : AMS Pub Date : 2022-04-20 DOI: 10.5114/aoms/146792

Liangliang Hao, Lina Alkry, Abdullah Alattar, Muhammad Faheem, Reem Alshaman, F. Shah, Shupeng Li

引用次数: 3

Multiple endocrine neoplasia type 1 with ectopic parathyroid adenoma 多发性内分泌肿瘤1型伴异位甲状旁腺瘤

Archives of Medical Science : AMS Pub Date : 2022-04-14 DOI: 10.5114/aoms/147737

Qiaorui Liu, Liming Wu, Xulei Zheng, Cong Ma, Risu Na, L. Qiu, Zhiwen Liu, Liyan Liao

引用次数: 0

Which patients at risk of cardiovascular disease might benefit the most from inclisiran? Polish experts’ opinion. The compromise between EBM and possibilities in healthcare 哪些有心血管疾病风险的患者可能从inclisiran获益最多?波兰专家的意见。循证医学与医疗保健可能性之间的妥协

Archives of Medical Science : AMS Pub Date : 2022-03-17 DOI: 10.5114/aoms/147435

M. Banach, J. Kaźmierczak, P. Mitkowski, K. Wita, M. Broncel, M. Gąsior, M. Gierlotka, R. Gil, P. Jankowski, M. Niewada, A. Witkowski

引用次数: 12

An individualized algorithm to predict mortality in COVID-19 pneumonia: a machine learning based study 预测COVID-19肺炎死亡率的个性化算法:一项基于机器学习的研究

Archives of Medical Science : AMS Pub Date : 2022-01-14 DOI: 10.5114/aoms/144980

M. Laino, E. Generali, T. Tommasini, G. Angelotti, A. Aghemo, A. Desai, Pierandrea Morandini, G. Stefanini, A. Lleo, A. Voza, V. Savevski

{"title":"An individualized algorithm to predict mortality in COVID-19 pneumonia: a machine learning based study","authors":"M. Laino, E. Generali, T. Tommasini, G. Angelotti, A. Aghemo, A. Desai, Pierandrea Morandini, G. Stefanini, A. Lleo, A. Voza, V. Savevski","doi":"10.5114/aoms/144980","DOIUrl":"https://doi.org/10.5114/aoms/144980","url":null,"abstract":"Introduction Identifying SARS-CoV-2 patients at higher risk of mortality is crucial in the management of a pandemic. Artificial intelligence techniques allow one to analyze large amounts of data to find hidden patterns. We aimed to develop and validate a mortality score at admission for COVID-19 based on high-level machine learning. Material and methods We conducted a retrospective cohort study on hospitalized adult COVID-19 patients between March and December 2020. The primary outcome was in-hospital mortality. A machine learning approach based on vital parameters, laboratory values and demographic features was applied to develop different models. Then, a feature importance analysis was performed to reduce the number of variables included in the model, to develop a risk score with good overall performance, that was finally evaluated in terms of discrimination and calibration capabilities. All results underwent cross-validation. Results 1,135 consecutive patients (median age 70 years, 64% male) were enrolled, 48 patients were excluded, and the cohort was randomly divided into training (760) and test (327) groups. During hospitalization, 251 (22%) patients died. After feature selection, the best performing classifier was random forest (AUC 0.88 ±0.03). Based on the relative importance of each variable, a pragmatic score was developed, showing good performances (AUC 0.85 ±0.025), and three levels were defined that correlated well with in-hospital mortality. Conclusions Machine learning techniques were applied in order to develop an accurate in-hospital mortality risk score for COVID-19 based on ten variables. The application of the proposed score has utility in clinical settings to guide the management and prognostication of COVID-19 patients.","PeriodicalId":190584,"journal":{"name":"Archives of Medical Science : AMS","volume":"438 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122789792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone up-regulates miR-145 expression and inhibits proliferation of gastric cancer cells 5,7,2,5-四羟基-8,6-二甲氧基黄酮上调miR-145表达，抑制胃癌细胞增殖

Archives of Medical Science : AMS Pub Date : 2021-04-13 DOI: 10.5114/aoms/121038

Chunhong Wei, Pengjun Jiang, Guang-Yan Li, Mengyang Li, L. Wang

{"title":"5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone up-regulates miR-145 expression and inhibits proliferation of gastric cancer cells","authors":"Chunhong Wei, Pengjun Jiang, Guang-Yan Li, Mengyang Li, L. Wang","doi":"10.5114/aoms/121038","DOIUrl":"https://doi.org/10.5114/aoms/121038","url":null,"abstract":"Introduction Gastric cancer is a frequently detected malignancy, and its incidence has increased over the past decades in East Asia. The present study investigated the effect of 5,7,2, 5-tetrahydroxy-8,6-dimethoxyflavone (THDMF) on gastric cancer cells and explored the underlying mechanism. The study analysed cell viability changes, apoptotic features, and metastasis potential of treatment with THDMF. Material and methods MTT colorimetric assay was used for measurement of MKN28, MKN45, and GES-1 cell proliferation and flow cytometry for the detection of apoptosis. Transwell and wound healing assays were used to observe the invasion and migration abilities of MKN28 cells. The expression of p21, MMP2/-9, PI3K, and c-Myc proteins was detected by western blotting. Results The THDMF treatment significantly (p < 0.05) reduced MKN28 and MKN45 cell proliferation without changing GES-1 cell viability. A significant increase in apoptotic cell population on treatment with THDMF was observed. Treatment of MKN28 cells with THDMF increased the percentage of cells in the G1 phase. Exposure of MKN28 cells to THDMF caused a marked decrease in invasion and migration potential in comparison to control cells. The expression of miR-145 was markedly increased in MKN28 cells on treatment with THDMF. In MKN28 cells expression of c-Myc, PI3K, p-AKT, MMP-2, and MMP-9 was suppressed markedly on exposure to THDMF. The expression of p21 protein in MKN28 cells was markedly promoted on exposure to THDMF. Conclusions THDMF exhibits anti-cancer effect on gastric cancer cells in vitro by activation of cell apoptosis and arrest of cell cycle. In addition, THDMF promoted miR-145 expression and down-regulation of PI3K/AKT signalling pathway in MKN28 cells. Therefore, THDMF may be utilised as a potential novel therapeutic agent for the treatment of gastric cancer.","PeriodicalId":190584,"journal":{"name":"Archives of Medical Science : AMS","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128642682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients 年轻患者的临床特征与中老年患者不同

Archives of Medical Science : AMS Pub Date : 2021-03-21 DOI: 10.5114/aoms/133090

Keqiang Wan, C. Su, Ling-Xi Kong, J. Liao, Wen-guang Tian, Hua-li Luo

{"title":"Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients","authors":"Keqiang Wan, C. Su, Ling-Xi Kong, J. Liao, Wen-guang Tian, Hua-li Luo","doi":"10.5114/aoms/133090","DOIUrl":"https://doi.org/10.5114/aoms/133090","url":null,"abstract":"Introduction Coronavirus disease-2019 (COVID-19) has spread worldwide. The study aimed to understand the clinical characteristics of young COVID-19 patients. Material and methods Ninety patients with severe COVID-19 infection in western Chongqing were collected from 21 January to 14 March 2020. They were divided into 4 groups based on age: youth (< 39 years), middle-aged (39–48 years), middle-elderly aged (49–60 years), and elderly (> 60 years). The clinical symptoms, laboratory findings, imaging findings, and treatment effects were compared among the groups. Results There were 22, 27, 19, and 22 cases in the youth, middle-aged, middle-elderly, and elderly groups, respectively. There were no significant differences with respect to gender or smoking status among the four groups. The clinical indicators of severe disease in the youth group were significantly different from the other three groups, and included the lymphocyte count (p < 0.001), C-reactive protein level (p = 0.03), interleukin-6 level (p = 0.01), chest computed tomography (CT) findings (p < 0.001), number of mild cases (p = 0.02), education level (p < 0.001), and CD4 + T lymphocyte level (p = 0.02) at the time of admission, and the pneumonia severity index (PSI) at the time of discharge (p < 0.001). The complications (p < 0.001) among the youth group were also significantly different from the other groups. Conclusions Young patients have milder clinical manifestations, which may be related to higher education level, higher awareness and higher acceptance of the prevention and control of the COVID-19 epidemic, as well as their good immune function.","PeriodicalId":190584,"journal":{"name":"Archives of Medical Science : AMS","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133762633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1