MRS Advances最新文献_第9页

A multidimensional approach to understanding wide band gap MgO: Structural, morphological, optical, and electron density insights 理解宽带隙MgO的多维方法:结构、形态、光学和电子密度见解

MRS Advances Pub Date : 2023-10-31 DOI: 10.1557/s43580-023-00669-0

J. Mangaiyarkkarasi, S. Sasikumar, V. Meenakumari, J. Shanthalakshmi Revathy

引用次数: 0

Study of physical properties of cold welding epoxy matrix with polypyrrole inclusions 含聚吡咯夹杂物的冷焊环氧基体的物理性能研究

MRS Advances Pub Date : 2023-10-31 DOI: 10.1557/s43580-023-00668-1

Juan José Reyes Salgado, Pablo Marco Trejo García, Laura Elvira Serrano de la Rosa, Emmanuel Eduardo Huelitl Ocelotl

引用次数: 0

Computational study of the $${text{DO}}_3+{text{L}}2_1$$ two-phase field in $$beta$$ Cu–Al–Mn $$beta$$ Cu-Al-Mn中$${text{DO}}_3+{text{L}}2_1$$两相场的计算研究

MRS Advances Pub Date : 2023-10-26 DOI: 10.1557/s43580-023-00664-5

Facundo Arriaga, Diego Velázquez, Fernando Lanzini

引用次数: 0

CTCF/cohesin organize the ground state of chromatin-nuclear speckle association. CTCF/内聚蛋白组织染色质-核散斑结合的基态。

MRS Advances Pub Date : 2023-10-24 DOI: 10.1101/2023.07.22.550178

Ruofan Yu, Shelby Roseman, Allison P Siegenfeld, Son C Nguyen, Eric F Joyce, Brian B Liau, Ian D Krantz, Katherine A Alexander, Shelley L Berger

{"title":"CTCF/cohesin organize the ground state of chromatin-nuclear speckle association.","authors":"Ruofan Yu, Shelby Roseman, Allison P Siegenfeld, Son C Nguyen, Eric F Joyce, Brian B Liau, Ian D Krantz, Katherine A Alexander, Shelley L Berger","doi":"10.1101/2023.07.22.550178","DOIUrl":"10.1101/2023.07.22.550178","url":null,"abstract":"<p><p>The interchromatin space in the cell nucleus contains various membrane-less nuclear bodies. Recent findings indicate that nuclear speckles, comprising a distinct nuclear body, exhibit interactions with certain chromatin regions in a ground state. Key questions are how this ground state of chromatin-nuclear speckle association is established and what are the gene regulatory roles of this layer of nuclear organization. We report here that chromatin structural factors CTCF and cohesin are required for full ground state association between DNA and nuclear speckles. Disruption of ground state DNA-speckle contacts via either CTCF depletion or cohesin depletion had minor effects on basal level expression of speckle-associated genes, however we show strong negative effects on stimulus-dependent induction of speckle-associated genes. We identified a putative speckle targeting motif (STM) within cohesin subunit RAD21 and demonstrated that the STM is required for chromatin-nuclear speckle association. In contrast to reduction of CTCF or RAD21, depletion of the cohesin releasing factor WAPL stabilized cohesin on chromatin and DNA-speckle contacts, resulting in enhanced inducibility of speckle-associated genes. In addition, we observed disruption of chromatin-nuclear speckle association in patient derived cells with Cornelia de Lange syndrome (CdLS), a congenital neurodevelopmental diagnosis involving defective cohesin pathways, thus revealing nuclear speckles as an avenue for therapeutic inquiry. In summary, our findings reveal a mechanism to establish the ground organizational state of chromatin-speckle association, to promote gene inducibility, and with relevance to human disease.</p>","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89325195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of precursor solution molarity on electrical and optical properties of spin-coated titanium dioxide (TiO2) thin films 前驱体溶液的摩尔浓度对自旋涂覆二氧化钛薄膜电学和光学性能的影响

MRS Advances Pub Date : 2023-10-23 DOI: 10.1557/s43580-023-00671-6

İmran Kanmaz, Murat Tomakin

引用次数: 0

Morphological and mechanical characterization of a novel porous silicon membrane used in a lung-on-a-chip system 用于肺芯片系统的新型多孔硅膜的形态学和力学特性

MRS Advances Pub Date : 2023-10-23 DOI: 10.1557/s43580-023-00667-2

Sahra Genc, Sally Thompson, Owen Hill, Leif Gislason, Dakota Rodriguez, Farjana Showme, Alex Motler, Sarah M. Schreiner, Adrian Gestos, Virginia L. Ferguson, Jeff Jessing

{"title":"Morphological and mechanical characterization of a novel porous silicon membrane used in a lung-on-a-chip system","authors":"Sahra Genc, Sally Thompson, Owen Hill, Leif Gislason, Dakota Rodriguez, Farjana Showme, Alex Motler, Sarah M. Schreiner, Adrian Gestos, Virginia L. Ferguson, Jeff Jessing","doi":"10.1557/s43580-023-00667-2","DOIUrl":"https://doi.org/10.1557/s43580-023-00667-2","url":null,"abstract":"Abstract In the last decade, organ-on-a-chip technology has been researched as an alternative to animal and cell culture models (Buhidma et al. in NPJ Parkinson’s Dis, 2020; Pearce et al. in Eur Cells Mater 13:1–10, 2007; Huh et al. in Nat Protoc 8:2135–2157, 2013). While extensive research has focused on the biological functions of these chips, there has been limited exploration of functional materials that can accurately replicate the biological environment. Our group concentrated on a lung-on-a-chip featuring a newly fabricated porous silicon bio-membrane. This bio-membrane mimics the interstitial space found between epithelial and endothelial cells in vivo, with a thickness of approximately 1 μm (Ingber in Cell 164:1105–1109, 2016). This study aims to establish a fabrication method for producing a thin, uniform porous silicon membrane with a predictable reduced modulus . We conducted mechanical and morphological characterization using scanning electron microscopy and nanoindentation. A small, parametric study was conducted to determine the reduced modulus of the porous silicon and how it may relate to the morphological features of the membrane. We compare our results to other works. Graphical Abstract","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"35 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135413524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction sites in the receptor-binding domain (RBD) of the spike wild-type SARS-CoV-2 protein of the posaconazole (POS) drug and its quantum–mechanical characterization 泊沙康唑(POS)药物刺突野生型SARS-CoV-2蛋白受体结合域(RBD)相互作用位点及其量子力学表征

MRS Advances Pub Date : 2023-10-19 DOI: 10.1557/s43580-023-00666-3

Juan Carlos Santiago-Jiménez, Fray De Landa Castillo-Alvarado, Alberto García-Quiroz, Gabriel Ramírez-Damaso

引用次数: 0

High thermal stability 1D borophosphate proton conducting polyelectrolytes 高热稳定性的一维硼磷酸质子导电聚电解质

MRS Advances Pub Date : 2023-10-19 DOI: 10.1557/s43580-023-00663-6

J. August Ridenour, Brian L. Chaloux, Michelle D. Johannes, Matthew T. Finn, Heonjune Ryou, Albert Epshteyn

{"title":"High thermal stability 1D borophosphate proton conducting polyelectrolytes","authors":"J. August Ridenour, Brian L. Chaloux, Michelle D. Johannes, Matthew T. Finn, Heonjune Ryou, Albert Epshteyn","doi":"10.1557/s43580-023-00663-6","DOIUrl":"https://doi.org/10.1557/s43580-023-00663-6","url":null,"abstract":"The ionic conductivity, thermal stability, and general viability for use as electrolytes in fuel cells are examined for two borophosphate polyelectrolyte compounds (e.g., sodium borophosphate (NaBOB, Na5[BOB(PO4)3)]) and ammonium borophosphate (NH4BOB, (NH4)3H2[BOB(PO4)3])). Bulk synthesis methods are presented for laboratory scale reactions (> 5 g) using low-temperature ionic liquid fluxes. Electrochemical impedance spectroscopy (EIS) was used to determine temperature-dependent ionic conductivities of the NH4BOB and NaBOB to be on the order of 2 µS cm−1 and 0.1 µS cm−1 at 200 °C, respectively. Although NH4BOB displays higher ionic conductivity compared to NaBOB at equivalent temperatures, thermal gravimetric analysis (TGA) shows much higher thermal stability for NaBOB, exhibiting no mass loss below 600 °C. The thermal stability of NaBOB was also assessed under reducing (~ 1 atm H2) conditions, finding no reductive thermal degradation below 400 °C. Ab initio molecular dynamics (AIMD) simulations show free proton (H+) movement is related to gyrational mobility of the polyanionic borophosphate chains.","PeriodicalId":19015,"journal":{"name":"MRS Advances","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study and formulation of microemulsions for the synthesis of Fe2O3–Ag nanoparticles: Characterization and evaluation of antimicrobial activity 制备纳米Fe2O3-Ag微乳的研究及抗菌性能评价

MRS Advances Pub Date : 2023-10-19 DOI: 10.1557/s43580-023-00656-5

Rossannie Guasamucare, Iris Miraballes, Ricardo Faccio, Silvana Albores, Juan Pereira, Livia Arizaga

引用次数: 0

Creep behavior and microstructural characterization of Inconel-625/Inconel-600 welded joint Inconel-625/Inconel-600焊接接头蠕变行为及显微组织表征

MRS Advances Pub Date : 2023-10-16 DOI: 10.1557/s43580-023-00662-7

Heriberto Granados-Becerra, Martin Ricardo Barajas-Álvarez, Víctor H. López-Morelos, Alberto Ruiz

引用次数: 0