Nefrologia最新文献_第3页

La implantación de la cardionefrología en España es una urgencia sanitaria 在西班牙实施心脏肾脏病学是一项紧急卫生任务。

IF 2 4区医学

Nefrologia Pub Date : 2024-09-01 DOI: 10.1016/j.nefro.2024.05.007

引用次数: 0

Niveles de creatinina elevados y cistatina normales en un paciente que recibe ribociclib "接受 Ribociclib 治疗的患者肌酐升高而胱抑素水平正常"。

IF 2 4区医学

Nefrologia Pub Date : 2024-09-01 DOI: 10.1016/j.nefro.2024.02.001

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Nefritis intersticial cariomegálica 钙化间质性肾炎

IF 2 4区医学

Nefrologia Pub Date : 2024-09-01 DOI: 10.1016/j.nefro.2024.03.003

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Mind the gap in kidney care: Translating what we know into what we do 关注肾脏护理中的差距：将我们的知识转化为我们的行动

IF 2 4区医学

Nefrologia Pub Date : 2024-09-01 DOI: 10.1016/j.nefro.2024.05.002

{"title":"Mind the gap in kidney care: Translating what we know into what we do","authors":"","doi":"10.1016/j.nefro.2024.05.002","DOIUrl":"10.1016/j.nefro.2024.05.002","url":null,"abstract":"<div><p>Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.</p></div>","PeriodicalId":18997,"journal":{"name":"Nefrologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0211699524000377/pdfft?md5=694bbd257e5ed54a9b863696d5a43532&pid=1-s2.0-S0211699524000377-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pielonefritis aguda en paciente trasplantado renal secundaria a infección por Delftia acidovorans: a propósito de un caso 肾移植患者继发于嗜酸海豚感染的急性肾盂肾炎：一例

IF 2 4区医学

Nefrologia Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2022.12.010

引用次数: 0

Irbesartan restored aquaporin-1 levels via inhibition of NF-kB expression in acute kidney injury model 厄贝沙坦通过抑制急性肾损伤模型中 NF-kB 的表达恢复水通道蛋白-1 的水平

IF 2 4区医学

Nefrologia Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.11.005

{"title":"Irbesartan restored aquaporin-1 levels via inhibition of NF-kB expression in acute kidney injury model","authors":"","doi":"10.1016/j.nefro.2023.11.005","DOIUrl":"10.1016/j.nefro.2023.11.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Acute kidney injury (AKI) is a serious pathology that progress with dysfunction of regulating blood pressure and fluid balance, concentrating urine due to decrement of aquaporin-1 (AQP) levels during the inflammation process. Irbesartan (IRN), angiotensin receptor blocker, is widely used in the treatment of hypertension, which also has anti-inflammatory, antioxidant and anti-apoptotic properties. The aim of this study is to investigate the protective effects of IRN in lipopolysaccharide (LPS)-induced kidney injury.</p></div><div><h3>Material and methods</h3><p>Twenty-four rats divided into three groups as control, LPS and LPS+IRN group. After 6h of LPS administration, rats were sacrificed. Blood samples and half of the kidney tissues were collected for biochemical analysis and remaining tissues were taken for histopathological and immunohistochemical analysis.</p></div><div><h3>Results</h3><p>In the LPS group, glomerular congestion and shrinkage, degeneration of distal tubules, mononuclear cell infiltration, cellular debris and intense proteinous accumulation in the tubules, increased expressions of Cas-3, nuclear factor kappa beta-p65 (NF-kB p65), levels of creatinin, TOS, OSI and decreased levels of TAS, AQP-1 were found significantly. IRN treatment reversed all these parameters. IRN's restorated AQP-1 levels by its anti-inflammatory, antioxidant and anti-apoptotic effects due to inhibiting NF-kB expression.</p></div><div><h3>Conclusion</h3><p>This study suggests that IRN can be used in conditions affecting the kidneys such as AKI. Further studies needed for detailed molecular investigation of IRN at different doses and durations.</p></div>","PeriodicalId":18997,"journal":{"name":"Nefrologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0211699523001765/pdfft?md5=1a73f917f523cbbdc48971de3c1b4b06&pid=1-s2.0-S0211699523001765-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Karyomegalic nephropathy – Letter to the Editor 巨红细胞性肾病 - 致编辑的信

IF 2 4区医学

Nefrologia Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.04.002

引用次数: 0

Targeting colonic BK channels: A novel therapeutic strategy against hyperkalemia in chronic kidney disease 靶向结肠 BK 通道：慢性肾病高钾血症的新型治疗策略

IF 2 4区医学

Nefrologia Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.01.001

引用次数: 0

Individualización y desafíos para la hemodiálisis de la próxima década 未来十年血液透析的个性化和挑战

IF 2 4区医学

Nefrologia Pub Date : 2024-07-01 DOI: 10.1016/j.nefro.2023.09.003