Nephron Experimental Nephrology最新文献

{"title":"Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.","authors":"Yelixiati Adelibieke,&nbsp;Maimaiti Yisireyili,&nbsp;Hwee-Yeong Ng,&nbsp;Shinichi Saito,&nbsp;Fuyuhiko Nishijima,&nbsp;Toshimitsu Niwa","doi":"10.1159/000365217","DOIUrl":"https://doi.org/10.1159/000365217","url":null,"abstract":"<p><strong>Background/aims: </strong>Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predictive value for outcome in chronic kidney disease (CKD) patients. The present study aimed to determine the effects of indoxyl sulfate (IS) on IL-6 expression in vascular cells.</p><p><strong>Methods: </strong>IS was administered to normo- and hypertensive rats. Human umbilical vein endothelial cells (HUVECs) and human aortic smooth muscle cells (HASMCs) were incubated with or without IS.</p><p><strong>Results: </strong>Immunohistochemistry revealed that IS-administered rats showed increased expression of IL-6 in the aortic tissues. IS increased IL-6 expression in HUVECs and HASMCs in a time- and dose-dependent manner. Knockdown of organic anion transporter 3 (OAT3) using small interfering RNA (siRNA) inhibited IS-induced expression of IL-6 in HUVECs and HASMCs. IS induced activation of aryl hydrocarbon receptor (AhR) and nuclear factor-κB (NF-κB) subunit p65 in HUVECs and HASMCs. Both AhR siRNA and p65 siRNA inhibited IS-induced expression of IL-6. AhR siRNA inhibited IS-induced phosphorylation and nuclear translocation of p65 without change in total p65 level. However, p65 siRNA did not inhibit IS-induced nuclear translocation of AhR. Thus, AhR is responsible for IS-induced p65 signaling transduction.</p><p><strong>Conclusion: </strong>IS induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3/AhR/NF-κB pathway.</p>","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"128 1-2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000365217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32797128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000357691","DOIUrl":"https://doi.org/10.1159/000357691","url":null,"abstract":"","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000357691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64697271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol. 123, 2013","authors":"Y. Gheisari, N. Ahmadbeigi, S. H. Aghaee-Bakhtiari, S. Nassiri, S. Amanpour, K. Azadmanesh, Athena Hajarizadeh, Zahra Mobarra, M. Soleimani, Kotaro Tamura, K. Uchio‐Yamada, N. Manabe, T. Noto, R. Hirota, A. Unami, M. Matsumoto, Yoichi Miyamae, Kyoko Sawada, Sumie Katayama, Youko Monobe, Yoshie Yamamoto, A. Ogura, Satz Mengensatzproduktion, D. R. Basel","doi":"10.1159/000357457","DOIUrl":"https://doi.org/10.1159/000357457","url":null,"abstract":"","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"123 1","pages":"I - IV"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000357457","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64695730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"Rediscover Vesalius","doi":"10.1159/000357451","DOIUrl":"https://doi.org/10.1159/000357451","url":null,"abstract":"Each paper needs an abstract of up to 250 words. It should be structured as follows: Background/Aims: What is the major problem that prompted the study? Methods: How was the study carried out? Results: Most important findings? Conclusion: Most important conclusion? Abstracts of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review.s of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review. Footnotes: Avoid footnotes. Tables and illustrations: Tables are part of the text. Place them at the end of the text file. Illustration data must be stored as separate files. Do not integrate figures into the text. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 800.– per page. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Number references in the order in which they are first mentioned in the text; do not list alphabetically. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www. icmje.org). Examples (a) Papers published in periodicals: Tomson C: Vascular calcification in chronic renal failure. Nephron Clin Pract 2003;93:c124–c130. (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: 10.1159/000063858. (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, 1996. (d) Edited bo","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000357451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64695191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000354852","DOIUrl":"https://doi.org/10.1159/000354852","url":null,"abstract":"","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000354852","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64674882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"K. Toyoda","doi":"10.1159/000353821","DOIUrl":"https://doi.org/10.1159/000353821","url":null,"abstract":"Each paper needs an abstract of up to 250 words. It should be structured as follows: Background/Aims: What is the major problem that prompted the study? Methods: How was the study carried out? Results: Most important findings? Conclusion: Most important conclusion? Abstracts of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review.s of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review. Footnotes: Avoid footnotes. Tables and illustrations: Tables are part of the text. Place them at the end of the text file. Illustration data must be stored as separate files. Do not integrate figures into the text. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 800.– per page. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Number references in the order in which they are first mentioned in the text; do not list alphabetically. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www. icmje.org). Examples (a) Papers published in periodicals: Tomson C: Vascular calcification in chronic renal failure. Nephron Clin Pract 2003;93:c124–c130. (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: 10.1159/000063858. (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, 1996. (d) Edited bo","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000353821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64668408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol. 122, 2012","authors":"I. Brenna, E. Volpi, D. Brancaccio, M. Cozzolino, Sandrine Roy, B. Gabrielli, David W. Johnson, G. Gobe, F. Nutter, A. Khwaja, J. Haylor, M. J. Desmond, S. Fraser, M. Katerelos, K. Gleich, S. Berkovic, D. Power, David M. Small, N. Bennett, Hisako Ushio-Yamana, Shintaro Minegishi, T. Ishigami, Naomi Araki, M. Umemura, K. Tamura, Emi Maeda, Y. Kakizoe, K. Kitamura, S. Umemura, J. Asakura, Hajime Hasegawa, K. Takayanagi, T. Shimazu, R. Suge, Taisuke Shimizu, T. Iwashita, Yosuke Tayama, A. Matsuda, K. Kanozawa, N. Araki, T. Mitarai, Dong Ho Lee, W. Minuth, L. Denk, P. Ciceri, F. Elli, Satz Mengensatzproduktion, D. R. Basel","doi":"10.1159/000353819","DOIUrl":"https://doi.org/10.1159/000353819","url":null,"abstract":"Chronic Kidney Disease and Hypertension Vlado Perkovic , Sydney Adeera Levin, Vancouver, B.C. Ron Gansevoort, Groningen Acute Kidney Injury Ravi Mehta, San Diego, Calif. Nitin Kolhe, Derby Dialysis John Daugirdas, Chicago, Ill. Colin Hutchison, Hawkes Bay Casper Fraansen, Groningen Patient Subjective Experience, Healthcare Delivery and Innovation in Practice Richard Fluck, Derby Edwina Brown, London Crossover States with Non-Renal Organ Systems Chris Chan, Toronto, Ont. Tobias Breidthardt, Basel Nick Selby, Derby Transplantation Anil Chandraker, Boston, Mass. Alan Salama, London Editor-in-Chief","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"122 1","pages":"I - IV"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000353819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64668259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"S. Beesley","doi":"10.1159/000351243","DOIUrl":"https://doi.org/10.1159/000351243","url":null,"abstract":"Each paper needs an abstract of up to 250 words. It should be structured as follows: Background/Aims: What is the major problem that prompted the study? Methods: How was the study carried out? Results: Most important findings? Conclusion: Most important conclusion? Abstracts of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review.s of Minireviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review. Footnotes: Avoid footnotes. Tables and illustrations: Tables are part of the text. Place them at the end of the text file. Illustration data must be stored as separate files. Do not integrate figures into the text. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 800.– per page. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Number references in the order in which they are first mentioned in the text; do not list alphabetically. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www. icmje.org). Examples (a) Papers published in periodicals: Tomson C: Vascular calcification in chronic renal failure. Nephron Clin Pract 2003;93:c124–c130. (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: 10.1159/000063858. (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, 1996. (d) Edited bo","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000351243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64653273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"Clayton, J. Bonventre","doi":"10.1159/000350280","DOIUrl":"https://doi.org/10.1159/000350280","url":null,"abstract":"Each paper needs an abstract of up to 250 words. It should be structured as follows: Background/Aims: What is the major problem that prompted the study? Methods: How was the study carried out? Results: Most important findings? Conclusion: Most important conclusion? Footnotes: Avoid footnotes. Tables and illustrations: Tables are part of the text. Place them at the end of the text file. Illustration data must be stored as separate files. Do not integrate figures into the text. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 800.– per page. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as ‘unpublished data’ and not be included in the reference list. The list of references should include only those publications which are cited in the text. Number references in the order in which they are first mentioned in the text; do not list alphabetically. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www. icmje.org). Examples (a) Papers published in periodicals: Tomson C: Vascular calcification in chronic renal failure. Nephron Clin Pract 2003;93:c124–c130. (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: 10.1159/000063858. (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, 1996. (d) Edited books: Kashihara N, Sugiyama H, Makino H: Implication of apoptosis in progression of renal diseases; in Razzaque MS, Taguchi T (eds): Renal Fibrosis. Contrib Nephrol. Basel, Karger, 2003, vol 139, pp 156–172. Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists. Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at www.doi.org. Supplementary Material Supplementary material ","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64647439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol. 121, 2012","authors":"Sarah J. Lee, E. Borsting, Anne-Émilie Declèves, Prabhleen Singh, R. Cunard, T. Bergler, U. Hoffmann, Elisabeth Bergler, B. Jung, M. Banas, Stephan W. Reinhold, B. Krämer, B. Banas, Su-mi Kim, Young-Wook Choi, Hwa-Young Seok, K. Jeong, Sang-ho Lee, T. Lee, C. Ihm, S. Lim, J. Moon, Chikage Sato-Horiguchi, D. Ogawa, J. Wada, H. Tachibana, Ryo Kodera, Jun Eguchi, A. Nakatsuka, N. Terami, K. Shikata, H. Makino, C-Hong Chang, J. A. Davies, L. Sánchez-Lozada, M. Lanaspa, Magdalena Cristóbal-García, F. García-Arroyo, Virgilia Soto, D. Cruz-Robles, T. Nakagawa, Min-A Yu, D. Kang, Richard J. Johnson, Satz Mengensatzproduktion, D. R. Basel","doi":"10.1159/000350281","DOIUrl":"https://doi.org/10.1159/000350281","url":null,"abstract":"Chronic Kidney Disease and Hypertension Vlado Perkovic , Sydney Adeera Levin, Vancouver, B.C. Ron Gansevoort, Groningen Acute Kidney Injury Ravi Mehta, San Diego, Calif. Nitin Kolhe, Derby Dialysis John Daugirdas, Chicago, Ill. Colin Hutchison, Hawkes Bay Casper Fraansen, Groningen Patient Subjective Experience, Healthcare Delivery and Innovation in Practice Richard Fluck, Derby Edwina Brown, London Crossover States with Non-Renal Organ Systems Chris Chan, Toronto, Ont. Tobias Breidthardt, Basel Nick Selby, Derby Transplantation Anil Chandraker, Boston, Mass. Alan Salama, London Editor-in-Chief","PeriodicalId":18993,"journal":{"name":"Nephron Experimental Nephrology","volume":"121 1","pages":"I - IV"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64647497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}