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Rapidly progressive renal failure-a rare presentation of granulomatous interstitial nephritis due to tuberculosis-case report and review of literature. 快速进展性肾衰竭-一例罕见的结核性肉芽肿间质性肾炎病例报告及文献复习。
NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-07-18 DOI: 10.1093/ndtplus/sfr067
Anupma Kaul, Raj K Sharma, Jaisuresh Krishnasamy, Vivek Ruhela, Niraj Kumari
{"title":"Rapidly progressive renal failure-a rare presentation of granulomatous interstitial nephritis due to tuberculosis-case report and review of literature.","authors":"Anupma Kaul,&nbsp;Raj K Sharma,&nbsp;Jaisuresh Krishnasamy,&nbsp;Vivek Ruhela,&nbsp;Niraj Kumari","doi":"10.1093/ndtplus/sfr067","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr067","url":null,"abstract":"<p><p>Granulomatous interstitial nephritis (GIN) is a rare manifestation of renal tuberculosis (TB). We report a case of rapidly progressive renal failure (RPRF), granulomatous inflammation of cervical lymph node and GIN as presenting manifestations of TB. Aspiration cytology of cervical lymph node showed granulomatous necrotizing inflammation with acid-fast bacilli (AFB). The renal biopsy and urine specimen did not show AFB. Urine polymerase chain reaction (PCR) for Mycobacterium tuberculosis was positive. We observe that GIN due to TB can present as RPRF and emphasize the value of PCR-based techniques in making a correct diagnosis. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"383-5"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33311849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
C1q nephropathy in a patient with Gitelman syndrome. Gitelman综合征患者的C1q肾病。
NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-09-06 DOI: 10.1093/ndtplus/sfr097
Consolación Rosado Rubio, Pilar Fraile Gómez, María Asunción Gómez Muñoz, Pedro Garcia-Cosmes, José Luis Lerma Márquez
{"title":"C1q nephropathy in a patient with Gitelman syndrome.","authors":"Consolación Rosado Rubio,&nbsp;Pilar Fraile Gómez,&nbsp;María Asunción Gómez Muñoz,&nbsp;Pedro Garcia-Cosmes,&nbsp;José Luis Lerma Márquez","doi":"10.1093/ndtplus/sfr097","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr097","url":null,"abstract":"<p><p>Bartter syndrome can manifest in three different forms and is rarely concomitant with glomerular nephropathies. However, this association is more frequently observed in children. We report the case of a 50-year-old woman with Gitelman syndrome for the past 30 years who also had a nephrotic syndrome of recent appearance. Her renal biopsy revealed hyperplasia of the juxtaglomerular apparatus and mesangial deposits of C1q, with no clinical or serological evidence of systemic erythematous lupus. We have not found any reports of instances of association of Gitelman syndrome and nephrotic syndrome arising from C1q nephropathy in adult patients. Our case suggests the possible existence of an association between hypokalaemic tubular nephropathies and glomerular nephropathies that may cause nephrotic syndrome. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"392-3"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33311852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The re-emergence of short daily haemodialysis. 再次出现每日短时间血液透析。
NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr122
Brigitte Schiller
{"title":"The re-emergence of short daily haemodialysis.","authors":"Brigitte Schiller","doi":"10.1093/ndtplus/sfr122","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr122","url":null,"abstract":"<p><p>Thrice weekly in-center hemodialysis is the standard of care for dialysis patients with end-stage renal disease (ESRD). However, there is ongoing debate as to whether more frequent hemodialysis, with its readier management of both toxin and fluid removal, benefits patients. New evidence from recent studies, both in center dialysis and in home haemodialysis patients, adds further confirmation of improved cardiovascular outcome and quality of life in patients undergoing short daily hemodialysis. A paradigm shift in ESRD care delivery may be facilitated due to new technology enabling daily therapy at home. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 Suppl 3","pages":"iii29-iii31"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33161912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Enabling self-management: selecting patients for home dialysis? 实现自我管理:选择家庭透析患者?
NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr151
Alastair J Hutchison, Jonathan J Courthold
{"title":"Enabling self-management: selecting patients for home dialysis?","authors":"Alastair J Hutchison,&nbsp;Jonathan J Courthold","doi":"10.1093/ndtplus/sfr151","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr151","url":null,"abstract":"<p><p>Pre-emptive living donor transplantation should always be promoted as the first-line treatment for kidney failure. Where that is not possible, patients must receive timely information and advice regarding all dialysis options available, including home-based peritoneal dialysis and haemodialysis. Where a dialysis unit enables and actively encourages self-management, patients will tend to select themselves, and if well motivated may overcome significant difficulties to exceed the expectations or predictions of dialysis staff. Patients then become advocates themselves and can provide other patients with the necessary motivation to consider a home treatment, such that they approach staff, rather than vice versa. For staff to be able to talk to patients with confidence requires direct experience of home dialysis, but in units which do not have a full range of home therapies, this may initially be difficult. Visiting patients in their home environment is an essential part of training for both medical and nursing staff. Before a patient is able to begin to engage in discussion about any dialysis therapy, they must have reached a point of acceptance that dialysis is necessary. If they are not at this point, then any attempt at 'education' will be largely futile. Once a patient has arrived at the point of choosing a home therapy, the pathway to their first dialysis at home must be as smooth and problem-free as possible. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 Suppl 3","pages":"iii7-iii10"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33161915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Senior-Loken syndrome secondary to NPHP5/IQCB1 mutation in an Iranian family. 伊朗家族继发于NPHP5/IQCB1突变的Senior-Loken综合征
NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-08-18 DOI: 10.1093/ndtplus/sfr096
Alireza Haghighi, Mohamed Al-Hamed, Safa Al-Hissi, Ann-Marie Hynes, Maryam Sharifian, Jamshid Roozbeh, Nasrollah Saleh-Gohari, John A Sayer
{"title":"Senior-Loken syndrome secondary to NPHP5/IQCB1 mutation in an Iranian family.","authors":"Alireza Haghighi,&nbsp;Mohamed Al-Hamed,&nbsp;Safa Al-Hissi,&nbsp;Ann-Marie Hynes,&nbsp;Maryam Sharifian,&nbsp;Jamshid Roozbeh,&nbsp;Nasrollah Saleh-Gohari,&nbsp;John A Sayer","doi":"10.1093/ndtplus/sfr096","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr096","url":null,"abstract":"<p><p>Senior-Loken syndrome (SLS) is a rare autosomal recessive disease characterized by nephronophthisis and early-onset retinal degeneration. We used a large Iranian family with SLS to establish a molecular genetic diagnosis. Following clinical evaluation, we undertook homozygosity mapping in two affected family members and mutational analysis in known SLS genes coinciding with regions of homozygosity. In a region of homozygosity coinciding with a known SLS locus on chromosome 3q21.1, we found a homozygous non-sense mutation R332X in NPHP5/IQCB1. This is the first report of a molecular genetic diagnosis in an Iranian kindred with SLS. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"421-3"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Cloudy dialysate-reconsidering initial empiric therapy. 浑浊的透析-重新考虑最初的经验性治疗。
NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-08-24 DOI: 10.1093/ndtplus/sfr103
Jeanette Normann, Vedat Schwenger
{"title":"Cloudy dialysate-reconsidering initial empiric therapy.","authors":"Jeanette Normann,&nbsp;Vedat Schwenger","doi":"10.1093/ndtplus/sfr103","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr103","url":null,"abstract":"Peritoneal fluid eosinophilia can be caused by many factors. It has been noted in helminthic infection or allergic diseases and can occur especially at the initiation of continuous ambulatory peritoneal dialysis (CAPD). \u0000 \u0000We show the case of a 53-year-old woman undergoing CAPD who was initially treated for bacterial peritonitis with antibiotics. Finally, she revealed an eosinophilic peritonitis most probably due to an allergic reaction to the antibiotics. \u0000 \u0000The importance of reconsidering your diagnosis and therapy in managing your patients is demonstrated by this case, which follows.","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"437-8"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Colonic necrosis and perforation due to calcium polystyrene sulfonate in a uraemic patient: a case report. 聚苯乙烯磺酸钙致尿毒症患者结肠坏死穿孔1例报告。
NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr113
Tulin Akagun, Halil Yazici, Mine G Gulluoglu, Gulcin Yegen, Aydin Turkmen
{"title":"Colonic necrosis and perforation due to calcium polystyrene sulfonate in a uraemic patient: a case report.","authors":"Tulin Akagun,&nbsp;Halil Yazici,&nbsp;Mine G Gulluoglu,&nbsp;Gulcin Yegen,&nbsp;Aydin Turkmen","doi":"10.1093/ndtplus/sfr113","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr113","url":null,"abstract":"<p><p>Sodium or calcium polystyrene sulfonate (Kayexalate or analog) is an ion-exchange resin commonly used to treat hyperkalaemia in patients with chronic kidney disease. It is known to cause digestive complications, such as nausea, vomiting and constipation. Although rare, colonic necrosis and perforation are very severe complications associated with the medication. In this case report, we present a case of calcium polystyrene sulfonate-induced colonic necrosis and perforation to remind clinicians of this rare, but dangerous, toxicity associated with this commonly used medication. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"402-3"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33313792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Personal experiences of home haemodialysis: patients' and carers' experiences. 家庭血液透析的个人体验:患者和护理人员的体验。
NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr125
Nick Maguire
{"title":"Personal experiences of home haemodialysis: patients' and carers' experiences.","authors":"Nick Maguire","doi":"10.1093/ndtplus/sfr125","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr125","url":null,"abstract":"<p><p>The discussions from a patient-led session at a national home haemodialysis conference are described. A number of discussion themes are described, together with patients' views on technical and social aspects of home dialysis. Issues highlighted included the preparation for home systems and the role of intrinsic motivation to change regimens and practice. A number of conclusions are drawn from the discussion, highlighting the role of patient beliefs about conducting haemodialysis at home. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 Suppl 3","pages":"iii25-iii26"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33161910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hyponatraemia caused by LGI1-associated limbic encephalitis. lgi1相关边缘脑炎引起的低钠血症。
NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-09-29 DOI: 10.1093/ndtplus/sfr105
Rory F McQuillan, Joanne M Bargman
{"title":"Hyponatraemia caused by LGI1-associated limbic encephalitis.","authors":"Rory F McQuillan,&nbsp;Joanne M Bargman","doi":"10.1093/ndtplus/sfr105","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr105","url":null,"abstract":"Limbic encephalitis (LE), once thought to be a rare paraneoplastic phenomenon, is increasingly diagnosed in patients without malignancy. Autoimmune LE has emerged as a distinct clinical entity. Autoantibodies to neuronal cell surface proteins have been described and may now be tested for. This has led to an exponential increase in the number of cases being reported. The most recently implicated autoantibody is to the leucine-rich anti-glioma 1 protein (LGI1). This protein is involved in synaptic transmission and inherited loss-of-function mutations cause autosomal dominant lateral temporal epilepsy. LGI1 is also expressed in specific tubules in the kidney. Anti-leucine-rich anti-glioma 1 protein (anti-LGI1) LE presents with sub acute onset of progressive neurological, cognitive and psychiatric disturbance. The condition is complicated in up to 60% of cases with severe and life threatening hyponatraemia. As well as causing significant morbidity, the co-existence of hyponatraemia may confuse the initial diagnosis. We present a case of anti-LGI1 which was complicated by hyponatraemia with a comprehensive review of the literature.","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"424-6"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Rhabdomyolysis and elevated liver function tests-what's the underlying cause? 横纹肌溶解和肝功能升高——潜在的原因是什么?
NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr154
M G Zeier, Vijay Thanaraj, Alexander Woywodt
{"title":"Rhabdomyolysis and elevated liver function tests-what's the underlying cause?","authors":"M G Zeier,&nbsp;Vijay Thanaraj,&nbsp;Alexander Woywodt","doi":"10.1093/ndtplus/sfr154","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr154","url":null,"abstract":"A 71-year-old man with a past history of carcinoma of the prostate was admitted in August 2011, feeling unwell and with new-onset weakness of the quadriceps muscles for the past 2 days. He had initially received a diagnosis of adenocarcinoma of the prostate in May 2011 and he had been treated with cyproterone acetate 300 mg since June 2011. He had also been on aspirin 75 mg and simvastatin 40 mg unchanged for the past 2 years. On admission, here, he appeared unwell but normotensive and afebrile. He had weakness of his lower limbs (power 2/5) with normal reflexes. Serum creatinine was 338 lmol/L and liver function tests were also markedly abnormal [alanine transaminase 887 U/L (normal < 41 U/L), c-glutamyltransferase 111 U/L (normal < 41 U/L)]. Previous serum creatinine results and liver function were all normal. Urine dipstick was positive for blood but urine microscopy was negative. Ultrasound showed normal sized kidneys and normal liver parenchyma. The creatine kinase was 78820 U/L. A complete virology and immunology screen, including Jo-1 antibodies, was negative.","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"447-8"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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