NDT Plus最新文献_第7页

Extreme lactic acidosis type B associated with metformin treatment. 极端乳酸性酸中毒B型与二甲双胍治疗相关。

NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-09-14 DOI: 10.1093/ndtplus/sfr110

Andreas Pikwer, Einar Vernersson, Anders Frid, Gunnar Sterner

引用次数: 6

Successful management of angiomyolipoma of the left kidney. 左肾血管平滑肌脂肪瘤的成功治疗。

NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-08-24 DOI: 10.1093/ndtplus/sfr101

G H Neild, Yuvaram N V Reddy, Yogesh N V Reddy, Deepika Lunawat, Georgi Abraham

{"title":"Successful management of angiomyolipoma of the left kidney.","authors":"G H Neild, Yuvaram N V Reddy, Yogesh N V Reddy, Deepika Lunawat, Georgi Abraham","doi":"10.1093/ndtplus/sfr101","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr101","url":null,"abstract":"A 57-year-old woman with a creatinine of 0.8 mg/dL and a normal urine analysis, was investigated with technetium-99m renogram and multidetector computerized tomography (MDCT) as a renal donor for her daughter. The glomerular filtration rate (GFR) was 100 mL/min with the left kidney 42 mL/min and right kidney 58 mL/ min. MDCT revealed a large lipomatous tumour on the renal cortex of the left lower pole with exophytic extension into the perirenal space measuring 7.3 3 5.2 cm (Figure 1). The arterial phase revealed dual arterial supply to the left kidney with the tumour being supplied by a branch from the lower renal artery (Figure 2a). The presence of fat [67 Hounsfield unit (HU)] with interposed soft tissue (42 HU), ectatic vessels and an aneurysm that measured 9 mm 3 8.9 mm with no direct arteriovenous shunting favoured the diagnosis of angiomyolipoma. Superselective catheterization of the feeding artery was performed and the neovascular vessels were embolized. Post-embolization MDCT revealed complete obliteration of the abnormal feeding artery and the aneurysmal lumen (Figure 2b). A week later, the GFR was 107 mL/min, left kidney 43 mL/min and right kidney 64 mL/min. Angiomyolipoma is a benign renal neoplasm with variable amounts of fat, vascular and smooth muscle elements. Attenuation of less than 20 HU on computerized tomography is widely accepted to confirm the presence of fat and this finding confirms the diagnosis of angiomyolipoma [1]. A tumour >4 cm with an aneurysm measuring >5 mm has a high risk of rupture [2].","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"449-50"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of hypoxia-inducible factor-1 alpha in TEMPI syndrome. 缺氧诱导因子-1 α在TEMPI综合征中的作用。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr143

Sujoy Khan

{"title":"The role of hypoxia-inducible factor-1 alpha in TEMPI syndrome.","authors":"Sujoy Khan","doi":"10.1093/ndtplus/sfr143","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr143","url":null,"abstract":"Sir, \u0000 \u0000Two recent reports in The New England Journal of Medicine on a newly described syndrome, namely TEMPI syndrome (telangiectasia, erythrocytosis, monoclonal paraprotein, paranephric fluid collections, intrapulmonary shunting) are fascinating [1, 2], considering the number of cases where the radiological finding of perinephric fluid collections are not investigated further [3] or the concomitant laboratory finding of a paraprotein is dismissed as another case of monoclonal gammopathy of undetermined significance (MGUS). Sykes et al. [2] hypothesize that the IgG paraprotein in TEMPI syndrome may be pathogenic due to the resolution of most clinical features after a trial with the proteasome inhibitor, bortezomib. But, as bortezomib also affects the function of hypoxia-inducible factor-1 alpha (Hif-1α) and down-stream transcription of vascular endothelial growth factor (VEGF) [4], inhibition of Hif-1α would also explain the resolution of the symptoms seen in the patient described by Sykes et al. \u0000 \u0000Expression of Hif-1α and Hif-1α messenger RNA has been detected in all human tissues [5]. Intratumoral hypoxia is known to induce Hif-1α expression that increases VEGF and angiogenesis, but growth factors and loss-of-function mutations in von Hippel Lindau gene and p53 also induce Hif-1α expression (and possibly development of telangiectasias and erythrocytosis) [6]. Zhang et al. [7] showed that even under normoxic conditions, the oncogenic c-Myc/Hif-1α pathway modulates multiple myeloma cell production and mediates production and secretion of VEGF. Bortezomib was also shown to decrease both c-Myc and Hif-1α levels. Specific inhibitors of Hif-1α may therefore reverse most of the pathological manifestations of TEMPI syndrome.","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 6","pages":"454-5"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33187147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Developing an assisted automated peritoneal dialysis (aAPD) service-a single-centre experience. 开发辅助自动腹膜透析（aAPD）服务--单中心经验。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr130

Nina Brown, Anand Vardhan

引用次数: 0

IgM antibodies towards pre-endothelial cells: strong indication for an association with accelerated rejection. A case report. 针对内皮前细胞的IgM抗体:与加速排斥反应相关的强烈迹象。一份病例报告。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr147

Maria L Kafetzi, Aliki G Iniotaki, George C Liapis, Maria N Darema, Ilias I N Doxiadis, John N Boletis

引用次数: 2

Nutcracker phenomenon presenting as loin pain haematuria syndrome. 胡桃夹子现象表现为腰痛血尿综合征。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr152

Holly B Vince, Charles R Tomson, Eric J Loveday, Paul A Lear, John B Eastwood

引用次数: 1

Sepsis and a painful shoulder in a haemodialysis patient. 血液透析患者的败血症和肩部疼痛。

NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-07-25 DOI: 10.1093/ndtplus/sfr088

Roshni Rathore, John Cheesbrough, Monika Pasztor, Alex Woywodt

引用次数: 1

Anticoagulation and dialysis access practice in home haemodialysis in the UK. 英国家庭血液透析中的抗凝和透析通路实践。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr132

Cormac Breen

引用次数: 0

Home dialysis-an international perspective. 家庭透析——一个国际视角。

NDT Plus Pub Date : 2011-12-01 DOI: 10.1093/ndtplus/sfr129

Martin Wilkie

{"title":"Home dialysis-an international perspective.","authors":"Martin Wilkie","doi":"10.1093/ndtplus/sfr129","DOIUrl":"https://doi.org/10.1093/ndtplus/sfr129","url":null,"abstract":"<p><p>Background. There is strong evidence from a range of long-term conditions of improved outcomes where patients are involved in self-management. Against this background, the international trend for home dialysis continues to decline, with centre-based haemodialysis continuing its dominance. Methods. An opinion-based commentary exploring practice patterns and drivers for home dialysis internationally. Data are drawn from a number of sources including the 2010 United States Renal Data System report. Results. Drivers behind the use of home dialysis are complex including factors relating to the patient and their carers, health care team, health care system, geography and cultural factors. There are important examples where local champions or public health initiatives have had a positive impact on the use of home dialysis; however, in many settings significant barriers remain. Better systems for giving patient information, shared decision making and involving patients in their own care may have the potential to act as a driver for change. Conclusion. Centre-based haemodialysis continues to dominate renal replacement therapy internationally with notable exceptions. Such dominance suggests that most patients worldwide do not get much choice when it comes to modality selection. </p>","PeriodicalId":18987,"journal":{"name":"NDT Plus","volume":"4 Suppl 3","pages":"iii4-iii6"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ndtplus/sfr129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33161914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Minimal-change disease as a paraneoplastic syndrome in a patient with ovarian carcinoma. 卵巢癌伴副肿瘤综合征的微小病变。

NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-09-30 DOI: 10.1093/ndtplus/sfr106

Guido R González-Fontal, Juan G Restrepo, Andrés F Henao-Martínez

引用次数: 2