Nestle Nutrition Institute workshop series最新文献_第6页

Building Future Health and Well-Being of Thriving Toddlers and Young Children 为茁壮成长的幼儿和幼儿建立未来的健康和福祉

Nestle Nutrition Institute workshop series Pub Date : 2020-12-08 DOI: 10.1159/isbn.978-3-318-06866-5

D. Bier, Katherine M McDonald, Nicole E. Logan, J. Hoch, B. Crim

引用次数: 3

Milk, Mucosal Immunity and the Microbiome: Impact on the Neonate 牛奶、粘膜免疫和微生物组：对新生儿的影响

Nestle Nutrition Institute workshop series Pub Date : 2020-04-24 DOI: 10.1159/isbn.978-3-318-06685-2

引用次数: 9

Global Landscape of Nutrition Challenges in Infants and Children 全球婴幼儿营养挑战概况

Nestle Nutrition Institute workshop series Pub Date : 2020-01-28 DOI: 10.1159/isbn.978-3-318-06649-4

引用次数: 4

Dedication. 奉献精神。

Nestle Nutrition Institute workshop series Pub Date : 2020-01-27 DOI: 10.2174/9789811432347120030003

Jinfu Yang, I. Daniel

引用次数: 28

Intergenerational Influences on Child Development: An Epigenetic Perspective. 代际对儿童发展的影响:一个表观遗传学的观点。

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-01-28 DOI: 10.1159/000503351

Matt J Silver

{"title":"Intergenerational Influences on Child Development: An Epigenetic Perspective.","authors":"Matt J Silver","doi":"10.1159/000503351","DOIUrl":"https://doi.org/10.1159/000503351","url":null,"abstract":"The link between poor maternal nutrition and suboptimal outcomes in offspring is well established, but underlying mechanisms are not well understood. Modifications to the offspring epigenome are a plausible mechanism for the transmission of intergenerational signals that could extend to effects of paternal nutrition mediated by epigenetic modifications in sperm. The epigenome is extensively remodeled in the early embryo. Attention has therefore focused on the periconceptional period as a time when differences in parental nutrition might influence the establishment of epigenetic marks in offspring. So-called \"natural experiments\" in The Gambia and elsewhere have highlighted loci that may be especially sensitive to periconceptional nutrition, and some are associated with health-related outcomes in later life. There is speculation that some epigenetic signals could be transmitted across multiple generations, although this would require epigenetic marks to evade epigenetic reprogramming events at conception and in primordial germ cells, and evidence for this is lacking in humans. Effects on child development spanning one or more generations could impose an intergenerational \"brake\" on a child's growth potential, limiting, for example, the rate at which populations can escape from stunting.","PeriodicalId":18986,"journal":{"name":"Nestle Nutrition Institute workshop series","volume":"93 ","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000503351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37586779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Summary on Protective Factors in Human Milk. 母乳中保护因素研究综述。

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-03-11 DOI: 10.1159/000505551

Bo Lönnerdal

引用次数: 0

Oligosaccharides and Viral Infection: Human Milk Oligosaccharides versus Algal Fucan-Type Polysaccharides. 低聚糖与病毒感染:人乳低聚糖与海藻富聚糖型多糖。

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-03-16 DOI: 10.1159/000505338

Franz-Georg Hanisch, Cem Aydogan

{"title":"Oligosaccharides and Viral Infection: Human Milk Oligosaccharides versus Algal Fucan-Type Polysaccharides.","authors":"Franz-Georg Hanisch, Cem Aydogan","doi":"10.1159/000505338","DOIUrl":"https://doi.org/10.1159/000505338","url":null,"abstract":"Norovirus infections belong to the most common causes of human gastroenteritis worldwide, and epidemic outbreaks are responsible for hundreds of thousands deaths annually. Strikingly, no antiviral treatment is available due to the difficulty in cultivating virions or in generating a vaccine, and due to the fact that their infection mechanisms are poorly understood. However, there is consent that noroviruses bind to histo-blood group antigens (HBGAs) on their way through the digestive tract. The HBGA profiles vary individually, making people more or less susceptible to different norovirus strains. In our current work, we tried to decipher the HBGA specificity of the most prevalent and clinically relevant norovirus GII.4 subfamily (Sydney 2012, JX459908) and its preferences for human milk oligosaccharides (HMOs) as potential anti-infectives. The structural evidence provided can explain at the molecular level why individuals with certain blood groups are at higher risk of infection, and how these infections may be prevented and treated by application of food additives. A central finding was that low-affinity binding of HMOs is surpassed by high-avidity binding of multivalent oligo- and polyfucoses as found in algal polysaccharides (fucoidans). Insight into structural details of fucoidans and their impact on noroviral-blocking efficiency is provided and discussed.","PeriodicalId":18986,"journal":{"name":"Nestle Nutrition Institute workshop series","volume":"94 ","pages":"124-132"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000505338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37742097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Selected Micronutrient Needs of Children 1-3 Years of Age. 1-3岁儿童的选定微量营养素需求

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-11-04 DOI: 10.1159/000511507

Steven A Abrams

{"title":"Selected Micronutrient Needs of Children 1-3 Years of Age.","authors":"Steven A Abrams","doi":"10.1159/000511507","DOIUrl":"https://doi.org/10.1159/000511507","url":null,"abstract":"Establishing dietary recommendations for micronutrients in young children is difficult. Techniques used to evaluate nutrient intake and bioavailability are hard to apply in this age group. Additionally, large variations in growth rates, dietary patterns, and nutrient losses in early childhood make determinations of dietary requirements difficult. Most recent studies have utilized stable isotopes to determine mineral absorption for iron, zinc, calcium, and magnesium. Vitamin D requirements have been established based on the dietary intake required to maintain a presumed adequate serum 25-hydroxyvitamin D concentration. Comparisons of nutrient requirements established using factorial methods involving absorption determinations and usual population intake are important to identify nutrients of concern related to deficient or excess intakes. Generally, in the USA, the intakes of calcium and magnesium are adequate to meet requirements in most toddler diets which include a milk source or a mineral-fortified milk alternative. Zinc and iron intakes can be below requirements in a substantial proportion of toddlers throughout the world, especially those with minimal meat consumption. Dietary vitamin D is generally below dietary recommendations, but clearly deficient serum 25-hydroxyvitamin D concentrations are less common, and the global role for routine vitamin D supplementation or fortification of the diet remains uncertain.","PeriodicalId":18986,"journal":{"name":"Nestle Nutrition Institute workshop series","volume":"95 ","pages":"67-77"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38567399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prelims 预备考试

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 DOI: 10.1159/000511545

引用次数: 0

Gut Microbiota, Host Gene Expression, and Cell Traffic via Milk. 肠道菌群，宿主基因表达和细胞通过牛奶运输。

Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-03-23 DOI: 10.1159/000504996

Josef Neu

{"title":"Gut Microbiota, Host Gene Expression, and Cell Traffic via Milk.","authors":"Josef Neu","doi":"10.1159/000504996","DOIUrl":"https://doi.org/10.1159/000504996","url":null,"abstract":"Contrary to common belief, the human neonate is often born with a nonsterile gastrointestinal tract, suggesting fetal colonization. This has been substantiated by numerous studies showing microbes in meconium. Shortly after birth, the infant is further colonized by microbes that reflect the diet, which in the newborn consists of milk. When fed milk from the mother's breast, the infant derives a set of live microbes that have the capability of colonizing the gastrointestinal tract. This milk also provides a source of enzymes, such as lipase and alkaline phosphatase. Milk also provides a multitude of proteins, microRNAs, and other components that putatively interact with the host intestinal innate mucosal immune system to control infection, modulate intestinal inflammation, and provide signaling to distal sites for the development of adaptive immunity as well as growth and communication with the central nervous system. Colostrum differs from transitional and mature milk by being particularly rich in immunoglobulins as well as leukocytes. Live microbes found in fresh mother's milk may be personalized for her infant and thus provide an impetus for either ensuring delivery of this personalized milk to the infant or, if that is not possible, to develop the means to personalize donor milk or formula.","PeriodicalId":18986,"journal":{"name":"Nestle Nutrition Institute workshop series","volume":"94 ","pages":"94-102"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000504996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37765252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1