Molecular immunology最新文献

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The conformational epitope of Ara h 5 was crucial to the severe reactivity of peanut allergy Ara h 5 的构象表位对花生过敏的严重反应性至关重要。
IF 3.2 3区 医学
Molecular immunology Pub Date : 2024-11-15 DOI: 10.1016/j.molimm.2024.10.004
Junjuan Wang , Mengzhen Hao , QianWei Wang , Manman Liu , Guirong Liu , Shiwen Han , Xiaoyan Zhao , Huilian Che
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引用次数: 0
Preclinical assessment of the efficacy of B7-H3 CAR-T in renal cell carcinoma B7-H3 CAR-T 对肾细胞癌疗效的临床前评估。
IF 3.2 3区 医学
Molecular immunology Pub Date : 2024-11-07 DOI: 10.1016/j.molimm.2024.10.006
Huizhong Li , Fei Wang , Haifang Zhao , Jiale Cao , Shiyuan Wang , Hongxia Li , Barbara Savoldo , Enyu Rao , Gianpietro Dotti , Hongwei Du
{"title":"Preclinical assessment of the efficacy of B7-H3 CAR-T in renal cell carcinoma","authors":"Huizhong Li ,&nbsp;Fei Wang ,&nbsp;Haifang Zhao ,&nbsp;Jiale Cao ,&nbsp;Shiyuan Wang ,&nbsp;Hongxia Li ,&nbsp;Barbara Savoldo ,&nbsp;Enyu Rao ,&nbsp;Gianpietro Dotti ,&nbsp;Hongwei Du","doi":"10.1016/j.molimm.2024.10.006","DOIUrl":"10.1016/j.molimm.2024.10.006","url":null,"abstract":"<div><div>B7-H3 is a type I transmembrane protein that belongs to the B7 immune checkpoint protein family, is aberrantly expressed in cancer cells, but rarely expressed in normal tissues, making it an attractive target for cancer therapy. Here, we found B7-H3 is highly expressed in the renal cell carcinoma (RCC) tumor tissues and RCC cell lines, but is undetectable in normal renal tissues. Therefore, we engineered second-generation CAR-T cells targeting B7-H3, incorporating either CD28 or 4–1BB co-stimulatory domains. Both CAR-T cell variants demonstrated potent antitumor activity against RCC tumors in vitro and in metastatic and orthotopic RCC mouse models. Furthermore, the B7-H3 CAR-T cells exhibited remarkable proliferation and robust cytokine release when co-cultured with RCC cancer cells. These findings demonstrated that targeting B7-H3 by CAR-T cells potentially offering a new treatment option for RCC patients.</div></div>","PeriodicalId":18938,"journal":{"name":"Molecular immunology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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