Neonatology最新文献_第5页

Impact of Retinopathy of Prematurity on Visual Motor Integration. 早产儿视网膜病变对视觉运动整合的影响。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000529594

Daniel Lukas Zimmermann, Hannah Schned, Lukas Unterasinger, Lieselotte Kirchner, Renate Fuiko, Monika Olischar, Katrin Klebermass-Schrehof, Angelika Berger, Manfred Weninger, Vito Giordano

{"title":"Impact of Retinopathy of Prematurity on Visual Motor Integration.","authors":"Daniel Lukas Zimmermann, Hannah Schned, Lukas Unterasinger, Lieselotte Kirchner, Renate Fuiko, Monika Olischar, Katrin Klebermass-Schrehof, Angelika Berger, Manfred Weninger, Vito Giordano","doi":"10.1159/000529594","DOIUrl":"https://doi.org/10.1159/000529594","url":null,"abstract":"Background: Preterm infants are at risk for neurodevelopmental deficits. An association between retinopathy of prematurity (ROP) and impaired cognitive outcome has already been described. However, less is known about the impact of ROP on visual motor integration (VMI), which is a prerequisite not only for fine motor abilities but also for further school skills. Therefore, the aim of this study was to retrospectively investigate the impact of ROP on VMI at preschool age.Methods: The study was conducted at the Medical University of Vienna, including patients born between January 2009 and December 2014 with a gestational age of less than 30 weeks and/or a birth weight of less than 1,500 g. VMI was determined by Beery-Buktenica Developmental Test of Visual Motor Integration (Beery VMI) at the age of 5 years.Results: Out of 1,365 patients, 353 met inclusion criteria for this study. Two hundred sixteen of them had no ROP, while 137 had ROP (stage 1: n = 23, stage 2: n = 74, stage 3: n = 40). Mean value of the Beery VMI score was significantly lower in the ROP group compared to the No-ROP group (90 ± 16 vs. 99 ± 14; p < 0.01). By correcting for other important medical conditions, ROP still had a significant impact on Beery VMI score (p < 0.01). Particularly, lower scores were found for stage 2 (p < 0.01) and stage 3 (p < 0.01).Conclusion: Beery VMI scores were significantly lower in preterm infants with ROP stage 2 and 3 than in infants without ROP. This study shows the negative impact of ROP on VMI skills at preschool age, even after adjustment for key demographic and medical characteristics.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":"120 3","pages":"317-324"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen Saturation Index: A Trigger for Neonatal Transfer? 氧饱和度指数:新生儿转移的触发因素?

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000529649

Srirupa Hari Gopal, Caraciolo J Fernandes

引用次数: 0

A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability. 一例伴有MIRAGE综合征的小胎龄婴儿，由于严重的体温不稳定而发生中暑和横纹肌溶解。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000529762

Kana Saito, Ryota Nakagawa, Satoshi Narumi, Hirofumi Ohashi, Akiko Ishiguro, Kazuhiko Kabe

引用次数: 0

Transition of Extremely Preterm Infants from Birth to Stable Breathing: A Secondary Analysis of the CORSAD Trial. 极度早产儿从出生到稳定呼吸的转变:CORSAD试验的二次分析。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000528754

Snorri Donaldsson, Elena Palleri, Baldvin Jonsson, Thomas Drevhammar

{"title":"Transition of Extremely Preterm Infants from Birth to Stable Breathing: A Secondary Analysis of the CORSAD Trial.","authors":"Snorri Donaldsson, Elena Palleri, Baldvin Jonsson, Thomas Drevhammar","doi":"10.1159/000528754","DOIUrl":"https://doi.org/10.1159/000528754","url":null,"abstract":"Objective: Exploratory secondary analysis of the CORSAD trial compared a new resuscitation system (rPAP) to the standard T-piece system. This analysis focused on the subgroup of infants who were not intubated in the delivery room. The aim was to compare the use of noninvasive positive pressure ventilation (PPV), oxygen saturation, and Apgar scores for the two resuscitation systems during the 30-min intervention period.Methods: This is secondary analysis of CORSAD trial using data from the intervention period in the delivery room. Infants in the original randomized system groups were divided into intubated and nonintubated groups. For nonintubated breathing infants, we compared demographics, the use of PPV, Apgar scores, and oxygen saturation at 5 and 10 min after birth. Generalized linear models were applied to calculate the risk difference and odds ratio with 95% CI between the two groups.Results: Among nonintubated infants, the use of PPV repeatedly (defined as PPV with at least 1 min of spontaneous breathing between PPV cycles) was less frequent in the rPAP group (26.8% vs. 43.3%, %RD -16.5, 95% CI [-31.7 to -1.1], p 0.04). The use of PPV after 5 min of age was also less common in the rPAP group (23.2% vs. 38.8%, %RD -15.6, 95% CI [-30.7 to -0.8], p 0.04). There were no statistically significant differences in Apgar scores or oxygen saturation levels between the groups.Conclusion: In the CORSAD trial, less PPV was needed to establish stable breathing in extremely preterm infants using the rPAP compared to using the standard T-piece without significant difference in Apgar scores or oxygenation.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":"120 2","pages":"250-256"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9341255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000527495

引用次数: 0

The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age. 出生后巨细胞病毒感染对足月龄极早产儿大脑(微)结构发育的影响。

IF 2.6 3区医学

Neonatology Pub Date : 2023-01-01 Epub Date: 2023-08-25 DOI: 10.1159/000532084

Yasmin Pellkofer, Marlene Hammerl, Elke Griesmaier, Maria Sappler, Elke Ruth Gizewski, Ursula Kiechl-Kohlendorfer, Vera Neubauer

{"title":"The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age.","authors":"Yasmin Pellkofer, Marlene Hammerl, Elke Griesmaier, Maria Sappler, Elke Ruth Gizewski, Ursula Kiechl-Kohlendorfer, Vera Neubauer","doi":"10.1159/000532084","DOIUrl":"10.1159/000532084","url":null,"abstract":"Introduction: There are some data indicating a negative impact of postnatal cytomegalovirus (CMV) infection on long-term neurodevelopmental outcome of preterm infants. So far, there is only little knowledge about a cerebral imaging correlate of these neurodevelopmental alterations induced by postnatal CMV infection in preterm infants. The aim of the current study was to investigate the effect of postnatal CMV infection on the incidence of brain injury and on microstructural brain maturation in very preterm infants at term-equivalent age.Methods: Infants <32 gestational weeks (02/2011-11/2018) received cerebral MRI including axial diffusion-weighted images at term-equivalent age. All infants were screened for CMV infection using urine/saliva samples, and infection was regarded as acquired postnatal if a sample became positive >5 postnatal days. We compared brain injury as well as fractional anisotropy and apparent diffusion coefficient in 14 defined cerebral regions between infants with and without postnatal CMV infection.Results: 401 infants were eligible, of whom 18 (4.5%) infants had a postnatal CMV infection. There were no significant differences in rates of brain injury or in microstructural brain development between both groups. This applied equally to the subgroup of infants <28 gestational weeks.Conclusion: Although infants with postnatal CMV infection were born more immature and more frequently suffered from complications related to immaturity, we neither observed a higher rate of preterm brain injury nor disadvantageous alterations in microstructural brain maturation at term-equivalent age.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":" ","pages":"727-735"},"PeriodicalIF":2.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Hypothermia for Neonatal Encephalopathy in Low-Resource Settings: Methodological Inaccuracies and Inconsistencies in the Latest Systematic Review. 低资源环境下治疗性低温治疗新生儿脑病:最新系统综述中方法的不准确和不一致。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000526596

Joseph L Mathew, Navneet Kaur, Jeanne Maria Dsouza

引用次数: 2

Incidence of Intermittent Hypoxemia Increases during Clinical Care and Parental Touch in Extremely Preterm Infants. 间断性低氧血症的发生率增加在临床护理和父母触摸在极早产儿。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000527725

Stephanie Margarete Mueller, Benjamin W Ackermann, Sven Martin, Katrin Seifert, Alina Mohr, Waseem Alali, Ulrich H Thome, Martin Grunwald

{"title":"Incidence of Intermittent Hypoxemia Increases during Clinical Care and Parental Touch in Extremely Preterm Infants.","authors":"Stephanie Margarete Mueller, Benjamin W Ackermann, Sven Martin, Katrin Seifert, Alina Mohr, Waseem Alali, Ulrich H Thome, Martin Grunwald","doi":"10.1159/000527725","DOIUrl":"https://doi.org/10.1159/000527725","url":null,"abstract":"Objectives: An increased frequency of intermittent hypoxemia (IH) is associated with a higher risk for poor developmental outcomes, disability, or death in extremely preterm infants. The objective of the prFesent study is to quantify the effect of hands-on medical and parental interventions on the incidence of IH in extremely preterm infants.Methods: An observational design with intraindividual comparisons was used. Blood oxygen saturation levels (SpO2) and time-lapse video were recorded. Frequency, duration, and time to occurrence of IH (SpO2 <80% for ≥10 s) were compared between nursing and medical care (NMC), health care by parents, skin-to-skin contact (SSC), touch in incubator, physiotherapy, and rest. Each infant was observed for six consecutive 24-h periods. Inclusion criteria were as follows: gestational age ≤28 weeks, birth weight <1500 g, postnatal age 0-6 weeks, gavage feeding, no severe illnesses or invasive procedures, no mechanical ventilation.Results: The highest proportion of time with IH occurred during NMC (2.49%) and incubator touch (1.32%), the lowest during SSC (0.74%) and health care by parents (0.67%). IH frequency per hour was highest during NMC (2.95, IQR 1.19-4.01) and lowest during SSC (0.88, IQR 0.37-2.32, p < 0.001). While an increase in IH during NMC was expected, the high incidence during incubator touch was surprising. Parental touch in the incubator is intended to be soothing, not stressful.Conclusions: Future studies need to clarify how preterm infants process touch, which attributes of touch are fundamental trigger mechanisms of IH, and which handling strategies are most effective in lowering the incidence of IH during hands-on medical care.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":"120 1","pages":"102-110"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9286468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why? 口服布洛芬对动脉导管未闭闭合比静脉注射布洛芬更有效:药代动力学模型能帮助我们理解原因吗?

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000526210

Cornelis Smit, Aline G J Engbers, Samira Samiee-Zafarghandy, Tamara van Donge, Sinno H P Simons, Robert B Flint, Marc Pfister, Catherijne A J Knibbe, John N van den Anker

{"title":"Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why?","authors":"Cornelis Smit, Aline G J Engbers, Samira Samiee-Zafarghandy, Tamara van Donge, Sinno H P Simons, Robert B Flint, Marc Pfister, Catherijne A J Knibbe, John N van den Anker","doi":"10.1159/000526210","DOIUrl":"https://doi.org/10.1159/000526210","url":null,"abstract":"Introduction: Oral ibuprofen is more effective than intravenous (IV) ibuprofen for closure of a patent ductus arteriosus (PDA). This study explored whether higher concentrations of the biologically active S-enantiomer or increased R- to S-conversion following oral dosing could explain this finding.Methods: Two datasets containing 370 S- and R-ibuprofen concentrations from 95 neonates with PDA treated with oral (n = 27, 28%) or IV ibuprofen were analyzed using nonlinear mixed effects modeling. Concentration-time profiles in typical neonates were explored and compared in different dosing or R- to S-conversion scenarios.Results: Postnatal age (PNA), gestational age (GA), and being small for GA impacted S- and R-ibuprofen clearance. Upon oral dosing, S-ibuprofen concentrations were lower compared to IV ibuprofen for a large part of the dosing interval. We could show that R- to S-conversion will not exceed 45%. Exploration of a 30% presystemic R- to S-conversion resulted in a 25-32% increase in S-ibuprofen exposure following oral administration with AUC72h values varying between 700-2,213 mg*h/L (oral) and 531-1,762 (IV) for the standard or 1,704-2,893 (oral) and 1,295-2,271 mg*h/L (IV) for PNA-based dosing.Discussion: The absence of higher S-ibuprofen concentrations does not support a beneficial concentration-time profile after oral dosing. While a fraction of up to 45% presystemic R- to S-conversion could not be ruled out, the impact of such a low conversion might be only relevant for the standard but not high dosing regimens, considering reported exposure-response targets. Perhaps, the lack of high peak concentrations observed following IV dosing may play a role in the observed effects upon oral dosing.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":"120 1","pages":"81-89"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exposed and Abandoned. Origins of the Foundling Hospital. 暴露和遗弃。育婴堂的起源。

IF 2.5 3区医学

Neonatology Pub Date : 2023-01-01 DOI: 10.1159/000527837

Michael Obladen

{"title":"Exposed and Abandoned. Origins of the Foundling Hospital.","authors":"Michael Obladen","doi":"10.1159/000527837","DOIUrl":"https://doi.org/10.1159/000527837","url":null,"abstract":"Abandoning undesired newborn infants was a Roman form of family limitation. They were exposed or given to foster mothers. Christianization alleviated their lot when in 374 CE, Emperor Valentinian's law provided some protection. The Milan Foundling Hospital was established in 787 CE. When the Carolingian Empire fell apart during the 10th century, monastic networks (the Holy Spirit Order and Daughters of Charity) took over social support for the poor, the sick, and the insane. Foundling hospitals proliferated in Italy between the 13th and 15th centuries, in France during the 16th and 17th, and in Germany and Austria in the 18th century. Metropolitan hospices admitted thousands of infants each year. Most were not \"found\" exposed but were admitted anonymously via a revolving box or registered in an open office. Soon after admission, they were transported for foster care to wet nurses in villages. Sick infants, especially those suspected of suffering from syphilis, were denied the breast, and artificial feeding was tried with little success. Official death statistics were falsified by relating infant deaths not to admissions but to the total number of children cared for. Over 60% died during their first year of life, mostly from pre-admission problems such as malformation, hypothermia, and disease; from poor hygiene in overcrowded wards; and from artificial feeding. Although not intended for that purpose, the hospices became medical research institutions when in late 18th century, physicians and surgeons were employed by maternity and foundling hospitals.","PeriodicalId":18924,"journal":{"name":"Neonatology","volume":"120 1","pages":"134-141"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0