Natural products chemistry & research最新文献_第10页

Identification of Five New Triterpenoids from Ethylacetate Bark Extract of Holoptelea integrifolia (Roxb.) Planch by GC-MS 全天麻树皮乙酸乙酯提取物中5个新三萜的鉴定气相色谱-质谱法测定

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000338

Amir Hassan, M. Rasheed, Mohsin Ali, Ghazala Ishrat, Mansoor M Ahmed

引用次数: 4

Insight into Saccharothrix espanaensis Grown in Different Media:Transcriptome and Natural Product Analysis 不同培养基中生长的西班牙糖丝菌:转录组和天然产物分析

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000333

S. Samra, B. Tokovenko, Monika Kaszubowska, Roman Makitrynskyy, Ahmad Alali, Yvonne Schmidt, E. Welle, Sandra Gross, T. Paululat, A. Luzhetskyy, A. Bechthold

{"title":"Insight into Saccharothrix espanaensis Grown in Different Media:Transcriptome and Natural Product Analysis","authors":"S. Samra, B. Tokovenko, Monika Kaszubowska, Roman Makitrynskyy, Ahmad Alali, Yvonne Schmidt, E. Welle, Sandra Gross, T. Paululat, A. Luzhetskyy, A. Bechthold","doi":"10.4172/2329-6836.1000333","DOIUrl":"https://doi.org/10.4172/2329-6836.1000333","url":null,"abstract":"In this study, we show that cultivating of Saccharothrix espanaensis in the amino acid-rich SPY medium led to the detection of antibacterial and antifungal products. The cultivation in GYM-, HA- or NL111-medium did not lead to the production of these compounds. Four products were isolated from Saccharothrix espanaensis-SPY culture and determined as the known compounds anthranilic acid, indol-3-carboxylic acid, benzoic acid, and phenylacetic acid. In order to investigate the influence of SPY medium on gene transcription and to identify candidate genes involved in the biosynthesis of the purified compounds a comparative RNA sequencing analysis of Saccharothrix espanaensis cultivated in different media was performed. Total transcriptome analysis demonstrated that media composition has an influence on the expression of several genes. Among them are genes encoding enzymes belong to amino acid metabolism enzymes. Furthermore, based on the collected data genes involved in the biosynthesis of anthranilic acid, indol-3-carboxylic acid, benzoic acid, and phenylacetic acid could be predicted. Deletion of the genes BN6_01860 and BN6_67950 revealed their importance in the biosynthesis of indole-3-carboxylic acid and benzoic acid, respectively.","PeriodicalId":18897,"journal":{"name":"Natural products chemistry & research","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78885336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of DPPH Free Radical Scavenging Activity by RP-HPLC, Rapid Sensitive Method for the Screening of Berry Fruit Juice Freeze Dried Extract 反相高效液相色谱法测定浆果果汁冻干提取物清除DPPH自由基的活性

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000341

P. Kumara, K. Sunil, B. Arunkumar

{"title":"Determination of DPPH Free Radical Scavenging Activity by RP-HPLC, Rapid Sensitive Method for the Screening of Berry Fruit Juice Freeze Dried Extract","authors":"P. Kumara, K. Sunil, B. Arunkumar","doi":"10.4172/2329-6836.1000341","DOIUrl":"https://doi.org/10.4172/2329-6836.1000341","url":null,"abstract":"USP official UV-VIS spectrophotometric method for the evaluation of antioxidant activity by scavenging the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical was not suitable to determine the antioxidant activity of Berry fruit juice freeze dried extract due to interferences from the matrix. Interference was also observed from the color pigments of the Berry fruit juice freeze dried extract. This has leads to the development of a specific analytical method for evaluation of the DPPH free radical scavenging activity of Berry fruit juice freeze dried extract. RP-HPLC method was developed on a Phenomenex Luna-C18 Column (250 mm × 4 mm, 5 μM) with mobile phase methanol and water mixed online in the ratio of 80:20 (v/v), pumped at a flow rate of 1 mL/min. DPPH peaks were quantified at wavelength 517 nm. Method was standardized using the anti-oxidant ascorbic acid. The 50% free radical scavenging activity (IC50) determined by the novel HPLC method was correlating with the results obtained by USP UV-VIS spectrophotometric method. While the USP UV-VIS spectrophotometric method failed to estimate the free radical scavenging activity of Berry fruit juice freeze dried extract, whereas the developed HPLC method was specific, sensitive, robust, accurate and precise and rapid in the determination.","PeriodicalId":18897,"journal":{"name":"Natural products chemistry & research","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89394027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Comparison of Medicinally Important Natural Products versus Synthetic Drugs-A Short Commentary 重要药用天然产物与合成药物的比较——简评

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000308

Bushra Nisar, Aeysha Sultan, S. Rubab

引用次数: 71

Antibacterial Activity of a Novel Depsipeptide and Prodigiosine of Serratia marcescans S823 一种新型粘质沙雷菌S823沉积肽和子芥子苷的抗菌活性研究

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000312

Linyan Zhu, Cuiping Pang, Liqun Chen, Xiangdong Zhu

引用次数: 5

Extracts from the Brown Macroalga Sargassum vulgare for Postharvest Suppression of Potato Fusarium Dry Rot 褐藻提取物采后对马铃薯枯萎病干腐病的抑制作用

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000329

N. Ammar, H. Jabnoun-Khiareddine, Ahlem Nefzia, Boutheina Mejdoub‐Trabelsi, M. Daami‐Remadi

{"title":"Extracts from the Brown Macroalga Sargassum vulgare for Postharvest Suppression of Potato Fusarium Dry Rot","authors":"N. Ammar, H. Jabnoun-Khiareddine, Ahlem Nefzia, Boutheina Mejdoub‐Trabelsi, M. Daami‐Remadi","doi":"10.4172/2329-6836.1000329","DOIUrl":"https://doi.org/10.4172/2329-6836.1000329","url":null,"abstract":"Sargassum vulgare aqueous and organic extracts were screened in vitro and in vivo for their antifungal potential toward Fusarium sambucinum the most aggressive causal agent of Fusarium dry rot in Tunisia. All extracts had suppressed pathogen growth depending on alga sampling sites, nature of extracts and tested concentrations. Aqueous extracts removed from Monastir, Mahdia1 and Mahdia2, applied at 100 mg/mL, were effective in reducing pathogen growth by more than 36% compared to control. Petroleum ether, methanol and chloroform extracts from Mahdia2, tested at 100 mg/mL, had suppressed F. sambucinum mycelial growth by up to 34%. Tested as tuber treatment Sargassum ethyl acetate extracts removed from Tunis and Monastir (applied at 5 mg/mL) exhibited important disease suppressive abilities by decreasing dry rot lesion diameter by 53.18 and 54.18%, and rot penetration was lowered by 70.66 and 61.85%, respectively, relative to pathogen-inoculated control. Variable amounts of phenolic compounds were determined according to Folin-Ciocalteau method. These results showed that S. vulgare may be explored for the isolation of antifungal compounds for Fusarium dry rot control useful in agriculture.","PeriodicalId":18897,"journal":{"name":"Natural products chemistry & research","volume":"21 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87433958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Heavy Metals Concentration in Facial Cosmetics 面部化妆品中的重金属含量

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2475-7675.1000303

Aldayel O, Hefne J, Alharbi Kn, Al Ajyan T

引用次数: 9

Isolation and Analytic Characterization of andbeta;-Sitosterol and GC-MS Analysis of Methanolic Leaves Extract of Pongamia pinnata (L.) pierre 桄榔子叶甲醇提取物中β -谷甾醇的分离、分析及GC-MS分析

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000348

S. Sangwan

引用次数: 0

Synthesis, Reactions and Medicinal Importance of Cyclic Sulfone Derivatives: A Review 环砜衍生物的合成、反应及药用价值综述

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2329-6836.1000350

M. A. Alam, K. Shimada, Aklima Jahan, M. Khan, M. H. Bhuiyan, M. Alam, M. Matin

{"title":"Synthesis, Reactions and Medicinal Importance of Cyclic Sulfone Derivatives: A Review","authors":"M. A. Alam, K. Shimada, Aklima Jahan, M. Khan, M. H. Bhuiyan, M. Alam, M. Matin","doi":"10.4172/2329-6836.1000350","DOIUrl":"https://doi.org/10.4172/2329-6836.1000350","url":null,"abstract":"Sulfones or the cyclic sulfones are the type of organosulfur compounds that attract the special interest to organic chemists. Vast applications are observed in different fields with these types of sulfone containing compounds and their derivatives like in medicinal chemistry and also give the importance to many kinds of biological activity. The sulfones and their derivatives are used in many other fields as pharmaceutical and polymeric agents. Sulfone containing compounds are also used for the treatment of different diseases like dermatitis herpetiformis, leprosy, tuberculosis and others. The researchers have been giving much concentration to synthesize many types of sulfone compounds because of their various strong medicinal activities like as biological, antimalarial, antimicrobial, antiinflammatory, anticancer, anti-HIV, and anti-inflammatory and in other sectors also. These kinds of vast importance encourage us to study about the synthesis, reactions and applications of cyclic sulfones and their derivatives. The present article will provide some important information about the synthesis, reactions and applications of cyclic sulfone type compounds to the chemists to facilitate them in advance research works with more concentration which will be more beneficial for the society as well as for upcoming science generation.","PeriodicalId":18897,"journal":{"name":"Natural products chemistry & research","volume":"99 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88310786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Isolation of a Potent Naturally Occurring Hallucinogen, Salvinorin A, from Salvia divinorum and Investigation of Its Photo-degradation 天然致幻剂Salvinorin a的分离及其光降解研究

Natural products chemistry & research Pub Date : 2018-01-01 DOI: 10.4172/2475-7675.1000305

Luann Wong, S. Stevens, M. Hengel, T. Shibamoto

引用次数: 0