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A transgenic rat model for reducing adult neurogenesis 减少成年神经发生的转基因大鼠模型
Nature Precedings Pub Date : 2012-07-20 DOI: 10.6084/M9.FIGSHARE.93088.V1
S. Jason, A. Heather, Brewer Michelle, Pickel Jim, Grigereit Laura
{"title":"A transgenic rat model for reducing adult neurogenesis","authors":"S. Jason, A. Heather, Brewer Michelle, Pickel Jim, Grigereit Laura","doi":"10.6084/M9.FIGSHARE.93088.V1","DOIUrl":"https://doi.org/10.6084/M9.FIGSHARE.93088.V1","url":null,"abstract":"The function of adult neurogenesis remains unclear. While many tools for manipulating neurogenesis have been developed for mice, there are fewer tools for rats. Radiological and chemical strategies have been used to inhibit adult neurogenesis in rats but these methods may also have undesired side effects. Since rats have a larger brain and can perform complex behaviors, it would be useful to have additional rat models for studying neurogenesis. To address this gap we therefore developed a transgenic GFAP-TK rat in which adult neurogenesis can be specifically inhibited. Preliminary results suggest that, as in mice, reduced adult neurogenesis leads to anhedonia.","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"29 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86849809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Electron Transfer Pathways in Cell 细胞中的电子传递途径
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7149.1
Yan Liu
{"title":"Electron Transfer Pathways in Cell","authors":"Yan Liu","doi":"10.1038/NPRE.2012.7149.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7149.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"1 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85916784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome Replikin Count Predicts Increased Lethality of Resistant Tuberculosis 基因组复制蛋白计数预测耐药结核病的致死率增加
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7141.1
S. Bogoch, E. Bogoch
{"title":"Genome Replikin Count Predicts Increased Lethality of Resistant Tuberculosis","authors":"S. Bogoch, E. Bogoch","doi":"10.1038/NPRE.2012.7141.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7141.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"35 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78672778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prelude report on molecular docking of HER2 protein towards comprehending anti-cancer properties of saponins from Solanum tuberosum HER2蛋白分子对接对了解龙葵皂苷抗癌作用的初步报道
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7147.1
P. Singh, Pratyoosh Shukla
{"title":"A prelude report on molecular docking of HER2 protein towards comprehending anti-cancer properties of saponins from Solanum tuberosum","authors":"P. Singh, Pratyoosh Shukla","doi":"10.1038/NPRE.2012.7147.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7147.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"44 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87516063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel apparatus/protocol designed for optogenetic manipulation and recording of individual neurons during a motivation and working memory task in the rodent 在啮齿类动物的动机和工作记忆任务中，设计了一种用于光遗传学操作和记录单个神经元的新设备/方案
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7152.1
Samuel D. Dolzani, D. Cooper
{"title":"A novel apparatus/protocol designed for optogenetic manipulation and recording of individual neurons during a motivation and working memory task in the rodent","authors":"Samuel D. Dolzani, D. Cooper","doi":"10.1038/NPRE.2012.7152.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7152.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80598157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine trpc1基因缺失及其对可卡因运动和条件位置偏好反应的影响
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7153.1
D. Cooper, Melissa A. Fowler, Andrew L. Varnell, A. Dietrich, L. Birnbaumer
{"title":"Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine","authors":"D. Cooper, Melissa A. Fowler, Andrew L. Varnell, A. Dietrich, L. Birnbaumer","doi":"10.1038/NPRE.2012.7153.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7153.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82761898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A call for disruptive innovation in science publishing with a new open data-sharing platform for the life sciences 呼吁在科学出版领域进行颠覆性创新，为生命科学提供一个新的开放数据共享平台
Nature Precedings Pub Date : 2012-04-04 DOI: 10.1038/NPRE.2012.7151.1
D. Cooper
{"title":"A call for disruptive innovation in science publishing with a new open data-sharing platform for the life sciences","authors":"D. Cooper","doi":"10.1038/NPRE.2012.7151.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7151.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80093700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Unfolded Protein Response and its potential role in Huntington's disease 未折叠蛋白反应及其在亨廷顿病中的潜在作用
Nature Precedings Pub Date : 2012-04-03 DOI: 10.1038/NPRE.2012.7145.1
R. Kalathur, Kamesh R. Ayasolla, M. Futschik
{"title":"The Unfolded Protein Response and its potential role in Huntington's disease","authors":"R. Kalathur, Kamesh R. Ayasolla, M. Futschik","doi":"10.1038/NPRE.2012.7145.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7145.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"40 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75251450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Generalized Theory of Life 广义生命理论
Nature Precedings Pub Date : 2012-04-03 DOI: 10.1038/NPRE.2012.7108.1
V. Kalmykov
{"title":"Generalized Theory of Life","authors":"V. Kalmykov","doi":"10.1038/NPRE.2012.7108.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7108.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"42 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86509353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information 线粒体遗传密码的起源:迈向遗传信息管理的统一数学框架
Nature Precedings Pub Date : 2012-04-03 DOI: 10.1038/NPRE.2012.7136.1
D. González, S. Giannerini, R. Rosa
{"title":"On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information","authors":"D. González, S. Giannerini, R. Rosa","doi":"10.1038/NPRE.2012.7136.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7136.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"17 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81742015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
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